T15088 |
Debio 0932
|
1061318-81-7
|
98%
|
|
Debio 0932 is an orally active inhibitor of HSP90 (IC50s: 100 and 103 nM for HSP90α and HSP90β, respectively).
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T13076 |
Tamoxifen-d5
|
157698-32-3
|
98%
|
|
Tamoxifen-d5 is a deuterium labeled Tamoxifen. Tamoxifen is a selective modulator of estrogen receptor (SERM). Tamoxifen is a potent activator of Hsp90 and enhan...
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T78808 |
NDNA4
|
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98%
|
|
NDNA4 (compound 17) is a selective Hsp90α inhibitor (IC50: 0.34 μM), characterized by its permanent charge and low membrane permeability. It exhibits minimal cyt...
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T78809 |
NDNA3
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|
98%
|
|
NDNA3 (compound 14) selectively inhibits Hsp90α with an IC50 of 0.51 μM, demonstrating low membrane permeability and minimal toxicity to Ovcar-8 and MCF-10A cell...
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T78863 |
HSP90-IN-25
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|
98%
|
|
HSP90-IN-25 (compound 4a) is an inhibitor targeting HSP90, specifically impeding its ATPase function [1].
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T78942 |
HSP90-IN-23
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|
98%
|
|
HSP90-IN-23 (Comp 12-1), a heat shock protein 90 (HSP90) inhibitor, exhibits potent activity with an IC50 of 9nM. It promotes apoptosis in tumor cells and arrest...
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T79083 |
HSP90-IN-22
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442898-75-1
|
98%
|
|
HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in SKB...
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T79285 |
TRAP1-IN-1
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|
98%
|
|
TRAP1-IN-1 (compound 35) is a potent, selective TRAP1 inhibitor affecting the mitochondrial variant of Hsp90. It exhibits over 250-fold greater selectivity for T...
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T79286 |
TRAP1-IN-2
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98%
|
|
TRAP1-IN-2, also known as compound 36, is a selective degrader of the TRAP1 client protein that does not affect Hsp90-cytosolic clients. It inhibits oxidative ph...
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T79323 |
PROTAC Hsp90α degrader 1
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|
98%
|
|
Compound X10g (PROTAC Hsp90α degrader 1) is a selective agent targeting Hsp90α for degradation and is utilized in breast cancer research. It demonstrates inhibit...
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T80742 |
Zelavespib hydrochloride
|
|
98%
|
|
Zelavespib (PU-H71) hydrochloride is a potent inhibitor of Hsp90, exhibiting an IC50 value of 51 nM in MDA-MB-468 cells.
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T82166 |
HSP90-IN-27
|
525577-38-2
|
98%
|
|
HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].
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T82167 |
HSP70/SIRT2-IN-2
|
1796557-72-6
|
98%
|
|
HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].
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T82802 |
BX-2819
|
1184181-50-7
|
98%
|
|
BX-2819 is an Hsp90 inhibitor that exhibits potent antiproliferative activity with an IC50 of 41 nM . It effectively suppresses the growth of NCI-N87 and HT-29 t...
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TN2360 |
Falcarinol
|
21852-80-2
|
98%
|
|
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-termin...
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T14905 |
CCT251236
|
1693731-40-6
|
98%
|
|
CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen. It inhibits HSF1-mediated HSP72 inducti...
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T73038 |
HSP90-IN-19
|
2927442-48-4
|
98%
|
|
HSP90-IN-19 is a potent inhibitor of heat shock protein 90 (Hsp90), exhibiting inhibitory activity with an IC50 of 0.27 μM. It is utilized in the research of vir...
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T73125 |
SMTIN-T140
|
2851532-40-4
|
98%
|
|
SMTIN-T140 (compound 6a), a potent TRAP1 (tumor-necrosis-factor-receptor associated protein 1) inhibitor with an IC50 of 1.646 μM, exhibits anticancer activity b...
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T13547 |
AMP-PCP
|
3469-78-1
|
98%
|
|
AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.
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TN3572 |
Calyxin H
|
202596-22-3
|
98%
|
|
Calyxin H at 1uM can increase the expression of heat shock factor 1 (HSF1), it has a possible application as a heat shock protein (HSP) inducer.
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