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Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.

  • BAY1217389
    T34341554458-53-5In house
    BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
    • $33
    In Stock
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  • GW406108X(Z/E)
    T9207L265098-01-9
    GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
    • $133
    In Stock
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  • CFI-402257
    T222891610759-22-2
    CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.
    • $115
    In Stock
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  • Eg5-IN-1
    T77586
    Eg5-IN-1 is a potent inhibitor of the kinesin family of motor proteins (Eg5) with an IC50 value of 1.97 µM for Eg5.Eg5-IN-1 can be used in cancer research.
    • $195
    In Stock
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    TargetMol | Inhibitor Sale
  • Litronesib
    T11859L910634-41-2In house
    Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
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    TargetMol | Inhibitor Sale
  • Eg5 Inhibitor V, trans-24
    T11155869304-55-2In house
    Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
    • $155
    In Stock
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  • Paprotrain
    T1235957046-73-8
    Paprotrain ((alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile) inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM.
    • $40
    In Stock
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    TargetMol | Inhibitor Sale
  • Betamethasone 17-benzoate
    T1615222298-29-9
    Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
    • $1,520
    Backorder
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    TargetMol | Inhibitor Sale
  • BRD9876
    T834232703-82-5
    BRD9876 is a selective inhibitor of MM1S growth.
    • $30
    In Stock
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    TargetMol | Inhibitor Sale
  • NMS-P715
    T122371202055-32-0
    NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
    • $72
    In Stock
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    TargetMol | Inhibitor Sale
  • (S)-Monastrol
    T4649254753-54-3
    Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
    • $595
    35 days
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    TargetMol | Inhibitor Sale
  • Dimethylenastron
    T3118863774-58-7
    Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
    • $30
    In Stock
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  • Mps1-IN-2
    T18391228817-38-6
    Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
    • $33
    In Stock
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  • GW406108X
    T92071644443-92-4
    GW406108X (GW108X) is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW406108X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block autophagic flux.
    • $148
    5 days
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  • GSK-923295
    T20391088965-37-0
    GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
    • $45
    In Stock
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  • CW-069
    T62091594094-64-0
    CW-069 (IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
    • $48
    In Stock
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  • ARQ 621
    T63931095253-39-6
    ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
    • $56
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  • PVZB1194
    T781251141768-04-8
    PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through inhibiting Eg5 ATPase activity. It binds to the α4/α6 allosteric pocket and demonstrates ATP-competitive activity [1].
    • Inquiry Price
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  • BOS-172722
    T147651578245-44-9
    BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
    • $74
    In Stock
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  • S-trityl-L-Cysteine
    T368162799-07-7
    S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. S-trityl-L-Cysteine inhibits the ATPase activity of Eg5 in basal and microtubule-stimulated states (IC50s = 1,000 and 140 nM, respectively). It is selective for Eg5 over nine other human kinesins in an enzyme-coupled assay. It reversibly inhibits Eg5-driven microtubule sliding velocity with an IC50 value of 500 nM using X. laevis recombinant Eg5. It induces cell cycle arrest in HeLa cells (IC50 = 700 nM), reversibly halting the cell cycle in the mitotic phase by inhibiting the separation of duplicated chromosomes and preventing bipolar spindle formation. S-trityl-L-Cysteine inhibits the growth of cancer cells in vitro when tested against the National Cancer Institute (NCI) 60 human cancer cell line panel (average GI50 = 1.3 μM) and in mouse xenograft models.
    • $30
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  • TC-Mps1-12
    T170071206170-62-8
    TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
    • $543
    35 days
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  • UMK57
    T29059342595-74-8
    UMK57 is a CENP-Ei and MCAK enhancer, selectively promoting k-MT attachment error correction to inhibit chromosome missegregation of small molecule compounds, and can improve chromosome separation conservation by disrupting the stability of kinetosomal microtubule (k-MT) attachment during mitosis.
    • $53
    In Stock
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  • EMD534085
    TQ0314858668-07-2
    EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
    • $98
    35 days
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  • CCT251455
    T149061400284-80-1
    CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
    • $1,820
    Backorder
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  • PF-2771
    T124342070009-55-9
    PF-2771 is a potent and selective centromere protein E (CENP-E) inhibitor. PF-2771 inhibits CENP-E motor activity with an IC 50 of 16.1 nM. PF-2771 is used as an anticancer agent.
    • $1,490
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  • Ispinesib
    T2103336113-53-2
    Ispinesib (SB-715992), a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.
    • $33
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  • MPI-0479605
    T23131246529-32-7
    MPI-0479605 is an ATP competitive and selective inhibitor.
    • $86
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  • K858 (Racemic)
    T312072926-24-0
    K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
    • $39
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  • Monastrol
    T4048329689-23-8
    Monastrol ((±)-Monastrol) is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
    • $41
    In Stock
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  • Mps1-IN-3
    T161301609584-72-6
    Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
    • $41
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  • AZ3146
    T26891124329-14-1
    AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
    • $35
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  • Empesertib
    T84871443763-60-7
    Empesertib (BAY 1161909) is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
    • $139
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  • SR31527
    T28848311814-78-5
    SR31527 (SR31527 chloride) is a potent KIFC1 inhibitor with an IC50 of 6.6 µM against KIFC1. SR31527 chloride has a moderate inhibitory effect on cell viability and colony formation.
    • $1,350
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  • AZD-4877
    T9682758722-49-5
    AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).
    • $293
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  • SB-743921 hydrochloride
    T2255940929-33-9
    SB-743921 hydrochloride (SB743921 HCl) is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).
    • $45
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