HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.

Cat. No.	Product name	CAS No.	Purity
T18018	HS-27	1562024-11-6	98%
T18018	HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
T6960	PU-H71	873436-91-0	98%
T6960	PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
TQ0131	Rocaglamide	84573-16-0	98%
TQ0131	Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
T15088	Debio 0932	1061318-81-7	98%
T15088	Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13076	Tamoxifen-d5	157698-32-3	98%
T13076	Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T39321	CC-99677	1887069-10-4	98%
T39321	CC-99677 is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonst...
TN2360	Falcarinol	21852-80-2	98%
TN2360	Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
T14905	CCT251236	1693731-40-6	98%
T14905	CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
T13547	AMP-PCP	3469-78-1	98%
T13547	AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
TN3572	Calyxin H	202596-22-3	98%
TN3572	Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
T13547L	AMP-PCP disodium	7414-56-4	98%
T13547L	AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
TN4160	Goniothalamin	17303-67-2	98%
TN4160	Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN4604	Myricanone	32492-74-3	98%
TN4604	Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T6804	Chetomin	1403-36-7	98%
T6804	Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T11355	Gamitrinib TPP	1131626-46-4	98%
T11355	Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
T6442	CH5138303	959763-06-5	98%
T6442	CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
TN3070	4beta-Hydroxywithanolide E	54334-04-2	98%
TN3070	4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T11356	Gamitrinib TPP hexafluorophosphate	1131626-47-5	98%
T11356	Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
T15671	KU-32	956498-70-7	98%
T15671	KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
TN5254	Wighteone	51225-30-0	98%
TN5254	Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...