CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.

Cat. No.	Product name	CAS No.	Purity
T16516	PG01	853138-65-5	98%
T16516	PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
T20341	DNDS	3709-43-1	98%
T20341	DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T10591	BPO-27 racemate	1314873-02-3	98%
T10591	BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
T2451	GlyH-101	328541-79-3	98.71%
T2451	GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T14935	Elexacaftor	2216712-66-0	98.87%
T14935	Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
T2486	IOWH-032	1191252-49-9	99%
T2486	IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T2263	Tezacaftor	1152311-62-0	99%
T2263	VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T2588	Ivacaftor	873054-44-5	99%
T2588	Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T1874	PPQ-102	931706-15-9	99.17%
T1874	PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T7083	GLPG1837	1654725-02-6	99.64%
T7083	GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T3135	KM11060	774549-97-2	99.67%
T3135	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T2595	Lumacaftor	936727-05-8	99.72%
T2595	VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T1634	Glibenclamide	10238-21-8	99.77%
T1634	Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1805	Ataluren	775304-57-9	99.84%
T1805	Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
T5312	CFTR corrector 2	1628416-28-3	99.88%
T5312	FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
T2355	CFTR(inh)-172	307510-92-5	99.94%
T2355	CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T16681	Nesolicaftor	1953130-87-4	98%
T16681	PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
T9499	Icenticaftor	1334546-77-8	98%
T9499	Icenticaftor is an orally active potentiator of CFTR channel.