substrates

Casein Kinase Substrates 3 (CKS3) is a substrate of casein kinase (CK).

GSK3 Substrate, α, β subunit, serves as a peptide substrate for Glycogen Synthase Kinase-3 (GSK-3), facilitating the measurement of GSK-3 activity [1].

Cathepsin D and E FRET Substrate acetate is a fluorogenic substrate selectively cleaved by cathepsins D and E at the Phe-Phe amide bond, demonstrating no activity towards cathepsins B, H, or L. This specificity renders it essential for routine assays and mechanistic studies focusing on cathepsins E and D[1].

The pp60 (v-SRC) Autophosphorylation Site, Phosphorylated is a phosphorylated peptide derived from an EGFR substrate, used as a critical tool for quantifying phosphorylated substrates in the screening of EGFR Kinase inhibitors.

Poly-L-lysine hydrochloride plays a key role in promoting cell attachment to solid substrates by enhancing the electrostatic interaction between the negatively charged ions present on the cell membrane and the surface of the culture substrate as a non-specific attachment factor.Poly-L-lysine hydrochloride is a peptide that at low concentrations Due to its cationic peptide nature, Poly-L-lysine hydrochloride is antimicrobially active. These properties make it an important component for enhancing cell adhesion, regulating phase separation kinetics and demonstrating antimicrobial activity.

Histone H1-derived peptide is a phosphopeptide with peptide substrates that consist of a sequence aligned with the optimal recognition motif for cyclin-dependent kinases (CDKs).

NH2-AKK-COOH, a synthetic tripeptide, acts as an ACE inhibitor with IC50 values of 0.090 μM, 0.178 μM, and 420.89 μM against substrates FAPGG, HHL, and angiotensin-I, respectively [1].

N-myristoyl-RKRTLRRL is a compound that impedes the binding of protein kinase C (PKC) substrates and inhibits calcium (Ca2+)- and phosphatidylserine (PS)-dependent phosphorylation of histones, exhibiting an IC50 of 5 μM. Additionally, it demonstrates an inhibitory effect on histone phosphorylation with an IC50 of 80 μM [1] [2].

PA22-2, an active biological peptide featuring the IKVAV sequence from the laminin A-chain fragment, is derived from mouse laminin alpha1 amino acid residues 2110-2127. Substrates composed of PA22-2 have been shown to facilitate neurite outgrowth.

Hyaluronan-IN-1, a biological active peptide comprising 12 amino acids, functions as an inhibitor of hyaluronan (HA), a high molecular weight glycosaminoglycan prevalent in the extracellular matrix and on cell surfaces. It demonstrates specific binding to various forms of HA, including soluble, immobilized, and cell-associated, and nearly completely inhibits leukocyte adhesion to HA substrates.

The peptide region containing residues 390-404 in Activated Protein C (APC) is essential for anticoagulant activity and is available for interaction with antibodies or with other proteins, such as the macromolecular substrates Factors Va or VIIIa. APC reg

Competitive inhibitor of cGMP-dependent protein kinase (PKG); analog of a substrate peptide corresponding to a phosphorylation site of histone H2B. Competes with synthetic substrates (Ki = 86 mM) but does not inhibit phosphorylation of intact histones by