116-a — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7698	BS194		CDK
	BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor.		CDK
T23426	TC-A 2317 hydrochloride		Others , Aurora Kinase
	TC-A 2317 hydrochloride is an inhibitor of Aurora kinase A with a Ki of 1.2 nM compared to Aurora kinase B with a Ki of 101 nM. TC-A 2317 hydrochloride shows antitumor activity.		Others , Aurora Kinase
T25060	Althiomycin	NS-102809,Matamycin,NSC 102809,NSC102809,116-A
	Althiomycin is an antibiotic.
T77519	FC-116	FC116	Apoptosis , Microtubule Associated
	FC-116 is a potent Tubulin inhibitor with antitumour activity and inhibits tumour growth in mice. FC-116 induces apoptosis in colorectal cancer (CRC) cells and promotes protein degradation.		Apoptosis , Microtubule Associated
TP1305L	LEP(116-130)(mouse)TFA(258276-95-8 free base)		Complement System
	LEP(116-130)(mouse) is a synthetic leptin peptide fragment.		Complement System
T14004	1A-116		Rho
	1A-116 is a specific inhibitor of Rac1 .		Rho
T1929	Filgotinib	GLPG0634	Tyrosine Kinases , JAK
	Filgotinib (GLPG0634) is a selective JAK1 inhibitor. The IC50 values against JAK1, JAK2, JAK3, and TYK2 are 10 nM, 28 nM, 810 nM, and 116 nM, respectively.		Tyrosine Kinases , JAK
T16411	Otenzepad	AF-DX 116	AChR
	Otenzepad (AF-DX 116) is a selective antagonist of M2 mAChR with IC50s of 386 nM and 640 nM for rat heart and rabbit peripheral lung.		AChR
TP1305	LEP(116-130)(mouse)		Others
	Leptin (116-130),mouse(C64H109N19O24S),a peptide with the sequence Ser-Cys-Ser-Leu-Pro-Gln-Thr-Ser-Gly-Leu-Gln-Lys-Pro-Glu-Ser-NH2. Leptin is an adipocyte-derived hormone that acts as a major regulator for food intake an...		Others
T25770	116-9e	MAL-2-11B,MAL2-11B,MAL211B,MAL 2 11B,MAL2 11B	Virus Protease
	116-9e (MAL2-11B) is a potent Hsp70 co-chaperone DNAJA1 inhibitor with antiviral properties, inhibition of simian virus 40 (SV40) replication, inhibition of tumour antigen (TAg) endogenous ATPase activity, and TAg-mediat...		Virus Protease
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T12906	SI-2 hydrochloride	EPH 116 hydrochloride	Src
	SI-2 hydrochloride (EPH 116 hydrochloride) is a highly promising inhibitor of SRC-3 SMI: SRC-3 (PPI)(IC50 values of 3-20 nM for breast cancer cell death), with acceptable oral availability.		Src
T3076	GLPG0634 analog	GLPG0634 analogue	Tyrosine Kinases , JAK
	GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.		Tyrosine Kinases , JAK
T80666	2-PCCA hydrochloride	2-PCCA hydrochloride（1609624-97-6 Free base)	cAMP
	2-PCCA hydrochloride, a racemate, is a potent and selective GPR88 receptor agonist showing inhibition of GPR88-mediated cAMP production in HEK293 cells with an EC50 value of 116 nM.		cAMP
T77729	MY-1076		Apoptosis , YAP
	MY-1076 is a potent YAP inhibitor with antigastric cancer activity.MY-1076 dose-dependently induced G2/M phase block, induced YAP degradation and apoptosis, and inhibited microtubule protein polymerization.MY-1076 inhibi...		Apoptosis , YAP
T2S2382	3'-Hydroxypterostilbene	3'-HPT	Apoptosis , Autophagy
	3'-Hydroxypterostilbene (3'-HPT), a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells with IC50s of 9.0, 40.2, and 70.9 μM for COLO 205, HCT-116, and HT-29 cells, respectively, b...		Apoptosis , Autophagy
T5753	Flavokawain C		Apoptosis
	Flavokawain C (FKC), a naturally occurring chalcone, which can be isolated from Kava.FKC has the potential to be developed into chemotherapeutic drug for the treatment of colon adenocarcinoma.		Apoptosis
T3S2344	β,β-Dimethylacrylshikonin	Dimethylacrylshikonin,β, β-Dimethylacrylshikonin	ERK , HIF/HIF Prolyl-Hydroxylase
	1. β,β-Dimethylacrylshikonin (Dimethylacrylshikonin) is a promising agent for developing an improved strategy for radiotherapy against tumors. (a) Injection of Dimethylacrylshikonin combined with IR treatment significant...		ERK , HIF/HIF Prolyl-Hydroxylase
TN1146	8-Prenylnaringenin	8-Prenylnaringenin	Apoptosis , ROS
	8-Prenylnaringenin is a phytoestrogen with high estrogenic activity,		Apoptosis , ROS
T1574	Etoricoxib	Arcoxia,MK-663,Tauxib,L-791456,Nucoxia,Desvenlafaxine	COX
	Etoricoxib (MK-663) is a synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic, and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenas...		COX