CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.

Cat. No.	Product name	CAS No.	Purity
T78240	(R)-Elexacaftor	2229860-99-3	98%
T78240	(R)-Elexacaftor, an enantiomer of Elexacaftor, functions as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It exhibits an EC50 of...
T79578	CFTR corrector 12	958941-60-1	98%
T79578	CFTR Corrector 12 (Compound 17C), a bithiazole derivative, functions as a CFTR corrector by remedying certain folding-defective mutants of the channel that regul...
T79793	CRF1 receptor antagonist-1	2635364-30-4	98%
T79793	CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].
T2355	CFTR(inh)-172	307510-92-5	99.94%
T2355	CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.
T20341	DNDS	3709-43-1	99.88%
T20341	DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T5312	CFTR corrector 2	1628416-28-3	99.88%
T5312	CFTR corrector 2 (FDL169) is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients w...
T16516	PG01	853138-65-5	99.87%
T16516	PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22...
T30293	Bamocaftor	2204245-48-5	99.85%
T30293	Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. C...
T7083	GLPG1837	1654725-02-6	99.73%
T7083	GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T2595	Lumacaftor	936727-05-8	99.72%
T2595	Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (...
T0429	Glucosamine	3416-24-8	99.72%
T0429	Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine ...
T3135	KM11060	774549-97-2	99.67%
T3135	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T63806	CFTR corrector 8	1918142-35-4	99.58%
T63806	CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for ut...
T1805	Ataluren	775304-57-9	99.45%
T1805	Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Du...
T1634	Glibenclamide	10238-21-8	99.39%
T1634	Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1874	PPQ-102	931706-15-9	99.17%
T1874	PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T26955	Cavosonstat	1371587-51-7	98.91%
T26955	Cavosonstat (N91115) is an orally active S-nitrosoglutathione reductase (GSNOR) inhibitor that promotes cystic fibrosis transmembrane conductance regulator (CFTR...
T14935	Elexacaftor	2216712-66-0	98.87%
T14935	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR ...
T2263	Tezacaftor	1152311-62-0	98.84%
T2263	Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T77604	WAY-326766	853138-67-7	98.76%
T77604	WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).