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Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.
Cat. No. Product name CAS No. Purity Chemical Structure
T16507 PF-5006739 1293395-67-1 98%
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range o...
T10829 CKI-7 free base 120615-25-0 98%
CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base...
T8305 Ellagic acid (hydrate) 314041-08-2 98%
Ellagic acid hydrate is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
T2440 IC261 186611-52-9 98%
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T6735 XL413 hydrochloride 2062200-97-7 98%
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exh...
T2449 D4476 301836-43-1 98%
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T14069 A-3 hydrochloride 78957-85-4 98%
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T2008 LY294002 154447-36-6 98%
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T0465 Ellagic acid 476-66-4 98%
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T6150 TAK-715 303162-79-0 98%
TAK-715 is a p38 MAPK inhibitor for p38α.
T9356 (E/Z)-GO289 694522-87-7 98%
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of canc...
T2048 LY-364947 396129-53-6 98%
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T7390 DMAT 749234-11-5 98%
DMAT is a potent and specific inhibitor of CK2(IC50 value of 130 nM).
T15024 Silmitasertib sodium salt 1309357-15-0 98%
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T2259 Silmitasertib 1009820-21-6 98%
CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
T2695 TBB 17374-26-4 98%
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
T60067 WAY-297174 442571-27-9 98%
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
T3073 PF-670462 950912-80-8 98%
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
T64350 WAY-296818 349438-77-3 98%
WAY-296818 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
T71339 BMS-863233 HCl 1169562-71-3 98%
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
PF-5006739
T16507
PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range o...
CKI-7 free base
T10829
CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base...
Ellagic acid (hydrate)
T8305
Ellagic acid hydrate is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
IC261
T2440
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
XL413 hydrochloride
T6735
XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exh...
D4476
T2449
D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
A-3 hydrochloride
T14069
A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
LY294002
T2008
LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
Ellagic acid
T0465
Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
TAK-715
T6150
TAK-715 is a p38 MAPK inhibitor for p38α.
(E/Z)-GO289
T9356
(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of canc...
LY-364947
T2048
LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
DMAT
T7390
DMAT is a potent and specific inhibitor of CK2(IC50 value of 130 nM).
Silmitasertib sodium salt
T15024
Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
Silmitasertib
T2259
CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
TBB
T2695
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
WAY-297174
T60067
WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
PF-670462
T3073
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
WAY-296818
T64350
WAY-296818 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
BMS-863233 HCl
T71339
BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...
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