lignans

(+)-pinoresinol-β-D-glucoside; (+)-pinor is the major active furanoid lignan in Lianxian. It shows antioxidant, hypotensive and cyclic adenosine monophosphate (cAMP) phosphodiesterase inhibitory activities.

Asperphenamate is a fungal metabolite of Aspergillus flatiipes. The IC50s for T47D cells, MDA-MB-231 cells, and HL-60 cells are 92.3 μM, 96.5 μM, and 97.9 μM. Asperphenamate shows an anticancer effect.

Phanginin A, a natural product discovered in Caesalpinia sappan Linn, activates SIK1 and inhibits gluconeogenesis in mouse primary hepatocytes. Phanginin A increases PDE4 activity and suppresses the hepatic cAMP/PKA/CREB pathway, improving metabolic disorders in ob/ob mice. It may be used in studies of type 2 diabetes.

Etoposide (VP-16-213) is a topoisomerase II inhibitor that inhibits DNA synthesis by forming a complex with topoisomerase II and DNA (IC50=60.3 μM). Etoposide has antitumor activity and induces apoptosis and autophagy.

Podofilox ((+)-Shikonin) is a lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.

(E)-2-Benzylidenesuccinic acid is commonly used in the synthesis of lignans, lignan amides and renin inhibitors.

Lariciresinol is an enterolignan precursor, it possesses fungicidal activities by disrupting the fungal plasma membrane and therapeutic potential as a novel antifungal agent for the treatment of fungal infectious diseases in humans. Dietary lariciresinol

Nortrachelogenin-8'-O-beta-glucoside is a lignan with a diarylhydroxybutyrolactone skeleton which isolated from the leaves and stems of Trachelospermum jasminoides (Lindl.) Lem.

Asatone, an active component isolated from Radix et Rhizoma Asari, has an anti-inflammatory effect via activation of NF-κB and downregulation of p-MAPK (ERK, JNK, and p38) pathways.

Isoasatone A, a natural product isolated from the plant [Heterotropa takaoi M.], exhibits anti-insect activity.

3-[3-(hydroxymethyl)-7-methoxy-2-(3-methoxy-4-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}phenyl)-2,3-dihydro-1-benzofuran-5-yl]propanoic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[4-(2H-1,3-benzodioxol-5-yloxy)-3a-hydroxy-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxol-4-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

4-[(3,4-dimethoxyphenyl)methyl]-3-{[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-4-methoxy-2,3-dihydro-1-benzofuran-6-yl]methyl}oxolan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

3-{[2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-4-methoxy-2,3-dihydro-1-benzofuran-6-yl]methyl}-4-[(4-hydroxy-3-methoxyphenyl)methyl]oxolan-2-one is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[4-(2H-1,3-benzodioxol-5-yl)-2,3-dimethylbutyl]-2H-1,3-benzodioxole is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

9-hydroxy-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.0^{2,7}.0^{14,18}]nonadeca-1(12),2(7),3,5,13,18-hexaen-8-yl (2E)-2-methylbut-2-enoate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,3aS,4R)-1,4-bis(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,3aS,4R)-4-(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)-1-(6-methoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

(1S,3aS,4R,6aR)-1,4-bis(4,6-dimethoxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-3a-yl acetate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[4-(4-hydroxy-2H-1,3-benzodioxol-5-yl)-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxol-4-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

5-[(1S,3aS,4R,6aR)-4-(2H-1,3-benzodioxol-5-yloxy)-3a-hydroxy-hexahydrofuro[3,4-c]furan-1-yl]-2H-1,3-benzodioxol-4-ol is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-2H,5H,6H,7H,8H-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

methyl 7-(hydroxymethyl)-8-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(3,4,5-trimethoxyphenyl)-2H,5H,6H,7H,8H-naphtho[2,3-d][1,3]dioxole-6-carboxylate is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.

7-(hydroxymethyl)-8-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(3,4,5-trimethoxyphenyl)-2H,5H,6H,7H,8H-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid is a high-purity biochemical reagent suitable for biochemical experiments and drug synthesis research.