interferon a 1

IFN-α, a cytokine expressed in human islets from individuals affected by type 1 diabetes, plays a key role in the pathogenesis of diabetes by upregulating inflammation, endoplasmic reticulum (ER) stress and MHC class I overexpression, three hallmarks of islet histology in early type 1 diabetes. IFN-alpha 1 IFNA1 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 45.88 kDa and the accession number is P01572.

Expression system: HEK293 Cells
Length: 24-189, Full Length of Mature Protein
Activity: SPR

Expression system: E. coli
Length: 24-195, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-114, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-108, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 21-228, Extracellular Domain
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-325, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: P. pastoris (Yeast)
Length: 1-211, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-568, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-470, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-470, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-340, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-340, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 21-228, Extracellular Domain
Activity: Not Tested

Expression system: HEK293 Cells
Length: 37-193, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 48-388, Partial
Activity: Not Tested

Interferon‑alpha beta receptor 1 (IFN‑ alpha beta R1), also known as IFNAR1, are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R. It interacts with STAT1 and STAT2, the interaction requires its phosphorylation at Tyr-466. It also interacts with FBXW11, the substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex.

Interleukin-18 (IL-18)is a protein which belongs to the IL-1 family. It is expressed as a 24 kDa precursor by endothelial and epithelial cells, keratinocytes, gamma δ T cells, and phagocytes. Mature mouse IL-18 shares 63% and 91% amino acid sequence identity with mouse and rat IL-18, respectively. IL-18 binds to the widely expressed IL-18 R alpha which recruits IL-18 R beta to form the signaling receptor complex. Its bioactivity is negatively regulated by interactions with IL-18 binding proteins and virally encoded IL-18BP homologs. It augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. In the presence of IL-12 or IL-15, IL-18 enhances anti-viral Th1 immune responses by inducing IFN-gamma production and the cytolytic activity of CD8+ T cells and NK cells. In the absence of IL-12 or IL-15, however, IL-18 promotes production of the Th2 cytokines IL-4 and IL-13 by CD4+ T cells and basophils.

Expression system: HEK293 Cells
Length: 23-125, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 155-341, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-149, Partial
Activity: Not Tested

The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.

Expression system: HEK293 Cells
Length: 27-461, Partial
Activity: ELISA