spp

SPP is a cleavable linker that can be used to form antibody-coupled compounds with therapeutic effects on cancer.

SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.

DMAC-SPP is a cleavable linker vital in ADC synthesis. DMAC-SPP joins cytotoxic drugs to antibodies, enabling precise delivery to cells or proteins. The cleavable nature ensures controlled drug release, optimizing ADC effectiveness.

NO2-SPP-sulfo-Me is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC)[1].

NO2-SPP is a cleavable linker used in the synthesis of antibody-drug conjugates (ADC).

SPP-DM1, a drug-linker conjugate for antibody-drug conjugates (ADC), demonstrates potent antitumor activity. It comprises DM1 (a potent microtubule-disrupting agent) connected through the ADC linker SPP[1].

Sulfo-DMAC-SPP is an ADC linker employed for the synthesis of antibody-drug conjugates (ADCs) [1].

Sulfo-SPP is a heterobifunctional, thiol-cleavable, and membrane-impermeable crosslinker.

NO2-SPP-sulfo is a cleavable linker essential in ADC synthesis, facilitating the attachment of cytotoxic drugs to antibodies for targeted delivery to cells or proteins. Its cleavable property ensures controlled drug release, thereby optimizing ADC effectiveness.

Avosentan(Ro 67-0565; SPP-301) is a potent endothelin receptor (ETA) antagonist with strong inhibitory effects on endothelin-1-induced contraction and may have protective effects against chronic kidney disease. [2]

Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.

Aliskiren (CGP 60536) D6 Hydrochloride is a deuterium-labeled Aliskiren. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).

BAL30072 shows MIC90 values of 4 μg/mL for MDR Acinetobacter spp. and 8 μg/mL for MDR P. aeruginosa, respectively[1][2]. BAL-30072, a siderophore sulfactam, is a monocyclic beta-lactam antibiotic, with activity against multiresistant gram-negative bacilli

Aliskiren (CGP 60536) is an orally active and potent renin inhibitor (IC50: 1.5 nM) with antihypertensive activity for the treatment of various cardiovascular diseases.

Aliskiren fumarate, an orally active, highly potent, and selective renin inhibitor with an IC50 of 1.5 nM, is utilized in the research of hypertension, cardiovascular diseases, and cancer cachexia.

SPP-037 is an orally active selective inhibitor of ST6GAL1, with an IC50 of 3.59 μM. It exhibits anti-migration activity against MDA-MB-231 cells by inhibiting integrin α2,6-sialylation and the integrin-FAK-paxillin pathway. In MDA-MB-231 xenograft mouse models, SPP-037 demonstrates antitumor properties. This compound is applicable in breast cancer research.

SPP-002 is a sulfate ester analogue that acts as a potential Sialyltransferase (ST) inhibitor. It selectively inhibits N-glycan sialylation with at least an order of magnitude greater potency compared to the unmodified parent lithocholic acid (LCA). By inhibiting the integrin/FAK/paxillin signaling pathway, SPP-002 reduces tumor cell migration and invasion. It is applicable in research on tumor metastasis.

Sulfo-SPP sodium is a heterobifunctional, thiol-cleavable, and membrane-impermeable crosslinker.

Aliskiren (CGP 60536) D6 hemifumarate is a deuterium-labeled Aliskiren hemifumarate. Aliskiren hemifumarate is a direct and orally active renin inhibitor (IC50: 1.5 nM).

Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived IgG2c, κ antibody inhibitor targeting mouse osteopontin/SPP1.

Anti-Mouse osteopontin/SPP1 Antibody (100D3) is an antibody derived from mouse IgG2c kappa, targeting osteopontin/SPP1.

Nalidixic acid (NSC-82174) is a synthetic 1, 8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA GYRASE.

Nalidixic acid sodium salt (Baktogram) is an antimicrobial agent with a limited bacteriocidal spectrum.

CaspPro is a selective activator of caspase 8 that acts by potentiating TRAIL-induced cell death.