DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates or can crosslink DNA. Alkylation is a chemical reaction that entails the transfer of an alkyl group. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion, or a carbene (or their equivalents). Alkylating agents are reagents for effecting alkylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with a class of drugs called alkylating antineoplastic agents.

Cat. No.	Product name	CAS No.	Purity
T3091	Carmustine	154-93-8	99.97%
T3091	Carmustine (bis-chloroethylnitrosourea) is a cell-cycle phase nonspecific alkylating antineoplastic agent.
T0164	Oxaliplatin	61825-94-3	99.93%
T0164	Oxaliplatin (L-OHP) is a DNA alkylating agent, an inhibitor of DNA synthesis. Oxaliplatin causes DNA cross-linking damage, preventing DNA replication and transcr...
T8554	KCC-07	315702-75-1	99.93%
T8554	KCC-07 is a selective, potent and brain-penetrant inhibitor of methyl-CpG-binding domain protein 2(MBD2) with anticancer activity. KCC-07 prevents binding of MBD...
T4169	N-Nitroso-N-methylurea	684-93-5	99.89%
T4169	N-Nitroso-N-methylurea (Methylnitrosourea) is a nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.
T1178	Temozolomide	85622-93-1	99.87%
T1178	Temozolomide (TMZ) is a DNA alkylating agent with blood-brain barrier permeability and oral activity. Temozolomide has antitumor activity and antiangiogenic acti...
T1601	Lomustine	13010-47-4	99.86%
T1601	Lomustine (NSC-79037) is an alkylating agent of value against both hematologic malignancies and solid tumors.
T1055	Ifosfamide	3778-73-2	99.86%
T1055	Ifosfamide (NSC-109724) alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. Ifosfamide is a synthetic analog of the...
T1241	Altretamine	645-05-6	99.84%
T1241	Altretamine (ENT-50852) is an alkylating agent with antineoplastic activity.
T0923	Busulfan	55-98-1	99.77%
T0923	Busulfan (Busulphan) is a synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully...
T1058	Carboplatin	41575-94-4	99.72%
T1058	Carboplatin (JM-8) is a cisplatin derivative, a DNA synthesis inhibitor. Carboplatin binds to DNA, inhibits replication and transcription, and induces cell death...
T6798	Tretazicar	21919-05-1	99.7%
T6798	CB1954(Tretazicar (NSC-115829)), an anticancer prodrug, is activated by NAD(P)H quinone oxidoreductase 2. It is converted in the presence of the enzyme NQO2 and ...
T0707	Cyclophosphamide hydrate	6055-19-2	99.65%
T0707	Cyclophosphamide hydrate is a DNA alkylating agent, an inhibitor of DNA synthesis. Cyclophosphamide hydrate has antitumor and immunosuppressive activities.
T1564	Cisplatin	15663-27-1	99.6%
T1564	Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also...
T0975	Chlorambucil	305-03-3	99.58%
T0975	Chlorambucil (CB-1348) is an orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cyc...
T36528	Illudin M	1146-04-9	99.56%
T36528	Illudin M is a cytotoxic sesquiterpene from the fungus O. illudens that alkylates DNA. It has a cytotoxicity of 6-100 nM against HL-60 human leukemia cells.Illud...
T16871	Semustine	13909-09-6	99.55%
T16871	Semustine, a DNA alkylating agent, is a cancer chemotherapy compound that is nephrotoxic in patients with malignant melanoma receiving adjuvant chemotherapy for ...
T17159	Treosulfan	299-75-2	99.26%
T17159	Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
T5017	Nimustine Hydrochloride	55661-38-6	99.2%
T5017	Nimustine Hydrochloride (Nidran hydrochloride) has been used in trials studying the treatment of Glioblastoma.
T4558	Trioxsalen	3902-71-4	98.96%
T4558	Trioxsalen (Trioxysalen) is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema. After ph...
T1507	Streptozocin	18883-66-4	98.89%
T1507	Streptozocin (NSC-85998) is an antibiotic that induces DNA methylation. Streptozocin is toxic to insulin-producing pancreatic islet B-cells and is commonly used ...