fto — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T40222	FTO-IN-3		Others
	FTO-IN-3 is a FTO inhibitor. FTO-IN-3 impairs self-renewal in glioblastoma stem cells.		Others
T9089	FTO-IN-1	UUN44923	Others
	UUN44923 is a FTO inhibitor. It may be useful for treating diseases assocd. with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a h...		Others
T40221	FTO-IN-2
	FTO-IN-2 is a FTO inhibitor that impairs self-renewal in glioblastoma stem cells.
T27393	FTO-IN-7d
	FTO-IN-7d is the first inhibitor of the RNA demethylase FTO with anticonvulsant activity.
T60994	FTO-IN-6
	FTO-IN-6 is a selective inhibitor of fat mass and obesity associated protein (FTO).
T82368	FTO-IN-10		Autophagy
	FTO-IN-10 (compound 7), a potent inhibitor of the human demethylase FTO (fat mass and obesity-associated protein), exhibits an IC50 of 4.5 μM. It interacts with the binding pocket of FTO's structural domain II via hydrop...		Autophagy
T63740	FTO-IN-4
	FTO-IN-4 is a potent and selective inhibitor of adiposity and obesity-associated protein (FTO).
T63843	FTO-IN-5
	FTO-IN-5 is a potent, selective inhibitor targeting the fat mass obesity-associated protein (FTO).
T61152	FTO-IN-8
	FTO-IN-8, also known as FTO-43, is an inhibitor of N6-methyladenosine demethylase FTO (fat mass- and obesity-associated protein). It exhibits an IC50 value of 5.5 μM and displays anti-cancer cell proliferative activity [...
T63447	FTO-IN-1 TFA
	FTO-IN-1 TFA is an inhibitor of adiposity and obesity-related enzymes (FTO) (IC50 < 1 μM).FTO-IN-1 TFA can be used to study cancer.
T8874	FB23		Others
	FB23 directly binds to FTO and selectively inhibits FTO's m6A demethylase activity. (FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis.)		Others
T2216	Entacapone	OR-611	Transferase
	Entacapone (OR-611) is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT).		Transferase
T11990	Meclofenamic acid	Meclofenamate	Others , Gap Junction Protein
	Meclofenamic acid (Meclofenamate) is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.		Others , Gap Junction Protein
T30293	Bamocaftor	VX-659	CFTR
	Bamocaftor is a CFTR channel (DeltaF508-CFTR mutation) corrector for CF transmembrane conductance regulators designed to restore F508del-CFTR protein function. Combined use of tezacaftor and VX-561 for the treatment of c...		CFTR
T0696	Naftopidil	KT-611,BM-15275	Adrenergic Receptor
	Naftopidil (KT-611) (INN, marketed under the brand name Flivas), an antihypertensive medicine, is used as a selective α1-adrenergic receptor antagonist or α-blocker.		Adrenergic Receptor
T14219	Aminaftone	Aminaphthone	Endothelin Receptor
	Aminaftone, a derivative of 4-aminobenzoic acid, inhibits endothelin-1 (ET-1) production and can be used to study hypertension and systemic sclerosis.		Endothelin Receptor
T14935	Elexacaftor	VX-445	CFTR , Autophagy
	Elexacaftor (VX-445) is a modulator of cystic fibrosis transmembrane conductance regulator (CFTR) and it also facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.		CFTR , Autophagy
T16681	Nesolicaftor	PTI-428	CFTR , Autophagy
	Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.		CFTR , Autophagy
T3897	Isoschaftoside		Anti-infection , Antifungal
	Isoschaftoside is used as an intercrop due to its allelopathic inhibition of parasitism by Striga hermonthica, an obligate parasitic weed that can devastate the maize crop. Isoschaftoside has anti-tumor, antioxidant, and...		Anti-infection , Antifungal
T39585	Ziftomenib	KO-539	Histone Methyltransferase
	Ziftomenib (KO-539) is an inhibitor of menin-MLL interaction with antitumor activity and can be used to study leukemia.		Histone Methyltransferase