Casein Kinase

The Casein kinase 1 family of protein kinases are serine/threonine-selective enzymes that function as regulators of signal transduction pathways in most eukaryotic cell types. CK1 isoforms are involved in Wnt signaling, circadian rhythms, nucleo-cytoplasmic shuttling of transcription factors, DNA repair, and DNA transcription.

Cat. No.	Product name	CAS No.	Purity
T16507	PF-5006739	1293395-67-1	98%
T16507	PF-5006739 is an effective and selective inhibitor of CK1δ/ε (IC50s: 3.9 nM and 17.0 nM, respectively). PF-5006739 is a potential therapeutic agent for a range o...
T10829	CKI-7 free base	120615-25-0	98%
T10829	CKI-7 free base is a potent and ATP-competitive inhibitor of casein kinase 1 (CK1; IC50: 6 μM; Ki: 8.5 μM) and a selective Cdc7 kinase inhibitor. CKI-7 free base...
T8305	Ellagic acid (hydrate)	314041-08-2	98%
T8305	Ellagic acid hydrate is a natural antioxidant and acts as a potent and ATP-competitive CK2 inhibitor (IC50:40 nM, Ki: 20 nM).
T2440	IC261	186611-52-9	98%
T2440	IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T6735	XL413 hydrochloride	2062200-97-7	98%
T6735	XL413 (BMS-863233) hydrochloride is a potent, selective and ATP competitive inhibitor of Cdc7, with an IC 50 of 3.4 nM. XL413 (BMS-863233) hydrochloride also exh...
T2449	D4476	301836-43-1	98%
T2449	D4476 is an effective, selective, and cell-permeant CK1 (casein kinase 1) inhibitor( IC50=300 nM in a cell-free assay).
T14069	A-3 hydrochloride	78957-85-4	98%
T14069	A-3 hydrochloride is a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases. A-3 hydrochloride also inhibits PKC and c...
T2008	LY294002	154447-36-6	98%
T2008	LY294002 is an inhibitor of PI3K (IC50s: 0.5/0.57/0.97 μM for PI3Kα/δ/β in cell-free assays). It also blocks autophagosome formation.
T0465	Ellagic acid	476-66-4	98%
T0465	Ellagic acid is a fused four ring compound isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clott...
T6150	TAK-715	303162-79-0	98%
T6150	TAK-715 is a p38 MAPK inhibitor for p38α.
T9356	(E/Z)-GO289	694522-87-7	98%
T9356	(E/Z)-GO289, which strongly lengthened circadian period, is a potent and selective inhibitor of CK2. (E/Z)-GO289 exhibited cell type-dependent inhibition of canc...
T2048	LY-364947	396129-53-6	98%
T2048	LY364947 is a potent ATP-competitive inhibitor of TGFβR-I.
T7390	DMAT	749234-11-5	98%
T7390	DMAT is a potent and specific inhibitor of CK2(IC50 value of 130 nM).
T15024	Silmitasertib sodium salt	1309357-15-0	98%
T15024	Silmitasertib sodium salt is a potent and orally bioavailable, highly selective inhibitor of CK2(IC50 of 1 nM, CK2α).
T2259	Silmitasertib	1009820-21-6	98%
T2259	CX-4945 is a potent, orally bioavailable inhibitor of casein kinase 2 (CK2; Ki: 0.38 nM).
T2695	TBB	17374-26-4	98%
T2695	TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).
T60067	WAY-297174	442571-27-9	98%
T60067	WAY-297174 is a human protein kinase CK2 inhibitor with IC50 of > 33 μM.
T3073	PF-670462	950912-80-8	98%
T3073	PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
T64350	WAY-296818	349438-77-3	98%
T64350	WAY-296818 (Compound 23a) is a casein kinase 1 delta (CK1d) inhibitor with a pIC50 of 6.5376 M.
T71339	BMS-863233 HCl	1169562-71-3	98%
T71339	BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215 and...