T1558 |
ResveratrolHOT |
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
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T9108 |
BI-0115 |
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of ...
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T0646 |
Mesalamine |
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
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T8002 |
3-Hydroxycoumarin |
3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
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TQ0180 |
Chebulagic acid |
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
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T5714 |
5-DEMETHYLNOBILETIN |
5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX...
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T5759 |
Marmesin |
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
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T4571 |
Balsalazide |
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
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T6S1699 |
6-Shogaol |
1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduce...
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T3879 |
Silychristin |
Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
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TJS0315 |
7,8-Dihydroxy-4-methylcoumarin |
1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radical...
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T4347 |
ML355 |
ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
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T1296 |
Aminopar |
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
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T8356 |
FPL 62064 |
FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthe...
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T6576 |
Malotilate |
Malotilate is a medicine used for the therapy of liver cirrhosis.
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T6485 |
Embelin |
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
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T3090 |
Abietic Acid |
Abietic Acid is the primary component of resin acid isolated from rosin.
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T1401 |
Meclofenoxate hydrochloride |
Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and...
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T2807 |
Caffeic Acid |
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
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T2798 |
Esculetin |
Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammat...
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T1420 |
Diethylcarbamazine citrate |
Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Lo...
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T1677 |
Montelukast |
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
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T6568 |
Licofelone |
Licofelone is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of...
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T8260 |
4',5-Dihydroxyflavone |
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
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TN1016 |
Kukoamine A |
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = ...
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T8950 |
CAY10698 |
CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).
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T10098 |
PGS-IN-1 |
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).
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T21902 |
ML351 |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
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T20533 |
NNK |
NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
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TN5174 |
Trichosanatine |
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
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TN5020 |
(+/-)-Sigmoidin A |
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
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TN4783 |
Picralinal |
Picralinal has anti-inflammatory and analgesic effects.
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TN4331 |
Isotachioside |
Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
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TL0014 |
Pinusolide |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
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T22398 |
Phenidone |
Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental autoimmune encephalomyelitis by suppressing its...
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T13764 |
Lycopodine |
Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive com...
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T16503 |
PF-4191834 |
PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity fo...
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T10821 |
Cirsiliol |
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
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TN1097 |
Beta-boswellic acid |
Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
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T10719 |
CCT365623 hydrochloride |
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF....
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T11196 |
Enazadrem |
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
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T12784 |
RWJ 63556 |
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
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T10438 |
AZD 4407 |
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
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T10151 |
5-Lipoxygenase-In-1 |
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
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TN2330 |
Caffeic Acid 3-Methyl Phenethyl Ester |
Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane indu...
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TN1871 |
Ligustroside |
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
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TN1255 |
3-O-Acetyl-11-hydroxy-beta-boswellic acid |
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
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TN1244 |
3'-Demethylnobiletin |
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
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TN1182 |
11-Keto-beta-boswellic acid |
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
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T0477 |
Zileuton |
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
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