Search Result

Search Results for " mesenchymal "

Targets

Compounds

Natural Products

111

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T1748	Kartogenin	KGN	TGF-beta/Smad
	Kartogenin (KGN) is an activator of the smad4/smad5 pathway, and promotes the selective differentiation of multipotent mesenchymal stem cells into chondrocytes.		TGF-beta/Smad
T9151	Teplinovivint		Wnt/beta-catenin
	Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.		Wnt/beta-catenin
T21981	Phthalazinone pyrazole		Aurora Kinase
	Phthalazinone pyrazole is potent, selective, and orally bioavailable inhibitor of Aurora-A kinase. Aurora-A is overexpressed in a variety of tumor types and displays oncogenic activity.		Aurora Kinase
T22814	GSA-10		Hedgehog/Smoothened
	Smoothened (Smo) receptor agonist		Hedgehog/Smoothened
T13410	ZLDI-8		Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
	ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T11847L	Liarozole	R75251 dihydrochloride	P450 , Retinoid Receptor
	Liarozole (R75251 dihydrochloride) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 1...		P450 , Retinoid Receptor
T0459	Sulindac	Arthrocine,MK-231,Clinoril,Sulindac sulfoxide	COX , Autophagy
	Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cycl...		COX , Autophagy
T1725	Y-27632 dihydrochloride	Y-27632 2HCl	ROCK , Apoptosis
	Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.		ROCK , Apoptosis
T8400	Pamidronic acid		Wnt/beta-catenin
	Pamidronic acid Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells		Wnt/beta-catenin
T4252	ML327		c-Myc , Autophagy
	ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).		c-Myc , Autophagy
T23446	TCS 2210		Others
	TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells and increases the neuronal markers β-III tubulin expression and neuron-specific enolase expression.		Others
T9601	Tepotinib hydrochloride(1 : x)		c-Met/HGFR , P-gp , ABC
	Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.		c-Met/HGFR , P-gp , ABC
T28164	Nexopamil	LU49938,LU 49938,LU-49938	Calcium Channel , 5-HT Receptor
	Nexopamil (LU-49938) is a calcium channel antagonist and a 5-hydroxytryptamine 2A receptor antagonist. Nexopamil inhibits 5-HT-induced contraction and proliferation of mesenchymal cells.		Calcium Channel , 5-HT Receptor
T73300	AXL-IN-13		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh...		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
T77701	FL118	FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin	Survivin
	FL118 is a novel survivin inhibitor that inhibits cancer stem cell-like properties.FL118 is a novel camptothecin analog with anticancer activity that inhibits epithelial-mesenchymal transition through the Wnt/β-catenin s...		Survivin
T38752	EW-7195		ALK , TGF-beta/Smad
	EW-7195 is a selective and potent inhibitor of ALK5 (TGFβR1) with an IC50 value of 4.83 nM.EW-7195 has an affinity for ALK5 that is more than 300-fold higher than that of p38α.EW-7195 has an inhibitory effect on TGF-β1-i...		ALK , TGF-beta/Smad
T9657	FiVe1		Others
	FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec...		Others
T63049	CHD1Li 6.11		Others
	CHD1Li 6.11 is a potent inhibitor of oncogenic CHD1L, acting on the cat-CHD1L recombinant protein (IC50: 3.3 μM). CHD1Li 6.11 is an orally active antitumour agent that significantly reduces the tumour volume of CRC xenog...		Others
T17044	Tesaglitazar		PPAR
	Tesaglitazar is a potent and selective peroxide PPARα / γ receptor dual agonist with a more potent affinity for PPARγ than PPARα, The EC50 values for rat PPARα and human PPARα were 13.4 μM and 3.6 μM, respectively, and 0...		PPAR
T11793	KY-05009		Wnt/beta-catenin
	KY-05009 is a chemical compound that effectively suppresses TGF-β1-induced epithelial-to-mesenchymal transition (EMT) in human lung adenocarcinoma cells, reduces TNIK protein expression and the transcriptional activity o...		Wnt/beta-catenin
T77697	BML-278	BML278,BML 278	Sirtuin , Histone Methyltransferase
	BML-278 is a SIRT1 activator with an EC150 of 1 μM.BML-278 increases H3K9 methylation and inhibits H3K9 acetylation in parental and maternal prokaryotes, and can be used to improve early embryonic development.BML-278 ind...		Sirtuin , Histone Methyltransferase
T36696	DMBA
	7,12-Dimethylbenz[a]anthracene (DMBA) is a polycyclic aromatic hydrocarbon (PAH) that has been found in tobacco smoke and diesel exhaust and has carcinogenic activity.1,2It undergoes metabolic activation by numerous enzy...
T34627	SFO	Safrole epoxide,Safrole oxide
	SFO is an endothelial-to-mesenchymal transition (EndoMT) inducer.
TP2437	Sarasinoside A1	Sarasinoside-A1
	Sarasinoside A1 is a triterpenoid saponin that reverses mesenchymal tumor transformation.
T31124	CW 008	CW-008,CW008
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized m...
T11187	EMT inhibitor-2		Others
	EMT Inhibitor-2, targeting both CYP3A4 testosteron and CYP2C9, exhibits inhibitory effects with IC50 values of 49.72 and 5.54 μM, respectively. Furthermore, it effectively impedes the epithelial-mesenchymal transition (E...		Others
T79789	DT-6		TGF-beta/Smad
	DT-6, a potent TGF-β1 inhibitor, impedes M2 macrophage-induced epithelial-to-mesenchymal transition and the invasive migration of cancer cells, thereby showing potential for cancer research applications [1].		TGF-beta/Smad
TP1152	Fibronectin Adhesion-promoting Peptide TFA	Heparin Binding Peptide TFA
	Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal...
T61417	PPARγ agonist 7
	PPARγ agonist 7 (Compound 3a) is a highly potent and selective agonist of the peroxisome proliferator-activated receptor gamma (PPARγ). It specifically stimulates adiponectin production in human bone marrow mesenchymal s...
T83076	Anticancer agent 93
	Anticancer Agent 93, a 4-Hydroxycoumarin derivative, inhibits the invasion and migration of lung cancer cells through modulation of epithelial-mesenchymal transition (EMT) effector expression [1].
T72880	PI3K/AKT-IN-2
	PI3K/AKT-IN-2, a dual inhibitor of PI3K and AKT, prevents the epithelial-mesenchymal transition (EMT) and promotes apoptosis. Additionally, it impedes tubulin polymerization.
T39531	RAD16-I hydrochloride	RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes....
T83075	Anticancer agent 94
	Anticancer agent 94, a 4-Hydroxycoumarin derivative, inhibits lung cancer cell invasion and migration by modulating the expression of epithelial-mesenchymal transition (EMT) effectors [1].
T76994	Sotevtamab
	Sotevtamab (16B5), a humanized IgG2 monoclonal antibody (mAb) targeting clusterin, acts as an inhibitor of the epithelial to mesenchymal transition, making it a valuable agent for cancer research [1] [2] [3].
T60792	NMDA receptor antagonist-3
	NMDA receptor antagonist-3 is a NMDA receptor antagonist with a significan recovery rate (40.0%, at 100 μM) and safe toxicological characteristics in SH-SY5Y and human adipose mesenchymal stem cells.
T61852	HCAIX-IN-8
	hCAIX-IN-8 (compound 7i) is a highly potent and selective inhibitor of hCAIX, demonstrating potent inhibitory activity against CAIX with an IC50 value of 0.024 μM. It also exhibits inhibitory activity against CAII and CA...
T73035	STAT3-IN-15
	STAT3-IN-15, a potent and orally active inhibitor targeting STAT3, effectively combats idiopathic pulmonary fibrosis (IPF) by hindering STAT3 phosphorylation. Additionally, it impedes TGF-β1-induced migration and deforma...
T82673	CPF-7	Caerulein precursor fragment
	CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti...
T73547	CPUL1
	CPUL1, a TrxR inhibitor, exhibits proliferation-inhibitory and anti-metastatic effects on A549 cells by modulating epithelial-mesenchymal transition (EMT) through the induction of ROS-mediated ERK/JNK signaling, achieved...
T63768	Antitumor agent-78
	Antitumor agent-78 inhibits GPx-4 and elevates COX2, leading to ferroptosis. antitumor agent-78 activates the tumor cell intrinsic apoptotic pathway (Bax-Bcl-2-caspase-3) and inhibits the epithelial mesenchymal transitio...
T71884	ß-Carboline-1-carboxylic acid
	β-Carboline-1-carboxylic acid is an alkaloid that has been found in P. quassioides and has diverse biological activities. It reduces LPS-induced increases in MCP-1, TNF-α, IL-6, and IL-1β levels in RAW 264.7 cells when u...
T36460	CAY10736	CAY10736
	CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal ...
T61746	Anticancer agent 82
	Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin ( VIM ), to induce hyperphosphorylation of Ser56, resulting selectiv...
T36497	CAY10735	CAY10735
	CAY10735 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.674-11.56 μM). CAY10735 inhibits migration of and the epithelial-to-mese...
T62822	CT1-3
	CT1-3 is a potent anti-cancer agent. CT1-3 regulates the JNK/Bcl-2/Bax/XIAP pathway, which induces mitochondria-mediated apoptosis. CT1-3 regulates the E-cadherin/Snail axis to inhibit epithelial mesenchymal transition (...
T62814	Antitumor agent-77
	Antitumor agent-77 inhibits the growth and migration of cancer cells and has anticancer effects. antitumor agent-77 inhibits GPx-4 and enhances COX2-induced iron sagging. antitumor agent-77 activates the intrinsic apopto...
T61585	Sulindac sodium
	Sulindac (sodium) (MK-231) is an orally active nonsteroidal anti-inflammatory agent. Sulindac (sodium) is used to reduce pain, swelling, and joint stiffness from arthritis. Sulindac is also used for the research of arthr...
T83848	VnP-16 TFA
	VnP-16, a synthetic peptide fragment mirroring amino acids 270-281 of vitronectin (a multifunctional glycoprotein involved in cell attachment, migration, and spreading), promotes attachment and spreading of isolated huma...
T35513	13C15-Nivalenol	13C15-Nivalenol
	13C15-Nivalenol is intended for use as an internal standard for the quantification of nivalenol by GC- or LC-MS. Nivalenol is a trichothecene mycotoxin that has been found inFusarium.1It is lethal to mice (LD50= 6.9 mg/k...

Compounds

Kartogenin

T1748

Synonym: KGN

Target: TGF-beta/Smad

Teplinovivint

T9151

Synonym:

Target: Wnt/beta-catenin

Phthalazinone pyrazole

T21981

Synonym:

Target: Aurora Kinase

GSA-10

T22814

Synonym:

Target: Hedgehog/Smoothened

ZLDI-8

T13410

Synonym:

Target: Apoptosis, Phosphatase, Gamma-secretase, Immunology/Inflammation related

Liarozole

T11847L

Synonym: R75251 dihydrochloride

Target: P450, Retinoid Receptor

Sulindac

T0459

Synonym: Arthrocine,MK-231,Clinoril,Sulindac sulfoxide

Target: COX, Autophagy

Y-27632 dihydrochloride

T1725

Synonym: Y-27632 2HCl

Target: ROCK, Apoptosis

Pamidronic acid

T8400

Synonym:

Target: Wnt/beta-catenin

ML327

T4252

Synonym:

Target: c-Myc, Autophagy

Tepotinib hydrochloride(1 : x)

T9601

Synonym:

Target: c-Met/HGFR, P-gp, ABC

Nexopamil

T28164

Synonym: LU49938,LU 49938,LU-49938

Target: Calcium Channel, 5-HT Receptor

AXL-IN-13

T73300

Synonym:

Target: FLT, TAM Receptor, PDGFR, TGF-beta/Smad

FL118

T77701

Synonym: FL 118,FL-118,10,11-(Methylenedioxy)-20(S)-camptothecin

Target: ALK, TGF-beta/Smad

Target: Wnt/beta-catenin

BML-278

T77697

Synonym: BML278,BML 278

Target: Sirtuin, Histone Methyltransferase

Synonym: Safrole epoxide,Safrole oxide

Target:

Sarasinoside A1

TP2437

Synonym: Sarasinoside-A1

Target:

CW 008

T31124

Synonym: CW-008,CW008

Target: TGF-beta/Smad

Fibronectin Adhesion-promoting Peptide TFA

TP1152

Synonym: Heparin Binding Peptide TFA

RAD16-I hydrochloride

T39531

Synonym: RAD16-I hydrochloride

NMDA receptor antagonist-3

Synonym: Caerulein precursor fragment

ß-Carboline-1-carboxylic acid

Synonym: 13C15-Nivalenol

Target:

Cat No.	Product Name	Synonyms	Targets
T3862	Irigenin		NF-κB , Integrin
	Irigenin mediates its antimetastatic effect by specifically and selectively blocking the α9β1 and α4β1 integrin binding sites on the C-C loop of the Extra Domain A domain. It can sensitize TRAIL-induced apoptosis by enha...		NF-κB , Integrin
T3S2072	3-Butylidenephthalide	Butylidene phthalide,n-Butylidenephthalide	Parasite , Glucosidase
	1. 3-Butylidenephthalide (Butylidene phthalide) has antihyperglycemic effect is due to inhibition of α-glucosidase at the intestinal level, inhibited the activity of yeast-α-glucosidase (IC(5) 2.35 mM) in a noncompetitiv...		Parasite , Glucosidase
T0518	Methacycline hydrochloride	Rondomycin,Methacycline HCl	ribosome , Antibacterial , Antibiotic
	Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period.		ribosome , Antibacterial , Antibiotic
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide	(9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14	Wnt/beta-catenin
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) induces osteogenic differentiation and subsequent bone formation of mesenchymal stem cells by activating the canonical Wnt/β-catenin signaling pa...		Wnt/beta-catenin
TN1198	19-Hydroxybufalin		Others
	19-Hydroxybufalin is a natural product, inhibits epithelial-mesenchymal transition and attenuates the migration and invasion of PC3 cells.		Others
TN2081	Maohuoside A		MAPK
	Maohuoside A promotes osteogenesis of rat mesenchymal stem cells via BMP and MAPK signaling pathways.		MAPK
T3330	Trans-Trimethoxyresveratrol	trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene	Reactive Oxygen Species
	trans-Trimethoxyresveratrol (MR-3), a natural methoxylated analog of resveratrol, inhibits breast Y cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchy...		Reactive Oxygen Species
T7982	3,6-Dihydroxyflavone		Others
	3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway.		Others
T2S0690	Ecliptasaponin A	Echinocystic acid-3-o-glucoside	Others
	1. Ecliptasaponin A (Echinocystic acid-3-o-glucoside) has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-...		Others
TN1433	Batatasin III		FAK , Others , Akt
	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-...		FAK , Others , Akt
T3674	Hydroxysafflor yellow A	HSYA,Safflomin A	TGF-beta/Smad
	Hydroxysafflor yellow A (Safflomin A) inhibited adipogenesis by increasing HSL promoter activities. Hydroxysafflor yellow A can effectively protect the liver from long-term alcohol injury by enhancing antioxidant capacit...		TGF-beta/Smad
T4S1383	Escin IA	Aescin IA,Escin IA;Aescin IA,Escin IA	HIV Protease
	Escin IA (Escin IA;Aescin IA) is a triterpene saponin isolated from horse chestnut, which inhibits HIV-1 protease with IC50 values of 35 μM. Escin IA has anti-TNBC metastasis activity, and its action mechanisms involved ...		HIV Protease
T3S2312	Poncirin	Isosakuranetin-7-neohesperidoside	Apoptosis , Others
	1. Poncirin (Isosakuranetin-7-neohesperidoside) shows a significant in vitro inhibitory effect on the growth of the human gastric cancer cells, SGC-791, in a dose-dependent manner. 2. Poncirin prevents adipogenesis, enha...		Apoptosis , Others
T4915	β-Glycerophosphate disodium salt hydrate		Phosphatase , Endogenous Metabolite
	β-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It func...		Phosphatase , Endogenous Metabolite
TL0008	Gigantol		Wnt/beta-catenin , Glucosidase
	Gigantol is a novel inhibitor of the Wnt/β-catenin pathway. It inhibits Wnt/β-catenin signaling through downregulation of phosphorylated LRP6 and cytosolic β-catenin in breast cancer cells. Gigantol may be developed as a...		Wnt/beta-catenin , Glucosidase
T6S1315	Oroxylin A	6-Methoxybaicalein,Baicalein 6-methyl ether	Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
	1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...		Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
TN4082	Friedelin 3,4-lactone		Others
	Friedelin-3,4-lactone has a promotion effect on the inducing proliferation of rat mesenchymal stem cells(rMSCs).		Others
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
TN3215	7,4'-Dihydroxy-8-methylflavan		Others
	7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has fre...		Others

Natural Products

Irigenin

T3862

Synonym:

Target: NF-κB, Integrin

3-Butylidenephthalide

T3S2072

Synonym: Butylidene phthalide,n-Butylidenephthalide

Target: Parasite, Glucosidase

Methacycline hydrochloride

T0518

Synonym: Rondomycin,Methacycline HCl

Target: ribosome, Antibacterial, Antibiotic

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,Macamide Impurity 14

Target: Wnt/beta-catenin

trans-Trimethoxyresveratrol

T3330

Synonym: trans-trismethoxy Resveratrol,E-Resveratrol Trimethyl Ether,MR-3,Tri-O-methylresveratrol,3,4',5-Trimethoxy-trans-stilbene,Trimethoxystilbene

Target: Reactive Oxygen Species

Synonym: Echinocystic acid-3-o-glucoside

Target: FAK, Others, Akt

Hydroxysafflor yellow A

T3674

Synonym: HSYA,Safflomin A

Target: TGF-beta/Smad

Escin IA

T4S1383

Synonym: Aescin IA,Escin IA;Aescin IA,Escin IA

Target: HIV Protease

Poncirin

T3S2312

Synonym: Isosakuranetin-7-neohesperidoside

Target: Apoptosis, Others

β-Glycerophosphate disodium salt hydrate

T4915

Synonym:

Target: Phosphatase, Endogenous Metabolite

Gigantol

TL0008

Synonym:

Target: Wnt/beta-catenin, Glucosidase

Oroxylin A

T6S1315

Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether

Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy

Friedelin 3,4-lactone

7,4'-Dihydroxy-8-methylflavan

TN3215

Synonym:

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00322	DEC-205 Protein, Human, Recombinant (His)	Human	HEK293
	LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways imp...
TMPJ-00735	PDGF-BB Protein, Human, Recombinant	Human	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPJ-00562	PDGF-BB Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (P...
TMPY-04333	LRRC15 Protein, Human, Recombinant (hFc)	Human	HEK293
	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)	Cynomolgus,Rhesus	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-01296	HGFR/c-Met Protein, Human, Recombinant (His)	Human	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-04329	Vimentin Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ...
TMPY-01896	HGFR/c-Met Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-02626	FGF-18 Protein, Human, Recombinant (His)	Human	HEK293
	Fibroblast growth factor 18 (FGF18) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes...
TMPY-05004	FGF-4 Protein, Human, Recombinant	Human	E. coli
	FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati...
TMPY-00413	TGF beta 2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	TGF beta 2 (Transforming growth factor beta 2), an extracellular glycosylated protein, which belongs to the TGF-beta family. TGF-beta regulates key mechanisms of tumor development, namely immunosuppression, metastasis, a...
TMPY-01020	Periostin/OSF-2 Protein, Human, Recombinant (His)	Human	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-06418	R-Spondin 2/RSPO2 Protein, Human, Recombinant (hFc)	Human	HEK293
	R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene...
TMPY-01613	Periostin/OSF-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01384	Endoglin/CD105 Protein, Human, Recombinant (His)	Human	HEK293
	Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD...
TMPJ-00375	HGF Protein, Human, Recombinant (His)	Human	Human Cells
	HGF, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases and contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF is secreted as an inactive 728 amino acid (aa) single chain propepti...
TMPY-00021	PADI4 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	Protein-arginine deiminase type-4, also known as HL-6 PAD, Peptidylarginine deiminase IV, Protein-arginine deiminase type I V and PADI4, is a cytoplasm and nucleus protein that belongs to the protein arginine deiminase f...
TMPY-02327	HGF Protein, Human, Recombinant	Human	CHO
	Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by ...
TMPY-03290	HGF Protein, Mouse, Recombinant	Mouse	HEK293
	Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain, and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. The hepatocyte growth factor is secreted by ...
TMPH-02971	Vimentin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-02970	Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc)	Mouse	E. coli
	Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPK-00967	DSG-2/Desmoglein-2 Protein, Human, Recombinant (His)	Human	HEK293
	Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells...
TMPK-00736	DSG-2/Desmoglein-2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells...
TMPY-01000	BVES Protein, Human, Recombinant (GST)	Human	E. coli
	Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...
TMPH-02135	SPRED1 Protein, Human, Recombinant (His & Myc & SUMO)	Human	E. coli
	Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase. Negatively regulates hematopoiesis of bone marrow. Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiati...
TMPK-01138	PLD4 Protein, Human, Recombinant (His)	Human	HEK293
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. fu...
TMPK-01299	CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His)	Cynomolgus	HEK293
	Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at meta...
TMPH-01848	PTHLH Protein, Human, Recombinant (His)	Human	E. coli
	Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and...
TMPK-01079	PLD4 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. fu...
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated p...
TMPH-02835	PDGFD Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role ...
TMPJ-01162	CTGF/CCN2 Protein, Human, Recombinant (hFc)	Human	Human Cells
	CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cel...
TMPY-03757	FAM3C Protein, Human, Recombinant (hFc)	Human	HEK293
	FAM3C, also known as ILEI, is a member of theFAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A ...
TMPJ-01161	CTGF/CCN2 Protein, Human, Recombinant	Human	Human Cells
	CTGF belongs to the CCN (CTGF/Cyr61/Cef10/NOVH) protein family, which is comprised of six secreted proteins that reside in the extracellular matrix (ECM). CTGF causes a variety of cellular responses including reduced cel...
TMPY-00299	FAM3C Protein, Human, Recombinant (His)	Human	HEK293
	FAM3C, also known as ILEI, is a member of theFAM3 family. It can be detected in resent in most secretory epithelia. FAM3C may be involved in retinal laminar formation. It promotes epithelial to mesenchymal transition. A ...
TMPJ-00521	CHL2 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Mouse Chordin-Like 2, also known as CHL2, is a novel chordin family member with structural homology to CHL1 which is implicated in tumor angiogenesis. The mouse CHL2 gene encodes a 426 amino acids (aa) protein with a 25...
TMPY-00610	RAB2 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	RAB2A, a protein essential for ER-to-Golgi transport, is critical in promoting proteolytic activity and 3D invasiveness of breast cancer (BC) cell lines.RAB2A is amplified and elevated in human BC and is a powerful and i...
TMPY-06910	LRRC15 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293
	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPY-06148	LRRC15 Protein, Human, Recombinant (His)	Human	HEK293
	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPJ-00159	EMMPRIN/CD147 Protein, Human, Recombinant (Avi & His), Biotinylated	Human	Human Cells
	Basigin/CD147 is a member of the immunoglobulin superfamily with homology to both the immunoglobulin V domain and MHC class II antigen beta-chain. This protein play important roles in variety of events including spermato...
TMPY-06919	LRRC15 Protein, Mouse, Recombinant (His & Avi), Biotinylated	Mouse	HEK293
	LRRC15 (Leucine-Rich Repeat Containing 15) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. The tumor antigen 15-leucine-rich repeat-containing membrane protein (LRRC15) is a transmemb...
TMPY-04899	OGN/Osteoglycin Protein, Human, Recombinant (His)	Human	HEK293
	OGN (Osteoglycin) is a Protein Coding gene. This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. It belongs to the small leucine-rich proteoglycan (SLRP) family. The encoded protei...
TMPH-02226	TEAD3 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
TMPY-00634	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant	Cynomolgus,Rhesus	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-06657	HGFR/c-Met Protein, Rat, Recombinant (His)	Rat	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-06278	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His), Biotinylated	Cynomolgus,Rhesus	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPJ-00288	TNF RII Protein, Human, Recombinant (mFc)	Human	Human Cells
	Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino a...
TMPY-02068	HGFR/c-Met Protein, Canine, Recombinant (His)	Canine	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPY-05607	HGFR/c-Met Protein, Human, Recombinant (His & Avi), Biotinylated	Human	HEK293
	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that is overexpressed and/or mutated in a variety of malignancies. HGFR...
TMPH-02224	TEAD4 Protein, Human, Recombinant (His & Myc)	Human	Baculovirus
	Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is...
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