Home Tools
Log in
Cart

HSP

Heat shock proteins (HSP) are a family of proteins that are produced by cells in response to exposure to stressful conditions. They were first described in relation to heat shock, but are now known to also be expressed during other stresses including exposure to cold, UV light and during wound healing or tissue remodeling. Many members of this group perform chaperone functions by stabilizing new proteins to ensure correct folding or by helping to refold proteins that were damaged by the cell stress.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T15088 Debio 0932 1061318-81-7 98%
Debio 0932
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
T13076 Tamoxifen-​d5 157698-32-3 98%
Tamoxifen-​d5
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
T78808 NDNA4 98%
NDNA4
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cyt...
T78809 NDNA3 98%
NDNA3
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cell...
T78863 HSP90-IN-25 98%
HSP90-IN-25
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].
T78942 HSP90-IN-23 98%
HSP90-IN-23
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrest...
T79083 HSP90-IN-22 442898-75-1 98%
HSP90-IN-22
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKB...
T79285 TRAP1-IN-1 98%
TRAP1-IN-1
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for T...
T79286 TRAP1-IN-2 98%
TRAP1-IN-2
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative ph...
T79323 PROTAC Hsp90α degrader 1 98%
PROTAC Hsp90α degrader 1
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibit...
T80742 Zelavespib hydrochloride 98%
Zelavespib hydrochloride
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.
T82166 HSP90-IN-27 525577-38-2 98%
HSP90-IN-27
HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].
T82167 HSP70/SIRT2-IN-2 1796557-72-6 98%
HSP70/SIRT2-IN-2
HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].
T82802 BX-2819 1184181-50-7 98%
BX-2819
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 t...
TN2360 Falcarinol 21852-80-2 98%
Falcarinol
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
T73038 HSP90-IN-19 2927442-48-4 98%
HSP90-IN-19
HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with an IC50 of 0.27 μM. It is utilized in the research of vir...
T73125 SMTIN-T140 2851532-40-4 98%
SMTIN-T140
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity b...
T13547 AMP-PCP 3469-78-1 98%
AMP-PCP
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
TN3572 Calyxin H 202596-22-3 98%
Calyxin H
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
TN4160 Goniothalamin 17303-67-2 98%
Goniothalamin
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
Debio 0932
T15088
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
Tamoxifen-​d5
T13076
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
NDNA4
T78808
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cyt...
NDNA3
T78809
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cell...
HSP90-IN-25
T78863
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].
HSP90-IN-23
T78942
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrest...
HSP90-IN-22
T79083
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKB...
TRAP1-IN-1
T79285
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for T...
TRAP1-IN-2
T79286
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative ph...
PROTAC Hsp90α degrader 1
T79323
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibit...
Zelavespib hydrochloride
T80742
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.
HSP90-IN-27
T82166
HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].
HSP70/SIRT2-IN-2
T82167
HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].
BX-2819
T82802
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 t...
Falcarinol
TN2360
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
HSP90-IN-19
T73038
HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with an IC50 of 0.27 μM. It is utilized in the research of vir...
SMTIN-T140
T73125
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity b...
AMP-PCP
T13547
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
Calyxin H
TN3572
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
Goniothalamin
TN4160
Goniothalamin induces apoptosis in various cancer cell lines and has gastroprotective activity.
1 2 3 4 5 6
TargetMol