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Search Results for " suppression "

Targets

88

Compounds

65

Natural Products

171

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T0220 Foscarnet sodium Phosphonoformate Virus Protease , Reverse Transcriptase , DNA/RNA Synthesis
Foscarnet sodium (Phosphonoformate) is an antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
T21422 Methylnaltrexone bromide Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728 Opioid Receptor
Methylnaltrexone bromide (MOA-728) is one of the newer agents of peripherally-acting μ-opioid antagonists. Methylnaltrexone bromide acts to reverse some of the side effects of opioid drugs such as constipation without af...
T7943 Fluphenazine decanoate Dopamine Receptor
Fluphenazine decanoate is dopamine D2 receptor blocke,and is a long-acting phenothiazine neuroleptic that used to treat schizophrenia.
T11174 (R)-Elagolix NBI-56418 GNRH Receptor
(R)-Elagolix (NBI-56418) is a short-acting, nonpeptide, GnRH antagonist with an IC50 and Ki of 0.25 and 3.7 nM, respectively. administered orally, that unlike injectable depot GnRH agonists and antagonists, produces a do...
T20802 Flumethasone pivalate Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten Others
Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang...
T8400 Pamidronic acid Wnt/beta-catenin
Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells
T11079 NMI 8739 n-docosahexaenoyl dopamine,Dha-DA conjugate Dopamine Receptor
NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor. NMI 8739 reduces NO production and elicits concentration-dependent suppression of CCL-20, MCP-1 and IL-6 release.
T60098 MSC2504877 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one Others
MSC2504877 is an inhibitor of tankyrase and enhances the effects of clinical CDK4/6 inhibitors. MSC2504877 suppresses the upregulation of Cyclin D2 and Cyclin E2 caused by palbociclib and enhances the suppression of phos...
T4981 Anisotropine Methylbromide Prostaglandin Receptor , AChR
Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.
T2498 Adjudin AF-2364 Chloride channel , Mitochondrial Metabolism
Adjudin (AF-2364) is a small molecule compound known to possess antispermatogenic function, attenuates microglia activation by suppression of the NF-κB pathway.
T9953 BT173 Others
BT173 is a novel inhibitor of homeodomain interacting protein kinase 2 (HIPK2 ), attenuating renal fibrosis through suppression of the TGF-ß1/Smad3 pathway.
T13974 ZL0580 Epigenetic Reader Domain , HIV Protease
ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
T13360 XRK3F2 Autophagy
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo.
T11669 IR415 HBV
IR415 selectively interacts with Hepatitis B virus X protein (HBx, Kd = 2 nM) and blocks HBV-mediated RNAi suppression, reverses the inhibitory effect of HBx protein on the activity of the dicer endoribonuclease. IR415 i...
T2589 Dolasetron Mesylate hydrate Dalasetron Mesylate Hydrate 5-HT Receptor
Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) , a selective serotonin receptor antagonist, competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radioth...
T11820 LAT1-IN-1 BCH Apoptosis , Others
LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral...
T1167 Cyproterone acetate Androcur,Cyproterone 17-O-acetate Androgen Receptor
Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and inhibiting the growth of testosterone-sensitive tumor cells. ...
T27392 FT001 Epigenetic Reader Domain
FT001 is a potent, selective and orally available inhibitor of BET Bromodomain with antitumor activity. FT001 inhibited the expression of MYC with the IC50 value of 0.46 μM). FT001 has potent antiproliferative effects ag...
T19854 Evoxine
Evoxine is a selective inhibitor of CO2-induced immune suppression. It inhibits hypercapnic suppression of interleukin-6 and the chemokine CCL2 expression in human THP-1 macrophages.
T21131 NASTRp Naphthol AS-TR phosphate
NASTRp, an inhibitor of CREB-CBP complex, possesses anti-cancer effects along with cell cycle regulation, autophagy suppression, and endoplasmic reticulum stress.
T27176 Dimethandrolone Undecanoate DMAU
Dimethandrolone Undecanoate is a selective androgen receptor modulator (SARM). Dimethandrolone Undecanoate has both androgenic and progestational activities, properties that may maximize gonadotropin suppression.
T20660 Revaprazan SB-641257,SB 641257,SB641257
Revaprazan is a novel, selective potassium-competitive acid blocker, to be specific, it reversibly inhibits gastric H(+)/K(+)-ATPase and shows effective acid suppression comparable to PPIs.
T13574 Besifovir Dipivoxil maleate LB80380 maleate Others
Besifovir Dipivoxil (LB80380) maleate is an oral prodrug of LB80317. Besifovir Dipivoxil maleate is effective in hepatitis B virus (HBV) DNA suppression for both treatment-naive and lamivudine-resistant chronic hepatitis...
T41081 Pyrazosulfuron-ethyl
Pyrazosulfuron-ethyl, a sulphonylurea herbicide belonging to the acetolactate synthase inhibiting category, has gained extensive application in the suppression of weed proliferation within commercial cereal, soybean, and...
T25576 KF 392 KF392,KF-392
KF 392 is antiulcer. It was found that KF-392 given orally to rats at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions.
T26577 AGN-201904Z AGN-201904-Z,AGN-201904
AGN-201904Z is a slowly absorbed, acid-stable pro-proton pump inhibitor (pro-PPI) rapidly converted to omeprazole in the systemic circulation giving a prolonged residence time. AGN 201904-Z produced a significantly great...
T24787 SGE-201
SGE-201 is an allosteric modulator of N-methyl-D-aspartate receptors. SGE-201 also unmasked differences among the blockers in neuronal networks - measured either by suppression of activity in multi-electrode arrays or by...
T34632 SH-5 SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II
SH-5, an AKT inhibitor potentiates apoptosis and inhibits invasion through the suppression of anti-apoptotic, proliferative and metastatic gene products regulated by IκBα kinase activation.
T61623 Ecabet
Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori er...
T68528 M-COPA
M-COPA is a golgi disruptor which inhibits cell surface expression of MET protein and the ADP-ribosylation factor 1 (Arf1) activation. M-COPA also inhibits angiogenesis through suppression of both VEGFR1/2 and nuclear fa...
T14282 Amuvatinib hydrochloride HPK 56 hydrochloride,MP470 hydrochloride Others
Amuvatinib hydrochloride (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret and is also a DNA repair suppress...
T61789 IDO1-IN-14
IDO1-IN-14 (compound 4a) is a highly effective inhibitor of the IDO1 enzyme, exhibiting an IC50 value of 396.9 nM. Additionally, IDO1-IN-14 demonstrates excellent suppression of cellular IDO1 activity, as observed in HeL...
T15831 M-525 Others
M-525 binds to menin (IC50: 3 nM) and achieves low nanomolar potencies in cell growth inhibition and in the suppression of MLL regulated gene expression in MLL leukemia cells. M-525 is a first-in-class, highly potent, ir...
T71520 LEQ-506
LEQ506, also known as NPV-LEQ506, is an orally bioavailable small-molecule Smoothened (Smo) antagonist with potential antineoplastic activity. Smoothened antagonist LEQ506 selectively binds to the Hedgehog (Hh)-ligand ce...
T61794 LASSBio-1632
LASSBio-1632 is a novel anti-asthmatic lead candidate that selectively inhibits PDE4A and PDE4D isoenzymes, leading to the suppression of airway hyper-reactivity (AHR) and TNF-α production in lung tissue. With high exper...
T61118 CD73-IN-12
CD73-IN-12 is a highly effective CD73 inhibitor that displays strong potential in tumor suppression. CD73, an enzyme intricately linked to tumor development, angiogenesis, and metastasis, is significantly inhibited by CD...
TP1916 [D-Phe12,Leu14]-Bombesin
Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.
T40211 EIF4E-IN-1 eIF4E-IN-1
eIF4E-IN-1 (WO2021003194A1, compound Y), is a highly effective inhibitor of eIF4E, a key protein involved in immunosuppression. By targeting immune checkpoint proteins such as PD-1, PD-L1, LAG3, TIM3, and IDO, eIF4E-IN-1...
T79096 IPG7236 CCR
IPG7236, a selective CCR8 antagonist, demonstrates notable tumor suppression in a mouse xenograft model of human breast cancer and is applicable in cancer research [1].
T61627 IMDK quarterhydrate
iMDK quarterhydrate, a potent PI3K inhibitor, is effective in inhibiting the growth factor MDK (also known as midkine or MK) while demonstrating suppression of non-small cell lung cancer (NSCLC). In combination with a ME...
T81144 SMP-93566
SMP-93566 is an antibody-drug conjugate (ADC) characterized by a low payload shedding rate, demonstrating in vivo tumor suppression in ovarian, gastric, and breast cancers [1].
TP2026 GRP (porcine)
Mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA re...
T69990 Ruboxistaurin mesylate monohydrate
Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and...
T79840 Bocodepsin hydrochloride OKI-179 hydrochloride HDAC
Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppression of both solid tumors and hematological malignancies [1].
T35524 (1S)-Calcitriol
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of kera...
T80909 Tyrosinase-IN-19 Tyrosinase
Tyrosinase-IN-19 (compound 9), a competitive tyrosinase inhibitor, exhibits potent antioxidant activities by neutralizing ROS, ABTS+, and DPPH radicals and demonstrates dose-dependent suppression of tyrosinase expression...
T69970 AZD5718
AZD5718 is a potent and selective FLAP inhibitor (IC50 = 2.0 nM) for Treatment of Coronary Artery Disease. AZD5718 demonstrated a dose dependent and greater than 90% suppression of leukotriene production over 24 h. Precl...
T37148 TML-6
TML-6, an oral curcumin derivative, demonstrates inhibitory effects on the synthesis of β-amyloid precursor protein and β-amyloid (Aβ). Additionally, TML-6 exhibits upregulation of Apo E, suppression of NF-κB and mTOR, a...
T3689L Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic ne...
T69193 SN-28049
SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIal...

Compounds

Foscarnet sodium
T0220
Synonym: Phosphonoformate
Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis
Methylnaltrexone bromide
T21422
Synonym: Relistor,MOA-728,MOA 728,Methylnaltrexone,MOA728
Target: Opioid Receptor
Fluphenazine decanoate
T7943
Synonym:
Target: Dopamine Receptor
(R)-Elagolix
T11174
Synonym: NBI-56418
Target: GNRH Receptor
Flumethasone pivalate
T20802
Synonym: Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten
Target: Others
Pamidronic acid
T8400
Synonym:
Target: Wnt/beta-catenin
NMI 8739
T11079
Synonym: n-docosahexaenoyl dopamine,Dha-DA conjugate
Target: Dopamine Receptor
MSC2504877
T60098
Synonym: 3-(4-(2-Hydroxypropan-2-yl)phenyl)-6-methylpyrrolo[1,2-a]pyrazin-1(2H)-one
Target: Others
Anisotropine Methylbromide
T4981
Synonym:
Target: Prostaglandin Receptor, AChR
Adjudin
T2498
Synonym: AF-2364
Target: Chloride channel, Mitochondrial Metabolism
BT173
T9953
Synonym:
Target: Others
ZL0580
T13974
Synonym:
Target: Epigenetic Reader Domain, HIV Protease
XRK3F2
T13360
Synonym:
Target: Autophagy
IR415
T11669
Synonym:
Target: HBV
Dolasetron Mesylate hydrate
T2589
Synonym: Dalasetron Mesylate Hydrate
Target: 5-HT Receptor
LAT1-IN-1
T11820
Synonym: BCH
Target: Apoptosis, Others
Cyproterone acetate
T1167
Synonym: Androcur,Cyproterone 17-O-acetate
Target: Androgen Receptor
FT001
T27392
Synonym:
Target: Epigenetic Reader Domain
Evoxine
T19854
Synonym:
Target:
NASTRp
T21131
Synonym: Naphthol AS-TR phosphate
Target:
Dimethandrolone Undecanoate
T27176
Synonym: DMAU
Target:
Revaprazan
T20660
Synonym: SB-641257,SB 641257,SB641257
Target:
Besifovir Dipivoxil maleate
T13574
Synonym: LB80380 maleate
Target: Others
Pyrazosulfuron-ethyl
T41081
Synonym:
Target:
KF 392
T25576
Synonym: KF392,KF-392
Target:
AGN-201904Z
T26577
Synonym: AGN-201904-Z,AGN-201904
Target:
SGE-201
T24787
Synonym:
Target:
SH-5
T34632
Synonym: SH5 PIA5. LchiroInositol 1deoxy6Omethyl 5(2R)2methoxy3(octadecyloxy)propyl hydrogen phosphate. Akt inhibitor II
Target:
Ecabet
T61623
Synonym:
Target:
M-COPA
T68528
Synonym:
Target:
Amuvatinib hydrochloride
T14282
Synonym: HPK 56 hydrochloride,MP470 hydrochloride
Target: Others
IDO1-IN-14
T61789
Synonym:
Target:
M-525
T15831
Synonym:
Target: Others
LEQ-506
T71520
Synonym:
Target:
LASSBio-1632
T61794
Synonym:
Target:
CD73-IN-12
T61118
Synonym:
Target:
[D-Phe12,Leu14]-Bombesin
TP1916
Synonym:
Target:
eIF4E-IN-1
T40211
Synonym: eIF4E-IN-1
Target:
IPG7236
T79096
Synonym:
Target: CCR
iMDK quarterhydrate
T61627
Synonym:
Target:
SMP-93566
T81144
Synonym:
Target:
GRP (porcine)
TP2026
Synonym:
Target:
Ruboxistaurin mesylate monohydrate
T69990
Synonym:
Target:
Bocodepsin hydrochloride
T79840
Synonym: OKI-179 hydrochloride
Target: HDAC
(1S)-Calcitriol
T35524
Synonym:
Target:
Tyrosinase-IN-19
T80909
Synonym:
Target: Tyrosinase
AZD5718
T69970
Synonym:
Target:
TML-6
T37148
Synonym:
Target:
Ruboxistaurin mesylate
T3689L
Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate
Target:
SN-28049
T69193
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T5788 XYLOBIOSE IL Receptor , TNF
XYLOBIOSE ia a natural product,and exhibited therapeutic potential for treating obesity which involved suppression of fat deposition and obesity-related metabolic disorders.
T6S0214 Dl-Maackiain (+)-Maackiain,Demethylpterocarpin Apoptosis , Parasite
1. dl-Maackiain (Demethylpterocarpin) induces apoptosis and growth suppression 2. MAK1 is the second functional gene cloned from Maackiain detoxification.
T6S1367 Procyanidin B2 Proanthocyanidin B2 Reactive Oxygen Species , NOD
Procyanidin B2 (Proanthocyanidin B2) has vascular protective, anti-diabetic nephropathy, anti-cancer, anti-inflammatory, and antioxidant activities. Procyanidin B2 inhibited NLRP3 inflammasome activation via suppression ...
T5665 Geraniol Others , Endogenous Metabolite , Antifungal
geraniol provides a potent protective effect against cardiac dysfunction induced by diabetes. This ameliorative effect could be attributed to its suppression of oxidative stress.
T5785 MALTOTETRAOSE Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose TNF , Endogenous Metabolite
Maltotetraose (Fujioligo 450) are potent inhibitors of TNF-α-induced intercellular adhesion molecule-1 (ICAM-1) expression, maltotetraose may be beneficial in the suppression of early atherosclerosis development.
T6S1141 Ganoderic acid A Apoptosis , NF-κB , Endogenous Metabolite , Autophagy
1. Ganoderic acid A exhibits antitumor activity, mediated through its inhibitory effect on nuclear transcription factor-kappaB and activator protein-1. 2. Ganoderic acid A can induce proliferation inhibition, apoptosis a...
T1721 2'-Deoxyuridine Uracil deoxyriboside,2-deoxyuridine,2'-dU Others , DNA/RNA Synthesis , Endogenous Metabolite
2'-Deoxyuridine (2-deoxyuridine). An antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemias due to vitamin B12...
T5S1000 Sophoraflavanone G Kushenol F,Vexibinol Apoptosis
Sophoraflavanone G (Kushenol F) (Kushenol F), isolated from Sophora flavescens, induces MDA-MB-231 and HL-60 cells apoptosis through suppression of MAPK-related pathways.
T1313 Nitrofurantoin Furadantine,Macrodantin,Furadonine Antibacterial , Antibiotic
Nitrofurantoin (Furadantine), an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoi...
TN1923 Mesaconine IL Receptor , NF-κB
Mesaconine is an ingredient from Aconitum carmichaelii Debx.. Mesaconine has a cardiac effect and anti-NF-κB activity. Mesaconine may be part of the material basis of Mahuang Fuzi Xixin decoction on anti-inflammation and...
T0603 Phthalic acid mono-2-ethylhexyl ester Phthalic Acid Monooctyl Ester P450 , Endogenous Metabolite
Phthalic acid mono-2-ethylhexyl ester (Phthalic Acid Monooctyl Ester is a major bioactive metabolite of diethylhexyl phthalate (DEHP), which inhibits the 17, 20 lyase activity of CYP17. Cyp17a1 gene is a specific target ...
T5S0993 Kurarinone BCL , Others , IκB/IKK , TNF , NF-κB , JAK , STAT
Kurarinone, a flavanoid derived from shrub Sophora flavescens,Kurarinone exhibits anti-tumor, estrogenic, and anti-inflammatory activities, it also shows strong inhibitory effect on immune responses. Kurarinone may ameli...
TN1410 Asperulosidic acid ASPA ERK , NF-κB
Asperulosidic acid (ASPA) has anti-tumor, anti-oxidant, and anti-inflammatory activities. ASPA is related to the inhibition of inflammatory cytokines (TNF-α, IL-6) and mediators via suppression of the NF-κB and mitogen-a...
TN1712 Gossypin NF-κB , S6 Kinase
Gossypin has antidiabetic, antioxdiant, anticonvulsant, anti-allergic, antiinflammatory, antinociceptive, cytotoxic and antibacterial activities; it inhibits the NF-kappaB activation pathway, which may explain its role i...
TN1557 Decursinol angelate ERK , VEGFR , PKC , JNK
Decursinol angelate has anti-tumor, anti-inflammatory, anti-oxidant, and hepatoprotective activities, it inhibits VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway; it also suppresses invasion an...
T3727 Methyl syringate Syringic Acid Methyl Ester TRP/TRPV Channel
Methyl syringate (Syringic Acid Methyl Ester) has a unique inhibitory activity toward aflatoxin production with a different mode of action from that of gallic acid. Methyl syringate from K. pictus is a specific and selec...
T4928 L-Kynurenine (S)-Kynurenine AhR , Aryl Hydrocarbon Receptor , Endogenous Metabolite
L-Kynurenine ((S)-Kynurenine) is a key intermediate in the breakdown pathway of tryptophan. L-Kynurenine is a substrate of kynureninase, KMO, and KAT associated with the suppression of antitumor immune responses. It has ...
T3S0645 N-trans-Feruloyltyramine Feruloyltyramine,N-Feruloyltyramine,Moupinamide Others , COX
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s...
TN1664 Ganoderic acid H NF-κB , DNA/RNA Synthesis , CDK
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting in the down-regulation of expression of Cdk4.
T4S1050 Pristimerin Celastrol methyl ester NF-κB , Antibacterial
1. Pristimerin (Celastrol methyl ester) has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell...
T6S0077 Byakangelicol COX
1. Byakangelicol may inhibit P-gp expressed at the BBB even under in vivo conditions. 2. Byakangelicol can inhibit IL-1beta-induced PGE2 release in A549 cells; this inhibition may be mediated by suppression of COX-2 expr...
T6717 Vanillin Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107 Others , Endogenous Metabolite
Vanillin (Zimco) is a single molecule extracted from vanilla beans and also a popular odor used widely in perfume, food and medicine.Vanillin can reversibly and non-competitively inhibit the cellulase activity at appropr...
T2854 Phillyrin Forsythin P450 , Influenza Virus , AMPK
Phillyrin (Forsythin) is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activ...
T3S1471 Cucurbitacin IIA Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA Apoptosis , Survivin
1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...
T3S1416 Decursin Decursinol angelate,(+)-Decursin Apoptosis , PKC
1. Decursin (Decursinol angelate) is able to attenuate kainic acid-induced seizures and could have potential as an antiepileptic drug. 2. Decursin exhibits hepatoprotective effects , potentially by inhibiting the TGF-β1 ...
T4S1469 Cucurbitacin IIb Apoptosis , Others
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-i...
T5S2358 Dehydrocorydaline Dehydrocorydalin,13-Methylpalmatine BCL , PARP , p38 MAPK , Caspase , Parasite , Autophagy
1. Dehydrocorydaline (13-Methylpalmatine) exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSC-LC cells. 2. Dehydrocorydaline stimulates p38 MAPK activation, which can enhance heterodimeriz...
T1027 Luteolin Luteolol,Flacitran,Digitoflavone,Luteoline Apoptosis , Nrf2 , Endogenous Metabolite , PDE , Autophagy
Luteolin (Luteolol) is a naturally occurring flavonoid. The flavonoids are polyphenolic compounds found as integral components of the human diet. In vitro work has concentrated on the direct and indirect actions of flavo...
T3417 Amentoflavone Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...
T4518 Licochalcone D ERK , NF-κB
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...
T5S1632 Barlerin 8-O-Acetylshanzhiside methyl ester,ND01 VEGFR , TNF , NF-κB , Akt , Caspase
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...
T4S2326 Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside ERK , p38 MAPK , NF-κB , JNK
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...
T5S2343 Acetylshikonin Acetyl shikonin Others , P450 , AChE
1. Acetylshikonin exhibits weak cytotoxicity against human umbilical vein endothelial cells (HUVECs) with IC5 of over 2 microM, exhibits the antiangiogenic and antitumorigenic effects by suppressing proliferation and ang...
T3S0027 Picropodophyllotoxin AXL 1717,Picropodophyllin IGF-1R
Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...
TN4633 Neocryptotanshinone II NOS , NF-κB
Neocryptotanshinone inhibits lipopolysaccharide-induced inflammation in RAW264.7 macrophages by suppression of NF-κB and iNOS signaling pathways.
TN4418 Lasiodiplodin ATPase , TNF
Lasiodiplodin may have potential anti-inflammatory activity, it shows moderate suppression effects on induced NO production. Lasiodiplodin inhibits electron transport chain.
T14330 Ascochlorin Ilicicolin D STAT
Ascochlorin (Ilicicolin D), an isoprenoid antibiotic, mediates its anti-tumor effects predominantly through the suppression of STAT3 signaling cascade. Ascochlorin induces apoptosis and it has Anti-inflammatory activity[...
TN6608 Cyanidin-3-O-arabinoside chloride
Cyanidin-3-O-arabinoside chloride has antioxidant activity. It reduces the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage, PARS activation and vascular dysfunction in HUVECs.
TN2507 1,6,7-Trihydroxyxanthone DNA/RNA Synthesis
1,6,7-Trihydroxyxanthone has anti-cancer activity ,at least in part, through the activation of miR-218 and suppression of Bmi-1 expression; can suppress cell growth and induce apoptosis in liver cancer cells.
TN3618 Cedrin Beta Amyloid , BCL , Caspase
Cedrin has protective effects on PC12 cells against the neurotoxicity induced by amyloid β1-42, the protective effect is related to the inhibition of oxidative stress, improvement of mitochondrial dysfunction and suppres...
TN4938 Samidin p38 MAPK , TNF , NF-κB , COX , DNA/RNA Synthesis , JNK
Samidin has anti-inflammatory properties through suppression of NF-κB and AP-1-mediated-genes in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
TN6547 Angustifoline
Angustifoline has activity against gram-positive bacteria. It inhibits human colon cancer cell growth by inducing autophagy along with mitochondrial-mediated apoptosis, suppression of cell invasion and migration and stim...
TMA0003 Trans-caffeic acid cAMP , Tyrosinase
Trans-caffeic acid stearyl ester is posited to inhibit melanogenesis signaling while suppressing cAMP levels and, subsequently, MC1R, MITF, tyrosinase, TRP-2 and TRP-1 down-regulation, resulting in the suppression of tyr...
TN4390 Kihadanin B Akt , PPAR , FOXO1
Kihadanin B can repress the adipogenesis by decreasing lipid accumulation through the suppression of the Akt-FOXO1-PPARγ axis in 3T3-L1 adipocytes.
TN1615 Epitheaflagallin 3-O-gallate MMP
Epitheaflagallin 3-O-gallate is a promising functional food material with potential antiobesity and antiperiodontal disease activities, it suppresses tumor growth through the suppression of angiogenesis.
TN1374 α-​Chaconine alpha-Chaconine IL Receptor , COX , DNA/RNA Synthesis
Alpha-Chaconine has anti-inflammatory effect, associated with the suppression of AP-1, and supports its possible therapeutic role for the treatment of sepsis. Alpha-Chaconine also has cytotoxic effects.
T39445 Korepimedoside C Epimedin I
Korepimedoside C, also known as Epimedin I, is a flavonol glycoside derived from the aerial parts of Epimedium koreanum Nakai. Epimedium koreanum Nakai is a renowned Chinese herbal medicine that has been extensively stud...
TN1663 Ganoderic acid DM PARP , Androgen Receptor , CDK
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendr...
TMA0291 Dehydroglyasperin D GSK-3 , p38 MAPK , ROS , Akt , COX , PI3K , DNA/RNA Synthesis , Prostaglandin Receptor , JNK
Dehydroglyasperin D exhibits anticancer, anti-inflammatory, anti-obesity, antioxidant and anti-aldose reductase effects, it inhibits the proliferation of HT-29 human colorectal cancer cells through direct interaction wit...
T82463 Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside
Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside (MFLNH I) (compound 5), which exhibits stomach pain suppression properties [1], is extracted from the seed kernel of the Thai medicinal plant Entada rheede...
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Natural Products

XYLOBIOSE
T5788
Synonym:
Target: IL Receptor, TNF
dl-Maackiain
T6S0214
Synonym: (+)-Maackiain,Demethylpterocarpin
Target: Apoptosis, Parasite
Procyanidin B2
T6S1367
Synonym: Proanthocyanidin B2
Target: Reactive Oxygen Species, NOD
Geraniol
T5665
Synonym:
Target: Others, Endogenous Metabolite, Antifungal
MALTOTETRAOSE
T5785
Synonym: Fujioligo 450,Amylotetraose,α-1,4-Tetraglucose
Target: TNF, Endogenous Metabolite
Ganoderic acid A
T6S1141
Synonym:
Target: Apoptosis, NF-κB, Endogenous Metabolite, Autophagy
2'-Deoxyuridine
T1721
Synonym: Uracil deoxyriboside,2-deoxyuridine,2'-dU
Target: Others, DNA/RNA Synthesis, Endogenous Metabolite
Sophoraflavanone G
T5S1000
Synonym: Kushenol F,Vexibinol
Target: Apoptosis
Nitrofurantoin
T1313
Synonym: Furadantine,Macrodantin,Furadonine
Target: Antibacterial, Antibiotic
Mesaconine
TN1923
Synonym:
Target: IL Receptor, NF-κB
Phthalic acid mono-2-ethylhexyl ester
T0603
Synonym: Phthalic Acid Monooctyl Ester
Target: P450, Endogenous Metabolite
Kurarinone
T5S0993
Synonym:
Target: BCL, Others, IκB/IKK, TNF, NF-κB, JAK, STAT
Asperulosidic acid
TN1410
Synonym: ASPA
Target: ERK, NF-κB
Gossypin
TN1712
Synonym:
Target: NF-κB, S6 Kinase
Decursinol angelate
TN1557
Synonym:
Target: ERK, VEGFR, PKC, JNK
Methyl syringate
T3727
Synonym: Syringic Acid Methyl Ester
Target: TRP/TRPV Channel
L-Kynurenine
T4928
Synonym: (S)-Kynurenine
Target: AhR, Aryl Hydrocarbon Receptor, Endogenous Metabolite
N-trans-Feruloyltyramine
T3S0645
Synonym: Feruloyltyramine,N-Feruloyltyramine,Moupinamide
Target: Others, COX
Ganoderic acid H
TN1664
Synonym:
Target: NF-κB, DNA/RNA Synthesis, CDK
Pristimerin
T4S1050
Synonym: Celastrol methyl ester
Target: NF-κB, Antibacterial
Byakangelicol
T6S0077
Synonym:
Target: COX
Vanillin
T6717
Synonym: Lioxin,m-Methoxy-p-hydroxybenzaldehyde,Zimco,p-Vanillin,p-Hydroxy-m-methoxybenzaldehyde,FEMA 3107
Target: Others, Endogenous Metabolite
Phillyrin
T2854
Synonym: Forsythin
Target: P450, Influenza Virus, AMPK
Cucurbitacin IIA
T3S1471
Synonym: Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA
Target: Apoptosis, Survivin
Decursin
T3S1416
Synonym: Decursinol angelate,(+)-Decursin
Target: Apoptosis, PKC
Cucurbitacin IIb
T4S1469
Synonym:
Target: Apoptosis, Others
Dehydrocorydaline
T5S2358
Synonym: Dehydrocorydalin,13-Methylpalmatine
Target: BCL, PARP, p38 MAPK, Caspase, Parasite, Autophagy
Luteolin
T1027
Synonym: Luteolol,Flacitran,Digitoflavone,Luteoline
Target: Apoptosis, Nrf2, Endogenous Metabolite, PDE, Autophagy
Amentoflavone
T3417
Synonym: Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin
Target: Apoptosis, P450, Phospholipase, Reactive Oxygen Species, Opioid Receptor, COX, Antibacterial, RSV, Antifungal
Licochalcone D
T4518
Synonym:
Target: ERK, NF-κB
Barlerin
T5S1632
Synonym: 8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Cornuside
T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Acetylshikonin
T5S2343
Synonym: Acetyl shikonin
Target: Others, P450, AChE
Picropodophyllotoxin
T3S0027
Synonym: AXL 1717,Picropodophyllin
Target: IGF-1R
Neocryptotanshinone II
TN4633
Synonym:
Target: NOS, NF-κB
Lasiodiplodin
TN4418
Synonym:
Target: ATPase, TNF
Ascochlorin
T14330
Synonym: Ilicicolin D
Target: STAT
Cyanidin-3-O-arabinoside chloride
TN6608
Synonym:
Target:
1,6,7-Trihydroxyxanthone
TN2507
Synonym:
Target: DNA/RNA Synthesis
Cedrin
TN3618
Synonym:
Target: Beta Amyloid, BCL, Caspase
Samidin
TN4938
Synonym:
Target: p38 MAPK, TNF, NF-κB, COX, DNA/RNA Synthesis, JNK
Angustifoline
TN6547
Synonym:
Target:
Trans-caffeic acid
TMA0003
Synonym:
Target: cAMP, Tyrosinase
Kihadanin B
TN4390
Synonym:
Target: Akt, PPAR, FOXO1
Epitheaflagallin 3-O-gallate
TN1615
Synonym:
Target: MMP
α-​Chaconine
TN1374
Synonym: alpha-Chaconine
Target: IL Receptor, COX, DNA/RNA Synthesis
Korepimedoside C
T39445
Synonym: Epimedin I
Target:
Ganoderic acid DM
TN1663
Synonym:
Target: PARP, Androgen Receptor, CDK
Dehydroglyasperin D
TMA0291
Synonym:
Target: GSK-3, p38 MAPK, ROS, Akt, COX, PI3K, DNA/RNA Synthesis, Prostaglandin Receptor, JNK
Entadamide A 2'-O-(6''-O-β-D-glucopyranosyl)-β-D-glucopyranoside
T82463
Synonym:
Target:

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPJ-00850 ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His) Mouse Human Cells
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPJ-00849 ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc) Mouse Human Cells
ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes....
TMPY-04753 IRE1 Protein, Human, Recombinant (aa 465-977) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPY-04413 IRE1 Protein, Human, Recombinant (aa 465-977, His & GST) Human Baculovirus-Insect Cells
Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell ...
TMPJ-01405 Kallikrein 5/KLK5 Protein, Human, Recombinant (His) Human Human Cells
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di...
TMPY-01786 EphB4 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Ephrin type-B receptor 4 is a protein that in humans is encoded by the EPHB4 gene. It is a single-pass type I membrane protein belonging to the ephrin receptor subfamily of protein kinase superfamily. Members of the ephr...
TMPY-03195 Serum Amyloid P Protein, Human, Recombinant (His) Human HEK293
Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identifie...
TMPY-00322 DEC-205 Protein, Human, Recombinant (His) Human HEK293
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp...
TMPY-01850 CEACAM3 Protein, Human, Recombinant (His) Human HEK293
CeACAM3 (CD66d), a member of carcinoembryonic antigen family, is a granulocyte-specific receptor involved in the opsonin-independent recognition of several bacterial pathogens. There are four members in this family: CD66...
TMPY-03564 TSPAN8 Protein, Human, Recombinant (His) Human HEK293
Tetraspanin 8 (TSPAN8) as an important modulator of melanoma invasiveness, and several of its transcriptional regulators, which affect TSPAN8 expression during melanoma progression toward an invasive stage. p53 as a nega...
TMPY-03432 KEAP1 Protein, Human, Recombinant Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-06074 B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His) Cynomolgus,Rhesus HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express...
TMPY-05322 B7-H4 Protein, Mouse, Recombinant (His) Mouse HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express...
TMPY-03888 KEAP1 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-03524 B7-H4 Protein, Human, Recombinant (His) Human HEK293
V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type-III membrane protein belonging to the B7 family of costimulatory proteins. These proteins are express...
TMPY-02101 KEAP1 Protein, Human, Recombinant (His & GST & Avi) Human Baculovirus-Insect Cells
Kelch-like ECH-associated protein 1, also known as a cytosolic inhibitor of Nrf2, Kelch-like protein 19, KEAP1, and INRF2, is a cytoplasm and nucleus protein that contains one BACK (BTB/Kelch associated) domain, one BTB ...
TMPY-02361 VEGFR2/KDR Protein, Human, Recombinant (His) Human HEK293
VEGFR2 also called KDR or Flk-1, is identified as the receptor for VEGF and VEGFC and an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. VEGFR2 was shown to be ...
TMPY-02130 Argonaute-2 Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small...
TMPY-01186 Argonaute-2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Argonaute 2 (AGO2), also known as Eukaryotic translation initiation factor 2C2 (EIF2C2), belongs to the Argonaute family, AGO subfamily, which is a component of the RNA-induced silencing complex (RISC) and mediates small...
TMPY-04114 GM-CSF/CSF2 Protein, Mouse, Recombinant Mouse HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-00750 GM-CSF/CSF2 Protein, Human, Recombinant (hFc) Human HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03662 GM-CSF/CSF2 Protein, Mouse, Recombinant (His) Mouse HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03858 GM-CSF/CSF2 Protein, Human, Recombinant Human HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPY-03713 GM-CSF/CSF2 Protein, Rat, Recombinant (His) Rat HEK293
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is one of an array of cytokines with pivotal roles in embryo implantation and subsequent development. Several cell lineages in the reproductive tract and gestatio...
TMPH-02383 Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His) MARV E. coli
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
TMPH-03028 HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc) Mycoplasma pneumoniae E. coli
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPH-02575 PDE5A Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Regulator of Ras expression. May play a role in tumor suppression. Plays a role in t...
TMPK-00305 TGFBR1 Protein, Human, Recombinant (mFc & Avi) Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPH-01179 COX4I1 Protein, Human, Recombinant (His & SUMO) Human E. coli
Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increase...
TMPK-00306 TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated Human HEK293
transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-04023 BCCIP Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPY-00578 BCCIP Protein, Human, Recombinant Human Baculovirus-Insect Cells
BCCIP was originally identified as a BRCA2 and CDKN1A interacting protein that has been implicated in maintenance of genomic stability, cell cycle regulation, and microtubule dynamics. The secondary genetic alternations ...
TMPK-01097 AFP Protein, Canine, Recombinant (His) Canine HEK293
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-der...
TMPK-00488 AFP Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-der...
TMPK-01034 SEMA4B Protein, Mouse, Recombinant (His) Mouse HEK293
Semaphorin 4B (SEMA4B) inhibits the invasion of non-small cell lung cancer (NSCLC) through PI3K-dependent suppression of MMP9 activation. SEMA4B may induce FoxO1 nuclear retention through suppressing PI3K/Akt signaling p...
TMPH-01001 BCL10 Protein, Human, Recombinant (His & SUMO) Human E. coli
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essenti...
TMPH-02327 ZW10 interactor/ZWINT Protein, Human, Recombinant (GST) Human E. coli
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Promotes assembly of stress granules (SGs), when overexpres...
TMPJ-01335 MOB1A Protein, Human, Recombinant (His) Human E. coli
MOB Kinase Activator 1A (MOB1A) belongs to the MOB1/phocein family, which acts as an activator of LATS1/2 in the Hippo signaling pathway, plays a key role in organ size control and tumor suppression by restricting prolif...
TMPK-01380 LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His) Cynomolgus,Rhesus macaque HEK293
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation.  LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ...
TMPK-01070 LRRC15 Protein, Mouse, Recombinant (His) Mouse HEK293
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation.  LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ...
TMPH-03727 Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His) ZEBOV E. coli
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD...
TMPK-01309 LRRC15 Protein, Canine, Recombinant (His) Canine HEK293
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation.  LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ...
TMPH-03728 Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His & Myc) ZEBOV Baculovirus
Plays an essential role virus particle assembly and budding. Acts by interacting with viral ribonucleocapsid and host members of the ESCRT (endosomal sorting complex required for transport) system such as host VPS4, PDCD...
TMPK-00338 LRRC15 Protein, Human, Recombinant (His & Avi) Human CHO
The chimeric protein binds in vitro and in vivo to a specific element upstream of LRRC15, leading to dramatic transcriptional activation.  LRRC15 encodes a leucine-rich transmembrane protein, present at the leading edge ...
TMPJ-00557 Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His) Human Human Cells
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di...
TMPJ-00468 KLK10 Protein, Human, Recombinant (His) Human Human Cells
Kallikreins are a subgroup of Serine Proteases having diverse physiological functions. Growing evidence suggests that many Kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other di...
TMPJ-00929 Serpin B3 Protein, Human, Recombinant (N-His) Human E. coli
Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in ...
TMPJ-00928 Serpin B3 Protein, Human, Recombinant (C-His) Human Human Cells
Serpin B3, also known as squamous cell carcinoma antigen-1 (SCCA-1), is a member of the serpin superfamily of serine protease inhibitors. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in ...
TMPJ-00175 B7-H4 Protein, Rhesus macaque, Recombinant (hFc) Rhesus macaque Human Cells
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negat...
TMPH-02271 BTK Protein, Human, Recombinant (His) Human Baculovirus
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell ...
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ST2/IL-1 RL1 Protein, Mouse, Recombinant (aa 27-337, His)
TMPJ-00850
Species: Mouse
Expression System: Human Cells
ST2/IL-1 RL1 Protein, Mouse, Recombinant (V192A, hFc)
TMPJ-00849
Species: Mouse
Expression System: Human Cells
IRE1 Protein, Human, Recombinant (aa 465-977)
TMPY-04753
Species: Human
Expression System: Baculovirus-Insect Cells
IRE1 Protein, Human, Recombinant (aa 465-977, His & GST)
TMPY-04413
Species: Human
Expression System: Baculovirus-Insect Cells
Kallikrein 5/KLK5 Protein, Human, Recombinant (His)
TMPJ-01405
Species: Human
Expression System: Human Cells
EphB4 Protein, Mouse, Recombinant (hFc)
TMPY-01786
Species: Mouse
Expression System: HEK293
Serum Amyloid P Protein, Human, Recombinant (His)
TMPY-03195
Species: Human
Expression System: HEK293
DEC-205 Protein, Human, Recombinant (His)
TMPY-00322
Species: Human
Expression System: HEK293
CEACAM3 Protein, Human, Recombinant (His)
TMPY-01850
Species: Human
Expression System: HEK293
TSPAN8 Protein, Human, Recombinant (His)
TMPY-03564
Species: Human
Expression System: HEK293
KEAP1 Protein, Human, Recombinant
TMPY-03432
Species: Human
Expression System: Baculovirus-Insect Cells
B7-H4 Protein, Cynomolgus, Rhesus, Recombinant (His)
TMPY-06074
Species: Cynomolgus,Rhesus
Expression System: HEK293
B7-H4 Protein, Mouse, Recombinant (His)
TMPY-05322
Species: Mouse
Expression System: HEK293
KEAP1 Protein, Human, Recombinant (His & GST)
TMPY-03888
Species: Human
Expression System: Baculovirus-Insect Cells
B7-H4 Protein, Human, Recombinant (His)
TMPY-03524
Species: Human
Expression System: HEK293
KEAP1 Protein, Human, Recombinant (His & GST & Avi)
TMPY-02101
Species: Human
Expression System: Baculovirus-Insect Cells
VEGFR2/KDR Protein, Human, Recombinant (His)
TMPY-02361
Species: Human
Expression System: HEK293
Argonaute-2 Protein, Mouse, Recombinant (His)
TMPY-02130
Species: Mouse
Expression System: Baculovirus-Insect Cells
Argonaute-2 Protein, Human, Recombinant (His)
TMPY-01186
Species: Human
Expression System: Baculovirus-Insect Cells
GM-CSF/CSF2 Protein, Mouse, Recombinant
TMPY-04114
Species: Mouse
Expression System: HEK293
GM-CSF/CSF2 Protein, Human, Recombinant (hFc)
TMPY-00750
Species: Human
Expression System: HEK293
GM-CSF/CSF2 Protein, Mouse, Recombinant (His)
TMPY-03662
Species: Mouse
Expression System: HEK293
GM-CSF/CSF2 Protein, Human, Recombinant
TMPY-03858
Species: Human
Expression System: HEK293
GM-CSF/CSF2 Protein, Rat, Recombinant (His)
TMPY-03713
Species: Rat
Expression System: HEK293
Lake Victoria marburgvirus (MARV) (strain Musoke-80) VP35 Protein (His)
TMPH-02383
Species: MARV
Expression System: E. coli
HMW3 Protein, Mycoplasma pneumoniae, Recombinant (His & Myc)
TMPH-03028
Species: Mycoplasma pneumoniae
Expression System: E. coli
PDE5A Protein, Mouse, Recombinant (His & Myc)
TMPH-02575
Species: Mouse
Expression System: E. coli
TGFBR1 Protein, Human, Recombinant (mFc & Avi)
TMPK-00305
Species: Human
Expression System: HEK293
COX4I1 Protein, Human, Recombinant (His & SUMO)
TMPH-01179
Species: Human
Expression System: E. coli
TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated
TMPK-00306
Species: Human
Expression System: HEK293
BCCIP Protein, Human, Recombinant (His & GST)
TMPY-04023
Species: Human
Expression System: Baculovirus-Insect Cells
BCCIP Protein, Human, Recombinant
TMPY-00578
Species: Human
Expression System: Baculovirus-Insect Cells
AFP Protein, Canine, Recombinant (His)
TMPK-01097
Species: Canine
Expression System: HEK293
AFP Protein, Cynomolgus, Recombinant (His)
TMPK-00488
Species: Cynomolgus
Expression System: HEK293
SEMA4B Protein, Mouse, Recombinant (His)
TMPK-01034
Species: Mouse
Expression System: HEK293
BCL10 Protein, Human, Recombinant (His & SUMO)
TMPH-01001
Species: Human
Expression System: E. coli
ZW10 interactor/ZWINT Protein, Human, Recombinant (GST)
TMPH-02327
Species: Human
Expression System: E. coli
MOB1A Protein, Human, Recombinant (His)
TMPJ-01335
Species: Human
Expression System: E. coli
LRRC15 Protein, Cynomolgus/Rhesus macaque, Recombinant (His)
TMPK-01380
Species: Cynomolgus,Rhesus macaque
Expression System: HEK293
LRRC15 Protein, Mouse, Recombinant (His)
TMPK-01070
Species: Mouse
Expression System: HEK293
Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His)
TMPH-03727
Species: ZEBOV
Expression System: E. coli
LRRC15 Protein, Canine, Recombinant (His)
TMPK-01309
Species: Canine
Expression System: HEK293
Zaire ebolavirus (strain Kikwit-95) VP40 Protein (His & Myc)
TMPH-03728
Species: ZEBOV
Expression System: Baculovirus
LRRC15 Protein, Human, Recombinant (His & Avi)
TMPK-00338
Species: Human
Expression System: CHO
Kallikrein 8/KLK8 Protein, Human, Recombinant (aa 29-260, His)
TMPJ-00557
Species: Human
Expression System: Human Cells
KLK10 Protein, Human, Recombinant (His)
TMPJ-00468
Species: Human
Expression System: Human Cells
Serpin B3 Protein, Human, Recombinant (N-His)
TMPJ-00929
Species: Human
Expression System: E. coli
Serpin B3 Protein, Human, Recombinant (C-His)
TMPJ-00928
Species: Human
Expression System: Human Cells
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
TMPJ-00175
Species: Rhesus macaque
Expression System: Human Cells
BTK Protein, Human, Recombinant (His)
TMPH-02271
Species: Human
Expression System: Baculovirus
Cat No. Product Name
L2170 Immuno-Oncology Compound Library

454 compounds
A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening;
TargetMol