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Estrogen/progestogen Receptor

Estrogen receptors are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol). Two classes of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and GPER (GPR30), which is a member of the rhodopsin-like family of G protein-coupled receptors.The progesterone receptor (PR), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. It is activated by the steroid hormone progesterone.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T0171 Norethynodrel 68-23-5
Norethynodrel
Norethynodrel (Lynestrol) is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of func...
T77724 OBHSA 1404508-27-5 98%
OBHSA
OBHSA(Oxabicycloheptane sulfonamide) is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.
TN2045 Pelargonidin-3-O-glucoside chloride 18466-51-8 98%
Pelargonidin-3-O-glucoside chloride
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflam...
TQ0149 Prinaberel 524684-52-4 98%
Prinaberel
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
TN2288 Uralenol 139163-15-8 98%
Uralenol
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
T6404 Bazedoxifene hydrochloride 198480-56-7 98%
Bazedoxifene hydrochloride
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM an...
T12278 NXT629 1454925-59-7 98%
NXT629
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
TN2200 Segetalin A 161875-97-4 98%
Segetalin A
Segetalin A has estrogen-like activity.
TN3802 Dehydrodiconiferyl alcohol 4263-87-0 98%
Dehydrodiconiferyl alcohol
Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an ...
T6827 Endoxifen Z-isomer hydrochloride 1032008-74-4 98%
Endoxifen Z-isomer hydrochloride
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
T21897 Methylpiperidino pyrazole 289726-02-9 98%
Methylpiperidino pyrazole
Methylpiperidino pyrazole is an ERα inhibitor and can prevent the BPS-induced Rb phosphorylation and cell cycle progression.
TN1690 Glabrene 60008-03-9 98%
Glabrene
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely t...
TQ0163 Sagittatoside A 118525-35-2 98%
Sagittatoside A
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
T16351 NSC16168 6837-93-0 98%
NSC16168
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
T12329 Ospemifene D4 98%
Ospemifene D4
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
T12312 OP-1074 1443752-76-8 98%
OP-1074
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
TN1679 Genistein 7,4'-di-O-β-D-glucoside 36190-98-4 98%
Genistein 7,4'-di-O-β-D-glucoside
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
T0139 Toremifene 89778-26-7 98%
Toremifene
Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
T11222 ERB-196 550997-55-2 98%
ERB-196
Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
T11231 ERRγ Inverse Agonist 1 2316832-86-5 98%
ERRγ Inverse Agonist 1
ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist (IC 50=40 nM) [1].
Norethynodrel
T0171
Norethynodrel (Lynestrol) is a synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of func...
OBHSA
T77724
OBHSA(Oxabicycloheptane sulfonamide) is a novel selective estrogen receptor depressant (SERD) that can be used to study breast cancer.
Pelargonidin-3-O-glucoside chloride
TN2045
Pelargonidin-3-O-glucopyranoside is the glucoside of Pelargonidin, an potential antidiabetic agent. Pelargonidin-3-O-glucopyranoside has antioxidant, anti-inflam...
Prinaberel
TQ0149
Prinaberel (ERB-041) is an effective and selective ERβ agonist and >200-fold selective for ERβ.
Uralenol
TN2288
Uralenol significantly shows the inhibitory activities against the PTP1B enzyme; it also shows inhibitory activities on mushroom tyrosinase using l-tyrosine as s...
Bazedoxifene hydrochloride
T6404
Bazedoxifene hydrochloride (TSE-424) is a novel, non-steroidal, indole-based estrogen receptor modulator (SERM) binding to both ERα and ERβ with IC50 of 23 nM an...
NXT629
T12278
NXT629 is a selective and competitive antagonist of PPAR-α(human PPARα with an IC50 of 77 nM).
Segetalin A
TN2200
Segetalin A has estrogen-like activity.
Dehydrodiconiferyl alcohol
TN3802
Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an ...
Endoxifen Z-isomer hydrochloride
T6827
Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.
Methylpiperidino pyrazole
T21897
Methylpiperidino pyrazole is an ERα inhibitor and can prevent the BPS-induced Rb phosphorylation and cell cycle progression.
Glabrene
TN1690
Glabrene, Liquiritin apioside, neolicuroside, and 18α²-glycyrrhetic acid are the predominant phenolic derivatives partitioning at the interface and most likely t...
Sagittatoside A
TQ0163
Sagittatoside A selectively activates estrogen response element (ERE)-luciferase activity via ERα.
NSC16168
T16351
NSC16168 inhibits DNA repair and potentiates CDDP efficacy in cancer. NSC16168 is a specific ERCC1-XPF inhibitor (IC50: 0.42 μM).
Ospemifene D4
T12329
Ospemifene D4 is a deuterium labeled Ospemifene. Ospemifene is a selective and orally active modulator of estrogen receptor.
OP-1074
T12312
OP-1074 is a pure antiestrogen and a selective degrader of ER, shows specific antiestrogenic activity for ERα and ERβ.
Genistein 7,4'-di-O-β-D-glucoside
TN1679
Genistein 7,4'-di-O-beta-D-glucopyranoside shows significant estrogenic proliferative effect in MCF-7 cell in sub-cytotoxic concentration range.
Toremifene
T0139
Toremifene (GTx 006) is a selective estrogen-receptor modulator (SERM).
ERB-196
T11222
Erb-196 is an estrogen receptor-receptor agonist with non-steroidal selectivity.
ERRγ Inverse Agonist 1
T11231
ERRγ Inverse Agonist 1 (Compound 12) is a potent, selective and orally bioavailable Estrogen-related Receptor grammar (ERRγ) inverse agonist (IC 50=40 nM) [1].
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TargetMol