od-1

Potent rat Nav1.7, human Nav1.4 and rat Nav1.6 channel activator (EC50 values are 7, 10 and 47 nM, respectively). Exhibits minimal activation at mammalian Nav1.2, Nav1.3 and Nav1.5 (EC50 values >3 μM). Inhibits fast inactivation on all channels. Increases

Tofersen (BIIB067) is an antisense oligonucleotide (ASO) that mediates RNase H-dependent degradation of SOD1 (superoxide dismutase 1) mRNA, inhibiting SOD1 protein synthesis for potential use in amyotrophic lateral sclerosis (ALS).

C12-iE-DAP hydrochloride is the hydrochloride salt form of C12-iE-DAP and is a biologically active peptide that functions as an agonist of NOD1, making it a useful research reagent for investigating innate immune recognition, pattern recognition receptor signaling, and host–pathogen interaction pathways.