protac linkers

6-Maleimidocapronic acid, an alkyl chain-based PROTAC linker, is utilized in the synthesis of PROTACs (proteolysis-targeting chimeras).

11-Aminoundecanoic acid, an alkyl chain-based PROTAC linker, is employed in PROTAC synthesis.

11-Maleimidoundecanoic acid is an alkyl chain-based PROTAC linker used in PROTAC synthesis (PROTAC is an acronym for [PROteolysis-TArgeting Chimera]).

5-Ethynyl-2'-deoxyuridine (EdU) is a nucleoside analog of thymidine used to monitor de novo DNA synthesis through click chemistry and serves as an alkyl chain-based PROTAC linker for synthesizing PROTACs.

Boc-NH-PEG3-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs.

Br-C10-methyl ester, a PROTAC linker characterized by its alkyl ether composition, plays a crucial role in the synthesis of a series of PROTACs (MS432). This compound incorporates a dual-ligand system connected via a linker; notably, one ligand interacts with the VHL portion.

m-PEG2-Br is a PEG-based PROTAC linker used in the synthesis of PROTACs.

N-Boc-4-pentyne-1-amine is an alkyl chain-based PROTAC linker compound used in the synthesis of PROTAC MG-277 [1].

NH2-C6-NH-Boc is a PROTAC linker used in the synthesis of the Mcl-1 inhibitor [based on PROTAC].

Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in PROTAC synthesis.

Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker employed in PROTAC synthesis [1].

Bromo-PEG3-C2-acid, a PEG-based PROTAC linker, can be utilized in PROTAC synthesis[1].

Propargyl-PEG3-acid is a non-cleavable (3-unit PEG) ADC linker and a PEG-based PROTAC linker, used to synthesize 6-OHDA-PEG3-yne, a compound containing 6-OHDA and Propargyl-PEG3-acid[1].

Boc-NH-C4-acid is a PROTAC linker of the Alkyl ether class, utilized in the synthesis of PROTAC1 for the degradation of EED, EZH2, and SUZ12 in [PRC2].

Boc-NH-O-C1-NHS ester, an alkyl ether-based PROTAC linker, is utilized in PROTAC synthesis.

PEG3-O-CH2COOH (PROTAC Linker 8) is a PEG-based linker utilized in the synthesis of SNIPERs.

tert-Butyl 11-aminoundecanoate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Boc-NH-PEG3 (PROTAC Linker 10) is a PEG derivative featuring a hydroxyl group and a Boc-protected amino group, used as a PROTAC linker.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

2-Phthalimidehydroxy-acetic acid is an alkyl chain-based PROTAC linker utilized in PROTAC synthesis.

Biotin-EDA, an alkyl chain-based PROTAC linker, is utilized in PROTAC synthesis.

Biotin-PEG2-C2-iodoacetamide (Biotin-PEG2-iodoacetamide) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Boc-NH-PEG4-CH2COOH is a cleavable ADC linker utilized in the development of antibody-drug conjugates (ADC)[1].