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CFTR

CFTR, a 12TM, ABC transporter-type protein, is a cAMP-regulated epithelial cell membrane Cl- channel involved in normal fluid transport across various epithelia.
Cat. No. Product name CAS No. Purity Chemical Structure
T16516 PG01 853138-65-5 98%
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
T20341 DNDS 3709-43-1 98%
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
T10591 BPO-27 racemate 1314873-02-3 98%
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
T2451 GlyH-101 328541-79-3 98.71%
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
T14935 Elexacaftor 2216712-66-0 98.87%
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
T2486 IOWH-032 1191252-49-9 99%
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
T2263 Tezacaftor 1152311-62-0 99%
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
T2588 Ivacaftor 873054-44-5 99%
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
T1874 PPQ-102 931706-15-9 99.17%
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
T7083 GLPG1837 1654725-02-6 99.64%
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
T3135 KM11060 774549-97-2 99.67%
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
T2595 Lumacaftor 936727-05-8 99.72%
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
T0429 Glucosamine 3416-24-8 99.72%
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
T1634 Glibenclamide 10238-21-8 99.77%
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
T1805 Ataluren 775304-57-9 99.84%
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
T5312 CFTR corrector 2 1628416-28-3 99.88%
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
T2355 CFTR(inh)-172 307510-92-5 99.94%
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
T16681 Nesolicaftor 1953130-87-4 98%
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
T9499 Icenticaftor 1334546-77-8 98%
Icenticaftor is an orally active potentiator of CFTR channel.
PG01
T16516
PG01 is effective on ΔF508 (Ka of 0.3 μM). PG01 is also an effective CFTR Cl- channel potentiator. PG01 increases ΔF508-CFTR Cl- current after adding Forskolin. ...
DNDS
T20341
DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).
BPO-27 racemate
T10591
BPO-27 racemate is an effective inhibitor of CFTR (IC50: 8 nM).
GlyH-101
T2451
GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.
Elexacaftor
T14935
Elexacaftor is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increa...
IOWH-032
T2486
IOWH032, a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.
Tezacaftor
T2263
VX-661 is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.
Ivacaftor
T2588
Ivacaftor (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells, respectively.
PPQ-102
T1874
PPQ-102, an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).
GLPG1837
T7083
GLPG1837 is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.
KM11060
T3135
KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma ...
Lumacaftor
T2595
VX-809 is a CFTR modulator that corrects the folding and trafficking of CFTR protein. It enhances F508del-CFTR protein maturation in FRT cells (EC50: 100 nM).
Glucosamine
T0429
Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to re...
Glibenclamide
T1634
Glyburide is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.
Ataluren
T1805
Ataluren is a novel, orally administered drug that targets nonsense mutations. Ataluren is approved for use by the European Medicines Agency to treat Duchenne Mu...
CFTR corrector 2
T5312
FDL-169 is a novel and potent CFTR (Cystic fibrosis transmembrane conductance regulator) corrector for treating cystic fibrosis (CF) patients who carry the F508d...
CFTR(inh)-172
T2355
CFTRinh-172 is a voltage-independent, selective CFTR inhibitor.
Nesolicaftor
T16681
PTI-428 is a specific amplifier of the cystic fibrosis transmembrane conductance regulator.
Icenticaftor
T9499
Icenticaftor is an orally active potentiator of CFTR channel.