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Microbiology/Virology

Penicillin-binding protein (PBP)

(4)

RSV

(89)

Reverse Transcriptase

Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).

Filter HomeSignaling PathwaysMicrobiology/VirologyVirus Protease

Leupeptin Hemisulfate

T6564103476-89-7

Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.

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B220

T10445112228-65-6In house

B220, an antiviral agent, inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV).

$178

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Xanthohumol

T33426754-58-1

Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects.

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Rifampicin

T068113292-46-1

Rifampicin (Rifamycin AMP) is a broad-spectrum antibiotic. Rifampicin has a strong antibacterial effect against Mycobacterium tuberculosis and is also effective against gram-positive and gram-negative bacteria and viruses.

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Artesunate

T043388495-63-0

Artesunate (WR-256283) is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin, Artesunate is soluble in water but has poor stability in aqueous solutions at neutral or acid pH.

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Rupintrivir

T16809223537-30-2

Rupintrivirvr (AG7088) is a selective rhinovirus (HRV) 3C cysteine protease mimetic peptide inhibitor with antiviral and immunomodulatory activities.Rupintrivirvr inhibits the replication of EV71 and EV-D68, and may be useful for the study of viral infections.

$118

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Cytarabine

T1272147-94-4

Cytarabine (Ara-C) is a nucleoside analog, an inhibitor of DNA synthesis (IC50=16 nM). Cytarabine inhibits DNA polymerase and induces cell cycle arrest, autophagy, and apoptosis. Cytarabine has antitumor activity.

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TTP-8307

T13221950225-08-8In house

TTP-8307 is an antiviral compound that inhibits the replication of rhinoviruses and enteroviruses, and inhibits coxsackievirus B3 and poliovirus by interfering with viral RNA synthesis.TTP-8307 can be used in the study of viral infections.

$107

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Dynasore

T1848304448-55-3

Dynasore (Dynamin Inhibitor I), a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.

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Brequinar

T501396187-53-0

Brequinar (NSC-368390) is a potent inhibitor of dihydroorotate dehydrogenase, with potent activities against a broad spectrum of viruses.

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Lanatoside C

T167017575-22-3

Lanatoside C (Ceglunate) is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). Lanatoside C can be used orally or by the intravenous route.

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EIDD-1931

T84983258-02-4

EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity that inhibits the replication of severe acute respiratory syndrome coronavirus [SARS-CoV] in Vero 76 cells, Middle East respiratory syndrome coronavirus [MERS-CoV] in Calu-3 2B4 cells, and SARS-CoV-2 in Vero cells (IC50s = 0.1, 0.15, and 0.3 μM, respectively).

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3-deazaneplanocin A HCl

T6360120964-45-6

3-deazaneplanocin A (DZNeP)HCl, an analog of adenosine, is a competitive inhibitor of S-adenosylhomocysteine hydrolase with Ki of 50 pM.

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Theaflavin 3,3′-digallate

T542930462-35-2

Theaflavin 3,3'-digallate, a major polyphenol found in black tea, is an inducer of oxidative stress which has anti-inflammatory and cancer chemopreventive actions, it reduces tumor angiogenesis by downregulating HIF-1αand VEGF.

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MOSLOFLAVONE

T5779740-33-0

MOSLOFLAVONE showed promising anti-inflammatory activity via inhibition of TNF-α and IL-1β with IC50 values of 0.71 μM and 7.8 μM, respectively.

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Vorinostat

T1583149647-78-9

Vorinostat (SAHA) is a pan-histone deacetylase (HDAC) inhibitor (IC50=10 nM) with inhibitory activity against HDAC1/2/3/6/7/11. Vorinostat has antitumor activity, induces cell differentiation, blocks the cell cycle and induces apoptosis.

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Fialuridine

T765569123-98-4

Fialuridine (DRG-0098) is a DNA-directed DNA polymerase inhibitor potentially for the treatment of HBV infection with potent activity against hepatitis B virus in vitro and in vivo.

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Retro-2 cycl

T127111429192-00-6

Retro-2 cycl is a dihydroquinazolinone (DHQZ) retrograde trafficking inhibitor. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus(IC50s of 54 μM and 160 μM, respectively),with antiviral agent.

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Cephaeline

TN1480483-17-0

Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeostasis.

$123

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Thymidine

TWP291150-89-5

Thymidine (DThyd) is a cell synchronizing agent and a specific precursor of deoxyribonucleic acid. Thymidine inhibits DNA synthesis and can cause cell cycle arrest in the G1/S phase.

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(-)-Epicatechin gallate

T27321257-08-5

(-)-Epicatechin gallate ((-)-Epicatechin 3-O-gallate) is one of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicidin A (gA) channels as probes. All the catechins alter gA channel function and modify bilayer properties, with a 500-fold range in potency. The gallate group causes current block, as evident by brief downward current transitions.

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Ribavirin

T068436791-04-5

Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.

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Plerixafor

T1776110078-46-1

Plerixafor (AMD-3329), a chemokine receptor antagonist, blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4.

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Mitoxantrone

T658865271-80-9

Mitoxantrone (mitozantrone) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin.

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