T2653 |
SB1317
|
1204918-72-8
|
98%
|
|
SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
|
T6193 |
Dovitinib Dilactic Acid
|
852433-84-2
|
98%
|
|
Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
|
T10592 |
BPR1K871
|
2443767-35-7
|
98%
|
|
BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC 50 s of 19 nM and 22 nM for FLT3 and AURKA, respectively. BPR1K871 is a preclinical developm...
|
T11712 |
Jasplakinolide
|
102396-24-7
|
98%
|
|
Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, ha...
|
T11731 |
JTV-519 free base
|
145903-06-6
|
98%
|
|
JTV-519 free base (K201 free base),Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (...
|
T12610L |
3-Hydroxy Midostaurin
|
179237-49-1
|
98%
|
|
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately...
|
T16995 |
TAS05567
|
1429038-15-2
|
98%
|
|
TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
|
TQ0235 |
AC710
|
1351522-04-7
|
98%
|
|
AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
|
T8317 |
5'-Fluoroindirubinoxime
|
861214-33-7
|
98%
|
|
5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
|
T35570 |
Chiauranib
|
1256349-48-0
|
98%
|
|
Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
|
T15335 |
FN-1501
|
1429515-59-2
|
98%
|
|
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1...
|
T6458 |
CYC-116
|
693228-63-6
|
98%
|
|
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
|
T13564 |
AZ7550
|
1421373-99-0
|
98%
|
|
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
|
T5164 |
Cabozantinib hydrochloride
|
1817759-42-4
|
98%
|
|
Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
|
T38562 |
AKN-028
|
1175017-90-9
|
98%
|
|
AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
|
T16750 |
Rigosertib
|
592542-59-1
|
98%
|
|
Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
|
T64370 |
JI6
|
856436-16-3
|
98%
|
|
JI6 is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 al...
|
TQ0166 |
Tesevatinib
|
781613-23-8
|
98%
|
|
Tesevatinib is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4).
|
TQ0317 |
R1530
|
882531-87-5
|
98%
|
|
R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
|
T2051 |
SKLB4771
|
1370256-78-2
|
98%
|
|
FLT3-IN-1 is a novel potent and selective Flt3 inhibitor.
|