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HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
Cat. No. Product name CAS No. Purity Chemical Structure
T18018 HS-27 1562024-11-6 98%
HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
T6960 PU-H71 873436-91-0 98%
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
TQ0131 Rocaglamide 84573-16-0 98%
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
T15088 Debio 0932 1061318-81-7 98%
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13076 Tamoxifen-​d5 157698-32-3 98%
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T39321 CC-99677 1887069-10-4 98%
CC-99677 is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonst...
TN2360 Falcarinol 21852-80-2 98%
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
T14905 CCT251236 1693731-40-6 98%
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
T13547 AMP-PCP 3469-78-1 98%
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
TN3572 Calyxin H 202596-22-3 98%
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
T13547L AMP-PCP disodium 7414-56-4 98%
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
TN4160 Goniothalamin 17303-67-2 98%
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
TN4604 Myricanone 32492-74-3 98%
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
T6804 Chetomin 1403-36-7 98%
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
T11355 Gamitrinib TPP 1131626-46-4 98%
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
T6442 CH5138303 959763-06-5 98%
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
TN3070 4beta-Hydroxywithanolide E 54334-04-2 98%
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
T11356 Gamitrinib TPP hexafluorophosphate 1131626-47-5 98%
Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
T15671 KU-32 956498-70-7 98%
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
TN5254 Wighteone 51225-30-0 98%
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
HS-27
T18018
HS-27 is a fluorescently-tethered inhibitor of Hsp90 with SNX-5422 tethered via a PEG linker to a fluorescein isothiocyanate or FITC. HS-27 can be used in see-an...
PU-H71
T6960
PU-H71 is an effective selective HSP90 inhibitor with an IC50 of 51 nM.
Rocaglamide
TQ0131
Rocaglamide, isolated from the genus Aglaia, can be used to treat coughs, injuries, asthma, and inflammatory skin diseases. It is a potent inhibitor of NF-κB act...
Debio 0932
T15088
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
Tamoxifen-​d5
T13076
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
CC-99677
T39321
CC-99677 is a selectively targeted covalent MAPKAPK2 (MK2) inhibitor for autoimmune diseases that translates biochemical potency into cellular potency as demonst...
Falcarinol
TN2360
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
CCT251236
T14905
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
AMP-PCP
T13547
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Calyxin H
TN3572
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
AMP-PCP disodium
T13547L
AMP-PCP disodium is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90...
Goniothalamin
TN4160
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
Myricanone
TN4604
Myricanone has antioxidant, and anticancer activities, it has apoptosis-promoting ability by triggering caspase activation, and suppression of cell proliferation...
Chetomin
T6804
Chetomin is an inhibitor of HIF-1 by weaken transcription of HIF-1, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.
Gamitrinib TPP
T11355
Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor exhibiting potent anti-cancer activity. Additionally, Gamitrinib TPP functions as a mitochondrial matr...
CH5138303
T6442
CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.
4beta-Hydroxywithanolide E
TN3070
4beta-Hydroxywithanolide E(4bHWE) can inhibit the growth of colon cancer monolayer and spheroid cultures, it assert its anti-tumor activity in carcinogenic progr...
Gamitrinib TPP hexafluorophosphate
T11356
Gamitrinib TPP hexafluorophosphate is a potent HSP90 inhibitor that specifically targets the mitochondria, demonstrating notable anti-cancer activity. It functio...
KU-32
T15671
KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.
Wighteone
TN5254
Wighteone is an antifungal isoflavone.Wighteone has in vitro cytocidal activity against KB cells, it has a potent anti-proliferative effect on human leukemia HL-...
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