MPP

MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).

MPP hydrochloride is a selective estrogen receptor (ERR) modulator.

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.

Cyclocurcumin is a minor curcuminoid derived from the rhizome of Curcuma longa that differs structurally from curcumin despite sharing the same molecular formula (C21H20O6), Cyclocurcumin features an α,β-unsaturated dihydropyranone moiety that drives trans–cis photoisomerization instead of the diketone/keto–enol tautomerism characteristic of curcumin. Cyclocurcumin demonstrates potent biochemical activities, including selective inhibition of human aromatase (CYP19A1) with an IC50 of 4.43 μM—approximately fivefold stronger than curcumin—making it valuable for studying estrogen-related pathways, and uniquely stimulates melanogenesis and melanin export in both melanocyte and melanoma models, positioning it as a promising research tool for investigating hypopigmentary skin disorders.

MPP+-D3 iodide is the deuterated variant of MPP+ (iodide). MPP+ iodide (T9169) is a toxic metabolite of the neurotoxin MPTP, which induces Parkinsonian symptoms in animal models by selectively destroying dopaminergic neurons in the substantia nigra. It is absorbed into dopaminergic neurons via the dopamine transporter and exerts its neurotoxic effects by interfering with mitochondrial respiratory chain complex I. Additionally, MPP+ iodide (T9169) is a high-affinity substrate for the serotonin transporter (SERT).

Labeled Amino Acid And Carnitine Mix30 Set Ii-2 (Standard) is a reference standard of Labeled Amino Acid And Carnitine Mix30 Set Ii-2 intended for quantitative analysis, quality control, and related biochemical research applications.

Mix-15,2-A group (Standard) is a reference standard of Mix-15,2-A group intended for quantitative analysis, quality control, and related biochemical research applications.

Mix-15 Set 2-B (Standard) is a reference standard of Mix-15 Set 2-B intended for quantitative analysis, quality control, and related biochemical research applications.

MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.

p-MPPF dihydrochloride is a selective 5-HT antagonist that dose-dependently antagonizes hypothermia induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and can be used to study neurological diseases.

p-MPPF is a selective 5-HT antagonist that dose-dependently antagonizes hypothermia induced by 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and can be used to study neurological diseases.

AMPPD (Lumi-Phos Plus) is a 1,2-dioxo-cyclohexane derivative and a substrate for hypersensitive alkaline phosphatase.

p-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with antidepressant and anxiolytic-like effects.

CMPPE is a positive allosteric modulator (PAM) of the GABAB receptor, which inhibits alcohol self-administration and relapse behavior in rats.

2-MPPA (GPI-5693) is an orally active, selective, and potent inhibitor of glutamate carboxypeptidase II (GCP II) (IC50: 90 nM) and also a NAALADase inhibitor, used in the study of neurological diseases.

High affinity κ agonist

BemPPOX is a potent inhibitor of DGL.

TMPPAA is an allosteric agonist of 5-HT3 receptor.

3-MPPI was a high-affinity nonselective α1-antagonist.

MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).

R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.

Torbafylline, a xanthine derivative, is a phosphodiesterase (PDE) inhibitor that attenuates burn-induced protein hydrolysis in rat skeletal muscle through activation of the PDE4/cAMP/EPAC/PI3K/Akt pathway, and inhibits the enhanced ubiquitin-proteasome-dependent protein hydrolysis in skeletal muscle of cancer- and sepsis-prone rats.

Isoprenaline hydrochloride (NCI-c55630) is a potent beta-adrenergic agonist with the peripheral vasodilator, bronchodilator, and cardiac stimulating properties.

AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.