tp-b

γ-[(6-Aminohexyl)-imido]-ATP-biotin is a versatile dye. Such dyes are vital tools in biological experiments, aiding researchers in observing and analyzing cell structures, tracking biomolecules, evaluating cell functionality, distinguishing cell types, detecting biomolecules, studying tissue pathology, and monitoring microorganisms. Their applications range widely from foundational science research to clinical diagnostics. Additionally, dyes are extensively used in traditional fields like textile dyeing and emerging sectors such as functional textile processing, food colorants, and dye-sensitized solar cells.

γ-(6-Aminohexyl)-ATP-biotin serves as a multifunctional dye with extensive applications across various fields. This compound is a critical tool in biological research, facilitating the observation and analysis of cell structures, tracking of biomolecules, evaluation of cell functions, differentiation of cell types, detection of biomolecules, examination of tissue pathology, and monitoring of microorganisms. Its usage extends beyond basic scientific research to include clinical diagnostics, textile dyeing, functional textile processing, food pigments, and dye-sensitized solar cells. This wide-reaching utility underscores the importance of dyes in both traditional and emerging industries.

Using specific antisera raised against synthetic peptides, we find that three distinct GTP-binding protein alpha subunits remain bound to the plasma membrane even after activation with nonhydrolyzable GTP analog. Trypsin cleaves each alpha subunit at a si

GTP-Binding Protein Fragment, Gs alpha is a polypeptide molecule with the sequence CKQLQKDKQVYRATHR.

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

AZD2906, a selective glucocorticoid receptor (GR) agonist, demonstrates inhibitory concentrations (IC50s) of 2.2 nM in human GR, 0.3 nM in rat peripheral blood mononuclear cells (PBMC), 41.6 nM in human whole blood, and 7.5 nM in rat whole blood, respectively[1]. Additionally, it induces an increase in micronucleated immature erythrocytes within rat bone marrow.

CTPB is a potent p300 histone acetyltransferase (HAT) activator that can be used in the preparation of hair growth promoters and/or hair loss treatments.

TPα/β antagonist-1 is a selective, dual thromboxane A2 receptor (TP receptor) antagonist that simultaneously targets both the TPα and TPβ subtypes, with IC₅₀ values of 1.52 nM and 0.79 nM, respectively. TPα/β antagonist-1 inhibits platelet aggregation. TPα/β antagonist-1 can be used in research on cardiovascular diseases.

CATPB is a potent and selective antagonist of free fatty acid receptor 2 (FFA2R/GPR43).

MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.

TPBM is a potent estrogen receptor α (ERα) inhibitor with an IC50 value of 9 μM for disruption of 17β-estradiol–ERα interaction, effectively reducing E2·ERα recruitment to endogenous estrogen-responsive genes and inhibiting E2-dependent proliferation of ERα-positive cancer cells with an IC50 of 5 μM, while remaining non-toxic and not affecting estrogen-independent cell growth, making it a selective probe for ERα signaling research.

IL-2-IN-1 is a potent inhibitor of IL-2 (IC50: 1978 nM) and demonstrates anti-proliferative effects.

TPB15 is an orally active inhibitor of Hh (Hedgehog) signalling. TPB15 significantly blocks the MDA-MB-468 cell cycle and induces apoptosis. TPB15 blocks Smo (Smoothened) translocation into cilia and reduces Smo protein and mRNA expression. TPB15 has good anti-tumour effects and low toxicity.

Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval.

MptpB-IN-1 is a potent, orally active MptpB inhibitor that targets the Mycobacterium tuberculosis protein-tyrosine-phosphatase B (MptpB), a secreted virulence factor evading host antimicrobial mechanisms. It effectively diminishes the survival and infection burden of multidrug-resistant Mycobacterium tuberculosis.

MptpB-IN-2 (compound 20), a selective inhibitor for mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), exhibits half maximal inhibitory concentrations (IC50) of 0.64 μM for MptpB, 4.06 μM for MptpA, and 4.14 μM for PTP1B. Despite its inhibition potency, MptpB-IN-2 demonstrates limited antituberculosis efficacy, with a minimum inhibitory concentration (MIC) of 64.9 μM against Mtb H37Rv [1].

Vorolanib (X-82) is an orally active VEGFR/PDGFR dual inhibitor.

SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes.SC99 inhibits platelet activation, aggregation and displays potent anti-myeloma, anti-thrombotic activities

CID44216842 (KUC103479N-02) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.

BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.

Anti-TPBG Antibody is a human-derived antibody expressed in CHO cells that targets TPBG. It features a huIgG1 heavy chain and a huκ light chain, with an estimated molecular weight (MW) of 145.8 kDa. For an isotype control, refer to Human IgG1 kappa, Isotype Control.

Anti-TPBG Antibody (PF-06263507) is a human antibody expressed in CHO cells, targeting TPBG. It features a huIgG1 type heavy chain and a huκ type light chain, with a predicted molecular weight (MW) of 145.8 kDa. For isotype control, refer to HumanIgG1kappa, Isotype Control.

Pd(II)TPBP is a biochemical reagent that can be used as a biomaterial for life science related research and as a sulfonylation reagent for organic synthesis and drug discovery.

HLDA-212 (Compound 43) is a bifunctional small molecule designed to target HaloTag-tagged protein (target protein, TP) and Aurora kinase A/B (AURKA/B, effector protein, EP). By binding TP and EP, it forms a stable ternary complex (TP:RIPTAC:EP) that inhibits the cell survival functions of EP, inducing apoptosis in cancer cells expressing TP. In 293_HFL cells, HLDA-212 demonstrates antiproliferative activity with a GI50 of 0.011 μM. This compound holds promise for treating cancers with high TP expression, such as prostate cancer and hematological malignancies.