defects — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9149	2BAct	2B-Act,2B Act	PERK
	2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response		PERK
T0062	Folic acid	Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,Folacin	DNA/RNA Synthesis , Endogenous Metabolite
	Folic acid (Vitamin B9)(Vitamin M; Vitamin B9) is indispensable for the production and maintenance of new cells, for DNA/RNA synthesis.		DNA/RNA Synthesis , Endogenous Metabolite
T25829	Mopidamol	RA233,RA 233,RA-233,Rapenton,OLX 102	PDE
	Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental diabetes.		PDE
T35074	VRT-325	CFcor 325,VRT-534,CFcor325,VRT 325,VRT325,CF-106951,CFcor-325	Others
	VRT-325 can repair folding defects by promoting dimerization of the two NBDs or by promoting folding of the TMD.VRT-325 accelerates the healing rate of CF cell monolayers.		Others
T14847	B I09		Others , IRE1
	B I09, an IRE-1 RNase inhibitor with an IC50 of 1230 nM, inhibits splicing of XBP1 mRNA in human WaC3 cells and expression of xbp-1 in LPS-stimulated B cells. B I09 can be used to simulate the defects of XBP-1 in CLL cel...		Others , IRE1
T0183	Pramiracetam	CI-879	Others
	Pramiracetam (CI-879), derived from piracetam, is a more effective nootropic drug . According to reports, Pramiracetam improved cognitive defects related with traumatic brain wounds. Pramiracetam was also potent in the t...		Others
T29114	VRT-532	CFpot-532,CFpot-532)	CFTR
	VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects. Arylsulfatase B (ARSB), which is necessary to reduce the accumulation of sulphate glyc...		CFTR
T4877	L-Homocystine		Endogenous Metabolite
	Homocystine is the double-bonded form of homocysteine, but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an ele...		Endogenous Metabolite
T4497L	Amifampridine phosphate	BRN0110232,3,6-DAP,SC10,BRN 0110232,BRN-0110232,NSC 521760
	Amifampridine is mainly used to treat many rare muscle diseases. In the United States, aminopyridine is being studied for the treatment of Lambert-Eaton myasmus syndrome (LEMS). Amifampridine is also used to treat many c...
T27562	Hydroxyellipticine-1a
	Hydroxyellipticine-1a, a selective r(CGG)exp probe, improves pre-mRNA splicing defects, inhibits formation of nuclear inclusions and RANT in a FXTAS cellular mode.l
T32125	Hyperphyllin	HP
	Hyperphyllin specifically mimics the branch defects of AMP1, including plastid reduction and expansion and proliferation of the branch meristem.
T22860	Imeglimin		Others
	Imeglimin is the first in a new tetrahydrotriazine-containing class of oral antidiabetic agents. It has been shown to act on the liver, muscle, and pancreatic β-cells to uniquely target the key defects of type 2 diabetes...		Others
T69440	Sephin1 Hydrochloride
	Sephin1 hydrochloride is a selective inhibitor of the phosphatase regulatory subunit PPP1R15A (R15A), which prolongs the benefit of eIF2α phosphorylation, thereby protecting cells from proteostatic defects.
T40908	KLD-12
	KLD-12, a 12-residue self-assembling peptide, displays properties that promote chondrogenic differentiation of bone marrow stromal cells (BMSCs). Moreover, KLD-12 hydrogel can effectively fill full-thickness osteochondra...
T73107	RAD51-IN-4
	RAD51-IN-4 is a potent RAD51 inhibitor, targeting a eukaryote gene critical for studies on conditions associated with mitochondrial defects.
T76649	Osteostatin (human)
	Osteostatin (human), a fragment derived from parathyroid hormone-related protein (PTHrP) 107-139, effectively promotes bone repair in animal models with bone defects and inhibits bone erosion in cases of inflammatory art...
T73702	Mecasermin
	Mecasermin (Human IGF-I; FK 780), a recombinant form of human insulin-like growth factor I (IGF-I), holds promise for investigating growth failure attributed to growth hormone (GH) insensitivity, which may be due to defe...
T25496	Hexaglutamate folate	Pteglu6
	Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in hum...
T82056	IP2
	IP2, an immunomodulatory agent, enhances PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells without exhibiting cytotoxicity. Additionally, IP2 has been shown to induce tumor growth defects in ...
T37666	Trihydroxycholestanoic Acid	Trihydroxycoprostanic Acid
	Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder char...