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Metabolism Lipoxygenase

Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
Cat No. product name
T1558 ResveratrolHOT Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T9108 BI-0115 BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of ...
T0646 Mesalamine Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
T8002 3-Hydroxycoumarin 3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
TQ0180 Chebulagic acid Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
T5714 5-DEMETHYLNOBILETIN 5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX...
T5759 Marmesin Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T4571 Balsalazide Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T6S1699 6-Shogaol 1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduce...
T3879 Silychristin Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
TJS0315 7,8-Dihydroxy-4-methylcoumarin 1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radical...
T4347 ML355 ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
T1296 Aminopar Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T8356 FPL 62064 FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthe...
T6576 Malotilate Malotilate is a medicine used for the therapy of liver cirrhosis.
T6485 Embelin Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T3090 Abietic Acid Abietic Acid is the primary component of resin acid isolated from rosin.
T1401 Meclofenoxate hydrochloride Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and...
T2807 Caffeic Acid Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
T2798 Esculetin Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammat...
T1420 Diethylcarbamazine citrate Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Lo...
T1677 Montelukast Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
T6568 Licofelone Licofelone is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of...
T8260 4',5-Dihydroxyflavone 4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
TN1016 Kukoamine A Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
T8950 CAY10698 CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).
T10098 PGS-IN-1 PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS; IC50: 0.28 μM) and also inhibits 5-lipoxygenase (IC50: 1.05 μM).
T21902 ML351 ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
T20533 NNK NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
TN5174 Trichosanatine Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
TN5020 (+/-)-Sigmoidin A Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
TN4783 Picralinal Picralinal has anti-inflammatory and analgesic effects.
TN4331 Isotachioside Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
TL0014 Pinusolide Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T22398 Phenidone Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
T13764 Lycopodine Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive com...
T16503 PF-4191834 PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity fo...
T10821 Cirsiliol Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
TN1097 Beta-boswellic acid Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
T10719 CCT365623 hydrochloride CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF....
T11196 Enazadrem Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
T12784 RWJ 63556 RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T10438 AZD 4407 AZD 4407 is a potent inhibitor of 5-lipoxygenase.
T10151 5-Lipoxygenase-In-1 5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
TN2330 Caffeic Acid 3-Methyl Phenethyl Ester Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane indu...
TN1871 Ligustroside Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN1255 3-O-Acetyl-11-hydroxy-beta-boswellic acid 3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
TN1244 3'-Demethylnobiletin 3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
TN1182 11-Keto-beta-boswellic acid 11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
T0477 Zileuton Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...
Resveratrol HOT
T1558CAS 501-36-0
Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
BI-0115
T9108CAS 4929-23-1
BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. It binding triggers receptor inhibition by formation of dimers of ...
Mesalamine
T0646CAS 89-57-6
Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the acti...
3-Hydroxycoumarin
T8002CAS 939-19-5
3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
Chebulagic acid
TQ0180CAS 23094-71-5
Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.
5-DEMETHYLNOBILETIN
T5714CAS 2174-59-6
5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of COX...
marmesin
T5759CAS 13849-08-6
Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
Balsalazide
T4571CAS 80573-04-2
Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
6-Shogaol
T6S1699CAS 555-66-8
1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduce...
Silychristin
T3879CAS 33889-69-9
Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
7,8-Dihydroxy-4-methylcoumarin
TJS0315CAS 2107-77-9
1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radical...
ML355
T4347CAS 1532593-30-8
ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
Aminopar
T1296CAS 65-49-6
Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
FPL 62064
T8356CAS 103141-09-9
FPL 62064 is a potent  dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthe...
Malotilate
T6576CAS 59937-28-9
Malotilate is a medicine used for the therapy of liver cirrhosis.
Embelin
T6485CAS 550-24-3
Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
Abietic Acid
T3090CAS 514-10-3
Abietic Acid is the primary component of resin acid isolated from rosin.
Meclofenoxate hydrochloride
T1401CAS 3685-84-5
Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, and...
Caffeic Acid
T2807CAS 331-39-5
Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activi...
Esculetin
T2798CAS 305-01-1
Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflammat...
Diethylcarbamazine citrate
T1420CAS 1642-54-2
Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Lo...
Montelukast
T1677CAS 158966-92-8
Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...
Licofelone
T6568CAS 156897-06-2
Licofelone is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both an analgesic and an anti-inflammatory. Inhibition of...
4',5-Dihydroxyflavone
T8260CAS 6665-67-4
4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
Kukoamine A
TN1016CAS 75288-96-9
Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidative...
CAY10698
T8950CAS 684236-01-9
CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).
PGS-IN-1
T10098CAS 102271-49-8
PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS; IC50: 0.28 μM) and also inhibits 5-lipoxygenase (IC50: 1.05 μM).
ML351
T21902CAS 847163-28-4
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
NNK
T20533CAS 64091-91-4
NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl oxidase which is a tumor suppressor.
Trichosanatine
TN5174CAS 169626-16-8
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatin...
(+/-)-Sigmoidin A
TN5020CAS 176046-04-1
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
Picralinal
TN4783CAS 20045-06-1
Picralinal has anti-inflammatory and analgesic effects.
Isotachioside
TN4331CAS 31427-08-4
Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
Pinusolide
TL0014CAS 31685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
Phenidone
T22398CAS 92-43-3
Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
Lycopodine
T13764CAS 466-61-5
Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive com...
PF-4191834
T16503CAS 1029317-21-2
PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity fo...
Cirsiliol
T10821CAS 34334-69-5
Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
Beta-boswellic acid
TN1097CAS 631-69-6
Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
CCT365623 hydrochloride
T10719CAS 2126136-98-7
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF....
Enazadrem
T11196CAS 107361-33-1
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
RWJ 63556
T12784CAS 190967-35-2
RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
AZD 4407
T10438CAS 166882-70-8
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
5-Lipoxygenase-In-1
T10151CAS 125235-15-6
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
Caffeic Acid 3-Methyl Phenethyl Ester
TN2330CAS 71835-85-3
Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane indu...
Ligustroside
TN1871CAS 35897-92-8
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
3-O-Acetyl-11-hydroxy-beta-boswellic acid
TN1255CAS 146019-25-2
3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
3'-Demethylnobiletin
TN1244CAS 112448-39-2
3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle a...
11-Keto-beta-boswellic acid
TN1182CAS 17019-92-0
11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifeste...
Zileuton
T0477CAS 111406-87-2
Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the fo...