T18018 |
HS-27
|
1562024-11-6
|
98%
|
|
HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
|
T6960 |
PU-H71
|
873436-91-0
|
98%
|
|
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
|
TQ0131 |
Rocaglamide
|
84573-16-0
|
98%
|
|
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
|
T15088 |
Debio 0932
|
1061318-81-7
|
98%
|
|
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
|
T13076 |
Tamoxifen-d5
|
157698-32-3
|
98%
|
|
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
|
T39321 |
CC-99677
|
1887069-10-4
|
98%
|
|
CC-99677 is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonst...
|
TN2360 |
Falcarinol
|
21852-80-2
|
98%
|
|
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
|
T14905 |
CCT251236
|
1693731-40-6
|
98%
|
|
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
|
T13547 |
AMP-PCP
|
3469-78-1
|
98%
|
|
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
|
TN3572 |
Calyxin H
|
202596-22-3
|
98%
|
|
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
|
T13547L |
AMP-PCP disodium
|
7414-56-4
|
98%
|
|
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
|
TN4160 |
Goniothalamin
|
17303-67-2
|
98%
|
|
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
|
TN4604 |
Myricanone
|
32492-74-3
|
98%
|
|
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
|
T6804 |
Chetomin
|
1403-36-7
|
98%
|
|
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
|
T11355 |
Gamitrinib TPP
|
1131626-46-4
|
98%
|
|
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
|
T6442 |
CH5138303
|
959763-06-5
|
98%
|
|
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
|
TN3070 |
4beta-Hydroxywithanolide E
|
54334-04-2
|
98%
|
|
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
|
T11356 |
Gamitrinib TPP hexafluorophosphate
|
1131626-47-5
|
98%
|
|
Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
|
T15671 |
KU-32
|
956498-70-7
|
98%
|
|
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
|
TN5254 |
Wighteone
|
51225-30-0
|
98%
|
|
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
|