aldehyde

m-PEG3-aldehyde is a PEG-based PROTAC linker with an aldehyde group at the end that can be used to synthesise PROTAC.

m-PEG4-aldehyde is a PROTAC linker belonging to the PEG class and can be used to synthesize PROTAC molecules.

m-PEG4-CH2-aldehyde is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.

Z-Ile-Leu-aldehyde is an effective and competitive peptide aldehyde inhibitor of γ-secretase and notch.

Biotin-PEG2-aldehyde is a PEG-based linker for PROTACs that connects two essential ligands crucial for forming PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.

Biotin-PEG2-C1-aldehyde is a polyethylene glycol (PEG)-based linker used in the synthesis of proteolysis targeting chimeras (PROTACs) [1].

Biotin-PEG3-aldehyde is a three-unit PEG linker with cleavable properties, specifically designed for the synthesis of antibody-drug conjugates (ADCs)[1].

DBCO-SS-aldehyde is an ADC linker employed for ADC synthesis[1]. This cleavable linker is designed to facilitate the conjugation of antibodies and drugs, resulting in antibody-drug conjugates (ADCs).

N3-PEG5-aldehyde is a 5-unit cleavable polyethylene glycol (PEG) linker specifically designed for antibody-drug conjugates (ADCs) synthesis[1].

Tetrazine-Ph-PEG4-Ph-aldehyde is a polyethylene glycol (PEG) derived linker, designed for synthesizing proteolysis-targeting chimeras (PROTACs) [1].

Phlebiakauranol aldehyde is an antifungal and cytotoxic metabolite.

(+)-JQ-1-aldehyde is the aldehyde derivative of (+)-JQ1, commonly used as a precursor for synthesizing PROTACs targeting the BET bromine domain[1].

Azido-PEG3-aldehyde is a PEG-based linker for PROTACs, joining two essential ligands necessary for forming PROTAC molecules, and enabling selective protein degradation through the ubiquitin-proteasome system within cells.

(+)-Abscisic Aldehyde (ABAld) is an intermediate product in the biosynthetic pathway of the plant hormone Abscisic Acid (ABA). It is produced from flavanone through dehydrogenation by flavanone dehydrogenase, followed by selective oxidation by abscisic aldehyde oxidase. This compound possesses oxidation activity for PsAOγ and is associated with ABA accumulation in the older leaves of pea plants under prolonged exposure to salinity, ammonium, or nitrogen deficiency. (+)-Abscisic Aldehyde is useful for research in plant growth and development.

ARP (Aldehyde reactive probe) is a chemical compound that serves as an aldehyde-reactive probe by specifically tagging AP sites in DNA with biotin residues. It is used to detect abasic sites, which are common forms of DNA damage and intermediates in mutagenesis and carcinogenesis. ARP is highly sensitive, capable of detecting abasic sites at the femtomolar level (fewer than 1 site per 10^4 nucleotides).

10-Undecenal is comprised of an 11-carbon chain featuring a double bond between the 9th and 10th carbon atoms, along with an aldehyde group connected to the 1st carbon atom. The compound exudes an irritant or fatty aroma and is commonly utilized as a flavoring agent in products such as baked goods, confections, and beverages.

4-Diethylaminobenzaldehyde, a reversible aldehyde dehydrogenase (ALDH) inhibitor (Ki: 4 nM for ALDH1), exhibits a potent anti-androgenic effect (IC50: 1.71 μM).

Pyruvic aldehyde (2-Oxopropanal) is a highly reactive dicarbonyl compound that can be converted to lactic acid by evolution from DHA and GLA.

Coniferaldehyde (Ferulaldehyde) is a member of the class of cinnamaldehydes that is cinnamaldehyde substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as an antifungal agent and a plant metabolite. It is a member of cinnamaldehydes, a phenylpropanoid and a member of guaiacols. It derives from a cinnamaldehyde.

Protocatechualdehyde (3,4-Dihydroxybenzaldehyde), a natural polyphenol compound derived from radix Salviae Miltiorrhizae roots, exhibits diverse biological activities and finds extensive medicinal applications as an antioxidant, anti-aging, antibacterial, and anti-inflammatory agent.

syringaldehyde is a polyphenolic compound belonging to the group of flavonoids and is found in different plant species like Manihot esculenta and Magnolia officinalis. Syringaldehyde moderately inhibits COX-2 activity with an IC50 of 3.5 μg/mL. Anti-hyperglycemic and anti-inflammatory activities.

1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells in vitro, down-regulation of the expression and function of BCR-ABL may be one of its most important anti-leukemia mechanisms. 3. Cinnamic aldehyde and cinnamic acid are cardioprotective in a rat model of ischemic myocardial injury, the mechanism is related to anti-oxidative and anti-inflammatory properties.

DL-Glyceraldehyde (Glyceric aldehyde) is produced from the action of the enzyme glyceraldehyde dehydrogenase, which converts glycerol to glyceraldehyde using NADP as a cofactor. When present at sufficiently high levels, DL-Glyceraldehyde can be a cytotoxin and a mutagen. A cytotoxin is a compound that kills cells. A mutagen is a compound that causes mutations in DNA. DL-Glyceraldehyde is a highly reactive compound that can modify and cross-link proteins. DL-Glyceraldehyde modified proteins appear to be cytotoxic, depress intracellular glutathione levels, and induce reactive oxygen species (ROS) production (PMID: 14981296 ). DL-Glyceraldehyde has been shown to cause chromosome damage to human cells in culture and is mutagenic in the Ames bacterial test.

1. Cinnamaldehyde (Cinnamic Aldehyde) has antipyretic activity. 2. Cinnamaldehyde is a sedative agent. 3. Cinnamaldehyde inhibits invasive capabilities of MDA-MB-435S cells was correlated with down-regulating the expression of miR-27a. 4. Cinnamaldehyde induces the generation of reactive oxygen species and exerts vasodilator and anticancer effects. 5. Cinnamaldehyde appears to be a promising candidate as an adjuvant in combination therapy with 5-fluorouracil (5-FU) and oxaliplatin (OXA), two chemotherapeutic agents used in CRC treatment. The possible mechanisms of its action may involve the regulation of drugmetabolizing genes. 6. Cinnamaldehyde plays a certain role in inhibiting the occurrence and progression of melanoma and its action mechanism may be manifested by inhibiting expression of VEGF and HIF-α, thus blood vessel simulation and formation of new blood vessels of melanoma cells, and growth of tumors accordingly.