arp1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T72553	ARTD10/PARP10-IN-1		PARP
	ARTD10/PARP10-IN-1 is a potent PARP inhibitor of the mono-ADP ribosyltransferases ARTD7/PARP15, ARTD8/PARP14, ARTD10/PARP10 and poly ADP-ribose polymerase-1 (ARTD1/PARP1), with potential anticancer and antitumour activit...		PARP
T9891	PARP1-IN-8	N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide	PARP
	PARP1-IN-8 (N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide) is an effective inhibito of PARP1 (IC50 = 97 nM).		PARP
T67932	PARP10-IN-3		PARP
	PARP10-IN-3 is a potent and selective mono-Adp-ribotransferase PARP10 inhibitor that inhibits human PARP10 (IC50:480 nM). PARP10-IN-3 also inhibited human PARP2 and human PARP15 with IC50 values of 1.7 μM.		PARP
T73007	PARP10-IN-2		PARP
	PARP10-IN-2 is a potent inhibitor of PARP10, a mono-ADP-ribosyltransferase, with an IC50 value of 3.64 μM for human PARP10.PARP10-IN-2 also inhibited PARP2 and PARP15, with IC50 values of 27 μM and 11 μM, respectively.		PARP
T9610	PARP1-IN-5 dihydrochloride		PARP
	PARP1-IN-5 dihydrochloride is an orally active, potent and selective PARP-1 inhibitor (IC50 =14.7 nM). PARP1-IN-5 dihydrochloride can be used for the research of cancer.		PARP
T72437	PARP1/2/TNKS1/2-IN-1		Apoptosis , PARP , Wnt/beta-catenin
	PARP1/2/TNKS1/2-IN-1 is a multi-target inhibitor of PARP-1, PARP-2, TNKS1 and TNKS2.PARP1/2/TNKS1/2-IN-1 has potential anti-tumor activity and induces apoptosis.		Apoptosis , PARP , Wnt/beta-catenin
T60567	PARP10/15-IN-2
	PARP10/15-IN-2 (Compound 8h) is a dual inhibitor of PARP10 and PARP15 with IC 50 values of 0.15 μM and 0.37 μM, respectively. PARP10/15-IN-2 can enter cells and rescue cells from apoptosis [1].
T60309	PARP10/15-IN-3
	PARP10/15-IN-3 (Compound 8a) is a potent PARP10 and PARP15 dual inhibitor with IC 50 values of 0.14 μM and 0.40 μM against PARP10 and PARP15, respectively. PARP10/15-IN-3 can enter cells and rescue cells from apoptosis [...
T62540	PARP1/BRD4-IN-2
	PARP1/BRD4-IN-2 is a potent and selective inhibitor of PARP1 (IC50: 197 nM) and BRD4 (IC50: 238 nM).PARP1/BRD4-IN-2 inhibits DNA damage repair, blocks the G0/G1 cell cycle transition, and induces apoptosis.PARP1/BRD4-IN-...
T60495	PARP10/15-IN-1
	PARP10/15-IN-1 (compound 8l) is a dual PARP10 and PARP15 inhibitor with IC50s of 160 nM and 370 nM, respectively. It can be used in cancer research[1].
T81544	PARP1-IN-16		PARP
	PARP1-IN-16 (compound 12a) serves as a potent PARP1 inhibitor, exhibiting an IC50 value of 1.89 nM. It possesses the capability to halt the cell cycle at the S phase and stimulate apoptosis in HCT-116 cells [1].		PARP
T62955	PARP1-IN-5
	PARP1-IN-5 is a potent, selective, orally active, low-toxicity PARP-1 inhibitor with an IC50 value of 14.7 nM. PARP1-IN-5 can be used in cancer research.
T72397	PARP11 inhibitor ITK7	ITK7
	PARP11 Inhibitor ITK7 (ITK7) is a potent, selective inhibitor of PARP11, demonstrating significant efficacy with an IC50 value of 14 nM. It is primarily utilized in research focused on cellular localization.
T73023	PARP1-IN-12
	PARP1-IN-12, a potent inhibitor of PARP1, demonstrates an IC50 value of 2.99 nM. It exhibits antiproliferative effects, induces apoptosis, and causes cell cycle arrest in the G2/M phase. Additionally, PARP1-IN-12 induces...
T60637	PARP1-IN-11
	PARP1-IN-11 (compound 49) is a potent inhibitor of PARP1 with IC50 value of 0.082 μM which shows complete inhibition of PARP1 and substantially inhibits PARP3, TNKS1 and TNKS2 [1].
T81543	PARP1-IN-17		PARP
	PARP1-IN-17 is an inhibitor that targets PARP-1 (IC50=19.24 nM ) with a slightly reduced affinity for PARP-2 (IC50=32.58 nM ) and induces apoptosis. It exhibits robust anti-proliferative activity [1].		PARP
T79405	PARP1-IN-15		PARP
	PARP1-IN-15 (Compound 6) is a PARP1 inhibitor that also inhibits tankyrase (TNKS) and promotes DNA double-strand breaks, leading to tumor cell apoptosis. It exhibits anti-cancer activity in triple-negative breast cancer ...		PARP
T12366	PARP14 inhibitor H10		PARP
	PARP14 inhibitor H10 is a selective inhibitor against PARP14 with IC50 of 490 nM		PARP
T63471	PARP1/BRD4-IN-1
	PARP1/BRD4-IN-1 is a highly selective and potent inhibitor of PARP1 (IC50: 49 nM) and BRD4 (IC50: 202 nM).PARP1/BRD4-IN-1 inhibits the expression and activity of PARP1 and BRD4, thereby synergistically suppressing the ma...
T13845	PROTAC PARP1 degrader		Others
	PROTAC PARP1 degrader is a degrader of PARP1 based on the PROTAC technology. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line (IC50 of 6.12 μM).		Others
T61694	PARP1-IN-10
	PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor, displaying an in vitro IC50 value of 50.62 nM. This compound effectively induces cell cycle arrest at the G2/M phase and apoptosis, while a...
T79593	PARP1-IN-14		PARP
	PARP1-IN-14 (compound 19k) is a potent PARP1 inhibitor demonstrating an inhibition concentration (IC50) of 0.6 ± 0.1 nM. It shows an antiproliferative effect on MDA-MB-436 (BRCA1 −/−) and Capan-1 (BRCA2 −/−) cells, with ...		PARP
T39139	PARP1-IN-6	PARP1-IN-6
	PARP1-IN-6, a dual-function inhibitor, targets both tubulin and PARP-1, demonstrating inhibitory concentration (IC50) values of 0.94 μM for tubulin and 0.48 μM for PARP-1.
T72554	ARTD10/PARP10-IN-2
	ARTD10/PARP10-IN-2 is a potent, non-selective inhibitor of mono-ADP-ribosyltransferases ARTD10/PARP10 and poly(ADP-ribose) polymerase-1 ARTD1/PARP1, exhibiting IC50 values of 2.0 μM and 9.7 μM, respectively.
T61325	PARP1-IN-9
	PARP1-IN-9 (Compound 5c) is a potent PARP1 inhibitor, displaying an IC 50 of 30.51 nM. With its ability to induce cell apoptosis and exhibit anticancer activity, PARP1-IN-9 surpasses Olaparib in terms of efficacy [1].
T61879	PARP1-IN-7
	PARP1-IN-7 functions as an anticancer agent by inhibiting poly(ADP-ribose) polymerase-1 (PARP1).

Compounds

ARTD10/PARP10-IN-1

T72553

Synonym: N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide

PARP1-IN-5 dihydrochloride

Target: Apoptosis, PARP, Wnt/beta-catenin

PARP11 inhibitor ITK7

PROTAC PARP1 degrader

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-03065	BACE2 Protein, Mouse, Recombinant (His)	Mouse	HEK293 Cells
	BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is th...
TMPH-01942	PARP14 Protein, Human, Recombinant (His & Myc)	Human	HEK293 Cells
	PARP14 Protein, Human, Recombinant (His & Myc) is expressed in HEK293.
TMPH-01879	PARP11 Protein, Human, Recombinant (His)	Human	E. coli
	Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Plays a role in nuclear envelope stability and nuclear remodeling during spermiogenesis. PARP11 Protein, Human, Recombinant (His) is exp...
TMPH-01941	PARP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	PARP12 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.