Search Result

Search Results for " fxr "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T6053	Turofexorate Isopropyl	XL335,FXR-450,WAY-362450	FXR , Autophagy
	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM		FXR , Autophagy
T40302	FXR/TGR5 agonist 1
	FXR/TGR5 agonist 1 acts as an agonist on both FXR and TGR5 receptors and is utilized for treating fatty liver disease.
T64144	FXR antagonist 1
	FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation...
T74996	FXR agonist 3
	FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ...
T72889	FXR agonist 4
	FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ...
T75160	FXR agonist 5
	FXR agonist 5 (compound 1), an FXR agonist, is utilized in research targeting diseases or disorders associated with metabolic inflammation [1].
T74754	FXR antagonist 2
	Compound A-26, also known as FXR antagonist 2, is a diarylamide derivative that functions as a moderate FXR antagonist. It is utilized in researching hyperlipidemia and type 2 diabetes [1].
T2015	Fexaramine		FXR , Autophagy
	Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.		FXR , Autophagy
T7886	Nidufexor		FXR , Autophagy
	Nidufexor is an agonist for the farnesoid X receptor (FXR).		FXR , Autophagy
T2233	GW 4064		FXR , Autophagy
	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).		FXR , Autophagy
T15806	LY2562175		FXR , Autophagy
	LY2562175 is an effective and selective FXR agonist (EC50: 193 nM).		FXR , Autophagy
T6344	Sevelamer hydrochloride	Sevelamer HCl	FXR , Autophagy
	Sevelamer hydrochloride (Sevelamer HCl) is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.		FXR , Autophagy
T31587	DY268	DY 268,DY-268	FXR
	DY268 is a compound based on trisubstituted pyrazolamide without any FXR agonist activity and cytotoxicity and can be used as an effective FXR antagonist (IC50 = 7.5 nM).		FXR
T4379	Tropifexor	LJN452	FXR , Autophagy
	Tropifexor (LJN452) is a novel and highly potent agonist of FXR with an EC50 of 0.2 nM.		FXR , Autophagy
T7436	Cilofexor		FXR , Autophagy
	Cilofexor inhibits binding of a synthetic peptide, Cilofexor is a farnesoid X receptor (FXR) agonist.		FXR , Autophagy
T11428	Glyco-Obeticholic acid		FXR
	Glyco-Obeticholic acid is an active metabolite of Obeticholic acid. Obeticholic acid is an agonist of the farnesoid X receptor (FXR).		FXR
T2601	Vidofludimus	SC12267,4sc-101	Dehydrogenase , DNA/RNA Synthesis , Interleukin
	Vidofludimus (SC12267) (4SC-101, SC12267) is a novel small molecule inhibitor of dihydroorotate dehydrogenase (DHODH).		Dehydrogenase , DNA/RNA Synthesis , Interleukin
T8471	Vonafexor	EYP001,PLX007,pxl007	FXR , HBV
	Vonafexor (EYP001) is a farnesoid X receptor (FXR, NR1H4) agonist, with anti-HBV effects		FXR , HBV
TQ0252	BAR502		FXR , GPCR19 , Autophagy
	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).		FXR , GPCR19 , Autophagy
T1789	Obeticholic Acid	INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA	FXR , Autophagy
	Obeticholic Acid (6-ECDCA) is a Farnesoid X Receptor Agonist. The mechanism of action of obeticholic acid is as a Farnesoid X Receptor Agonist.		FXR , Autophagy
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR
T27460	GSK2324	GSK-2324,GSK 2324	FXR
	GSK2324 is a potent FXR agonist for the treatment of NAFLD by controlling hepatic lipids through reduced uptake and selective reduction of fatty acid synthesis.		FXR
T63042	NDB		FXR
	NDB is a selective and potent hFXRα antagonist that inhibits GW4064-stimulated FXR/RXR interactions and FXRα target gene expression in primary mouse hepatocytes.NDB is used in the study of diabetes.		FXR
T11426	Gly-β-MCA		FXR
	Gly-β-MCA is an orally bioactive, enteroselective and potent inhibitor of the farnesoid X receptor (FXR), a bile acid, used in the study of obesity and diabetes.		FXR
T8818	TC-G 1005		GPCR19
	TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.		GPCR19
T12583	PX20606 trans racemate	PX-102 trans racemate	Others
	PX20606 trans racemate is an agonist of FXR (EC50s of 32 and 34 nM for FXR in FRET and M1H assay, respectively).		Others
T13093	Tauro-β-muricholic acid sodium	T-βMCA sodium	FXR
	Tauro-β-muricholic Acid sodium is a endogenous metabolite, is a competitive and reversible antagonist of farnesoid X receptor (FXR)(IC50 of 40 μM).		FXR
T68612	DM175
	DM175 is a novel partial FXR agonist, causing specific modulatory effects on FXR activity that clearly differ from classical FXR agonists.
T25417	Fexarene
	Fexarene is a non-steroidal FXR agonist.
T24837	ST-1892
	ST-1892 is a soluble partial FXR agonist.
T27492	GSK-8062	GSK 8062
	GSK-8062 is an agonist of farnesoid X receptor (FXR).
T73414	EDP-305
	EDP-305, an orally active, potent, and selective agonist of the farnesoid X receptor (FXR), exhibits EC50 values of 34 nM in chimeric FXR within CHO cells and 8 nM in full-length FXR in HEK cells. Demonstrating a potent ...
T12251	NR1H4 activator 1		Others
	NR1H4 activator 1 is a potent and selective agonist of Famesoid X Receptor (FXR).		Others
T63818	Omesdafexor
	Omesdafexor is an FXR agonist that can be used to study diseases caused by liver disease or metabolic inflammation.
T70899	Vidofludimus hemicalcium	4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium
	Vidofludimus hemicalcium (4sc-101; SC12267) is an orally active compound that acts as a dihydroorotate dehydrogenase (DHODH) inhibitor and serves as a novel modulator of the farnesoid X receptor (FXR). This immunomodulat...
T69724	Cilofexor tromethamine
	Cilofexor, also known as GS-9674, is a farnesoid X receptor (FXR) agonist. The nonsteroidal FXR agonist cilofexor (GS-9674) improves markers of cholestasis and liver injury in patients with PSC. In clinical study, cilof...
T11661	INT-767		FXR , GPCR19
	INT-767 is a potent farnesoid X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral adipose brown lipogenesis and mitochondrial function for the study of non-alcoholic steatohepatitis.		FXR , GPCR19
T37414	CAY10771
	CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively)...
T69686	BMS-986318
	BMS-986318 is a potent nonbile acid FXR agonist, displaying EC50 values of 53 nM and 350 nM in FXR Gal4 and SRC-1 recruitment assays, respectively. It exhibits a favorable ADME profile and shows effectiveness in mouse mo...
T78910	ZLY28		FXR
	ZLY28 is a novel, first-in-class compound with specific intestinal restriction and oral activity, serving as a dual modulator of FXR and FABP1. Additionally, it is a pioneering anti-NASH agent, utilized in the study of n...		FXR
T73155	BMS-986339
	BMS-986339 is an orally active, potent FXR agonist that interacts via H-bond formation with the His298 and ASN287 residues. It is utilized in research focused on primary biliary cirrhosis (PBC), primary sclerosing cholan...
T37416	Tauro-α-muricholic Acid (sodium salt)
	Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but h...
T83858	Tauro-Obeticholic Acid sodium	Tauro-6-Ethylchenodeoxycholic Acid,Tauro-6-Ethyl-CDCA,Obeticholic Acid Taurine Conjugate,Tauro-OCA,T-ECDCA
	Tauro-obeticholic acid, a farnesoid X receptor (FXR) agonist and semisynthetic derivative of chenodeoxycholic acid, is an active metabolite of obeticholic acid. This compound undergoes taurine conjugation in the liver to...

Compounds

Turofexorate Isopropyl

T6053

Synonym: XL335,FXR-450,WAY-362450

Target: FXR, Autophagy

Target: FXR, Autophagy

Nidufexor

T7886

Synonym:

Target: FXR, Autophagy

GW 4064

T2233

Synonym:

Target: FXR, Autophagy

LY2562175

T15806

Synonym:

Target: FXR, Autophagy

Sevelamer hydrochloride

T6344

Synonym: Sevelamer HCl

Target: FXR, Autophagy

DY268

T31587

Synonym: DY 268,DY-268

Target: FXR, Autophagy

Cilofexor

T7436

Synonym:

Target: FXR, Autophagy

Glyco-Obeticholic acid

Synonym: SC12267,4sc-101

Target: Dehydrogenase, DNA/RNA Synthesis, Interleukin

Vonafexor

T8471

Synonym: EYP001,PLX007,pxl007

Target: FXR, GPCR19, Autophagy

Obeticholic Acid

T1789

Synonym: INT-747,6-Ethylchenodeoxycholic acid,6-ECDCA

Target: FXR, Autophagy

T0901317

T6690

Synonym:

Target: Apoptosis, FXR, Liver X Receptor, ROR

GSK2324

T27460

Synonym: GSK-2324,GSK 2324

PX20606 trans racemate

T12583

Synonym: PX-102 trans racemate

Target: Others

Tauro-β-muricholic acid sodium

T13093

Synonym: T-βMCA sodium

Vidofludimus hemicalcium

T70899

Synonym: 4sc-101 hemicalcium,SC12267 hemicalcium,4sc-101 hemicalcium ; SC12267 hemicalcium

Target:

Cilofexor tromethamine

Target: FXR, GPCR19

Tauro-α-muricholic Acid (sodium salt)

T37416

Synonym:

Target:

Tauro-Obeticholic Acid sodium

T83858

Synonym: Tauro-6-Ethylchenodeoxycholic Acid,Tauro-6-Ethyl-CDCA,Obeticholic Acid Taurine Conjugate,Tauro-OCA,T-ECDCA

Target:

Cat No.	Product Name	Synonyms	Targets
T13092	Tauro-Obeticholic acid		FXR
	Tauro-Obeticholic acid is an active Obeticholic acid metabolite. Obeticholic acid is an orally bioavailable agonist of farnesoid-X receptor (FXR).		FXR
T0847	Chenodeoxycholic acid	CDCA,Chenodiol	Potassium Channel , FXR , Endogenous Metabolite , Autophagy
	Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ...
T2939	Forskolin	Coleonol,Colforsin	FXR , Adenylyl cyclase , AChR , Autophagy
	Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM). Forskolin increases cAMP levels, activates PXR and FXR, and induces autophagy. Forskolin produces positive inotropic effects in the...		FXR , Adenylyl cyclase , AChR , Autophagy
T5574	Guggulsterone	Guggulsterone E&Z	Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
	Guggulsterone (Guggulsterone E&Z) E&Z is a 3-hydroxy steroid. It has a role as an androgen.		Apoptosis , FXR , Akt , Caspase , JNK , Autophagy
T0700	Ursodeoxycholic acid	UDCA,Ursodiol	Potassium Channel , Endogenous Metabolite
	Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.		Potassium Channel , Endogenous Metabolite
T29078	Ursodeoxycholic acid sodium	UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR , Endogenous Metabolite , GPCR19
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it...		FXR , Endogenous Metabolite , GPCR19
T6S2246	Alisol B 23-acetate	Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B	Others
	1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotiv...		Others
T8895	Altenusin		FXR
	Altenusin is a natural nonsteroidal fungal metabolite, as a novel selective agonist of FXR with an EC50 value of 3.2 ± 0.2 μM.		FXR
T36563	(E)-Guggulsterone
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulat...
T75538	Alismanol M
	Alismanol M, a protostane-type triterpenoid isolated from the rhizome of Alisma orientale, functions as a farnesoid X receptor (FXR) agonist with an EC50 value of 50.25 μM. It is utilized in researching cholestasis and n...
T81030	Tauro-β-muricholic acid	TβMCA	FXR
	Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic effects by inhibiting bile acid-induced hepatocellular apoptosi...		FXR
TN4628	Nelumol A		FXR
	Nelumol A, and nelumal A show a potency comparable to the endogenous ligand, they may as a valuable potential novel lead compound in the search for FXR agonists.		FXR

Natural Products

Tauro-Obeticholic acid

T13092

Synonym:

Target: FXR

Chenodeoxycholic acid

T0847

Synonym: CDCA,Chenodiol

Target: Potassium Channel, FXR, Endogenous Metabolite, Autophagy

Forskolin

T2939

Synonym: Coleonol,Colforsin

Target: FXR, Adenylyl cyclase, AChR, Autophagy

Guggulsterone

T5574

Synonym: Guggulsterone E&Z

Target: Apoptosis, FXR, Akt, Caspase, JNK, Autophagy

Ursodeoxycholic acid

T0700

Synonym: UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Ursodeoxycholic acid sodium

T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

Alisol B 23-acetate

T6S2246

Synonym: Alisol B Acetate,Alisol B monoacetate,23-O-Acetylalisol B,23-Acetylalismol B

Tauro-β-muricholic acid

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-06756	NR1H4 Protein, Mouse, Recombinant (His)	Mouse	E. coli

TMPY-06768	NR1H4 Protein, Human, Recombinant (His)	Human	E. coli

TMPH-01355	FXR1 Protein, Human, Recombinant (His)	Human	E. coli
	RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs.
TMPY-02987	Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...
TMPY-02706	Vitamin D Receptor/VDR Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	VDR (vitamin D (1,25- dihydroxyvitamin D3) receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal...