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Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T27026 CJ-13,610 179420-17-8 99.64%
CJ-13,610
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expr...
T37974 (S)-Coriolic acid 29623-28-7 97.11%
(S)-Coriolic acid
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, ...
T10719 CCT365623 hydrochloride 2126136-98-7 98%
CCT365623 hydrochloride
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
TN2688 2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone 33900-74-2 98%
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a natural product obtained from Parinari hypochrysea (Chrysobalanaceae). 2,3,4'-Trihydroxy-3',5'-dimethoxypropi...
T78820 5-LOX-IN-5 98%
5-LOX-IN-5
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining...
T79158 H15-LOX-2 inhibitor 1 478040-08-3 98%
h15-LOX-2 inhibitor 1
Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].
T79360 COX-2/15-LOX-IN-2 98%
COX-2/15-LOX-IN-2
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibi...
T79361 COX-2/15-LOX-IN-3 98%
COX-2/15-LOX-IN-3
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respecti...
T79362 COX-2/15-LOX-IN-4 98%
COX-2/15-LOX-IN-4
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-infl...
T80651 (-)-Bornyl ferulate 55511-07-4 98%
(-)-Bornyl ferulate
(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-li...
T10151 5-Lipoxygenase-In-1 125235-15-6 98%
5-Lipoxygenase-In-1
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
T11196 Enazadrem 107361-33-1 98%
Enazadrem
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TN1871 Ligustroside 35897-92-8 98%
Ligustroside
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN5174 Trichosanatine 169626-16-8 98%
Trichosanatine
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TL0014 Pinusolide 31685-80-0 98%
Pinusolide
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10438 AZD 4407 166882-70-8 98%
AZD 4407
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN4783 Picralinal 20045-06-1 98%
Picralinal
Picralinal has anti-inflammatory and analgesic effects.
T4571 Balsalazide 80573-04-2 98%
Balsalazide
Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
TN5020 (+/-)-Sigmoidin A 176046-04-1 98%
(+/-)-Sigmoidin A
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
T67870 DKI5 1101130-96-4 98%
DKI5
DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) is a LOX-1 inhibitor with an IC50 value of 22.5 μM.DKI5 may have anti-inflammatory and antioxidant activitie...
CJ-13,610
T27026
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expr...
(S)-Coriolic acid
T37974
(S)-Coriolic acid (13(S)-HODE) is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, ...
CCT365623 hydrochloride
T10719
CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone
TN2688
2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a natural product obtained from Parinari hypochrysea (Chrysobalanaceae). 2,3,4'-Trihydroxy-3',5'-dimethoxypropi...
5-LOX-IN-5
T78820
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in research pertaining...
h15-LOX-2 inhibitor 1
T79158
Compound 105 (h15-LOX-2 inhibitor 1) is a potent inhibitor of human epithelial 15-lipoxygenase-2 (h15-LOX-2), exhibiting an IC50 of 0.34 μM [1].
COX-2/15-LOX-IN-2
T79360
COX-2/15-LOX-IN-2 is a potent inhibitor of both COX-2 and 15-LOX, demonstrating IC50 values of 0.065 μM for COX-2 and 1.86 μM for 15-LOX. Additionally, it exhibi...
COX-2/15-LOX-IN-3
T79361
COX-2/15-LOX-IN-3 (compound 5k) serves as a dual inhibitor for COX-2 and 15-LOX, demonstrating inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respecti...
COX-2/15-LOX-IN-4
T79362
COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 μM for COX-2 and 1.97 μM for 15-LOX. It inhibits LPS-induced production of pro-infl...
(-)-Bornyl ferulate
T80651
(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-li...
5-Lipoxygenase-In-1
T10151
5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor.
Enazadrem
T11196
Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
Ligustroside
TN1871
Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
Trichosanatine
TN5174
Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
Pinusolide
TL0014
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
AZD 4407
T10438
AZD 4407 is a potent inhibitor of 5-lipoxygenase.
Picralinal
TN4783
Picralinal has anti-inflammatory and analgesic effects.
Balsalazide
T4571
Balsalazide (Balsalazido) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
(+/-)-Sigmoidin A
TN5020
Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
DKI5
T67870
DKI5 ((E)-N'-benzylidenehydrazinecarbothiohydrazide) is a LOX-1 inhibitor with an IC50 value of 22.5 μM.DKI5 may have anti-inflammatory and antioxidant activitie...
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TargetMol