tcf

BML-284 (Wnt agonist 1) is a potent, selective and , cell-permeable Wnt signaling activator.

Compound TCFN95222 is a useful organic compound for research related to life sciences. The catalog number is T131720 and the CAS number is 52387-14-1.

Compound TCFN97859 is a useful organic compound for research related to life sciences. The catalog number is T131721 and the CAS number is 103476-99-9.

Compound TCFN91628 is a useful organic compound for research related to life sciences. The catalog number is T131723 and the CAS number is 724434-08-6.

Hispidin is a natural product, protein kinase C inhibitor, which belongs to the group of 2-pyrones and catechols. It has anti-inflammatory activity, anti-cancer activity, inhibition of oxidative stress and anti-apoptosis.

Compound TCFN92881 is a useful organic compound for research related to life sciences. The catalog number is T131726 and the CAS number is 90536-47-3.

Compound TCFN00444 is a useful organic compound for research related to life sciences. The catalog number is T131730 and the CAS number is 579-21-5.

tCFA15, a trimethyl cyclohexenonic long-chain fatty alcohol with a 15-carbon atom side chain, may regulate Notch signaling and promote neuronal differentiation.

TCF199, a conformational stabilizer, facilitates the interaction between the 14-3-3ζ E R α peptide and the 14-3-3ζ Chibby peptide, thereby stabilizing the 14-3-3 TAZ peptide complex. The dissociation constant (Kd) of TCF199 with the 14-3-3 TAZ complex is 122 μM.

TCF4 β-catenin-IN-1 (Compound 8b) is an inhibitor of TCF4 β-catenin that induces apoptosis. This compound enhances the expression of p53, caspase-3, caspase-8, caspase-9, and Bax proteins, while reducing Bcl-2 protein levels. TCF4 β-catenin-IN-1 also inhibits CYP3A4, CYP1A2, and CYP2C19, demonstrating significant cytotoxic activity in cancer cells.

Adavivint (SM04690) is a selective inhibitor of the typical Wnt signaling pathway. In SW480 cells, EC50=19.5 nM was measured using high-throughput TCF LEF reporter gene experiments.

ICG001 is a β-catenin/TCF-mediated transcription inhibitor that selectively blocks β-catenin/CBP interaction without interfering with β-catenin/p300 interaction. It specifically binds to CREB protein with an IC50 of 3 μM.

CCT 031374 hydrobromide is a TCF/β-catenin inhibitor with antitumor activities.

MTOB (α-keto-γ-Methylthiobutyric acid) is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

WAY262611 is a Wnt β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.

ICG001 antagonizes Wnt β-catenin TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300.

CWP232228, a potent and selective Wnt β-catenin signaling inhibitor, antagonizes the binding of β-catenin to T-cell factor (TCF) in the nucleus. CWP232228 inhibits the formation and metastasis of tumors by inhibiting the growth of breast cancer and live

FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT β-catenin pathway.

CCT070535 inhibits TCF-dependent transcription at the TCF level, displaying GI50 values of 17.6 μM in HT29 (APC mutation), 11.1 μM in HCT116 (oncogenic β-catenin), 11.8 μM in SW480 (APC mutation), and 13.4 μM in SNU475 (Axin mutation) cells.

BML-286 is a WNT pathway modulator with potential anticancer activity, inducing β-catenin- and TCF-dependent transcriptional activity, and can be used in the study of degenerative diseases, intestinal, breast, bladder, gastric, melanoma, leukemia, hepatocellular carcinoma and nephroblastoma.

I-67, a structural isomer of I-66, is a potent β-catenin inhibitor with an IC50 of less than 50 nM. It disrupts the interaction between β-catenin and T cell factor (TCF) transcription factors and exhibits anticancer properties.

TC-F 2 is a FAAH inhibitor.

β-Catenin-IN-37 is a selective inhibitor of the protein-protein interaction between β-Catenin and T-cell factor (Tcf), known as β-catenin/Tcf PPI. It effectively inhibits canonical Wnt signaling and impedes the growth of colorectal cancer cells SW480 and HCT116, with IC50 values of 20 μM and 31 μM, respectively.

TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM.TA-02 especially inhibits TGFBR-2.