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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5513 | RO-3 | P2X Receptor | |
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor | |||
T34360 | Ro 3-7410 | Ro-3-7410 | |
Ro 3-7410 is an active hydroxy metabolite of bufuralol. | |||
T34359 | Ro 3-5940 HCl | Ro 3 5940 HCl | |
Ro 3-5940 HCl is a psychoactive agent, increasing in production of serotonin in central nervous system tissue. | |||
T6312 | R547 | Ro 4584820 | Apoptosis , GSK-3 , PKA , CDK |
R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. | |||
T3915 | Ginsenoside Ro | Chikusetsusaponin 5,Polysciasaponin P3,Chikusetsusaponin V | Calcium Channel , Reductase , Prostaglandin Receptor |
Ginsenoside Ro (Chikusetsusaponin V) can reduce TXA2 production, weakly reduce COX-1 and TXAS activities, and has antiplatelet effects as a Ca2+ antagonist with an IC50 of 155 μM. | |||
T0110 | Zalcitabine | Dideoxycytidine,ddC,NSC 606170,Ro 24-2027/000,2',3'-Dideoxycytidine | HIV Protease , Reverse Transcriptase |
Zalcitabine (Dideoxycytidine)(Dideoxycytidine;ddC; 2', 3'-Dideoxycytidine) is a nucleoside analog reverse transcriptase inhibitor (NRTI); At low concentrations, It can potently inhibit HIV replication by binding to rever... | |||
T0860L | Mefloquine | Ro215998,WR 142490,Ro-215998,Lariam,Ro 215998 | Others |
Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic l... | |||
T30611 | Bufuralol | Ro3-4787,Ro 3-4787,Ro-3-4787 | |
Bufuralol is a Adrenergic Agent. | |||
T10119 | 3-O-Methyltolcapone | Ro 40-7591 | Transferase |
3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier and can be used for treatment of Parkinson's disease. | |||
T19706 | Ro 20-1724 | Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724 | PDE |
Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) is a widely used inhibitor of cyclic nucleotide phosphodiesterase with IC50 of 2.0 μM and Ki of 3.1 μM. | |||
T12571 | PSI-6206 13C,d3 | Sofosbuvir metabolite GS-331007 13CD3,RO-2433 13CD3,PSI-6206 13CD3,GS-331007 13CD3 | Others |
PSI-6206 13CD3 is the deuterium labeled PSI-6206. PSI-6206 is a potent and selective HCV NS5B polymerase inhibitor. | |||
T2087 | AF-353 | Ro-4 | P2X Receptor |
AF-353 (Ro-4), an effective and orally bioavailable antagonist of the P2X3/P2X2/3 receptor, inhibits human and rat P2X3 (pIC50= 8.0). | |||
T1896 | Ro 61-8048 | Hydroxylase | |
Ro 61-8048 is a potent and selective inhibitor of kynurenine hydroxylase with an IC50 value of 37 nM. | |||
T6643 | Ro 31-8220 Mesylate | Ro 31-8220 methanesulfonate,Bisindolylmaleimide IX,Bisindolylmaleimide IX mesylate | PKC |
Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor for PKC-α/βI/βII/γ/ε (IC50: 5/24/14/27/24 nM), and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β. | |||
T28598 | Ro-23-9424 | Ro 239424,Ro23-9424 | |
Ro-23-9424 is a dual-action cephalosporin with a fleroxacin esterified at the 3' position and aminothiazolylmethoxyimino-type side chain at the 7 position. Ro-23-9424 has broad and potent antibacterial activity in vitro... | |||
T10118 | 3-O-Methyltolcapone D7 | Ro 40-7591 D7 | Transferase |
3-O-Methyltolcapone D7 (Ro 40-7591 D7) is a deuterium labeled 3-O-Methyltolcapone. 3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone which is a potent COMT inhibitor. Tolcapone crosses the blood-brain barrier... | |||
T28775 | Sibrafiban | RO-48-3657/001,RO-48-3657,RO 48-3657/001 | |
Sibrafiban (RO 48-3657) is the orally active, nonpeptide, double-prodrug of Ro 44-3888 which is a selective glycoprotein IIb/IIIa receptor antagonist. Sibrafiban inhibits platelet aggregation [1] [2] [3]. | |||
T21684 | Bufuralol (hydrochloride) | ||
Bufuralol hydrochloride (Ro 3-4787 hydrochloride) is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity, which is also a CYP2D6 probe substrate [1] [2]. | |||
T6643L | Ro 31-8220 | ||
Ro 31-8220 is a potent inhibitor of PKC with IC 50 s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively. Ro 31-8220 also significantly inhibits MAPKAP-K1b, MSK1, S6K1 and G... | |||
T71000 | RO-5328673 | ||
RO-5328673 is a dual NK2/NK3 antagonist. O5328673. [(3)H]RO5328673 bound to a single saturable site on hNK2, hNK3 and gpNK3 with high-affinity. RO5328673 acted as an insurmountable antagonist at both human and guinea-pig... |