hk-2

UC2288 is a relatively selective p21 attenuator which is synthesized based Sorafenib. UC2288 attenuates p21 protein levels with minimal effect on p21 protein stability.

HK2-IN-3 (compound 12) is a potent hexokinase 2 (HK2) inhibitor with an IC50 of 56.4 nM. It reduces glucose uptake and downregulates GLUT1/GLUT4 expression in oral squamous cell carcinoma (OSCC). HK2-IN-3 induces mitophagy (mitophagy) and apoptosis (apoptosis). In OSCC xenograft mouse models, HK2-IN-3 suppresses tumor growth and angiogenesis. It can be utilized in OSCC research.

HK-2-IN-1 is an inhibitor of Hexokinase 2 (HK-2). It exhibits non-activation effects on human recombinant HK-2 enzyme. HK-2-IN-1 possesses antitumor activity, impacting immune cells within the tumor microenvironment. It has immunomodulatory properties and is applicable in research on cancers such as colon cancer, liver cancer, and breast cancer.

KHK-2898 represents a highly specialized humanized monoclonal antibody specifically engineered to target the CD98 heavy chain (CD98hc/SLC3A2) with exceptional binding affinity to the human and monkey LAT1/CD98hc complex. It effectively facilitates the measurable blockade of amino acid transport and the induction of potent antibody-dependent cellular cytotoxicity (ADCC) across various preclinical experimental models to evaluate the disruption of tumor nutrient uptake and metabolic homeostasis during strictly monitored laboratory observation periods and functional cell viability assays.

The Anti-Chikungunya virus E2 Antibody (CHK-265) is a monoclonal antibody derived from mouse IgG2c that targets the B domain of the E2 glycoprotein of the chikungunya virus. The isotype control for this antibody is Mouse IgG2c kappa, Isotype Control.

KHK-2866 is a humanized monoclonal antibody targeting Heparin-Binding Epidermal Growth Factor-like Growth Factor (HB-EGF). By binding to HB-EGF, KHK-2866 blocks its interaction with EGFR and HER4 receptors, thereby inhibiting the proliferation and survival of tumor cells. HB-EGF is frequently overexpressed in various solid tumors, making it a key therapeutic target.

L-Ornithine hydrochloride ((S)-2,5-Diaminopentanoic acid) has an antifatigue effect by increasing the efficiency of energy consumption and promoting the excretion of ammonia. It is one of the key reactants in the urea cycle.

Fenoldopam mesylate (Corlopam mesylate) is a selective dopamine-1 receptor (DA1) agonist with natriuretic/diuretic properties. It lowers blood pressure through arteriolar vasodilation.

Baricitinib (INCB028050) is a JAK1 and JAK2 inhibitor (IC50=5.9/5.7 nM) with selective and oral activity. Baricitinib has potential anti-inflammatory, immunomodulatory and anti-tumor activity.

Prexasertib (LY2606368) is a selective checkpoint kinase 1 (CHK1) inhibitor (Ki 0.9 nM, IC50<1 nM). Prexasertib causes double-stranded DNA breaks and replication mutations, leading to apoptosis. Prexasertib has antitumor activity.

G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic that selectively inhibits eukaryotic protein synthesis by blocking peptide chain elongation.

Pancreatic Polypeptide, rat acetate is an agonist of NPY receptor, with high affinity at NPYR4.

ANI-7 is an activator of the aryl hydrocarbon receptor (AhR) pathway, inhibiting the growth of various cancer cells and selectively inhibiting the growth of MCF-7 breast cancer cells (GI50: 0.56 μM).

CCT241533 is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).

CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity.

SLP9101555 is a potent and selective sphingosine kinase 2 (SphK2) inhibitor with a Ki of 90 nM.SLP9101555 has a high affinity for SphK2, which is 200-fold higher than that of SphK1.SLP9101555 dramatically reduces extracellular S1P sphingosine 1-phosphate (S1P) levels.

K145 hydrochloride is a selective sphk2 inhibitor with substrate competitiveness and oral activity, with IC50 of 4.3 µM and Ki of 6.4 µM. K145 hydrochloride can induce apoptosis and has strong antitumor activity.

Tenofovir hydrate (GS 1278 hydrate) is a nucleotide reverse transcriptase inhibitor with antiviral activity, inhibits EBV replication, and is used in the study of HIV and HBV.

L-Glutamic acid is an excitatory amino acid neurotransmitter and a Glutamic acid receptor agonist, including metabolic glutamic acid receptor (mGluR), AMPA receptor, NMDA receptor and KA receptor. L-Glutamic acid has an excitatory effect on the process of DA release from dopaminergic nerve endings. L-Glutamic acid can be used in the research of neurological diseases. L-Glutamic acid acts on ionic and metabolic Glutamic acid receptors.

Piericidin A is a natural mitochondrial NADH- ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A interferes with the electron transfer chain by inhibiting the activity of NADH- ubiquinone reductase, thus inhibiting mitochondrial respiration, which shows a certain neurotoxic effect. Piericidin A has potential quorum sensing inhibitory activity, antibacterial, antitumor and insecticidal activities.

4′-Bromoflavone is a flavonoid derivative that acts as a chemopreventive agent against cancer and is an effective inducer of phase II detoxification enzymes.

Tubulin polymerization-IN-4 is an effective inhibitor of tubulin polymerization, and its IC₅₀ is 4.6 μM m. In HeLa cells, Tubulin polymerization-IN-4 can interfere with microtubule assembly and destroy the intracellular microtubule network, leading to cell cycle stagnation in G2/M phase, inducing cell apoptosis, and inhibiting cell clone formation and migration ability.

CCT241533 hydrochloride is an effective and selective ATP competitive inhibitor of CHK2 (Ki: 1.16 nM; IC50: 3 nM).

K145 is inactive against SphK1 and other protein kinases. K145 induces cell apoptosis and has potently antitumor activity. K145 is a selective, substrate-competitive and orally active SphK2 inhibitor with an IC50 of 4.3 µM and a Ki of 6.4 µM.