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Antifection

An infection is the invasion of tissues by pathogens, their multiplication, and the reaction of host tissues to the infectious agent and the toxins they produce. Antifection includes antibiotics, antifungals, antiprotozoa and antivirals.

  • Allicin
    T3123539-86-6
    Allicin exerts antioxidant, bactericidal, anti-cancer, anti-inflammatory activities, it exerts an inhibitory immunomodulatory effect on intestinal epithelial cells. Allicin could significantly inhibit vascular smooth muscle cells' proliferation and migration induced by insulin, which may be related to the inhibition of the activation of ERK signal path. Allicin is beneficial in reducing blood cholesterol, triglycerides levels and systolic blood pressure in hypercholesterolemic rats, it may beneficially affect two risk factors for atherosclerosis-hyperlipidemia and hypertension.
    • $40
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  • Ganciclovir
    T068882410-32-0
    Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
    • $51
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    TargetMol | Citations Cited
  • Chlorhexidine diacetate
    T1000L56-95-1
    Chlorhexidine diacetate (Bactigras) is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.
    • $39
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  • Tivicilovir
    T67813103024-93-7In house
    Tivicilovir (AM188) is a hepatitis B virus inhibitor. tiviclovir is a guanine-related acyclic 2'-deoxyguanine analogue with anti-herpesvirus activity.
    • $138
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  • Kamebanin
    TN437539388-57-3
    Kamebanin, a natural diterpenoid, has antibacterial activity. It also shows efficient cytotoxic activity against HeLa and HL-60 cells.
    • $786
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  • Calycanthoside
    TN1463483-91-0
    Calycanthoside (Isofraxidin 7-O-beta-D-Glucoside) is a natural compound isolated from Angelica tenuissima. Calycanthoside shows anti-inflammatory and antibacterial effects.
    • $106
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  • Trichorabdal A
    TN517385329-59-5
    Trichorabdal A shows a very strong in vitro antibacterial activity against Helicobacter pylori.
    • $829
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  • Dehydroabietinol
    TN37903772-55-2
    Dehydroabietinol (Pomiferin A) inhibits growth of chloroquine-sensitive as well as chloroquine-resistant strains of Plasmodium falciparum cultivated in erythrocytes in vitro (IC 50 26-27 microM).
    • $117
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  • GR-95168
    T6780095463-56-2In house
    GR-95168 ((+)-C-BVDU) is an antiviral compound for the study of herpes simplex virus infections type 1 and type 2.
    • $293
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  • Hydrangenol
    TN4234480-47-7In house
    Hydrangenol is a natural product and can be isolated from Hydrangea serrata leaves. Hydrangenol is an antiphotoaging compound with oral activity. Hydrangenol can reduce MMP and inflammatory cytokine expression and increase moisturizing factors and antioxidant genes level, result in preventing wrinkle formation.
    • $139
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  • STING agonist-30
    T748092951078-67-2In house
    STING agonist-30 is a potent STING agonist that triggers STING-dependent immune activation.STING agonist-30 shows broad-spectrum inhibitory effects against a variety of viruses including HSV (Herpes Simplex Virus), rotavirus, and SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2).
    • $293 TargetMol
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  • Eprociclovir
    T31659145512-85-2In house
    Eprociclovir (A-5021) is a novel acyclovir analog that is a potent inhibitor of EHV1 replication and may be used for the treatment and/or prevention of infections with this virus.Eprociclovir has potent anti-herpetic activity against most human herpesviruses.
    • $160
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  • Rifampicin
    T068113292-46-1
    Rifampicin (Rifamycin AMP) is an antibacterial drug of the class of rifamycin.
    • $45
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  • Fluconazole
    T138886386-73-4
    Fluconazole (UK-49858) is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS.
    • $36
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  • Voriconazole
    T0120137234-62-9
    Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A.
    • $30
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  • Corchoionoside C
    TN3699185414-25-9
    Corchoionoside C has antioxidant activity, shows strong scavenging activities on DPPH radical, it also shows weak antifungal activity. Corchoionosides A, B, and C inhibit the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
    • $620
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  • Kielcorin
    TN438864280-48-4
    Kielcorin shows antibacterial activity against strain EMRSA-16. It also shows in vitro anti-inflammatory (respiratory burst) inhibiting activities using isolated human neutrophils (IC (50) = 965.21 ± 65.80 uM). trans-Kielcorin has hepatoprotective activity, it can prevent tert-butylhydroperoxide-induced lipid peroxidation and cell death in freshly isolated rat hepatocytes.
    • $2,389
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  • Garcinone E
    TN4113112649-21-5
    Garcinone E is active constituents in the anticomplement assay used. Garcinone E exhibits potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM. It has potent cytotoxic effect on all hepatocellular carcinomas cell lines as well as on the other gastric and lung cancer cell lines included in the screen, may be potentially useful for the treatment of certain types of cancer.
    • $2,798
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  • Lysicamine
    TN447115444-20-9
    Lysicamine shows significant antioxidant capacity in the ORAC(FL) assay and it is active against S. epidermidis and C. dubliniensis, with MIC values in the range 12.5-100 microg mL(-1). Lysicamine has antimicrobial and anti-inflammation activity, the mini
    • $730
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  • 3-O-trans-p-Coumaroyltormentic acid
    TN2977121064-78-6
    3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
    • $1,918
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  • Bonducellpin D
    TN3528197781-85-4
    Bonducellpin D may show inhibitory activities on the Para3 virus. It also exhibits moderate activity against four tested human cancer cell lines, HepG-2, K562, HeLa, and Du145.
    • $740
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  • Coronarin E
    TN3710117591-81-8
    Coronarin E exhibits weak antimicrobial activity.
    • $1,398
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  • 7',8'-Dihydroobolactone
    TN32201240403-82-0
    7',8'-Dihydroobolactone can inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.
    • $660
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  • Methyl 3-O-feruloylquinate
    TN4531154418-15-2
    Methyl 3-O-feruloylquinate inhibits the activity of bacteria and viruses and to regulate immunity.
    • $2,840
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  • 5-Heneicosylresorcinol
    TN311270110-59-7
    5-Heneicosylresorcinol shows inhibitory effects on the release of β-hexosaminidase from RBL-2H3 cells, it also prevents triglyceride accumulation in 3T3-L1 cells. 5-Heneicosylresorcinol has nematicidal activity against nematodes Panagrellus redivivus, Cae
    • $240
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  • Chlorophorin
    TN3644537-41-7
    Chlorophorin shows high anti-protozoal activity with an MIC of 0.25 microg/ml. Chlorophorin can strongly inhibit mushroom tyrosinase activity with IC50 values of 2.5 ± 0.408 uM; it inhibits α-melanocyte-stimulating hormone-induced melanin production in B16F10 melanoma cells.
    • $2,280
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  • beta-Yohimbine
    TN3507549-84-8
    Beta-Yohimbine has approximately twice as toxic as yohimbine and corynanthine about one fifth as toxic. Beta-yohimbine has alpha-1 and alpha-2 adrenoceptor blocking activities, it has cardiovascular effects. Beta-Yohimbine has anti-plasmodial and anti-mal
    • $1,950
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  • Cristacarpin
    TN371974515-47-2
    Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
    • $1,980
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  • Torachrysone-8-O-b-D-glucoside
    TN227764032-49-1
    Torachrysone-8-O-b-D-glucoside shows alpha-glucosidase inhibitory activities, it may be used for the management of type 2 diabetes.
    • $113
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  • Penduletin
    TN4748569-80-2
    Penduletin has anti-inflammatory,anti-tumor cells, and anti-bacterical activities,it inhibits growth of the Gram-negative pathogen neisseria gonorrhoeae. Penduletin has strong activity in vitro against EV71 with low cytotoxicity.
    • $797
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  • Phaseollidin hydrate
    TN476076122-57-1
    Phaseollidin hydrate shows less antifungal activity than the original phytoalexin phaseollidin.
    • $798
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  • 7-Angeloylretronecine
    TN32216029-82-9
    7-Angeloylretronecine may have antibacterial effects.
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  • Latifolin
    TN442010154-42-4
    Latifolin is a strong DPPH-scavenger, it attenuates inflammatory responses by inhibiting NF-κB activation via Nrf2-mediated heme oxygenase-1 expression. Latifolin displays potent anticarcinogenic phase II marker enzyme, quinone reductase (QR) inducing activity and high chemopreventive indices. Latifolin also shows antifungal activity against white- and brown-rot fungi.
    • $540
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  • Isocudraniaxanthone B
    TN4276199851-52-0
    Isocudraniaxanthone B may have antimalarial activity.
    • $2,468
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  • Anisofolin A
    TN342283529-71-9
    Anisofolin A has promising antimalarial activity (IC50 4.39 ± 0.25 uM). It has promising antimycobacterium activity [IC50 4.50 ± 0.75 uM (3.31 ug/mL)] against M. tuberculosis H37Ra and at 100 ug/mL, shows 55.6 % inhibition of M. bovis.
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  • Norchelerythrine
    TN19916900-99-8
    Norchelerythrine shows significant inhibitory activity against Staphylococcus aureus ATCC 6538 with MIC values ranging from 12.5 to 50 ug/mL. It exhibits strong antifeeding activity in a concentration-dependant manner with the EC50 of 62.67 ppm.
    • $1,678
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  • 2,3,24-Trihydroxy-12-ursen-28-oic acid
    TN268589786-83-4
    2α,3α,24-Trihydroxyurs-12-en-28-oic acid, a triterpenoid phytoalexin, shows antifungal activity against the fungus mentioned. It also shows in vitro cytotoxic activity against tumor cell lines including PLC,Hep3B,HepG2,HeLa,SW480,MCF-7 and Bel7402.
    • $620
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  • 14-Deoxy-17-hydroxyandrographolide
    TN2623869384-82-7
    14-Deoxy-17-hydroxyandrographolide is a natural product of Andrographis, Acanthaceae. The catalog number is TN2623 and the CAS number is 869384-82-7. 14-Deoxy-17-hydroxyandrographolide can be used as a reference standard.
    • $740
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  • Calceolarioside A
    TN356884744-28-5
    Calceolarioside A shows potent activity against visceral leishmaniasis. It can induce a dose-related aggregant effect on rabbit platelets, which may be partly related to a calcium-dependent mechanism. Calceolarioside A also has potent antioxidative activi
    • $538
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  • Methylenetanshinquinone
    TN193067656-29-5
    Methylenetanshinquinone shows antiplasmodial and antitrypanosomal activity, it is active against both Trypanosoma brucei rhodesiense and Plasmodium falciparum.
    • $870
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  • Quassin
    TN212076-78-8
    Quassin has female anti-fertility properties, possibly acting via inhibition of estrogen secretion.
    • $213
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  • 24-Methylenecycloartan-3-ol
    TN28201449-09-8
    24-Methylenecycloartan-3-ol and methyl caffeate show weak activity against Staphylococcus aureus and Escherichia coli.
    • $460
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  • Albaspidin AA
    T2S11153570-40-9
    Albaspidin AA displays strong antibacterial activity against the vegetative form of P. larvae (MIC ranging from 0.168-220 uM). It may have in vitro nematocidal activity against L4 stage larvae.
    • $200
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  • Norsanguinarine
    TN1993522-30-5
    Norsanguinarine has antifungal activity, it exhibits 100 % inhibition of A. brassicicola and C. maculans at 1000 ppm whereas. It shows significant cytotoxic activities (ED (50) values < 4 microg/ml) against P-388, KB16, A549, and HT-29 cell lines.
    • $540
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  • 2,6-Dimethoxy-1-acetonylquinol
    TN27382215-96-5
    2,6-Dimethoxy-1-acetonylquinol shows varying degrees of in vitro antimalarial activity against Plasmodium falciparum. It is devoid of significant cytotoxicity to the human oral epidermoid KB cancer cell line.
    • $360
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  • Torachrysone
    TN227822649-04-3
    Torachrysone shows promising antioxidant activity. Torachrysone, toralactone , aloe-emodin, rhein and emodin show noticeable antibacterial effects on four strains of methicillin-resistant Staphylococcus aureus with a minimum inhibitory concentration of 2-
    • $638
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  • (-)-Corynoxidine
    TN152757906-85-1
    (-)-Corynoxidine is an AChE inhibitor derived from tubers of Stephania succifera. Corynoxidine exhibits antibacterial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus strains in different degrees.
    • $64
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  • 10-Hydroxycanthin-6-one
    TN256786293-41-6
    10-Hydroxycanthin-6-one has potential to be an antimicrobial agent. 10-Hydroxycanthin-6-one has in vitro antimalarial activity; it also has cytotoxic activity, it could be a plant anticancer agent.
    • $630
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  • Asimilobine
    TN14096871-21-2
    (-)-Asimilobine shows antioxidative, anti-acetylcholinesterase (AChE), anti-α±-glucosidase, anti-leishmanial and anti-fungal activities; it displays weak inhibition against Streptococcus mutans (ATCC 25175), with a minimum inhibition concentration (MIC) o
    • $369
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  • Glabranine
    TN168941983-91-9
    Glabranin has antimicrobial activity, it shows significant activities on DPPH free radical with the IC50 value of 240.20 ug/ml. Glabranin or a derivative thereof could be used to stimulate hair growth. Glabranine exerts a dose-dependent inhibitory effect
    • $348
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