staphylococcus

Ethacridine lactate hydrate is a topically applied anti-infective agent.

Ethacridine lactate (Acrinol) is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor.

α-Hemolysin (Staphylococcus aureus), a polypeptide virulence factor of Staphylococcus aureus, disrupts host cell plasma membranes. Upon binding to the cell surface, its monomers create a homoheptamic prepore, which evolves into a mature transmembrane pore, facilitating K+ and Ca2+ ion transport that induces necrotic death in target cells [1].

Sphingomyelinase, Staphylococcus aureus (EC 3.1.4.12), is a hydrolase enzyme involved in sphingolipid metabolism. It is part of the DNase I superfamily of enzymes and is responsible for breaking down sphingomyelin (SM) into phosphocholine and ceramide.

D-Lactic Dehydrogenase from Staphylococcus epidermidis (EC 1.1.1.28) catalyzes the conversion of D-lactic acid to D-pyruvic acid, concurrently reducing NAD+ to NADH and H+.

TopoisomeraseIV, Staphylococcus aureus (EC 5.99.1.), is produced by overexpressing the subunits in Escherichia coli.

Mupirocin (BRL-4910A) is a RNA synthetase inhibitor antibacterial. It has shown excellent activity against gram-positive staphylococci and streptococci.

Sclareolide (Norambreinolide) is a sesquiterpene lactone natural product derived from various plant sources including Salvia yosgadensis, Salvia sclarea, and cigar tobacco. It is a close analog of Sclareol, a plant antifungal compound.

Mupirocin calcium hydrate is an antibiotic produced by Pseudomonas fluorescens, showed a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria

Cyclo-L-Trp-L-Trp is a broad-spectrum antifungal. It also induces a high degree of acetylation of histones.

MRSA antibiotic 2 is an antibiotic compound effective against various Gram-positive bacteria, including B. subtilis, S. aureus, and methicillin-resistant S. aureus (MRSA).

Dryocrassin ABBA (Dryocrassin) is a flavonoid natural product derived from Dryopteris crassirhizoma, with antiviral and antibacterial activities.

Cefapirin sodium is the sodium salt of Cephapirin, an antimicrobial agent.

HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by increasing ROS levels, and damaging cell

ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. ZG297 degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity against S. aureus 8325-4 and MRSA strains with a MIC range of 0.063–256 μg/mL, and ZG297 is utilized in antimicrobial research focused on bacterial protease activation, cell division machinery disruption, and ClpP-mediated proteolysis systems.

Micronomicin sulfate (Gentamicin C2b sulfate) is an aminoglycoside antibiotic with antimicrobial activity that inhibits neuraminidase N1 of influenza A virus.

Cefuroxime (Cephuroxime) is an orally active second-generation cephalosporin antibiotic with antimicrobial activity that inhibits both Gram-positive and Gram-negative bacteria, and is used in the study of soft tissue infections.

Methicillin sodium salt (Meticillin sodium) is a β-lactam antibiotic (natural product), a penicillin-binding protein inhibitor (anti-Staphylococcus aureus MIC=2.1 μg/mL), used for research on Staphylococcus aureus infections and inflammation-related studies.

Lanopepden (GSK 1322322) is a potent peptide deformylase inhibitor effective against Staphylococcus aureus strains ATCC 29213 and ATCC 25923, and is applicable in the study of pneumonia, dermatological, and infectious diseases.

(S,S)-TAPI-1 FA is a TNF-α processing inhibitor with potential anti-inflammatory effects, blocks TACE, and can inhibit TNF-α signaling can be used to study Staphylococcus aureus arthritis.

Vinaxanthone (SM-345431) is a small molecule compound derived from Penicillium chrysogenum that acts as a selective and potent inhibitor of semaphorin3A, phospholipase C (PLC), and FabI, exhibiting antimicrobial activity by blocking intracellular fatty acid synthesis and inhibiting the growth of Staphylococcus aureus.

Lanopepden mesylate is a peptide deformylase inhibitor against Staphylococcus aureus.

Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.

Azelaic acid (Anchoic acid) is a component of hair and skin conditioners and is produced by the ozonolysis of oleic acid. Azelaic acid has bacteriostatic activity against Propionibacterium acnes and Staphylococcus epidermidis by inhibiting protoprotein synthesis in microbial cells. Azelaic acid also has the ability to inhibit pigmentation due to its free radical scavenging action.