helix

Col003 is a selective and potent inhibitor of Hsp47, competitively binding to the collagen-binding site on Hsp47 (IC50: 1.8 μM). It is useful for researching fibrosis.

Thioether-cyclized helix B peptide (CHBP) enhances metabolic stability and exerts renoprotective effects by promoting autophagy through the inhibition of mTOR C1 and activation of mTOR C2 [1].

Thioether-cyclized helix B peptide, CHBP (TFA), is the trifluoroacetic (TFA) salt of CHBP, enhancing metabolic stability and exhibiting renoprotective effects by promoting autophagy through inhibition of mTOR C1 and activation of mTOR C2 [1].

PTBP1α3-helix derived peptide P1 is a polypeptide that inhibits RNA binding [1].

Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1].

Lectin from Helix pomatia, biotin conjugate, is a carbohydrate-binding protein found extensively in fungi, plants, and animals. It is commonly utilized for characterizing, imaging, or targeting glycoconjugates, serving as a valuable tool in glycomics analysis.

Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.

6-Thioguanosine (6-Mercaptoguanosine) is an active nucleoside, a metabolite of Azathioprine, and a low molecular weight gel.6-Thioguanosine is immunosuppressive and has been used to study the formation of the RNA double helix.

Amylose is a polysaccharide composed of α-D-glucose units linked by α(1→4) glycosidic bonds, accounting for about 20% of the total amount of starch. Amylose spatial conformation curls into a helix and forms a blue complex with iodine, which is widely used in the food industry, and can be used in a variety of researches as a natural product and a biochemical reagent.

Saponins (Sapogenins Glycosides) are a mixture of triterpene and steroid saponins isolated from medicinal plants such as Aesculus hippocastanum L., Hedera helix L. and Ruscus aculeatus L., which are claimed to be effective for the treatment prevention of venous insufficiency.

Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with aminoalkyl side chains containing benzo and quinoline ring structures.BQQ is triple-helix specific stabilizing compounds by preferentially binding to DNA triple junctions and inserting between the bases.Complexes of BQQ with 1,10-phenanthroline are able to bind specifically to and cleave double-stranded DNA at the cleave double-stranded DNA at sites that form triple structures.

SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective. SAG regulates Smo activity by binding directly to the Smo helix and can activate the Hedgehog signaling pathway.

Apramycin(Nebramycin II) is an aminoglycoside antibiotic used in veterinary medicine. IC50 value:Target: Apramycin stands out among aminoglycosides for its mechanism of action which is based on blocking translocation and its ability to bind also to the eukaryotic decoding site despite differences in key residues required for apramycin recognition by the bacterial target. The drug binds in the deep groove of the RNA which forms a continuously stacked helix comprising non-canonical C.A and G.A base pairs and a bulged-out adenine. The binding mode of apramycin at the human decoding-site RNA is distinct from aminoglycoside recognition of the bacterial target, suggesting a molecular basis for the actions of apramycin in eukaryotes and bacteria. [1]. Apramycin, From Wikipedia

Phe-Met-Arg-Phe Like Peptide acetate (Pqdpflrfamide acetate) is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues.

C-MYC PEPTIDE EPITOPE TFA, the product of the c-myc proto-oncogene, is a helix-loop-helix leucine zipper phosphoprotein that regulates gene transcription in cell proliferation, cell differentiation and apoptosis. This peptide is a human c-myc epitope.

BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).

GSK1702934A, a selective TRPC3 agonist, modulates cardiac contractility and arrhythmogenesis through TRPC3 activation.

PS210 is a potent and selective activator of PDK1 (Kd: 3 μM), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.

RNAse L RIBOTAC (compound C64) is an RNA-degrading chimera that binds to a four-way RNA helix called SL5 located in the 5’ UTR of the SARS-CoV-2 RNA genome, thereby inhibiting viral replication in pulmonary epithelial cancer cells.

RNA recruiter 1 is the RNA ligand segment of RNAse L RIBOTAC, an RNA degradation chimera capable of binding the four-stranded RNA helix SL5 in the 5' untranslated region of the SARS-CoV-2 RNA genome, thereby inhibiting viral replication in lung epithelial carcinoma cells. RNA recruiter 1 is useful for the synthesis of RIBOTAC.

RNA recruiter-linker 1 is part of the RNA ligand-linker in RNAse L RIBOTAC, which is an RNA-degrading chimera designed to bind the four-stranded RNA helix SL5 within the 5' untranslated region of the SARS-CoV-2 RNA genome. This binding inhibits the replication of the virus in lung epithelial carcinoma cells. RNA recruiter-linker 1 is also useful in RIBOTAC synthesis.

Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.

Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin which binds and intercalates DNA to damage the integrity of the double helix.

Allotrap is a small synthetic peptide derived from the alpha1 helix of the heavy chain of HLA class I proteins. It suppresses human T cell responses in vitro. It prolongs allograft survival in rats and mice.