FLT

The fms-like tyrosine kinase (Fit) is a transmembrane receptor in the tyrosine kinase family. Expression of fit complementary DNA in COS cells conferred specific, high-affinity binding of vascular endothelial growth factor, also known as vascular permeability factor (VEGF-VPF).

Cat. No.	Product name	CAS No.	Purity
T2653	SB1317	1204918-72-8	98%
T2653	SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T6193	Dovitinib Dilactic Acid	852433-84-2	98%
T6193	Dovitinib Dilactic acid (TKI258 Dilactic acid) is the Dilactic acid of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with ...
T10592	BPR1K871	2443767-35-7	98%
T10592	BPR1K871 is a potent and selective dual FLT3/AURKA inhibitor with IC 50 s of 19 nM and 22 nM for FLT3 and AURKA, respectively. BPR1K871 is a preclinical developm...
T11712	Jasplakinolide	102396-24-7	98%
T11712	Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, ha...
T11731	JTV-519 free base	145903-06-6	98%
T11731	JTV-519 free base (K201 free base),Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (...
T12610L	3-Hydroxy Midostaurin	179237-49-1	98%
T12610L	3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately...
T16995	TAS05567	1429038-15-2	98%
T16995	TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, ...
TQ0235	AC710	1351522-04-7	98%
TQ0235	AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).
T8317	5'-Fluoroindirubinoxime	861214-33-7	98%
T8317	5'-Fluoroindirubinoxime is a potent FLT3 inhibitor( IC50 : 15 nM).
T35570	Chiauranib	1256349-48-0	98%
T35570	Chiauranib is a multi-target inhibitor against tumor angiogenesis and exhibits potent anticancer effects. Chiauranib potently inhibits the angiogenesis-related k...
T15335	FN-1501	1429515-59-2	98%
T15335	FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1...
T6458	CYC-116	693228-63-6	98%
T6458	CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active a...
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T5164	Cabozantinib hydrochloride	1817759-42-4	98%
T5164	Cabozantinib (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6 nM).
T38562	AKN-028	1175017-90-9	98%
T38562	AKN-028 is an orally active and potent FLT3 tyrosine kinase inhibitor ( IC 50 = 6 nM). AKN-028 causes dose-dependent inhibition of FLT3 autophosphorylation.
T16750	Rigosertib	592542-59-1	98%
T16750	Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
T64370	JI6	856436-16-3	98%
T64370	JI6 is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 al...
TQ0166	Tesevatinib	781613-23-8	98%
TQ0166	Tesevatinib is an orally available, multi-target tyrosine kinase inhibitor (IC50s: 0.3, 16, 1.5, 8.7, and 1.4 nM for EGFR, ErbB2, KDR, Flt4, and EphB4).
TQ0317	R1530	882531-87-5	98%
TQ0317	R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.
T2051	SKLB4771	1370256-78-2	98%
T2051	FLT3-IN-1 is a novel potent and selective Flt3 inhibitor.