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Search Result

Search Results for " mpp "

Targets

Estrogen Receptor/ERR

22

Compounds

6

Natural Products

3

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T21897L MPP hydrochloride MPP hydrochloride (289726-02-9 Free base) Estrogen Receptor/ERR
MPP hydrochloride is a selective estrogen receptor (ERR) modulator.
T9169 MPP+ iodide Mitochondrial Metabolism , Autophagy
MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) ex...
T12101 MPP dihydrochloride (289726-02-9 Free base) Others
MPP dihydrochloride is a highly selective antagonist of estrogen receptor alpha (ERα).
T16421 P-MPPI hydrochloride 5-HT Receptor
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
T4058 R-IMPP Others , Serine/threonin kinase
R-IMPP is an inhibitor of PCSK9 translation. R-IMPP stimulates uptake of LDL-C in hepatoma cells by increasing LDL-R levels, without altering levels of secreted transferrin.
T14280 AMPPD Lumigen PPD,3-(2'-Spiroadamantane)-4-methoxy-4-(3''-phosphoryloxy)phenyl-1,2-dioxetane,PPD,Lumi-Phos Plus Others
AMPPD (Lumi-Phos Plus) is a 1,2-dioxo-cyclohexane derivative and a substrate for hypersensitive alkaline phosphatase.
T28077 MMPP VEGFR , STAT
MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.
T23043 N-MPPP Hydrochloride Others
High affinity κ agonist
T37893 3-MPPI
3-MPPI was a high-affinity nonselective α1-antagonist.
T38212 MPPG
MPPG is a selective L-AP4-sensitive receptor antagonist (kD=9.2 μM).
T22497 2-MPPA Others
glutamate carboxypeptidase II (GCP II) inhibitor
T69750 P-MPPF dihydrochloride
p-MPPF dihydrochloride is a selective 5-ht1a serotonin receptor antagonist
T28986 TMPPAA
TMPPAA is an allosteric agonist of 5-HT3 receptor.
T33493 Mppf F-18 J1.050.795B,P-18FMPPF,(18F) Mppf,(18F)Mppf,(18F)-Mppf
Mppf F-18, which has been used as a radioactive ligand for positron emission tomography, is a compound that binds to the serotonin-1A receptor.
T26766 BemPPOX
BemPPOX is a potent inhibitor of DGL.
T40063 CBR-470-1 Nrf2
CBR-470-1 is a potent inhibitor of glycolytic phosphoglycerate kinase 1 (PGK1) that activates NRF2 by increasing methylglyoxal levels. CBR-470-1 is a non-covalent Nrf2 activator with neuroprotective activity that protect...
T4081 MPTP hydrochloride MPTP-hydrochloride Apoptosis , Dopamine Receptor
MPTP hydrochloride is a precursor of MPP+, a dopamine neurotoxin with blood-brain barrier permeability. MPTP hydrochloride is toxic to dopaminergic neurons, which can lead to Parkinson's disease, and is widely used in th...
T3570 SU4312 SU 4312,NSC 86429 VEGFR , PDGFR
SU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 (SU 4312) unexpectedly protects against MPP(+) -induced neurotox...
T61268 Vutiglabridin HSG4112 Phosphatase
Vutiglabridin (HSG4112) is a novel and safe modulator of PON2, a racemic compound. vutiglabridin is an optimized structural analogue of Glabridin and is superior to Glabridin in terms of weight loss and chemical stabilit...
T38516 IDT307
IDT307, an analog of the organic cation MPP+, serves as a specific fluorescent substrate for DAT, identified as APP+.
T79333 LZWL02003 Reactive Oxygen Species
LZWL02003, an anti-neuroinflammatory agent, demonstrates a protective effect on MPP+-induced neuronal damage and reduces ROS expression. Additionally, it enhances cognition, memory, learning, and athleticism in Rotenone-...
T68547 SNJ-1945
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. SNJ-1945 protects SH-SY5Y cells against MPP(+) ...
Cat No. Product Name Synonyms Targets
TN1038 Galgravin Apoptosis
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec...
T2860 Vanillyl Alcohol 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol Apoptosis , Others
Vanillyl Alcohol (3-Methoxy-4-hydroxybenzyl alcohol) possesses anti-angiogenic, anticonvulsive, anti-inflammatory, anti-oxidant, neuroprotective, and anti-nociceptive activities. Vanillyl alcohol can effectively inhibit ...
T2230 Paeoniflorin Peoniflorin HSP , COX
Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.
TN4435 Licopyranocoumarin P450 , ROS , JNK
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK.
T4954L Smilagenin PYM50028,Cogane,AI3-44895,PYM 50028
Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease.
TN3741 Cyclocurcumin TNF , ROS
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It m...

Natural Products

Galgravin
TN1038
Synonym:
Target: Apoptosis
Vanillyl Alcohol
T2860
Synonym: 4-Hydroxy-3-methoxybenzenemethanol,3-Methoxy-4-hydroxybenzyl alcohol,4-Hydroxy-3-methoxybenzyl alcohol,Vanillin alcohol,Vanillic alcohol
Target: Apoptosis, Others
Paeoniflorin
T2230
Synonym: Peoniflorin
Target: HSP, COX
Licopyranocoumarin
TN4435
Synonym:
Target: P450, ROS, JNK
Smilagenin
T4954L
Synonym: PYM50028,Cogane,AI3-44895,PYM 50028
Target:
Cyclocurcumin
TN3741
Synonym:
Target: TNF, ROS

Recombinant Proteins

Species：
Human (2)
E. coli (1)
Expression System：
E. coli (2)
HEK293 Cells (1)
Tag：
C-6xHis (1)
C-Myc (1)
N-6xHis-SUMO (1)
Cat No. Product Name Species Expression System
TMPJ-00913 MPZ Protein, Human, Recombinant (His) Human HEK293 Cells
Myelin Protein P0 (MPZ) is a single-pass type I membrane glycoprotein which belongs to the myelin P0 protein family. MPZ contains one Ig-like V-type (immunoglobulin-like) domain, absent in the central nervous system. MPZ...
TMPH-00706 MppA Protein, E. coli, Recombinant (His & SUMO) E. coli E. coli
Essential for the uptake of the murein peptide L-alanyl-gamma-D-glutamyl-meso-diaminopimelate. Also transports some alpha-linked peptides such as Pro-Phe-Lys with low affinity. The transport is effected by the oligopepti...
TMPH-01898 PARL Protein, Human, Recombinant (Myc) Human E. coli
Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apopt...
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