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Virus Protease

Virus protease or 3C protease are virus cysteine proteases which have essential role in viral replication. The protease cleaves the precursor viral polyprotein to produce functional proteins and enzymes.Virus proteases are attractive target for therapeutic agents for treatment of diseases caused by the common cold virus.Viral protease - a Cys protease fold is similar to that of trypsin-like serine proteases. The active site triad contains Cys147, His40 and Glu71 (PDB entry 1cqq).
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T78618 NSC 288387 61369-43-5 98%
NSC 288387
NSC 288387, a pan-flavivirus MTase inhibitor, binds to the SAM-binding pocket and effectively inhibits Zika virus (ZIKV) with an IC50 of 0.2 μM, also preventing ...
T78653 NS2B/NS3-IN-3 hydrochloride 2832876-91-0 98%
NS2B/NS3-IN-3 hydrochloride
NS2B/NS3-IN-3 hydrochloride is a Flavivirus NS2B-NS3 protease inhibitor [1].
T79141 Mosnodenvir 2890688-86-3 98%
Mosnodenvir
Mosnodenvir (JNJ-1802), a pan-serotype dengue antiviral agent, exhibits picomolar to low nanomolar in vitro activity with a high barrier to resistance and is saf...
T79630 CDK9-IN-25 98%
CDK9-IN-25
CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM. It also exhibits affinity for the main protease o...
T79676 SARS-CoV-2 3CLpro-IN-21 98%
SARS-CoV-2 3CLpro-IN-21
SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Addi...
T79677 SARS-CoV-2-IN-58 98%
SARS-CoV-2-IN-58
SARS-CoV-2-IN-58 (Compound 21H) serves as an antiviral agent targeting SARS-CoV-2, demonstrating efficacy with an EC50 of 18 μM. It specifically inhibits the SAR...
T79867 Ibuzatrelvir 2755812-39-4 98%
Ibuzatrelvir
Ibuzatrelvir (PF-07817883) is an antiviral compound designed to inhibit the SARS-CoV-2 3CL protease, and is utilized in the treatment of COVID-19 [1].
T80002 Wulfenioidin F 98%
Wulfenioidin F
Wulfenioidin F, a diterpenoid isolated from the whole plant of Orthosiphon wulfenioides, exhibits anti-Zika virus (ZIKV) activity with an EC50 of 8.07 μM and hin...
T80657 SARS-CoV-2 3CLpro-IN-15 3156-41-0 98%
SARS-CoV-2 3CLpro-IN-15
SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral ...
T80691 β-Herpesvirus protease-IN-1 98%
β-Herpesvirus protease-IN-1
β-Herpesvirus protease-IN-1 (compound 19) serves as an inhibitor of β-herpesvirus protease, exhibiting IC50 values of 2.5 μM for HCMVPro and 0.33 μM for HHV6Pro ...
T81641 NS2B-NS3pro-IN-2 98%
NS2B-NS3pro-IN-2
Compound 11, also known as NS2B-NS3pro-IN-2, functions as an inhibitor of the Zika Virus NS2B-NS3 protease and exhibits antiviral properties at a concentration o...
T81642 NS2B-NS3pro-IN-1 98%
NS2B-NS3pro-IN-1
NS2B-NS3pro-IN-1, a potent Zika Virus NS2B-NS3 protease inhibitor, exhibits an EC50 of 50 μM and is significant in the ZIKV replication cycle [1].
T74083 4-Hydroxy-2-methylbenzenesulfonic acid ammonium 2742982-16-5 98%
4-Hydroxy-2-methylbenzenesulfonic acid ammonium
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity found in Policresulen, which serves as a powerful NS2B/NS3 protease inhibitor, exhibiting an IC50 ...
T38399 (Rac)-Golgicide A 1005036-73-6 98%
(Rac)-Golgicide A
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.
T16702 QL47 1469988-75-7 98%
QL47
QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translatio...
T0254 Probucol 23288-49-5 99.99%
Probucol
Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
T0011 2-Phenylethanol 60-12-8 99.99%
2-Phenylethanol
2-Phenylethanol (Phenylethanol) is an antimicrobial, antiseptic, and disinfectant. It is used also as an aromatic essence and preservative in pharmaceutics and p...
T2875 Angelicin 523-50-2 99.98%
Angelicin
Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
T5S1923 Schisandrin C 61301-33-5 99.98%
Schisandrin C
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
T0008 Phenytoin sodium 630-93-3 99.96%
Phenytoin sodium
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
NSC 288387
T78618
NSC 288387, a pan-flavivirus MTase inhibitor, binds to the SAM-binding pocket and effectively inhibits Zika virus (ZIKV) with an IC50 of 0.2 μM, also preventing ...
NS2B/NS3-IN-3 hydrochloride
T78653
NS2B/NS3-IN-3 hydrochloride is a Flavivirus NS2B-NS3 protease inhibitor [1].
Mosnodenvir
T79141
Mosnodenvir (JNJ-1802), a pan-serotype dengue antiviral agent, exhibits picomolar to low nanomolar in vitro activity with a high barrier to resistance and is saf...
CDK9-IN-25
T79630
CDK9-IN-25 (compound 4a), an imidazopyrazine derivative, functions as a CDK9 inhibitor with an IC50 of 0.24 μM. It also exhibits affinity for the main protease o...
SARS-CoV-2 3CLpro-IN-21
T79676
SARS-CoV-2 3CLpro-IN-21 (Compound D6) is an irreversible, covalent inhibitor of SARS-CoV-2 3CL pro, demonstrating potent inhibition with an IC50 of 0.03 μM. Addi...
SARS-CoV-2-IN-58
T79677
SARS-CoV-2-IN-58 (Compound 21H) serves as an antiviral agent targeting SARS-CoV-2, demonstrating efficacy with an EC50 of 18 μM. It specifically inhibits the SAR...
Ibuzatrelvir
T79867
Ibuzatrelvir (PF-07817883) is an antiviral compound designed to inhibit the SARS-CoV-2 3CL protease, and is utilized in the treatment of COVID-19 [1].
Wulfenioidin F
T80002
Wulfenioidin F, a diterpenoid isolated from the whole plant of Orthosiphon wulfenioides, exhibits anti-Zika virus (ZIKV) activity with an EC50 of 8.07 μM and hin...
SARS-CoV-2 3CLpro-IN-15
T80657
SARS-CoV-2 3CLpro-IN-15 (compound a), a beta-nitrostyrene derivative, acts as an inhibitor of the SARS-CoV-2 3CL protease (3CLpro), effectively inhibiting viral ...
β-Herpesvirus protease-IN-1
T80691
β-Herpesvirus protease-IN-1 (compound 19) serves as an inhibitor of β-herpesvirus protease, exhibiting IC50 values of 2.5 μM for HCMVPro and 0.33 μM for HHV6Pro ...
NS2B-NS3pro-IN-2
T81641
Compound 11, also known as NS2B-NS3pro-IN-2, functions as an inhibitor of the Zika Virus NS2B-NS3 protease and exhibits antiviral properties at a concentration o...
NS2B-NS3pro-IN-1
T81642
NS2B-NS3pro-IN-1, a potent Zika Virus NS2B-NS3 protease inhibitor, exhibits an EC50 of 50 μM and is significant in the ZIKV replication cycle [1].
4-Hydroxy-2-methylbenzenesulfonic acid ammonium
T74083
4-Hydroxy-2-methylbenzenesulfonic acid ammonium is an impurity found in Policresulen, which serves as a powerful NS2B/NS3 protease inhibitor, exhibiting an IC50 ...
(Rac)-Golgicide A
T38399
(Rac)-Golgicide A ((Rac)-GCA) is a racemate of Golgicide A. It is used in the manufacture of Golgicide A.
QL47
T16702
QL47 is a host-targeted small molecule antiviral agent with antiviral activity against dengue and other RNA viruses.QL47 acts as an inhibitor of viral translatio...
Probucol
T0254
Probucol (DH-581), an anti-hyperlipidemic drug, can lower the level of cholesterol in the bloodstream by increasing the LDL catabolic rate.
2-Phenylethanol
T0011
2-Phenylethanol (Phenylethanol) is an antimicrobial, antiseptic, and disinfectant. It is used also as an aromatic essence and preservative in pharmaceutics and p...
Angelicin
T2875
Angelicin (Isopsoralen), is a furanocoumarin with anti-Y, antiviral, anti-inflammatory activity.
Schisandrin C
T5S1923
Schisandrin C (Wuweizisu-C) is a phytochemical lignan isolated from Schizandra chinensis Baill; shows anticancer-effects in human leukemia U937 cells.
Phenytoin sodium
T0008
Phenytoin sodium (Diphantoine) is an inactive stabilizer for voltage-gated sodium channel .
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TargetMol