Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.

Cat. No.	Product name	CAS No.	Purity
T10208	A-69412	123606-23-5	98%
T10208	A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to treat ulcerative colitis and asthma, and possibly other in...
T25737	Linetastine	159776-68-8	98%
T25737	Linetastine is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of...
T68037L	CBS-1114 HCl	33244-00-7	98%
T68037L	CBS-1114 HCl is a 5-lipoxygenase inhibitor and an anti-inflammatory compound in a good eye-permeable model.CBS-1114 HCl maintains and improves cardiac function, ...
T62606	ALOX15-IN-2	2764818-23-5	98%
T62606	ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate...
T34624	Setileuton	910656-27-8	98%
T34624	Setileuton is a specific 5-LOX inhibitor and can be used in research on asthma and atherosclerosis.
T77288	KKII5	6381-55-1	98%
T77288	KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers of s...
T68173	ZD-2138	140841-32-3	98%
T68173	ZD-2138 is a potent and selective specific inhibitor of 5-lipoxygenase (5-LOX) that inhibits allergen-induced pulmonary bronchoconstriction and reduces neurally-...
T37974	(S)-Coriolic acid	29623-28-7	98%
T37974	(S)-Coriolic acid is an important intracellular signaling agent, generated by the reaction of linoleic acid with plant and mammalian lipoxygenases, and is involv...
T27026	CJ-13,610	179420-17-8	98%
T27026	CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expr...
T10719	CCT365623 hydrochloride	2126136-98-7	98%
T10719	CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
TN2688	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone	33900-74-2	98%
TN2688	2,3,4'-Trihydroxy-3',5'-dimethoxypropiophenone is a natural product obtained from Parinari hypochrysea (Chrysobalanaceae). 2,3,4'-Trihydroxy-3',5'-dimethoxypropi...
T10151	5-Lipoxygenase-In-1	125235-15-6	98%
T10151	5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
T11196	Enazadrem	107361-33-1	98%
T11196	Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TN1871	Ligustroside	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN5174	Trichosanatine	169626-16-8	98%
TN5174	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
TL0014	Pinusolide	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10438	AZD 4407	166882-70-8	98%
T10438	AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN4783	Picralinal	20045-06-1	98%
TN4783	Picralinal has anti-inflammatory and analgesic effects.
T4571	Balsalazide	80573-04-2	98%
T4571	Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
TN5020	(+/-)-Sigmoidin A	176046-04-1	98%
TN5020	Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.