Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.

Cat. No.	Product name	CAS No.	Purity
T8305	Ellagic acid (hydrate)	314041-08-2	98%
T8305	Ellagic acid hydrate is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
T10829	CKI-7 free base	120615-25-0	98%
T10829	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base...
T16507	PF-5006739	1293395-67-1	98%
T16507	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range o...
T71339	BMS-863233 HCl	1169562-71-3	98%
T71339	BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
T77500	Casein kinase 1δ-IN-6	1579991-01-7	98%
T77500	Casein kinase 1δ-IN-6 is a potent and selective inhibitor of the protein kinase CK-1δ with an IC50 of 23 nM.Casein kinase 1δ-IN-6 shows neuroprotective and anti-...
T35557	CK2 inhibitor 2	2641079-92-5	98%
T35557	CK2 inhibitor 2 is a potent, selective and orally active CK2 inhibitor, with an IC 50 of 0.66 nM. CK2 inhibitor 2 shows high selectivity for Clk2 (IC 50 =32.69 n...
T8987	Epiblastin A	16470-02-3	98%
T8987	Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells...
T3972	SR-3029	1454585-06-8	98%
T3972	SR 3029 is a potent and highly specific CK1δ/CK1ε inhibitor.
T19913	CKI-7	1177141-67-1	98%
T19913	CKI-7 2HCl is an inhibitor of casein kinase 1 (CK1).
T10547	BioE-1115	1268863-35-9	98%
T10547	BioE-1115 is a selective and potent inhibitor of serine-threonine protein kinase (PASK, IC50 = 4 nM). BioE-1115 is a potent inhibitor of CK2α (IC50 = 10 μM).
T1828	TTP 22	329907-28-0	98%
T1828	TTP 22 is a high affinity, ATP-competitive casein kinase 2 (CK2) inhibitor with IC50/Ki of 0.1 uM/40 nM, and shows selectivity >250-fold for CK2 over JNK3, ROCK1...
T14072	A-443654	552325-16-3	98%
T14072	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T7949	NCC007	2342583-66-6	98%
T7949	NCC007 is a novel CKIα and CKIδ dual inhibitors by structural modification of N9 and C2 position of longdaysin.
T1877	LH846	639052-78-1	98%
T1877	LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); exhibits no inhibitory activity at CK2.
T5056	PF-4800567	1188296-52-7	98%
T5056	PF-4800567 is a selective inhibitor of casein kinase 1ε (CK1ε; IC50 = 32 nM) with greater than 20-fold selectivity over CK1δ.
T12237	NMS-P715	1202055-32-0	98%
T12237	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T60005	WAY-296817	349438-74-0	98%
T60005	WAY-296817 is casein kinase 1 (CK1) inhibitor and can be used for research on the treatment or prevention of diseases associated with circadiantiazol rhythm, inf...
T5393	CK1-IN-1	1784751-20-7	98%
T5393	CK1-IN-1, compound 1c reported in patent WO2015119579A1, is a casein kinase 1 (CK1) inhibitor. It has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK,...
T10827	CK2/ERK8-IN-1	1085822-09-8	98%
T10827	CK2/ERK8-IN-1 is a dual inhibitor of casein kinase 2 (CK2) (Ki: 0.25 µM) and ERK8 (IC50s: 0.50 μM) with pro-apoptotic efficacy. CK2/ERK8-IN-1 also binds to PIM1,...
T2695	TBB	17374-26-4	98%
T2695	TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).