a 293

AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation.

CRBN ligand-293 is an E3 ubiquitin ligase cereblon (CRBN) ligand designed for recruiting cereblon protein. By attaching to a target protein ligand via a linker, CRBN ligand-293 can form a PROTAC.

GNE-293 is a potent and selective PI3Kδ inhibitor.

PIK-293 is a PI3K inhibitor, for PI3Kδ( IC50=0.24 μM), and less potent for PI3Kα/β/ γ.

(S)-BAY-293 is a potent pan-KRAS inhibitor used in the study of primary non-small cell lung and pancreatic cancers.

BAY-293 is a potent, cell-active SOS1 inhibitor that disrupts the KRAS-SOS1 interaction (IC50: 21 nM).

Antibacterialagent 293 (Compound 5) is an antibacterial agent with potent activity against Gram-negative bacteria. It demonstrates inhibitory effects on Escherichia coli, Acinetobacter baumannii, and Klebsiella pneumoniae. Antibacterialagent 293 is suitable for studies related to diseases caused by Gram-negative bacterial infections.

Chromanol 293B is an inhibitor of the slow component (IK) of delayed rectifier potassium currents in cardiac cells (IC50 = 1–10 μM) and a weak inhibitor of KATP channels. It also blocks CFTR chloride currents (IC50 = 19 μM) and can be used in arrhythmia research.

SV293 is a selective antagonist of D2 dopamine receptor.

DB293 is an inhibitor of PIT-1 and BRN-3 transcription factors. DB293 binds as head-to-tail stacked dimers in the minor groove of 5'-ATGA sequence, thereby leading to an increase in the size of minor groove.

293P-1 is a hepatocyte-specific homing peptide characterized by the sequence SNNNVRPIHIWP [1].

CVN293 is a selective inhibitor of the potassium channel KCNK13, with the advantages of brain permeability and oral bioavailability. It inhibits the production of the pro-inflammatory cytokine IL-1β induced by NLRP3 in microglia and can be used for research into neurodegenerative diseases.

LP293-p is a lipid compound with an activated ester group, utilized in the synthesis of ATXN2 RNAi. It can be applied to enhance targeting within the central nervous system (CNS).

V-9302 (V9302) is a competitive antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 (IC50: 9.6 uM).

AHR antagonist 4 is a potent aryl hydrocarbon receptor (AHR) antagonist(example 293; IC50: 82.2 nM).It has anti-cancer effects.

B-TPMF is a highly efficient and selective KCa2.1 channel inhibitor with an IC50 of 31 nM, interacting with the serine residue at position 293 to inhibit KCa2.1.

Dooku1 is an analog of Yoda1 and a selective antagonist of endogenous Piezo1 channels. Dooku1 inhibits Ca2+ entry induced by 2μMYoda1 with IC50 values of 1.3μM (in HEK 293 cells) and 1.5μM (in HUVEC). Dooku1 inhibits Yoda1-induced aortic relaxation.

Longilactone inhibits NF-κB in TNF-α-activated HEK 293 cells (IC₅₀ = 4.7 μM) and can be used in life science research.

TSHR antagonist S37a is a selective, orally bioavailable TSHR (thyroid-stimulating hormone receptor) antagonist that inhibits TSH-induced cyclic adenosine monophosphate (cAMP) in TSHR-expressing HEK 293 cells, suitable for studying Graves' orbitopathy.

Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively.

GNE-0946 is an effective and selective RORγ/RORc/NR1F3 antagonist (inverse agonist) with an EC50 of 4 nM in HEK-293 cells. It inhibits IL-17 production in human PBMC cells (IC50 = 17 nM) and can be used in autoimmune disease research.

GNE-6468 is a potent and selective agonist of RORγ(RORc) (EC50: 13 nM for HEK-293 cell).

Praliciguat (IW-1973) stimulates sGC in HEK-293 cells (EC50: 197 nM). Praliciguat is an effective and orally active soluble guanylate cyclase stimulator. It also enhances NO signaling and acts as a vasodilator.

NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.