dab

3,3′-Diaminobenzidine, also known as 3,3',4,4'-tetraaminobiphenyl, is composed of a biphenyl backbone with amino groups attached to each of the four para carbon atoms of the benzene rings. This compound is commonly used as a ligand in coordination chemistry and catalysis, where it coordinates with metal ions to form stable complexes with various applications. It is also utilized as a starting material for synthesizing other organic compounds and polymers.

Fmoc-Dab(Boc)-OH is a chemical intermediate used for chemical synthesis.

High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive

L-DABA (L-2,4-Diaminobutyric acid) is an inhibitor of GABA transaminase with an IC50 greater than 500 μM.

1,4-Dideoxy-1,4-Imino-D-Arabinitol Hydrochloride is a naturally occurring, polyhydroxylated pyrrolidine alkaloid that has been isolated and characterized from various plant species, including Arachniodes standishii and Angylocalyx boutiqueanus, 1,4-Dideoxy-1,4-Imino-D-Arabinitol Hydrochloride functions as a potent inhibitor of certain glycosidase enzymes due to its structural mimicry of monosaccharide substrates.

Aplindore Fumarate (DAB-452) is a small molecule dopamine D2 receptor partial agonist.Aplindore Fumarate exhibits high affinity for dopamine D2 and D3 receptors, and low affinity for dopamine D4, 5-hydroxytryptophan (5-HT2), and α1-adrenergic receptors.Aplindore Fumarate is used in the study of Parkinson's disease and schizophrenia. Fumarate can be used to study Parkinson's and schizophrenia.

SLM6031434 (free base) is an inhibitor of sphingosine kinase type 2 (SphK2). It consists of pedant 1-guanidino-2-phenyloxadiazolylpyrrolidine group.

N-4′-(p-Trifluoromethylphenyl)butyl-DAB (compound 5g) acts as an agonist for lysosomal acid α-glucosidase (GAA), dose-dependently enhancing intracellular GAA activities in Pompe disease patient fibroblasts harboring the M519V mutation [1].

N3-D-Dab(Boc)-OH is a click chemistry reagent that contains an azide group, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with molecules that possess an alkyne group. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition reactions (SPAAC) with molecules containing DBCO or BCN groups.

N3-L-Dab(Boc)-OH is a click chemistry reagent featuring an azide group. It is utilized in various biochemical studies.

N3-L-Dab(Fmoc)-OH is a click chemistry reagent characterized by its azide group. Click chemistry has substantial potential in linking nucleic acids, lipids, proteins, and other molecules, and is employed across various research areas due to its high yield, high specificity, and simplicity.

Boc-L-2,4-Diaminobutyric acid, a derivative of L-2,4-Diaminobutyric acid [1], is a specialized chemical compound used in various biochemical applications.

DAB2-DTPA is a conjugate of DTPA and two DABs employed in photooxidation experiments.

Bz-Dab(nbd)-ala-trp-phe-pro-pro-nle-NH2 is a fluorescent NK2 antagonist.

DAB (tetrahydrochloride hydrate) is commonly utilized as a chromogenic substrate in immunohistochemistry and enzyme histochemistry to reveal specific antigens or enzymes. Upon oxidation by hydrogen peroxide, DAB (tetrahydrochloride hydrate) forms a brown precipitate at the location of the antigen or enzyme, facilitating microscopic detection and observation. Additionally, DAB (tetrahydrochloride hydrate) holds potential applications in various research fields, such as the development of biosensors and the study of cellular oxidative stress.

Lei-Dab7 TFA, a selective and high-affinity blocker of the K Ca 2.2 (SK2) channel with a dissociation constant (K d) of 3.8 nM, demonstrates over 200-fold selectivity for K Ca 2.2 compared to K Ca 2.1, K Ca 2.3, K Ca 3.1, K v, and Kir2.1. Furthermore, Lei-Dab7 TFA enhances theta-burst responses and long-term potentiation (LTP) in rat hippocampal slices in vitro.

Tyr-(D-Dab4,Arg5,D-Trp8)-cyclo-Somatostatin-14 (4-11) is a somatostatin agonist used in cancer research [1].

(d(CH2)5[Tyr(Me)2, Dab5]AVP), a vasopressin V1a receptor-specific antagonist, demonstrates a pA2 value of 6.71 [1].

Anti-Mouse DDR2 Antibody (DAB0065) is a monoclonal inhibitory antibody targeting mouse DDR2, applicable to tumor microenvironment-related research.

Dabelotine (UNII-6RY56RB98P) is an adrenergic agonist used in the study of dementia.

Dabigatran etexilate (BIBR 1048) is a thrombin inhibitor that binds to thrombin, blocking its thrombogenic activity and preventing thrombus formation.

Dabrafenib (GSK2118436A) is a Raf inhibitor that inhibits C-Raf and B-RafV600E (IC50=5/0.6 nM) and is ATP-competitive. Dabrafenib exhibits antitumor activity for the treatment of B-RafV600E-mutated melanoma.

Dabigatran Etexilate Mesylate (BIBR 1048MS) is the orally active prodrug of dabigatran. Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI, Ki: 4.5 nM).

Dabrafenib Mesylate (GSK2118436 Mesylate) is a B-Raf inhibitor(IC50s of 0.6 and 5.0 nM for RafV600E and c-Raf, respectively).