ms 1

MS 1 (Momordica saponin I) is an adjuvant used in vaccines and is found in the seeds of the perennial fruit, bitter melon [Momordica cochinchinensis Spreng].

MS-PEG1-THP is a PEG-based linker for PROTACs that joins two essential ligands, crucial for forming PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

Benzyl-PEG1-Ms is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.

MS83epimer 1 is the epimer of MS83, a proof-of-concept PROTAC compound. MS83 is created by linking a KEAP1 ligand to a BRD4/3/2 binder.

MS 154 is a potent and selective cereblon-recruiting Degrader (PROTAC®) of mutant epidermal growth factor receptor (EGFR), comprising a cereblon-binding moiety joined by a linker to gefitinib(Iressa). MS 154 decreases EGFR protein levels, inhibits downstream signaling in and inhibits proliferation of mutant EGFR-bearing lung cancer cells (DC50values are 11 and 25 nM in HCC-827 and H3255 cells, respectively; Dmax> 95% at 50 nM), but not in WT-EGFR-bearing ovarian and lung cancer cells lines. Bioavailable in mice following ip administration.

MS 154N is a negative control for MS 154. The compound exhibits high binding-affinity for WT and L858R-mutant EGFR (Kdvalues are 3 and 4.3 nM, respectively), but does not significantly induce degradation of EGFR mutants.

BMS 183920 is a potent Angiotensin II Receptor antagonist that improves improves Caco-2 cell permeability in vivo.

SMS 121 is a novel CD36 inhibitor that impairs fatty acid uptake and cell viability in acute myeloid leukaemia (AML) cells.

BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.

BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.

BMS 193885 is a selective and competitive neuropeptide Y(1) receptor antagonist with affinity of 3.3 nM.

BMS 180742 is an exosite inhibitor of thrombin.

BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.

Bms 188107 is a calcium antagonist, it has cardioprotective effects.

BMS 199264 hydrochloride is the salt form of BMS 199264.BMS 199264 is a potent and selective inhibitor of mitochondrial F1F0 ATP hydrolase (IC50=0.5 μM) without affecting ATP synthetase, thus preventing ATP reduction to ameliorate cardiac necrosis during ischemia, and is commonly used in studies of the cardiovascular system.

BMS 180448 is a prototype mitochondrial ATP-sensitive K+ (Mitok (ATP)) channel opener with cardioprotective and vasodilating properties.

BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae.

BMS-181101 is a novel antidepressant that has pharmacological characteristics as a serotonin reuptake inhibitor and a serotonin 5-HT receptor agonist.

BMS 182264 is a bio-active chemical.

BMS 186318 is a human immunodeficiency virus (HIV) protease inhibitor designed to examine the possibility of developing resistance when two protease inhibitors are used together in recombination.

BMS 187071 is a bio-active chemical.

OMS 1092 is a bioactive chemical.

MS 15203 is a selective GPR171 agonist that increases morphine antinociception and is effective in reducing chronic pain. It can reduce chronic neuropathic and inflammatory pain in male mice.

BMS 188745 Potassium Salt inhibits the biosynthesis of the Staphylococcus aureus virulence factor staphyloxanthin via inhibition of dehydrosqualene synthase (CrtM).