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Search Results for " vascular endothelial growth factor receptor "

20

Compounds

Cat No. Product Name Synonyms Targets
T5466 Tyrosine kinase-IN-1 VEGFR , FGFR , FLT , PDGFR
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively)
T9724 VEGFR2-IN-2 Others
VEGFR2-IN-2 has anti-inflammatory and analgesic activities.
T6996 SU 5402 SU5402 VEGFR , FGFR , PDGFR
SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.
T2642 PD173074 Apoptosis , EGFR , VEGFR , FGFR , IGF-1R , Src
PD173074 is an effective FGFR1 inhibitor (IC50: 25 nM) and also inhibits VEGFR2 (IC50: 100-200 nM) in cell-free assays. The selectivity is higher ~1000-fold for FGFR1 than PDGFR and c-Src.
T4425 JK-P3 VEGFR
JK-P3 is a pyrazole-based inhibitor of VEGFR-2 (IC50: 7.8 μM). JK-P3 inhibits FGFR 1/3 kinase activity in vitro, but has no effect on FGFR signaling in cell-based assays. The compound blocks wound healing and tube format...
T8213 Isolinderalactone NOS , STAT
Isolinderalactone shows anti-inflammatory and anticancer capacity, and it exhibits moderate iNOS inhibitory activity, with the IC50 value of 0.30 uM.
T12598 Pz-1 VEGFR , c-RET
Pz-1 is an inhibitor of VEGFR2 and RET (rearranged during transfection) tyrosine kinase that blocks the blood supply required for RET-stimulated growth.
T16975 TAK-593 VEGFR , PDGFR
TAK-593 is an effective VEGFR and PDGFR family inhibitor (IC50s: 3.2, 0.95, 1.1, 4.3, and 13 nM for VEGFR1, VEGFR2, VEGFR3, PDFGRα, and PDFGRβ, respectively).
T5475 ZD-4190 EGFR , VEGFR
ZD-4190 is a compound that inhibits both the vascular endothelial growth factor receptor 2 (VEGFR2) and the epidermal growth factor receptor (EGFR) signaling pathways, utilized in cancer treatment.
TQ0321 BIBF 1202 VEGFR
BIBF 1202 is a VEGFR2 kinase inhibitor (IC50: 62 nM).
T2446 KI8751 EGFR , VEGFR , FGFR , PDGFR , c-Kit
KI8751 is a potent and selective inhibitor of VEGFR2 with IC50 of 0.9 nM.
T9979 VEGFR-2-IN-29 VEGFR
VEGFR-2-IN-29 is a VEGFR2 inhibitor.
T7945 SU14813 VEGFR , PDGFR , c-Kit
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
TQ0041 Ningetinib Tosylate VEGFR , c-Met/HGFR , TAM Receptor
Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.
T6012 SAR131675 SAR 131675 VEGFR
SAR131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM.
T15185 Lucitanib E-3810 VEGFR , FGFR
Lucitanib (E-3810) is a novel VEGFR and FGFR inhibitor. It potently and selectively inhibits VEGFR1, VEGFR2, VEGFR3, FGFR1 and FGFR2 (IC50s: 7 nM, 25 nM, 10 nM, 17.5 nM, and 82.5 nM, respectively).
T1777 Nintedanib BIBF 1120,Intedanib VEGFR , FGFR , FLT , PDGFR , Src
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM). Nintedanib has an...
T3566 SU5205 SU 5205 VEGFR
SU5205 is a VEGFR2 inhibitor.
T9929 Ramucirumab VEGFR
Ramucirumab is a human VEGFR-2 antagonist for the treatment of solid tumors.
T4A2456 Gamabufotalin Gamabufagin COX
1. Gamabufotalin (Gamabufagin) , a major bufadienolide of Chansu, has been used for treatment of COX-2-mediated diseases and cancer therapy due to its desirable metabolic stability and less adverse effect.
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TargetMol