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Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.
Cat. No. Product name CAS No. Purity Chemical Structure
T5539 GS-443902 1355149-45-9 98%
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T77551 6'-hydroxydihydrocinchonidine 5962-19-6 98%
6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococc...
T12095 Monomethyl fumarate 2756-87-8 98%
Monomethyl fumarate is a potent agonist of GPR109A .
T37514 Hydroxy Dimetridazole 936-05-0 98%
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
TN1352 N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide 883715-22-8 98%
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a Macamide impurity that may be used in the study of metabolic diseases.
T11039 Didesethyl chloroquine 4298-14-0 98%
Didesethyl chloroquine is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chlo...
T24047 Etilevodopa hydrochloride 39740-30-2 98%
Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T18750 N-Deshydroxyethyl Dasatinib 910297-51-7 98%
N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.N...
T4282 S-methyl-KE-298 143584-75-2 98%
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
T4350 Palifosfamide 31645-39-3 98%
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
TQ0045 2-Hydroxy atorvastatin calcium salt 265989-46-6 98%
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
T13564 AZ7550 1421373-99-0 98%
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T5320 Tulipalin A 547-65-9 98%
Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
T7440 P,p'-DDE 72-55-9 98%
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T4000 (±)-Equol 94105-90-5 98%
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
T5158 N-Desmethylclozapine 6104-71-8 98%
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T0050 Ampyrone 83-07-8 98%
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
T11641 N-Desmethyl imatinib 404844-02-6 98%
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T6328 Desmethyl Erlotinib 183321-86-0 98%
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
T2687 Omeprazole sulfide 73590-85-9 98%
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
GS-443902
T5539
GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
6'-hydroxydihydrocinchonidine
T77551
6'-hydroxydihydrocinchonidine is a metabolite of quinine, with antimicrobial and antitumor activity, and inhibitory effect on Trypanosoma brucei and Streptococc...
Monomethyl fumarate
T12095
Monomethyl fumarate is a potent agonist of GPR109A .
Hydroxy Dimetridazole
T37514
Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide
TN1352
N-(3-Methoxybenzyl-(9z,12z)-octadecadienamide is a Macamide impurity that may be used in the study of metabolic diseases.
Didesethyl chloroquine
T11039
Didesethyl chloroquine is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chlo...
Etilevodopa hydrochloride
T24047
Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
N-Deshydroxyethyl Dasatinib
T18750
N-Deshydroxyethyl Dasatinib is a metabolite of Dasatinib, a dasatinib-based molecule that degrades ABL by binding to the IAP ligand via a linker to form SNIPER.N...
S-methyl-KE-298
T4282
S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
Palifosfamide
T4350
Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
2-Hydroxy atorvastatin calcium salt
TQ0045
2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
AZ7550
T13564
AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
Tulipalin A
T5320
Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
p,p'-DDE
T7440
4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
(±)-Equol
T4000
Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
N-Desmethylclozapine
T5158
N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
Ampyrone
T0050
4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.
N-Desmethyl imatinib
T11641
N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
Desmethyl Erlotinib
T6328
OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
Omeprazole sulfide
T2687
Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
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