Lipoxygenase

Lipoxygenases are a family of (non-heme) iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells.The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives.

Cat. No.	Product name	CAS No.	Purity
T10719	CCT365623 hydrochloride	2126136-98-7	98%
T10719	CCT365623 hydrochloride is an orally active inhibitor of lysyl oxidase (LOX) (IC50: 0.89 μM). It suppresses EGFR (pY1068) and AKT phosphorylation driven by EGF.
T10821	Cirsiliol	34334-69-5	98%
T10821	Cirsiliol is a selective inhibitor of 5-lipoxygenase and a competitive low-affinity ligand of benzodiazepine receptors.
TN5020	(+/-)-Sigmoidin A	176046-04-1	98%
TN5020	Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.
TN4783	Picralinal	20045-06-1	98%
TN4783	Picralinal has anti-inflammatory and analgesic effects.
TN4331	Isotachioside	31427-08-4	98%
TN4331	Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.
T10438	AZD 4407	166882-70-8	98%
T10438	AZD 4407 is a potent inhibitor of 5-lipoxygenase.
TN1871	Ligustroside	35897-92-8	98%
TN1871	Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin E2 (PGE2)-release. Ligustrosid...
TN5174	Trichosanatine	169626-16-8	98%
TN5174	Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development process with the PP2A- α protein. Trichosanatine...
T11196	Enazadrem	107361-33-1	98%
T11196	Enazadrem is a 5-lipoxygenase inhibitor with antiinflammatory activities.
TL0014	Pinusolide	31685-80-0	98%
TL0014	Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, a...
T10151	5-Lipoxygenase-In-1	125235-15-6	98%
T10151	5-Lipoxygenase-In-1 (compound example 4.10) is a 5-Lipoxygenase inhibitor extracted from patent EP 331232 A2.
T4571	Balsalazide	80573-04-2	98%
T4571	Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
T13764	Lycopodine	466-61-5	98%
T13764	Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Lycopodine, a pharmacologically important bioactive comp...
T39986	LOX-IN-3 dihydrochloride	2409964-23-2	98%
T39986	LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50<10 μM) and human LOXL2 (IC50<1 μM)activities...
T9878	CROCONAZOLE	77175-51-0	98%
T9878	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the syn...
T21838	1-Naphthyl 3,5-dinitrobenzoate	93261-39-3	98%
T21838	1-Naphthyl 3,5-dinitrobenzoate is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.
T5759	S-(+)-Marmesin	13849-08-6
T5759	Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.
T22054	BW 755C	66000-40-6
T22054	BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid	146019-25-2
TN1255	3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).
T1677	Montelukast	158966-92-8	100%
T1677	Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked t...