aldos

Aldose reductase-IN-1 (AT-001, Caficrestat) is a highly potent inhibitor of aldose reductase with an IC50 value of 28.9 pM, which can target the relaxin hormone signaling pathway in prostate cancer models.

Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure.

Aldosterone, the primary mineralocorticoid, is synthesized and secreted by the zona glomerulosa of the adrenal cortex in response to activation of the renin-angiotensin system or high dietary potassium.

Aldose reductase-IN-7 (Compound 6k) is a potent inhibitor targeting Aldose reductase, demonstrating significant enzymatic inhibitory activity (Ki = 0.186 ± 0.020 μM), surpassing Epalrestat. It exhibits minimal cytotoxicity while maintaining effective anticancer properties.

Aldosterone-3-(O-carboxymethyl)oximino-(2-iodohistamine) is a biochemical.

Aldosterone 21-sulfate sodium salt is a cholesterol metabolite discovered in urine.

Aldose reductase-IN-4 (compound IIc) is an inhibitor of aldose reductase with IC50 values of 11.70 μM for ALR1 and 0.98 μM for ALR2, respectively [1].

Aldose reductase-IN-5 is an inhibitor of aldose reductase (ALR2) that enhances the combination of inhibitory excitability and antioxidant capacity, thereby delaying the diabetes complications progress.

Aldose reductase-IN-6 (Compound 3) is a competitive inhibitor of aldose reductase (AR) with an IC50 of 3.164 μM and a Ki of 0.018 μM. Notably, Aldose reductase-IN-6 demonstrates no cytotoxicity toward normal cells [1].

Aldose reductase-IN-3 (Compound 5) is an effective and moderately selective aldose reductase (AR) inhibitor (IC50=3.99 μM) with research potential in sepsis, a molecular target involved in various inflammatory diseases (including sepsis).

Aldose reductase-IN-2 (Compound 5f) is a potent aldose reductase (AR) inhibitor with antioxidant properties, making it a promising drug for anti-diabetic complications.

Aldose 1-epimerase (mutarotases), an essential enzyme for carbohydrate metabolism, facilitates the interconversion between α- and β-anomers of hexose sugars, including glucose and galactose. This enzyme plays a vital role in normal carbohydrate metabolism and the synthesis of complex oligosaccharides [1].

Tetrahydro Aldosterone is a steroidal compound that inhibits the adrenal angiotensin II receptor, with an IC50 of 10 μM.

(E)-Aldosecologanin is a natural product from Lonicera japonica.

(Z)-Aldosecologanin is a natural product from Lonicera japonica.

Galdosol is a natural product found in Perovskia abrotanoides.