Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.

Cat No.	product name
T0477	Zileuton	Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the f...
T0646	Mesalamine	Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the act...
T10098	PGS-IN-1	PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS; IC50: 0.28 μM) and also inhibits 5-lipoxygenase (IC50: 1.05 μM).
T10151	5-Lipoxygenase-In-1	5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
T10438	AZD 4407	AZD 4407 is a potent inhibitor of 5-lipoxygenase.
T10719	CCT365623 hydrochloride	CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF...
T10821	Cirsiliol	Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
T11196	Enazadrem	Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
T12784	RWJ 63556	RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
T1296	Aminopar	Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.
T13764	Lycopodine	Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive co...
T1401	Meclofenoxate hydrochloride	Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to improve memory and general cognition, an...
T1420	Diethylcarbamazine citrate	Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or L...
T1558	ResveratrolHOT	Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.
T16503	PF-4191834	PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity f...
T1677	Montelukast	Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked ...
T21902	ML351	ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).
T22398	Phenidone	Phenidone, a dual inhibitor of cyclooxygenase (COX) and lipoxygenase (LOX), is an organic compound primarily used as a photographic developer.
T2798	Esculetin	Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical properties including anti-edema, anti-inflamma...
T2807	Caffeic Acid	Caffeic Acid is an orally bioavailable, hydroxycinnamic acid derivative and polyphenol, with potential anti-oxidant, anti-inflammatory, and antineoplastic activ...
T3090	Abietic Acid	Abietic Acid is the primary component of resin acid isolated from rosin.
T3879	Silychristin	Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor of horseradish peroxidases and lipoxygenase.
T4347	ML355	ML355, a specific, effective 12-Lipoxygenase(12-LOX) inhibitors(IC50=0.34 μM), possess favorable ADME properties.
T4571	Balsalazide	Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T5714	5-DEMETHYLNOBILETIN	5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition of 5-LOX, without affecting the expression of CO...
T5759	marmesin	Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T6485	Embelin	Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T6576	Malotilate	Malotilate is a medicine used for the therapy of liver cirrhosis.
T6S1699	6-Shogaol	1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. 2. 6-shogaol has anti-inflammatory property, reduc...
T8002	3-Hydroxycoumarin	3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors
T8260	4',5-Dihydroxyflavone	4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).
T8356	FPL 62064	FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synth...
T8950	CAY10698	CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 µM).
TJS0315	7,8-Dihydroxy-4-methylcoumarin	1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radica...
TL0014	Pinusolide	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, ...
TN1016	Kukoamine A	Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, it also has neuroprotective effects through inhibiting oxidativ...
TN1097	Beta-boswellic acid	Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic activities.
TN1182	11-Keto-beta-boswellic acid	11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose dependent cardioprotective effect manifest...
TN1244	3'-Demethylnobiletin	3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human colon cancer cells, cause cell-cycle ...
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid	3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
TN1291	5-Hydroxy-3',4',7-trimethoxyflavone	5-Hydroxy-3',4',7-trimethoxyflavone has anti-inflammatory, antibacterial and antifungal activities, it also shows moderate antitrypanosomal activity with MIC va...
TN1871	Ligustroside	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosi...
TN2330	Caffeic Acid 3-Methyl Phenethyl Ester	Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances apoptosis in azoxymethane ind...
TN4331	Isotachioside	Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
TN4783	Picralinal	Picralinal has anti-inflammatory and analgesic effects.
TN5020	(+/-)-Sigmoidin A	Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
TN5174	Trichosanatine	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanati...
TQ0180	Chebulagic acid	Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.