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Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Cat. No. Product name CAS No. Purity Chemical Structure
T5539 GS-443902 1355149-45-9 98%
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T37514 Hydroxy Dimetridazole 936-05-0 98%
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
T36061 N-Desmethyl Sildenafil 139755-82-1 98%
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
T13564 AZ7550 1421373-99-0 98%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T20723 LGE-899 1221722-10-6 98%
LGE-899 is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.
T12095 Monomethyl fumarate 2756-87-8
Monomethyl fumarate is a potent agonist of GPR109A .
T11641 N-Desmethyl imatinib 404844-02-6
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T24047 Etilevodopa hydrochloride 39740-30-2
Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T2687 Omeprazole sulfide 73590-85-9 100%
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
T4282 S-methyl-KE-298 143584-75-2 96.90%
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
T4350 Palifosfamide 31645-39-3 97%
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
TQ0045 2-Hydroxy atorvastatin calcium salt 265989-46-6 97.06%
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
T5320 Tulipalin A 547-65-9 98%
Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
T7440 P,p'-DDE 72-55-9 98%
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T10157 Regorafénib N-oxyde (M2) 835621-11-9 98.03%
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
T10152 4-Methylamino antipyrine 519-98-2 98.20%
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
T4000 (±)-Equol 94105-90-5 98.28%
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
T4710 3-Methoxytyramine hydrochloride 1477-68-5 98.42%
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be foun...
T5158 N-Desmethylclozapine 6104-71-8 98.45%
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T0050 Ampyrone 83-07-8 98.57%
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
Hydroxy Dimetridazole
T37514
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
N-Desmethyl Sildenafil
T36061
N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
LGE-899
T20723
LGE-899 is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.
Monomethyl fumarate
T12095
Monomethyl fumarate is a potent agonist of GPR109A .
N-Desmethyl imatinib
T11641
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
Etilevodopa hydrochloride
T24047
Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
Omeprazole sulfide
T2687
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
S-methyl-KE-298
T4282
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
2-Hydroxy atorvastatin calcium salt
TQ0045
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
Tulipalin A
T5320
Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
p,p'-DDE
T7440
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
Regorafénib N-oxyde (M2)
T10157
Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
4-Methylamino antipyrine
T10152
4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
(±)-Equol
T4000
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
3-Methoxytyramine hydrochloride
T4710
3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be foun...
N-Desmethylclozapine
T5158
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
Ampyrone
T0050
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
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