Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.

Cat. No.	Product name	CAS No.	Purity
T78125	PVZB1194	1141768-04-8	98%
T78125	PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through inh...
T16152	Betamethasone 17-benzoate	22298-29-9	98%
T16152	Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
TQ0314	EMD534085	858668-07-2	98%
TQ0314	EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T9207	GW406108X	1644443-92-4	98%
T9207	GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) a...
T14906	CCT251455	1400284-80-1	98%
T14906	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T28848	SR31527	311814-78-5	98%
T28848	SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability ...
T11859L	Litronesib	910634-41-2	98%
T11859L	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T12434	PF-2771	2070009-55-9	98%
T12434	PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor. PF-2771 inhibits CENP-E motor activity with an IC 50 of 16.1 nM. PF-2771 is used as an...
T4649	(S)-Monastrol	254753-54-3	98%
T4649	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T17007	TC-Mps1-12	1206170-62-8	98%
T17007	TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
T9682	AZD-4877	758722-49-5	99.87%
T9682	AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, ind...
T16130	Mps1-IN-3	1609584-72-6	99.85%
T16130	Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
T29059	UMK57	342595-74-8	99.81%
T29059	UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, an...
T14765	BOS-172722	1578245-44-9	99.79%
T14765	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
T9207L	GW406108X(Z/E)	265098-01-9	99.71%
T9207L	GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
T2039	GSK-923295	1088965-37-0	99.71%
T2039	GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
T12359	Paprotrain	57046-73-8	99.69%
T12359	Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.
T2103	Ispinesib	336113-53-2	99.57%
T2103	Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic prope...
T3434	BAY1217389	1554458-53-5	99.54%
T3434	BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
T3120	K858 (Racemic)	72926-24-0	99.5%
T3120	K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.