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Cat No. | Product Name | Synonyms | Targets |
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T0220 | Foscarnet sodium | Phosphonoformate | Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis |
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV. | |||
T21422 | Methylnaltrexone bromide | Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 | Opioid Receptor |
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af... | |||
T7943 | Fluphenazine decanoate | Dopamine Receptor | |
Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia. | |||
T11174 | (R)-Elagolix | NBI-56418 | GNRH Receptor |
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do... | |||
T20802 | Flumethasone pivalate | Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten | Others |
Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang... | |||
T8400 | Pamidronic acid | Wnt/beta-catenin | |
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells | |||
T11079 | NMI 8739 | n-docosahexaenoyl dopamine,Dha-DA conjugate | Dopamine Receptor |
NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release. | |||
T60098 | MSC2504877 | 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one | Others |
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos... | |||
T4981 | Anisotropine Methylbromide | Prostaglandin Receptor , AChR | |
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion. | |||
T2498 | Adjudin | AF-2364 | Chloride channel , Mitochondrial Metabolism |
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway. | |||
T9953 | BT173 | Others | |
BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway. | |||
T13974 | ZL0580 | Epigenetic Reader Domain , HIV Protease | |
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. | |||
T13360 | XRK3F2 | Autophagy | |
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | |||
T11669 | IR415 | HBV | |
IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 i... | |||
T2589 | Dolasetron Mesylate hydrate | Dalasetron Mesylate Hydrate | 5-HT Receptor |
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radioth... | |||
T11820 | LAT1-IN-1 | BCH | Apoptosis , Others |
LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral... | |||
T1167 | Cyproterone acetate | Androcur,Cyproterone 17-O-acetate | Androgen Receptor |
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ... | |||
T27392 | FT001 | Epigenetic Reader Domain | |
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects ag... | |||
T19854 | Evoxine | ||
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages. | |||
T21131 | NASTRp | Naphthol AS-TR phosphate | |
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress. | |||
T27176 | Dimethandrolone Undecanoate | DMAU | |
Dimethandrolone Undecanoate is a selective androgen receptor modulator (SARM). Dimethandrolone Undecanoate has both androgenic and progestational activities, properties that may maximize gonadotropin suppression. | |||
T20660 | Revaprazan | SB-641257,SB 641257,SB641257 | |
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs. | |||
T13574 | Besifovir Dipivoxil maleate | LB80380 maleate | Others |
Besifovir Dipivoxil (LB80380) maleate is an oral prodrug of LB80317. Besifovir Dipivoxil maleate is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis... | |||
T41081 | Pyrazosulfuron-ethyl | ||
Pyrazosulfuron-ethyl, a sulphonylurea herbicide belonging to the acetolactate synthase inhibiting category, has gained extensive application in the suppression of weed proliferation within commercial cereal, soybean, and... | |||
T25576 | KF 392 | KF392,KF-392 | |
KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. | |||
T26577 | AGN-201904Z | AGN-201904-Z,AGN-201904 | |
AGN-201904Z is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly great... | |||
T24787 | SGE-201 | ||
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by... | |||
T34632 | SH-5 | SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II | |
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IκBα kinase activation. | |||
T61623 | Ecabet | ||
Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori er... | |||
T68528 | M-COPA | ||
M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear fa... | |||
T14282 | Amuvatinib hydrochloride | HPK 56 hydrochloride,MP470 hydrochloride | Others |
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret and is also a DNA repair suppress... | |||
T61789 | IDO1-IN-14 | ||
IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeL... | |||
T15831 | M-525 | Others | |
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, ir... | |||
T71520 | LEQ-506 | ||
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce... | |||
T61794 | LASSBio-1632 | ||
LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high exper... | |||
T61118 | CD73-IN-12 | ||
CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD... | |||
TP1916 | [D-Phe12,Leu14]-Bombesin | ||
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo. | |||
T40211 | EIF4E-IN-1 | eIF4E-IN-1 | |
eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1... | |||
T79096 | IPG7236 | CCR | |
IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer research [1]. | |||
T61627 | IMDK quarterhydrate | ||
iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a ME... | |||
T81144 | SMP-93566 | ||
SMP-93566 is an antibody-drug conjugate (ADC) characterized by a low payload shedding rate, demonstrating in vivo tumor suppression in ovarian, gastric, and breast cancers [1]. | |||
TP2026 | GRP (porcine) | ||
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA re... | |||
T69990 | Ruboxistaurin mesylate monohydrate | ||
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and... | |||
T79840 | Bocodepsin hydrochloride | OKI-179 hydrochloride | HDAC |
Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppression of both solid tumors and hematological malignancies [1]. | |||
T35524 | (1S)-Calcitriol | ||
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of kera... | |||
T80909 | Tyrosinase-IN-19 | Tyrosinase | |
Tyrosinase-IN-19 (compound 9), a competitive tyrosinase inhibitor, exhibits potent antioxidant activities by neutralizing ROS, ABTS+, and DPPH radicals and demonstrates dose-dependent suppression of tyrosinase expression... | |||
T69970 | AZD5718 | ||
AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Precl... | |||
T37148 | TML-6 | ||
TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a... | |||
T3689L | Ruboxistaurin mesylate | LY-333531,LY333531,LY 333531,LY-333531 Mesylate | |
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne... | |||
T69193 | SN-28049 | ||
SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIal... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5788 | XYLOBIOSE | IL Receptor , TNF | |
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders. | |||
T6S0214 | Dl-Maackiain | (+)-Maackiain,Demethylpterocarpin | Apoptosis , Parasite |
1. dl-Maackiain (Demethylpterocarpin) induces apoptosis and growth suppression 2. MAK1 is the second functional gene cloned from Maackiain detoxification. | |||
T6S1367 | Procyanidin B2 | Proanthocyanidin B2 | Reactive Oxygen Species , NOD |
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ... | |||
T5665 | Geraniol | Others , Endogenous Metabolite , Antifungal | |
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress. | |||
T5785 | MALTOTETRAOSE | Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose | TNF , Endogenous Metabolite |
Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development. | |||
T6S1141 | Ganoderic acid A | Apoptosis , NF-κB , Endogenous Metabolite , Autophagy | |
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a... | |||
T1721 | 2'-Deoxyuridine | Uracil deoxyriboside,2-deoxyuridine,2'-dU | Others , DNA/RNA Synthesis , Endogenous Metabolite |
2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12... | |||
T5S1000 | Sophoraflavanone G | Kushenol F,Vexibinol | Apoptosis |
Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways. | |||
T1313 | Nitrofurantoin | Furadantine,Macrodantin,Furadonine | Antibacterial , Antibiotic |
Nitrofurantoin (Furadantine), an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoi... | |||
TN1923 | Mesaconine | IL Receptor , NF-κB | |
Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and... | |||
T0603 | Phthalic acid mono-2-ethylhexyl ester | Phthalic Acid Monooctyl Ester | P450 , Endogenous Metabolite |
Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17. Cyp17a1 gene is a specific target ... | |||
T5S0993 | Kurarinone | BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT | |
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameli... | |||
TN1410 | Asperulosidic acid | ASPA | ERK , NF-κB |
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a... | |||
TN1712 | Gossypin | NF-κB , S6 Kinase | |
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i... | |||
TN1557 | Decursinol angelate | ERK , VEGFR , PKC , JNK | |
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an... | |||
T3727 | Methyl syringate | Syringic Acid Methyl Ester | TRP/TRPV Channel |
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec... | |||
T4928 | L-Kynurenine | (S)-Kynurenine | AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite |
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
TN1664 | Ganoderic acid H | NF-κB , DNA/RNA Synthesis , CDK | |
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4. | |||
T4S1050 | Pristimerin | Celastrol methyl ester | NF-κB , Antibacterial |
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell... | |||
T6S0077 | Byakangelicol | COX | |
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr... | |||
T6717 | Vanillin | Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107 | Others , Endogenous Metabolite |
Vanillin (Zimco) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropr... | |||
T2854 | Phillyrin | Forsythin | P450 , Influenza Virus , AMPK |
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ... | |||
T3S1471 | Cucurbitacin IIA | Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA | Apoptosis , Survivin |
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ... | |||
T3S1416 | Decursin | Decursinol angelate,(+)-Decursin | Apoptosis , PKC |
1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ... | |||
T4S1469 | Cucurbitacin IIb | Apoptosis , Others | |
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i... | |||
T5S2358 | Dehydrocorydaline | Dehydrocorydalin,13-Methylpalmatine | BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy |
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz... | |||
T1027 | Luteolin | Luteolol,Flacitran,Digitoflavone,Luteoline | Apoptosis , Nrf2 , Endogenous Metabolite , PDE , Autophagy |
Luteolin (Luteolol) is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavo... | |||
T3417 | Amentoflavone | Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin | Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal |
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib... | |||
T4518 | Licochalcone D | ERK , NF-κB | |
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect... | |||
T5S1632 | Barlerin | 8-O-Acetylshanzhiside methyl ester,ND01 | VEGFR , TNF , NF-κB , Akt , Caspase |
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e... | |||
T4S2326 | Cornuside | 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside | ERK , p38 MAPK , NF-κB , JNK |
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi... | |||
T5S2343 | Acetylshikonin | Acetyl shikonin | Others , P450 , AChE |
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang... | |||
T3S0027 | Picropodophyllotoxin | AXL 1717,Picropodophyllin | IGF-1R |
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti... | |||
TN4633 | Neocryptotanshinone II | NOS , NF-κB | |
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways. | |||
TN4418 | Lasiodiplodin | ATPase , TNF | |
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain. | |||
T14330 | Ascochlorin | Ilicicolin D | STAT |
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis and it has Anti-inflammatory activity[... | |||
TN6608 | Cyanidin-3-O-arabinoside chloride | ||
Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs. | |||
TN2507 | 1,6,7-Trihydroxyxanthone | DNA/RNA Synthesis | |
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells. | |||
TN3618 | Cedrin | Beta Amyloid , BCL , Caspase | |
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppres... | |||
TN4938 | Samidin | p38 MAPK , TNF , NF-κB , COX , DNA/RNA Synthesis , JNK | |
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. | |||
TN6547 | Angustifoline | ||
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim... | |||
TMA0003 | Trans-caffeic acid | cAMP , Tyrosinase | |
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr... | |||
TN4390 | Kihadanin B | Akt , PPAR , FOXO1 | |
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes. | |||
TN1615 | Epitheaflagallin 3-O-gallate | MMP | |
Epitheaflagallin 3-O-gallate is a promising functional food material with potential antiobesity and antiperiodontal disease activities, it suppresses tumor growth through the suppression of angiogenesis. | |||
TN1374 | α-Chaconine | alpha-Chaconine | IL Receptor , COX , DNA/RNA Synthesis |
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects. | |||
T39445 | Korepimedoside C | Epimedin I | |
Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively stud... | |||
TN1663 | Ganoderic acid DM | PARP , Androgen Receptor , CDK | |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendr... | |||
TMA0291 | Dehydroglyasperin D | GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK | |
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit... | |||
T82463 | Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside | ||
Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside (MFLNH I) (compound 5), which exhibits stomach pain suppression properties [1], is extracted from the seed kernel of the Thai medicinal plant Entada rheede... | |||
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Cat No. | Product Name | Species | Expression System |
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TMPJ-00850 | ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) | Mouse | Human Cells |
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes.... | |||
TMPJ-00849 | ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) | Mouse | Human Cells |
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes.... | |||
TMPY-04753 | IRE1 Protein, Human, Recombinant (aa 465-977) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPY-04413 | IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) | Human | Baculovirus-Insect Cells |
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ... | |||
TMPJ-01405 | Kallikrein 5/KLK5 Protein, Human, Recombinant (His) | Human | Human Cells |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di... | |||
TMPY-01786 | EphB4 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephr... | |||
TMPY-03195 | Serum Amyloid P Protein, Human, Recombinant (His) | Human | HEK293 |
Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identifie... | |||
TMPY-00322 | DEC-205 Protein, Human, Recombinant (His) | Human | HEK293 |
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp... | |||
TMPY-01850 | CEACAM3 Protein, Human, Recombinant (His) | Human | HEK293 |
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66... | |||
TMPY-03564 | TSPAN8 Protein, Human, Recombinant (His) | Human | HEK293 |
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega... | |||
TMPY-03432 | KEAP1 Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-06074 | B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express... | |||
TMPY-05322 | B7-H4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express... | |||
TMPY-03888 | KEAP1 Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-03524 | B7-H4 Protein, Human, Recombinant (His) | Human | HEK293 |
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express... | |||
TMPY-02101 | KEAP1 Protein, Human, Recombinant (His & GST & Avi) | Human | Baculovirus-Insect Cells |
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ... | |||
TMPY-02361 | VEGFR2/KDR Protein, Human, Recombinant (His) | Human | HEK293 |
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ... | |||
TMPY-02130 | Argonaute-2 Protein, Mouse, Recombinant (His) | Mouse | Baculovirus-Insect Cells |
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small... | |||
TMPY-01186 | Argonaute-2 Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small... | |||
TMPY-04114 | GM-CSF/CSF2 Protein, Mouse, Recombinant | Mouse | HEK293 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio... | |||
TMPY-00750 | GM-CSF/CSF2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio... | |||
TMPY-03662 | GM-CSF/CSF2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio... | |||
TMPY-03858 | GM-CSF/CSF2 Protein, Human, Recombinant | Human | HEK293 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio... | |||
TMPY-03713 | GM-CSF/CSF2 Protein, Rat, Recombinant (His) | Rat | HEK293 |
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio... | |||
TMPH-02383 | Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His) | MARV | E. coli |
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression. | |||
TMPH-03028 | HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) | Mycoplasma pneumoniae | E. coli |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t... | |||
TMPH-02575 | PDE5A Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t... | |||
TMPK-00305 | TGFBR1 Protein, Human, Recombinant (mFc & Avi) | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPH-01179 | COX4I1 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increase... | |||
TMPK-00306 | TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated | Human | HEK293 |
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup... | |||
TMPY-04023 | BCCIP Protein, Human, Recombinant (His & GST) | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPY-00578 | BCCIP Protein, Human, Recombinant | Human | Baculovirus-Insect Cells |
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ... | |||
TMPK-01097 | AFP Protein, Canine, Recombinant (His) | Canine | HEK293 |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-der... | |||
TMPK-00488 | AFP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-der... | |||
TMPK-01034 | SEMA4B Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p... | |||
TMPH-01001 | BCL10 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essenti... | |||
TMPH-02327 | ZW10 interactor/ZWINT Protein, Human, Recombinant (GST) | Human | E. coli |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpres... | |||
TMPJ-01335 | MOB1A Protein, Human, Recombinant (His) | Human | E. coli |
MOB Kinase Activator 1A (MOB1A) belongs to the MOB1/phocein family, which acts as an activator of LATS1/2 in the Hippo signaling pathway, plays a key role in organ size control and tumor suppression by restricting prolif... | |||
TMPK-01380 | LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) | Cynomolgus,Rhesus macaque | HEK293 |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ... | |||
TMPK-01070 | LRRC15 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ... | |||
TMPH-03727 | Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His) | ZEBOV | E. coli |
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD... | |||
TMPK-01309 | LRRC15 Protein, Canine, Recombinant (His) | Canine | HEK293 |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ... | |||
TMPH-03728 | Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His & Myc) | ZEBOV | Baculovirus |
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD... | |||
TMPK-00338 | LRRC15 Protein, Human, Recombinant (His & Avi) | Human | CHO |
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation. LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ... | |||
TMPJ-00557 | Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His) | Human | Human Cells |
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di... | |||
TMPJ-00468 | KLK10 Protein, Human, Recombinant (His) | Human | Human Cells |
Kallikreins are a subgroup of Serine Proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di... | |||
TMPJ-00929 | Serpin B3 Protein, Human, Recombinant (N-His) | Human | E. coli |
Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in ... | |||
TMPJ-00928 | Serpin B3 Protein, Human, Recombinant (C-His) | Human | Human Cells |
Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in ... | |||
TMPJ-00175 | B7-H4 Protein, Rhesus macaque, Recombinant (hFc) | Rhesus macaque | Human Cells |
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negat... | |||
TMPH-02271 | BTK Protein, Human, Recombinant (His) | Human | Baculovirus |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ... | |||
------------------------ More ------------------------ |
Cat No. | Product Name | ||
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L2170 | Immuno-Oncology Compound Library | 454 compounds | |
A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening; |