protac linkers

Boc-NH-PEG3-NHS ester is a PEG-based linker utilized in the synthesis of PROTACs.

DBCO-PEG4-NHS ester is a PEG-based PROTAC linker utilized in PROTAC synthesis[1].

Mal-amido-PEG8-NHS ester, a PEG-based PROTAC linker, is utilized in the synthesis of PROTACs.

Biotin-PEG2-C2-iodoacetamide (Biotin-PEG2-iodoacetamide) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Lenalidomide-Br (Compound 41), a derivative of Lenalidomide, acts as a ligand for cereblon (CRBN) - an E3 ubiquitin ligase involved in protein recruitment. This compound can be conjugated to a protein ligand via a linker to create PROTACs, such as the PROTAC STAT3 degrader SD-36.

NH2-C5-NH-Boc (PROTAC Linker 23) is an alkyl chain-based PROTAC linker used in the synthesis of PROTACs.

Boc-C16-COOH is a alkyl-chain-based PROTAC linker. Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Fmoc-8-amino-3,6-dioxaoctanoic acid (Fmoc-NH-PEG2-CH2COOH) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) and a PEG-based PROTAC linker for the synthesis of PROTACs.

Boc-NH-PEG1-OH is a PEG-based PROTAC linker utilized in the synthesis of PROTACs.

11-Aminoundecanoic acid, an alkyl chain-based PROTAC linker, is employed in PROTAC synthesis.

Boc-GABA-OH serves as a PROTAC linker essential for synthesizing UNC6852, an EED-targeted PROTAC[1].

Boc-11-aminoundecanoic acid is an alkyl ether-based PROTAC linker used in the synthesis of [MS432].

1-Bromo-6-chlorohexane (Hexane, 1-bromo-6-chloro-) is used as PROTAC linker.

Pentaethylene glycol di(p-toluenesulfonate) (Penta(ethylene glycol) bis(p-toluenesulfonate)) is a PEG-based PROTAC linker. Pentaethylene glycol di(p-toluenesulfonate) can be used in the synthesis of PROTACs.

NH2-C4-NH-Boc (compound 15) is a PROTAC linker of the Alkyl ether class, suitable for synthesizing various PROTAC molecules.

TGN-020 is an inhibitor of Aquaporin 4 (AQP4, IC50: 3.1 μM), the most abundant water channel in the brain.

NH2-C2-NH-Boc (PROTAC Linker 22), an alkyl chain-based PROTAC linker, can be used in the synthesis of PROTACs.

Diethylene glycol bis(p-toluenesulfonate) (Bis-Tos-PEG2) is a PEG-based PROTAC linker that can be used in PROTAC synthesis.

Monoethyl pimelate is a PROTAC linker, which refers to the alkyl ether composition. Monoethyl pimelate can be used in the synthesis of (S,R,S)-AHPC-Me-C7 ester, a specific BCL-XL PROTAC degrader[1].