Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).

Cat. No.	Product name	CAS No.	Purity
T72041	Flaviviruses-IN-2	1009762-84-8	98%
T72041	Flaviviruses-IN-2 is a potent flaviviruses inhibitor. Flaviviruses-IN-2 reduces West Nile virus (WNV) protease activity and inhibits WNV by 56%.
T38960	QL-X-138	1469988-63-3	98%
T38960	QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, ...
T63143	DENV-IN-5	2375781-06-7	98%
T63143	Denv-in-5 is an effective and selective dengue virus (DENV) inhibitor with EC50 values of 1.47, 9.23, 7.08, 8.91 μM for denV-I-IV and 0.1512 μM for HIV-1IIIB.
T0011	2-Phenylethanol	60-12-8	98%
T0011	Phenethyl alcohol is an antimicrobial, antiseptic, and disinfectant. It is used also as an aromatic essence and preservative in pharmaceutics and perfumery.
T2875	Angelicin	523-50-2	98%
T2875	Angelicin, is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
T5S1923	Schisandrin C	61301-33-5	98%
T5S1923	Schisandrin C is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
T0939	Phenytoin	57-41-0	98%
T0939	Phenytoin is a hydantoin derivative and a non-sedative antiepileptic agent with anticonvulsant activity. Phenytoin potentially acts by promoting sodium efflux fr...
T1583	Vorinostat	149647-78-9	98%
T1583	Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
T6516	Golgicide A	1139889-93-2	98%
T6516	Golgicide A is a potent and rapidly reversible GBF1 inhibitor.
T0433	Artesunate	88495-63-0	98%
T0433	Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore...
T11138L	LHF-535	1450929-77-7	98%
T11138L	LHF-535 is an antiviral compound. It has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively.
TN1480	Cephaeline	483-17-0	98%
TN1480	Cephaeline was highly active against protected primary CLL cells (relative IC50's 35nM ) and acted by repressing HIF-1α± and disturbing intracellular redox homeo...
T4536	Pleconaril	153168-05-9	98%
T4536	Pleconaril is a capsid inhibitor used previously to treat enterovirus infections. Pleconaril is effective in inhibiting replication (IC50: 50 nM).
T6377	Aloperine	56293-29-9	98%
T6377	Aloperine exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties.
T5S2360	Corydaline	518-69-4	98%
T5S2360	1. Corydaline, an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and...
T2616	PIK-93	593960-11-3	98%
T2616	PIK-93 is the first potent, synthetic PI4K inhibitor with IC50 of 19 nM; inhibits PI3Kα with IC50 of 39 nM.
T1670	Lanatoside C	17575-22-3	98%
T1670	Lanatoside C is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia (irregular heartbeat). L...
T3717	Hinokitiol	499-44-5	98%
T3717	β-thujaplicin can inhibit ultraviolet B-induced apoptosis in keratinocytes and strongly suggest that the inhibitory mechanism is due to the antioxidant activity ...
T2732	(-)-Epicatechin gallate	1257-08-5	98%
T2732	One of the catechin isomers and a potent antioxidant that can modulate a wide range of membrane proteins. Its bilayer-modifying potency was tested using gramicid...
T13006	ST-193	489416-12-8	98%
T13006	ST-193 is a potent inhibitor of broad-spectrum arenavirus(Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1.4 and 3.1 nM, respectively)...