Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).

Cat. No.	Product name	CAS No.	Purity
T11138L	LHF-535	1450929-77-7	98%
T11138L	LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
TN1202	(-)-α-Pinene	7785-26-4	98%
TN1202	(1S)-(-)-Alpha-Pinene is a natural product
T13397	ZINC03129319	1777807-64-3	98%
T13397	ZINC03129319 is an inhibitor of dengue virus (DENV) NS2B-NS3 protease,and has inhibition constants (Ki1) of 92 μM and Ki3 of 20 μM.
T9761	VUN65671	2479465-67-1	98%
T9761	VUN65671is a Potent Entry Inhibitor of Ebola and Marburg Virus Infections. VUN65671 was reported in Journal of Medicinal Chemistry (2020), 63(13), 7211-7225. Thi...
T0220	Foscarnet sodium	63585-09-1
T0220	Foscarnet sodium is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T18928	Brilliant Black BN	2519-30-4
T18928	Brilliant black BN (E151) is an azo dye and a food colorant. It is a promising antiviral agent against EV71 infection via inhibiting the interaction between EV71...
T2A2498	L-Lysine	56-87-1	100%
T2A2498	Lysine is one of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and da...
T4061	LY2334737	892128-60-8	100%
T4061	LY2334737 is an orally available prodrug of gemcitabine with antineoplastic activity.
T5666	Dipotassium glycyrrhizinate	68797-35-3	89.63%
T5666	Dipotassium glycyrrhizinate is an anionic surfactant having anti-allergic and anti-inflammatory activities.
T6327	Tubacin	537049-40-4	95.63%
T6327	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
T6309	AZ960	905586-69-8	96.02%
T6309	AZ 960 is an effective ATP competitive JAK2 inhibitor (IC50/Ki: <3 nM and0.45 nM).
T8903	Retro-2	1201652-50-7	96.08%
T8903	Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endos...
T3S1852	Cephaeline hydrochloride	3738-70-3	97.81%
T3S1852
T5S1805	5,7-Dihydroxychromone	31721-94-5	98%
T5S1805	1. 5, 7-Dihydroxychromone isolated from DME is one of the active compounds that may contribute to regulate blood glucose levels. 2. 5, 7-Dihydroxychromone exerts...
T6S0095	Genkwanin	437-64-9	98%
T6S0095	1. Genkwanin exerts its anti-inflammatory effect mainly through the regulation of the miR-11/MKP-1/MAPK pathway. 2. Genkwanin is transported by both passive diff...
T8071	L-Lysine hydrochloride	657-27-2	98%
T8071	L-lysine hydrochloride is an essential amino acid for humans with various benefits including treating herpes, reducing diabetes-related illnesses, increasing cal...
T5779	MOSLOFLAVONE	740-33-0	98%
T5779	MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.
T7366	NGI-1	790702-57-7	98%
T7366	NGI-1 is a a cell-permeable inhibitor of oligosaccharyltransferase (OST).can effectively reduce virus infectivity without affecting cell viability.
T6605	NH125	278603-08-0	98.04%
T6605	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
T8371	ML188	1417700-13-0	98.04%
T8371	ML188 is a selective noncovalent SARS-CoV 3CLpro inhibitor(IC50 : 1.5 μM), with moderate MW and good enzyme and antiviral inhibitory activity.