arachidonic

Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then converted to mediators of inflammation

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 μM. In guinea pig leukocytes, 5-LO is inhibited by 5,6-dehydro arachidonic acid with an IC50 value of 10 μM.

Omega-3 Arachidonic Acid methyl ester, primarily represented by docosahexaenoic acid, eicosapentaenoic acid, and α-linolenic acid, is an essential dietary nutrient crucial for normal growth and development. It is the neutral, fat-soluble form of the rare fatty acid, ω-3 Arachidonic Acid. The ω-3 fatty acids group is associated with reduced inflammation and autoimmune activity, as well as decreased thrombosis and platelet activation.

Arachidonic Acid-biotin (Arachidonic Acid-biotinamide) is a complex formed by linking biotin and arachidonic acid.

omega-3 Arachidonic acid ethyl ester is a polyunsaturated fatty acid suitable for biochemical experiments and drug synthesis research.

Arachidonic acid (Standard) is the standard substance of Arachidonic acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.

Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC).

ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor.

20-HETE promotes cell proliferation and migration in cancer and can be used to study prostate tumors and cardiac hypertrophy by activating the protein kinase C pathway to increase FBXO10 expression.

CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages.

Arachidonoyl-N,N-dimethyl amide (Arachidonic acid-N,N-dimethyl amide) is an endogenous cannabinoid that interacts with central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Its biological activity is terminated through cellular uptake and hydrolysis of the amide bond by fatty acid amide hydrolase. As an analog of arachidonoyl amide, it binds weakly or not at all to human central cannabinoid (CB1) receptors (Ki >1 μM). At a concentration of 50 μM, it can fully inhibit gap junction intercellular communication in rat glial cells.

Ethyl arachidonate (arachidonic acid ethyl ester) is the esterified form of arachidonic acid (AA), which serves as a precursor or substitute for AA and is associated with alcohol metabolism.

Arachidonic acidsulfonate (AA sulfonate) sodium is a sulfonic acid derivative of arachidonic acid.

Arachidonic acid sodium salt is a polyunsaturated omega-6 fatty acid that is a major component of biological membranes, serving as a substrate for various lipid mediators including prostaglandins (PG). It can improve cognitive responses and cardiovascular function, and can also be used to induce paw swelling models.

Arachidonic acid-13C4 (Immunocytophyt-13C4) is a 13C-labeled version of arachidonic acid. As a polyunsaturated omega-6 fatty acid, arachidonic acid (Immunocytophyt) is a key component of biological membranes. It also serves as a substrate for various lipid mediators, such as prostaglandins (PG). Additionally, arachidonic acid can enhance cognitive response and cardiovascular function.

Arachidonic acid (Immunocytophyt) is a polyunsaturated omega-6 essential fatty acid that serves as a major component of biological membranes and animal phospholipids. It is synthesized from dietary linoleic acid and acts as a precursor to lipid mediators such as prostaglandins, thromboxanes, and leukotrienes. Arachidonic acid can improve cognitive responses and cardiovascular function and is commonly used to induce paw edema models.

ω-3 Arachidonic acid, a poly fatty acid essential for infant growth and development, inhibits arachidenol-CoA synthetase with Ki values of 14 µM and shows an IC50 of approximately 5 µM in calf brain extract [1] [2].

Arachidonic acid-d8 is the deuterated form of Arachidonic acid. Arachidonic acid is an essential fatty acid that serves as a primary component of biological membranes.

Arachidonic acid-d5 is the deuterated form of Arachidonic acid, an essential fatty acid that serves as a key component of biological membranes.

Arachidonic acid-d11 is the deuterated form of Arachidonic acid, an essential fatty acid and a key component of biological membranes.

Arachidonic Acid-[D7] (Standard) is a reference standard of Arachidonic Acid-[D7] intended for quantitative analysis, quality control, and related biochemical research applications.

SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).

Linoleic acid (9,12-octadecadienoic acid) is a naturally occurring polyunsaturated fatty acid found in animal and vegetable oils. Linoleic acid is an essential fatty acid that is part of membrane phospholipids.