aldehyde

3-Hydroxybenzaldehyde is a compound useful in organic synthesis.

MG-132 (Z-Leu-Leu-Leu-al) is a 26S proteasome inhibitor (IC50=100 nM) that is cell-permeable and reversible. MG-132 acts as an autophagy activator and also induces apoptosis.

CM10 is an aldehyde dehydrogenase 1A family(ALDH1A) inhibitor.

m-PEG3-aldehyde is a PEG-based PROTAC linker with an aldehyde group at the end that can be used to synthesise PROTAC.

m-PEG4-aldehyde is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

m-PEG4-CH2-aldehyde is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.

Biotin-PEG2-aldehyde is a PEG-based linker for PROTACs that connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Biotin-PEG2-C1-aldehyde is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs).

N3-PEG5-aldehyde is a 5-unit cleavable polyethylene glycol (PEG) linker specifically designed for antibody-drug conjugates (ADCs) synthesis[1].

Tetrazine-Ph-PEG4-Ph-aldehyde is a polyethylene glycol (PEG) derived linker, designed for synthesizing proteolysis-targeting chimeras (PROTACs) [1].

Aldehyde-benzyl-PEG5-alkyne is a PROTAC linker within the PEG category, utilized for synthesizing PROTAC molecules. This compound functions as a click chemistry reagent, containing an alkyne group that enables it to undergo a copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) with molecules that have an azide group.

(S,S,S)-VH032-cyclopropane-F-C4-aldehyde is a conjugate of an E3 ligase ligand-linker. It is utilized in the synthesis of PROTACcis-VZ185.

Hycanthone aldehyde (XII) is a thioxanthene derivative of lucanthone, known for its antitapeworm properties and potential anticancer activity.

Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite.

(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for synthesizing PROTACs targeting the BET bromine domain[1].

Azido-PEG3-aldehyde is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Ac-Tyr-Val-Lys-Asp-aldehyde is a caspase-1 inhibitor used in research on various anemias, including chronic disease-related anemia, chemotherapy-induced anemia, and Diamond-Blackfan anemia.

Aldehyde dehydrogenase NAD(P) (ALDH) is an enzyme that facilitates the conversion of aldehydes into their respective carboxylic acids while simultaneously reducing the cofactor NAD(P) to NAD(P)H, making it a key component in biochemical research. This enzyme plays a crucial role in mitigating aldehyde stress by being part of the body's array of enzymatic defenses [1].

Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B, with an inhibitory concentration (IC50) of 4 nM. It significantly reduces quinolinic acid-induced cell death in the striatum and results in the accumulation of LC3-II [1].

Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor, with a K_i value of 56 pM [1][2].

Oleanolic aldehyde, an antimicrobial agent, effectively hinders the growth of oral pathogens Streptococcus mutans and Porphyromonas gingivalis, implicated in dental caries and periodontal disease. The compound exhibits minimum inhibitory concentrations (MICs) of 488 µg/mL and 250 µg/mL against these bacteria respectively [1].

Z-Pro-Pro-aldehyde-dimethyl acetal is a potent prolyl endopeptidase (PREP) inhibitor, effectively impeding the activity of this cytoplasmic serine endoprotease with an IC50 of 12 nM. Its significance lies in its role in modulating cognitive dysfunction associated with aging and neurodegenerative conditions, such as Alzheimer's disease [1] [2].