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HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
Cat. No. Product name CAS No. Purity Chemical Structure
TN3572 Calyxin H 202596-22-3 98%
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TN1901 (-​)​-Maackiain 2035-15-6 98%
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
T14905 CCT251236 1693731-40-6 98%
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
TN2360 Falcarinol 21852-80-2 98%
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pan...
T6442 CH5138303 959763-06-5 98%
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
T13076 Tamoxifen-​d5 157698-32-3 98%
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T18018 HS-27 1562024-11-6 98%
HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
T16719 Radicicol 12772-57-5 98%
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: ...
T11355 Gamitrinib TPP 1131626-46-4 98%
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor.
T11356 Gamitrinib TPP hexafluorophosphate 1131626-47-5 98%
Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA...
TN3070 4beta-Hydroxywithanolide E 54334-04-2 98%
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T15088 Debio 0932 1061318-81-7 98%
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
TN4604 Myricanone 32492-74-3 98%
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T6804 Chetomin 1403-36-7 98%
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T13547L AMP-PCP disodium 7414-56-4 98%
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
TN5254 Wighteone 51225-30-0 98%
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
T15671 KU-32 956498-70-7 98%
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
TN4183 Hardwickiic acid 1782-65-6 98%
Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic ac...
T13547 AMP-PCP 3469-78-1 98%
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
TP1496L P5 Ligand for Dnak and DnaJ acetate TP1496L 98%
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).
Calyxin H
TN3572
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
(-​)​-Maackiain
TN1901
(-)-Maackiain, a phytoalexin, which is an anti-allergic compound that suppresses the up-regulation of the histamine H1 receptor (H1R) gene.
CCT251236
T14905
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
Falcarinol
TN2360
Falcarinol (Panaxynol) is a natural, orally active Hsp90 inhibitor targeting both the N-terminal and C-terminal of Hsp90 with limited toxicities. Falcarinol (Pan...
CH5138303
T6442
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
Tamoxifen-​d5
T13076
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
HS-27
T18018
HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
Radicicol
T16719
Radicicol is an antifungal antibiotic, impairs mitochondrial replication by targeting P. falciparum topoisomerase VIB. Radicicol is an inhibitor of Hsp90 (IC50: ...
Gamitrinib TPP
T11355
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor.
Gamitrinib TPP hexafluorophosphate
T11356
Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity. Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA...
4beta-Hydroxywithanolide E
TN3070
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
Debio 0932
T15088
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
Myricanone
TN4604
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Chetomin
T6804
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
AMP-PCP disodium
T13547L
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
Wighteone
TN5254
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
KU-32
T15671
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
Hardwickiic acid
TN4183
Hardwickiic acid modulates hippocampal [(3)H]NA overflow evoked by a mild depolarizing stimulus by acting at presynaptic opioid receptor subtypes. Hardwickiic ac...
AMP-PCP
T13547
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
p5 Ligand for Dnak and DnaJ acetate
TP1496L
p5 Ligand for Dnak and DnaJ acetate is a nonapeptide. It is a high-affinity ligand for DnaK (E. coli Hsp70) and DnaJ (E. coli Hsp40).
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