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Search Results for " cns "

Targets

205

Compounds

14

Natural Products

109

Recombinant Proteins

6

Libraries

Cat No. Product Name Synonyms Targets
T10852 CNS-5161 hydrochloride CNS 5161A NMDAR
CNS-5161 hydrochloride (CNS 5161A) is a new antagonist of NMDA ion-channel. It interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
T27055 CNS-5161 CNS 5161
CNS-5161 is an NMDA antagonist.
T69411 CNS-5788
CNS-5788 is a potential ischemia-selective N-methyl-D-aspartate (NMDA) receptor ion-channel blocker
T26645 Aptiganel CNS-1102,CNS 1102,Cerestat,CNS1102
Aptiganel acts as a noncompetitive NMDA antagonist with neuroprotective effects.
T0183L Pramiracetam Sulfate CNS-1879,CI879,CI-879,CI 879,Pramiracetam
Thurfyl salicylate is a reddening agent for the treatment of musculoskeletal, joint, periarticular, and soft tissue pain.
T9786 Lu AF27139 P2X Receptor
Lu AF27139 is an effective and selective antagonist of P2X7 receptor (IC50s of 12 and 2.4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively). Lu AF27139 can be used in CNS diseases st...
T7626 Budipine Others
Budipine is a low affinity, N-methyl-D-aspartate receptor antagonist,is an antiparkinsonian agent.
T7688 4-Nonylphenylboronic acid FAAH
4-Nonylphenylboronic acid is a inhibitor of FAAH.
T9697 ASK1-IN-1 ASK
ASK1-IN-1 is an inhibitor of apoptosis signal-regulating kinase 1 which is a key mediator in the apoptotic and inflammatory cellular stress response with an IC50 of 21 nM in biochemica assays.
T7946 AER-271 Aquaporin
AER-271 is an inhibitor of aquaporin-4.
T60003 AC1-IN-1 Adenylyl cyclase
AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).
T11689 ITI-214 ITI214 PDE
ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ...
T7388 GSK805 ROR
GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...
T9070 ASP2905 ASP-2905 Potassium Channel
ASP-2905 is a potent and selective inhibitor of potassium channel Kv12.2 encoded by the Kcnh3/BEC1 gene. It can cross the blood-brain barrier and has antipsychotic activities
T2625 MK-0752 Beta Amyloid , Gamma-secretase
MK-0752, a γ-secretase inhibitor, reduces Aβ40 production(IC50=5 nM).
T5513 RO-3 P2X Receptor
RO3 is a selective antagonist of homomeric P2X3 and heteromeric P2X2/3 receptor
T1787 Levobupivacaine Sodium Channel
Levobupivacaine is an amino-amide local anaesthetic drug belonging to the family of n-alkylsubstituted pipecoloxylidide. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AstraZ...
T2086 ELN-441958 ELN 441958 Bradykinin Receptor
ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958(ELN 441958) is highly selective for B1 over B2 receptors.
T2026 CYM5442 S1P Receptor , LPL Receptor
CYM5442 is an S1P agonist, targeting to Sphingosine.
T3119 JNJ-63533054 JNJ 63533054 GPR
JNJ-63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
T9149 2BAct 2B-Act,2B Act PERK
2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress response
T6039 TAK-285 TAK285,TAK 285 EGFR , MEK , HER , Aurora Kinase
TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. Phase 1.
T16849 SB-222200 Neurokinin receptor
SB-222200 is a selective, reversible, and competitive antagonist of the human NK-3 receptor(Ki=4.4 nM).
T21995 XAP044 GluR
XAP044 is a mGlu7-selective antagonist which inhibits lateral amygdala long term potentiation (LTP) in brain slices from wild type mice with a half-maximal blockade at 88 nm[1].
T1052 Proglumide cholecystokinin
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is...
T24984 5J-4 Calcium Channel
5J-4 is a potent a blocker of calcium release-activated calcium (CRAC) channel and store-operated calcium entry (SOCE). 5J-4 reduces the production of IL-17 and decreases the expression of RORα and RORγt.
T4316 ML365 Potassium Channel
ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).
T14835 BTRX-335140 CYM-53093 Opioid Receptor
BTRX-335140 (CYM-53093) is a potent and selective, orally active κ opioid receptor (KOR) antagonist, has antagonist activity for κOR, μOR and δOR with IC50 values of 0.8 nM, 110 nM, and 6500 nM, respectively. BTRX-335140...
T14864 Caracemide NSC-253272 Others , DNA/RNA Synthesis , Antibacterial
Caracemide (NSC-253272) inhibits the enzyme ribonucleotide reductase of Escherichia coli. Caracemide can be used in anticancer studies.
T9713 δ-secretase inhibitor 11 Beta Amyloid , Caspase
δ-secretase inhibitor 11 is an inhibitor of δ-secretase and can be used as a lead compound for translational development of AD treatment.
T0682 Lamivudine GR109714X,BCH-189 HIV Protease , Reverse Transcriptase
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
T6566 Levobupivacaine hydrochloride Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride Sodium Channel
Levobupivacaine hydrochloride ((S)-(-)-Bupivacaine monohydrochloride) is a reversible neuronal sodium channel inhibitor, which is the pure S(-)-enantiomer of bupivacaine. It was utilized as a long-acting local anesthetic...
T24047 Etilevodopa hydrochloride Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester Others , Dopamine Receptor , Drug Metabolite
Etilevodopa hydrochloride (L-DOPA ethyl ester) is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T0688 Ganciclovir BW 759,RS-21592,2'-Nor-2'-deoxyguanosine Nucleoside Antimetabolite/Analog , Others , Antibiotic , Antifection , HSV
Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegaloviru...
T0370 Pheniramine maleate Daneral,Inhiston,Trimetose 5-HT Receptor , Histamine Receptor
Pheniramine maleate (Trimetose), an alkylamine derivative with antihistaminic and vasodilatory properties, binds to histamine H1 receptors, thereby inhibiting phospholipase A2 and production of the endothelium-derived re...
T22337 Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium Nucleoside Antimetabolite/Analog , Others , Antifection , HSV
Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1).
T16800 (RS)-AMPA (±)-AMPA iGluR
(RS)-AMPA ((±)-AMPA) is a glutamate analog. (RS)-AMPA is an agonist of effective and selective excitatory neurotransmitter L-glutamic acid.
T7065 Tizanidine Adrenergic Receptor
Tizanidine is an α2-adrenergic receptor agonist and inhibits neurotransmitter release from CNS noradrenergic neurons.
T13323 VU6012962 GluR
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
T0290 Tizanidine hydrochloride Tizanidine HCl,DS 103-282 Adrenergic Receptor
Tizanidine hydrochloride (Tizanidine HCl), an α2-adrenergic receptor agonist, inhibits neurotransmitter release from CNS noradrenergic neurons.
T1483 Citalopram hydrobromide Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,Citalopram HBr 5-HT Receptor , Serotonin Transporter , Autophagy
Citalopram hydrobromide (XU-62-320) , a selective serotonin reuptake inhibitor (SSRI), selectively inhibits the CNS neuronal reuptake of serotonin, thereby potentiating serotonergic activity in the central nervous system...
T5353 ABX-1431 Elcubragistat Lipase
ABX-1431 (Elcubragistat) is a selective and orally available CNS-penetrant monoacylglycerol lipase (MAGL/MGLL) inhibitor (IC50: 14 nM).
T11175 Elenbecestat E2609 Beta-Secretase , BACE
Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease.
T5411 PDE10-IN-1 SEP-0372814 PDE
PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.
T13321 VU6005649 GluR
VU6005649 is an agonist of CNS penetrant mGlu7/8 receptor (EC50s: 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively).
T5494 MW-150 MW01-18-150SRM p38 MAPK , Autophagy
MW-150 (MW01-18-150SRM) is a unique protein kinase inhibitor, is a selective, CNS penetrant, and orally active inhibitor of p38α MAPK with a Ki of 101 nM.
T21470L Davunetide acetate Davunetide acetate(211439-12-2 Free base) Beta Amyloid , Microtubule Associated
Davunetide acetate is derived from activity-dependent neuroprotective protein existing in the mammalian CNS. Davunetide acetate is a microtubule-stabilizing peptide and inhibits Aβ aggregation and Aβ-induced neurotoxicit...
T12679 (Rac)-VU 6008667 Others , AChR
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) with IC50 of 1.8 μM and pIC50 of 5.75, has high CNS penetration.
T5956 VP3.15 dihydrobromide GSK-3 , PDE
VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.)
T12899L SEP-363856 hydrochloride SEP-856 hydrochloride Others , 5-HT Receptor
SEP-363856 hydrochloride (SEP-856 hydrochloride) is an agent of orally active and CNS active psychotropic with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects, has the potential to trea...

Compounds

CNS-5161 hydrochloride
T10852
Synonym: CNS 5161A
Target: NMDAR
CNS-5161
T27055
Synonym: CNS 5161
Target:
CNS-5788
T69411
Synonym:
Target:
Aptiganel
T26645
Synonym: CNS-1102,CNS 1102,Cerestat,CNS1102
Target:
Pramiracetam Sulfate
T0183L
Synonym: CNS-1879,CI879,CI-879,CI 879,Pramiracetam
Target:
Lu AF27139
T9786
Synonym:
Target: P2X Receptor
Budipine
T7626
Synonym:
Target: Others
4-Nonylphenylboronic acid
T7688
Synonym:
Target: FAAH
ASK1-IN-1
T9697
Synonym:
Target: ASK
AER-271
T7946
Synonym:
Target: Aquaporin
AC1-IN-1
T60003
Synonym:
Target: Adenylyl cyclase
ITI-214
T11689
Synonym: ITI214
Target: PDE
GSK805
T7388
Synonym:
Target: ROR
ASP2905
T9070
Synonym: ASP-2905
Target: Potassium Channel
MK-0752
T2625
Synonym:
Target: Beta Amyloid, Gamma-secretase
RO-3
T5513
Synonym:
Target: P2X Receptor
Levobupivacaine
T1787
Synonym:
Target: Sodium Channel
ELN-441958
T2086
Synonym: ELN 441958
Target: Bradykinin Receptor
CYM5442
T2026
Synonym:
Target: S1P Receptor, LPL Receptor
JNJ-63533054
T3119
Synonym: JNJ 63533054
Target: GPR
2BAct
T9149
Synonym: 2B-Act,2B Act
Target: PERK
TAK-285
T6039
Synonym: TAK285,TAK 285
Target: EGFR, MEK, HER, Aurora Kinase
SB-222200
T16849
Synonym:
Target: Neurokinin receptor
XAP044
T21995
Synonym:
Target: GluR
Proglumide
T1052
Synonym:
Target: cholecystokinin
5J-4
T24984
Synonym:
Target: Calcium Channel
ML365
T4316
Synonym:
Target: Potassium Channel
BTRX-335140
T14835
Synonym: CYM-53093
Target: Opioid Receptor
Caracemide
T14864
Synonym: NSC-253272
Target: Others, DNA/RNA Synthesis, Antibacterial
δ-secretase inhibitor 11
T9713
Synonym:
Target: Beta Amyloid, Caspase
Lamivudine
T0682
Synonym: GR109714X,BCH-189
Target: HIV Protease, Reverse Transcriptase
Levobupivacaine hydrochloride
T6566
Synonym: Levobupivacaine HCl,(S)-(-)-Bupivacaine HCl,(S)-(-)-Bupivacaine monohydrochloride
Target: Sodium Channel
Etilevodopa hydrochloride
T24047
Synonym: Levodopa ethyl ester,Etilevodopa HCl, L-DOPA ethyl ester
Target: Others, Dopamine Receptor, Drug Metabolite
Ganciclovir
T0688
Synonym: BW 759,RS-21592,2'-Nor-2'-deoxyguanosine
Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV
Pheniramine maleate
T0370
Synonym: Daneral,Inhiston,Trimetose
Target: 5-HT Receptor, Histamine Receptor
Ganciclovir sodium
T22337
Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium
Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV
(RS)-AMPA
T16800
Synonym: (±)-AMPA
Target: iGluR
Tizanidine
T7065
Synonym:
Target: Adrenergic Receptor
VU6012962
T13323
Synonym:
Target: GluR
Tizanidine hydrochloride
T0290
Synonym: Tizanidine HCl,DS 103-282
Target: Adrenergic Receptor
Citalopram hydrobromide
T1483
Synonym: Lu 10-171,Nitalapram HBr,Bonitrile HBr,XU-62-320,Lu 10-171 HBr,Citalopram HBr
Target: 5-HT Receptor, Serotonin Transporter, Autophagy
ABX-1431
T5353
Synonym: Elcubragistat
Target: Lipase
Elenbecestat
T11175
Synonym: E2609
Target: Beta-Secretase, BACE
PDE10-IN-1
T5411
Synonym: SEP-0372814
Target: PDE
VU6005649
T13321
Synonym:
Target: GluR
MW-150
T5494
Synonym: MW01-18-150SRM
Target: p38 MAPK, Autophagy
Davunetide acetate
T21470L
Synonym: Davunetide acetate(211439-12-2 Free base)
Target: Beta Amyloid, Microtubule Associated
(Rac)-VU 6008667
T12679
Synonym:
Target: Others, AChR
VP3.15 dihydrobromide
T5956
Synonym:
Target: GSK-3, PDE
SEP-363856 hydrochloride
T12899L
Synonym: SEP-856 hydrochloride
Target: Others, 5-HT Receptor
1 2 3 4 5
Cat No. Product Name Synonyms Targets
T0508 γ-Aminobutyric acid Gamma-aminobutyric acid,4-Aminobutyric acid,GABA,4-Aminobutanoic acid,Piperidic acid GABA Receptor , Endogenous Metabolite
γ-Aminobutyric acid (4-Aminobutyric acid) is the most common inhibitory neurotransmitter in the central nervous system.
T15643 Kainic acid Others
In the CNS, Kainic acid is an effective agonist at excitatory amino acid receptor subtypes.
T2209 Serotonin hydrochloride 5-HT hydrochloride,5-HT HCl,Serotonin HCl,5-Hydroxytryptamine hydrochloride 5-HT Receptor , Endogenous Metabolite , Transferase
Serotonin hydrochloride (Serotonin HCl) is an endogenous 5-HT receptor agonist, a monoamine neurotransmitter in the CNS, and a catechol O-methyltransferase (COMT) inhibitor(Ki=44 μM).
T12139 N-(3-Methoxybenzyl)Palmitamide FAAH
N-(3-Methoxybenzyl)Palmitamide is a promising FAAH inhibitor, treatment of pain, inflammation and CNS degenerative disorders.
TN1048 Cnidilin Knidilin
Cnidilin (Knidilin) is found in association with Angelica dahurica roots, has high BBB permeability and has pharmacokinetic potential in the treatment of CNS disorders.
T3S2105 N-Benzylpalmitamide Macamide 1,N-Benzylhexadecanamide Others , FAAH , Autophagy
N-Benzylpalmitamide (Macamide 1) inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders...
T7033 Rosmanol Antioxidant , COX
Rosmanol has antioxidant activity, it can activate the antioxidant response element. Rosmanol has biphasic modulation of GABAA receptors, demonstrates CNS activity in mouse models of antinociception, antidepressant and a...
TN2437 Serotonin 5-hydroxytryptamine,5-HT Others , 5-HT Receptor , Endogenous Metabolite , Transferase
Serotonin (5-hydroxytryptamine) is a natural product from animals
T0848 L-DOPA Levodopa,3,4-Dihydroxyphenylalanine Dopamine Receptor , Endogenous Metabolite
L-DOPA (Levodopa) is an amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brai...
T23305 Salsolinol-1-carboxylic acid Others
amino acid that occurs naturally in the CNS
T2S2363 Corydine IL Receptor , Antifection
Corydine is the adrenolytic and weak cholinergic agent, it shows antimicrobial, and antineoplastic activities. Corydine shows irritant and respiratory stimulant and CNS depressant activities. Injected intravenously in ra...
TMA0805 Lupanine ATPase , Potassium Channel , Calcium Channel
Lupanine has a weak sedative effect on the central nervous system, interaction with specific drugs used for treatment of the CNS and for analgesic activity. Lupanine improves glucose homeostasis by influencing KATP-chann...
TN2084 Piperitol Others
Piperitol has in vitro antioxidant potential, it also exhibits a stronger CNS depressant effect than that of M. rotundifolia.
T14831 Bryostatin 1 HIV Protease , PKC
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.0...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-00740 SDF-1 Protein, Human, Recombinant (hFc) Human HEK293
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02820 SDF-1 Protein, Human, Recombinant (isoform a) Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02591 SDF-1 Protein, Human, Recombinant Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02424 Prolactin Protein, Mouse, Recombinant (His) Mouse Baculovirus-Insect Cells
Prolactin (PRL) is a hormone with multiple actions in the central nervous system (CNS) spanning from physiology to pathology. PRL exerts different actions through its receptors that can be found in both neurons and glial...
TMPY-04778 Prolactin Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Prolactin (PRL) is a hormone with multiple actions in the central nervous system (CNS) spanning from physiology to pathology. PRL exerts different actions through its receptors that can be found in both neurons and glial...
TMPJ-00135 BDNF Protein, Human/Murine/Rat, Recombinant Human,Mouse,Rat E. coli
Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. I...
TMPY-03425 Tau Protein, Human, Recombinant (His) Human E. coli
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are...
TMPY-05510 BDNF Protein, Mouse, Recombinant (His) Mouse HEK293
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B...
TMPJ-01467 Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His) Human E.coli
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, ...
TMPY-00751 TrkB Protein, Human, Recombinant (His) Human HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-02231 TrkB Protein, Mouse, Recombinant (His) Mouse HEK293
TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kin...
TMPY-00432 TREM-2 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01148 TREM-2 Protein, Human, Recombinant (His) Human HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-01703 TREM-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Triggering receptor expressed on myeloid cells 2 ( TREM2 ) is a single Ig domain receptor. It is expressed on macrophages and dendritic cells but not on granulocytes or monocytes. Its expression is most abundant in the b...
TMPY-03467 IFN-beta Protein, Mouse, Recombinant Mouse HEK293
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-00831 IFN-beta Protein, Human, Recombinant (hFc) Human HEK293
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPY-03145 IFN-beta Protein, Human, Recombinant Human CHO
Interferons (IFNs) are natural glycoproteins belonging to the cytokine superfamily and are produced by the cells of the immune system of most vertebrates in response to challenges by foreign agents such as viruses, paras...
TMPK-00544 TLR3 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, whi...
TMPK-00480 IL-8/CXCL8 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.Several promising approaches that target directly or indirectly IL...
TMPK-00406 TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated Human HEK293
TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, whi...
TMPY-02946 TAFA2/FAM19A2 Protein, Human, Recombinant (hFc) Human HEK293
FAM19A2 belongs to the FAM19/TAFA family. FAM19/TAFA family members are chemokine-like proteins. The biological functions of TAFA family members remain to be determined, but there are a few tentative hypotheses. First, T...
TMPK-00279 RGMA Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its recept...
TMPK-00278 RGMA Protein, Human, Recombinant (His & Avi) Human HEK293
Repulsive guidance molecule (RGM) is a glycosylphosphatidylinositol (GPI)-anchored glycoprotein that has diverse functions in the developing and pathological central nervous system (CNS). The binding of RGM to its recept...
TMPY-01056 Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-01221 Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc) Mouse HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-03175 Claudin-11 Protein, Human, Recombinant (mFc) Human HEK293
Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands function as a physical barrier to prevent solut...
TMPH-03756 Wint7b Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d...
TMPY-03144 Nogo Receptor/RTN4R Protein, Human, Recombinant (His) Human HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPY-01163 Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His) Mouse HEK293
Reticulon 4 receptor (RTN4R), also known as Nogo-66 Receptor (NgR), is a glycosylphosphoinositol (GPI)-anchored protein that belongs to the Nogo recptor family including three members. Mouse RTN4R cDNA contains 1 LRP (Le...
TMPH-02573 WISP3/CCN6 Protein, Mouse, Recombinant (His) Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway. Required for normal fusion of the chorion and the allantois during placenta d...
TMPJ-01279 TAFA4 Protein, Human, Recombinant (His) Human E. coli
FAM19A4 is a secreted, 12 kDa member of the FAM19/TAFA family of chemokine-like proteins. Like other members of the FAM19/TAFA family, with the exception of TAFA5, mature FAM19A4 contains 10 regularly spaced cysteine res...
TMPY-01856 MGAT5 Protein, Human, Recombinant (His) Human HEK293
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, also known as Alpha-mannoside beta-1,6-N-acetylglucosaminyl-transferase, Mannoside acetylglucosaminyltransferase 5, N-acetylglucosaminyl-transferas...
TMPH-00964 ATP5PB Protein, Human, Recombinant (His & Myc) Human E. coli
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPY-02184 SDF-1 Protein, Rhesus, Recombinant (hFc) Rhesus HEK293
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-03289 SDF-1 Protein, Mouse, Recombinant Mouse E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02749 SDF-1 Protein, Human, Recombinant (His) Human E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPH-02576 TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is ...
TMPY-04662 MAG Protein, Mouse, Recombinant (hFc) Mouse HEK293
The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin ...
TMPY-04676 MAG Protein, Mouse, Recombinant (His) Mouse HEK293
The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin ...
TMPY-03580 SDF-1 Protein, Canine, Recombinant Canine E. coli
The human stromal cell-derived factor-1 (SDF1), also known as CXCL12, is a small (8 kDa) cytokine highly conserved chemotactic cytokine belonging to the large family of CXC chemokines. SDF1 is expressed in two isoforms f...
TMPY-02569 MAG Protein, Human, Recombinant (His) Human HEK293
The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin ...
TMPY-03147 MAG Protein, Human, Recombinant (hFc) Human HEK293
The myelin-associated glycoprotein (MAG) contains five immunoglobulin-like domains and belongs to the sialic-acid-binding subgroup of the Ig superfamily. MAG is a transmembrane glycoprotein of 100kDa localized in myelin ...
TMPJ-00332 TPA Protein, Human, Recombinant (His) Human Human Cells
Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs...
TMPJ-00990 S100B Protein, Mouse, Recombinant (His) Mouse E. coli
S100-B, is an acidic protein with a molecular weight of 21 kDa belonging to the S100 family. S100-B contains two EF-hand-type calcium-binding motifs separated by a hinge region with a hydrophobic cleft. S100-B plays an i...
TMPJ-01296 SULT4A1 Protein, Human, Recombinant Human E. coli
Sulfotransferase 4A1 (ST4A1) is a member of the Sulfotransferase 1 family. ST4A1 is highly expressed in the cerebral cortex and frontal lobe, but no expression is detected in the pancreas. ST4A1 is a brain-specific sulfo...
TMPH-03010 EsxB Protein, Mycobacterium tuberculosis, Recombinant (His) Mycobacterium tuberculosis Yeast
Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. Binding to UNC5C might cause d...
TMPJ-00827 Tau-D Protein, Human, Recombinant (His) Human E. coli
Microtubule-Associated Protein TAU is abundantly expressed in neurons of the central nervous system and less commonly expressed elsewhere, but is also expressed at very low levels in CNS astrocytes and oligodendrocytes. ...
TMPY-00350 Doppel/PRND Protein, Human, Recombinant (His) Human HEK293
Doppel (PRND) is a paralogue of the mammalian prion (PRNP) gene. It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS). Besides, doppel overexpression correlat...
TMPY-00347 Doppel/PRND Protein, Human, Recombinant (hFc) Human HEK293
Doppel (PRND) is a paralogue of the mammalian prion (PRNP) gene. It is abundant in testis and, unlike PRNP, it is expressed at low levels in the adult central nervous system (CNS). Besides, doppel overexpression correlat...
TMPY-00286 Neuropeptide Y Protein, Human, Recombinant (hFc) Human HEK293
NPY (Neuropeptide Y) is a Protein Coding gene. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress ...
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SDF-1 Protein, Human, Recombinant (hFc)
TMPY-00740
Species: Human
Expression System: HEK293
SDF-1 Protein, Human, Recombinant (isoform a)
TMPY-02820
Species: Human
Expression System: E. coli
SDF-1 Protein, Human, Recombinant
TMPY-02591
Species: Human
Expression System: E. coli
Prolactin Protein, Mouse, Recombinant (His)
TMPY-02424
Species: Mouse
Expression System: Baculovirus-Insect Cells
Prolactin Protein, Human, Recombinant (His)
TMPY-04778
Species: Human
Expression System: Baculovirus-Insect Cells
BDNF Protein, Human/Murine/Rat, Recombinant
TMPJ-00135
Species: Human,Mouse,Rat
Expression System: E. coli
Tau Protein, Human, Recombinant (His)
TMPY-03425
Species: Human
Expression System: E. coli
BDNF Protein, Mouse, Recombinant (His)
TMPY-05510
Species: Mouse
Expression System: HEK293
Oncostatin M/OSM Protein, Human, Recombinant (E. coli, His)
TMPJ-01467
Species: Human
Expression System: E.coli
TrkB Protein, Human, Recombinant (His)
TMPY-00751
Species: Human
Expression System: HEK293
TrkB Protein, Mouse, Recombinant (His)
TMPY-02231
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (hFc)
TMPY-00432
Species: Mouse
Expression System: HEK293
TREM-2 Protein, Human, Recombinant (His)
TMPY-01148
Species: Human
Expression System: HEK293
TREM-2 Protein, Mouse, Recombinant (His)
TMPY-01703
Species: Mouse
Expression System: HEK293
IFN-beta Protein, Mouse, Recombinant
TMPY-03467
Species: Mouse
Expression System: HEK293
IFN-beta Protein, Human, Recombinant (hFc)
TMPY-00831
Species: Human
Expression System: HEK293
IFN-beta Protein, Human, Recombinant
TMPY-03145
Species: Human
Expression System: CHO
TLR3 Protein, Cynomolgus, Recombinant (His)
TMPK-00544
Species: Cynomolgus
Expression System: HEK293
IL-8/CXCL8 Protein, Cynomolgus, Recombinant (His)
TMPK-00480
Species: Cynomolgus
Expression System: HEK293
TLR3 Protein (Primary Amine Labeling), Human, Recombinant (His), Biotinylated
TMPK-00406
Species: Human
Expression System: HEK293
TAFA2/FAM19A2 Protein, Human, Recombinant (hFc)
TMPY-02946
Species: Human
Expression System: HEK293
RGMA Protein, Human, Recombinant (His & Avi), Biotinylated
TMPK-00279
Species: Human
Expression System: HEK293
RGMA Protein, Human, Recombinant (His & Avi)
TMPK-00278
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Human, Recombinant (His & hFc)
TMPY-01056
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His & hFc)
TMPY-01221
Species: Mouse
Expression System: HEK293
Claudin-11 Protein, Human, Recombinant (mFc)
TMPY-03175
Species: Human
Expression System: HEK293
Wint7b Protein, Human, Recombinant (His & Myc & SUMO)
TMPH-03756
Species: Human
Expression System: E. coli
Nogo Receptor/RTN4R Protein, Human, Recombinant (His)
TMPY-03144
Species: Human
Expression System: HEK293
Nogo Receptor/RTN4R Protein, Mouse, Recombinant (His)
TMPY-01163
Species: Mouse
Expression System: HEK293
WISP3/CCN6 Protein, Mouse, Recombinant (His)
TMPH-02573
Species: Mouse
Expression System: E. coli
TAFA4 Protein, Human, Recombinant (His)
TMPJ-01279
Species: Human
Expression System: E. coli
MGAT5 Protein, Human, Recombinant (His)
TMPY-01856
Species: Human
Expression System: HEK293
ATP5PB Protein, Human, Recombinant (His & Myc)
TMPH-00964
Species: Human
Expression System: E. coli
SDF-1 Protein, Rhesus, Recombinant (hFc)
TMPY-02184
Species: Rhesus
Expression System: HEK293
SDF-1 Protein, Mouse, Recombinant
TMPY-03289
Species: Mouse
Expression System: E. coli
SDF-1 Protein, Human, Recombinant (His)
TMPY-02749
Species: Human
Expression System: E. coli
TAFA1/FAM19A1 Protein, Mouse, Recombinant (His & Myc)
TMPH-02576
Species: Mouse
Expression System: E. coli
MAG Protein, Mouse, Recombinant (hFc)
TMPY-04662
Species: Mouse
Expression System: HEK293
MAG Protein, Mouse, Recombinant (His)
TMPY-04676
Species: Mouse
Expression System: HEK293
SDF-1 Protein, Canine, Recombinant
TMPY-03580
Species: Canine
Expression System: E. coli
MAG Protein, Human, Recombinant (His)
TMPY-02569
Species: Human
Expression System: HEK293
MAG Protein, Human, Recombinant (hFc)
TMPY-03147
Species: Human
Expression System: HEK293
tPA Protein, Human, Recombinant (His)
TMPJ-00332
Species: Human
Expression System: Human Cells
S100B Protein, Mouse, Recombinant (His)
TMPJ-00990
Species: Mouse
Expression System: E. coli
SULT4A1 Protein, Human, Recombinant
TMPJ-01296
Species: Human
Expression System: E. coli
EsxB Protein, Mycobacterium tuberculosis, Recombinant (His)
TMPH-03010
Species: Mycobacterium tuberculosis
Expression System: Yeast
Tau-D Protein, Human, Recombinant (His)
TMPJ-00827
Species: Human
Expression System: E. coli
Doppel/PRND Protein, Human, Recombinant (His)
TMPY-00350
Species: Human
Expression System: HEK293
Doppel/PRND Protein, Human, Recombinant (hFc)
TMPY-00347
Species: Human
Expression System: HEK293
Neuropeptide Y Protein, Human, Recombinant (hFc)
TMPY-00286
Species: Human
Expression System: HEK293
Cat No. Product Name
L5900 CNS-Penetrant Compound Library

516 compounds
A unique collection of 516 CNS-Penetrant compounds for high throughput screening (HTS) and high content screening (HCS);
L2600 Neuronal Signaling Compound Library

2540 compounds
A unique collection of 2540 compounds targeting CNS signaling for high throughput screening (HTS) and high content screening (HCS) for new drugs;
L7700 Neural Regeneration Compound Library

529 compounds
A unique collection of 149 neuroregeneration related compounds for high throughput and high content screening;
L2800 Serotonin Receptor-Targeted Compound Library

275 compounds
A unique collection of 275 compounds targeting serotonin receptors for high throughput screening and high content screening;
L4300 Wnt/Hedgehog/Notch Compound Library

240 compounds
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
L2610 Neurotransmitter Receptor Compound Library

1513 compounds
A unique collection of 1513 neurotransmitter receptor compounds, can be used for HTS and HCS screening;
TargetMol