mrsa

Mupirocin calcium hydrate is an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria

Neogambogic acid, an active ingredient in garcinia, can inhibit the growth of some solid tumors [resulting in an anticancer effect], and may be responsible for the inhibition of proliferation of human breast cancer cell line MCF-7 cells.

Blasticidin S HCl is a natural product and an inhibitor of protein synthesis. Blasticidin S HCl is a broad-spectrum antibiotic that can inhibit the cell growth of prokaryotes, fungi, plants and mammalian cells.

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Closthioamide is a potent inhibitor of bacterial DNA gyrase and is highly effective against MRSA, Ec, VRE, and Mv [MICs: 0.58 μM, 9.00 μM, 0.58 μM, and 72.03 μM, respectively].

6-Ethoxychelerythrine (Ethoxychelerythrin) has anti-bacterial activity, it exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).

3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003). 3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both).3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively).4 References1. Kurobane, I., Vining, L.C., McInnes, A.G., et al. 3-Hydroxyterphenyllin, a new metabolite of Aspergillus candidus. Structure elucidation by 1H and 13C nuclear magnetic resonance spectroscopy. J. Antibiot. (Tokyo) 32(6), 559-564 (1979).2. Yen, G.-C., Chang, Y.-C., Sheu, F., et al. Isolation and characterization of antioxidant compounds from Aspergillus candidus broth filtrate. J. Agric. Food Chem. 49(3), 1426-1431 (2001).3. Wang, W., Liao, Y., Tang, C., et al. Cytotoxic and antibacterial compounds from the coral-derived fungus Aspergillus tritici SP2-8-1. Mar. Drugs 15(11), E348 (2017).4. Singh, S.B., Jayasuriya, H., Dewey, R., et al. Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites. J. Ind. Microbiol. Biotechnol. 30(12), 721-731 (2003).

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (1 μM) inhibits cytokine expression and nitric oxide production induced by LPS.[3] Nargenicin (200 μM), when used in combination with 1,25-dihydroxyvitamin D3 or all-trans retinoic acid , reduces cell proliferation by 37-47% and increases cell differentiation by 82-85% in HL-60 human myeloid leukemia cells.[4]

Talaromycesone A is a fungal metabolite originally isolated fromTalaromyces.1It is active againstS. epidermidisand methicillin-resistantS. aureus(MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50= 7.49 μM for the human enzyme). 1.Wu, B., Ohlendorf, B., Oesker, V., et al.Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458Mar. Biotechnol. (NY)17(1)110-119(2015)

PSMα3 is a peptide compound that can be utilized to induce tolerance in dendritic cells (DCs) for DC vaccination strategies. It effectively penetrates and modulates human monocyte-derived DCs by modifying the maturation process induced by TLR2 or TLR4. Additionally, PSMα3 inhibits the production of both pro- and anti-inflammatory cytokines and decreases antigen uptake. Notably, PSMα3 is a significant virulence factor released by the most pathogenic strains of methicillin-resistant Staphylococcus aureus (MRSA).

1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. Xanthatin may have therapeutic potential against NSCLC. 4. Xanthatin can inhibit murine melanoma B16-F1 cell proliferation possibly associated wit

Laburnetin, an isoflavone antibacterial agent, exhibits antibacterial activity against fungi and S. vesicarium, and enhances the susceptibility of Methicillin-resistant Staphylococcus aureus (MRSA) strains to Methicillin. It is also effective in controlling pests of cultivated species [1] [2] [3].

Thiomarinol A (4-Hydroxythiomarinol C), a potent antibiotic, is a hybrid compound comprising dithiolopyrrolone and marinolic acid, exhibiting antimicrobial activity. It effectively inhibits MRSA IleRS in a dose-dependent manner, with an apparent K_i value of 19 nM [1].

Glicophenone, an antibacterial agent, demonstrates minimum inhibitory concentrations (MICs) of 32 μg mL against multiple strains, including MRSA OM481, MRSA OM505, MRSA OM584, MRSA OM623, and MSSA 209P [1].

Kalimantacin A, a potent antibiotic, exhibits effective antibacterial activity against Staphylococcus, including methicillin-resistant Staphylococcus aureus (MRSA) [1] [2].

Teicoplanin sodium (Antibiotic MDL-507 sodium) is a potent lipoglycopeptide antibiotic . Teicoplanin sodium shows antiviral activity for HIV-1 , SARS-CoV1 and SARS-CoV2. Teicoplanin sodium shows anti-MRSA activity [1] [2] .

Pristinamycin, synthesized by Streptomyces pristinaespiralis, is an orally administered antibiotic resembling streptogramin, comprising two distinct components: Pristinamycin I (PI) and Pristinamycin II (PII). This compound exhibits a high efficacy against various antibiotic-resistant pathogens, especially Gram-positive bacteria such as Methicillin-resistant Staphylococcus aureus (MRSA), Vancomycin-resistant S. aureus (VRSA), and Enterococcus faecium (VREF) [1].

(6E,12E)-Tetradecadiene-8,10-diyne-1,3-diol is an antibacterial compound isolated from the roots of Atractylodes japonica, exhibiting anti-methicillin-resistant Staphylococcus aureus (MRSA) activity with MIC values of 4-32 μg mL, and can be used for the research of bacterial infection [1].

4(1H)-Quinolinone, 1-methyl-2-(5Z)-5-undecen-1-yl- (compound 2), a quinolone alkaloid extracted from Cnidium, demonstrates activity against methicillin-resistant Staphylococcus aureus (MRSA), with minimum inhibitory concentration (MIC) values of 32 μg mL (ATCC 33591) and 16 μM mL (ATCC 25923) respectively [1].

Longistyline A (Longistylin A), a natural stilbene extracted from the leaves of Cajanus cajan, exhibits antimicrobial activity with a minimum inhibitory concentration (MIC) value of 1.56 μg mL against MRSA and demonstrates neuroprotective effects, suggesting its potential for research in infection and neurological disorders [1] [2].

6-C-Methylquercetin-3,4'-dimethyl ether, a flavonol derivative extracted from Bauhinia thonningii Schum leaves, exhibits antibacterial effects on Gram-negative multidrug-resistant bacteria and methicillin-resistant Staphylococcus aureus (MRSA) strains [1].

6-Methoxydihydrosanguinarine is a natural product. 6-Methoxydihydrosanguinarine shows strong cytotoxicity against MCF-7 and SF-268 cell lines with IC50 values of 0.61 μM and 0.54 μM, respectively.It has antibacterial activity against Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentrations (MICs) ranging from1.9 to 3.9 microg/ml

Protosappanin A (PTA) has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammation signal pathway; it exerts anti-neuroinflammatory effect by inhibiting JAK2-STAT3 pathway in lipopolysaccharide-induced BV2 microglia. Protosappanin A induces immunosuppression of rats heart transplantation targeting T cells in grafts via NF-kappaB pathway. Protosappanin A and protosappanin B have antimicrobial activity, they show both alone activities and resistance reversal effects of amikacin and gentamicin against MRSA. Protosappanin A shows strong effect against HIV-1 IN with an IC50 value of 12.6 uM.

Deoxytopsentin is a compound found in marine sponges that acts as an inhibitor of methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase (PK) with an IC50 of 240 nM. Deoxytopsentin is useful in research focused on anti-infection.