Drug Metabolite

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom oxygenations, reductions, and dehydrogenations, heteroatom dealkylations, hydroxylations, can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No.	Product name	CAS No.	Purity
T5539	GS-443902	1355149-45-9	98%
T5539	GS-441524 was shown to be a safe and effective treatment for feline infectious peritonitis (FIP). The optimum dosage was found to be 4.0 mg/kg SC q24h for at lea...
T37514	Hydroxy Dimetridazole	936-05-0	98%
T37514	Dimetridazole is a nitroimidazole-based compound with antibacterial and anticoccidial activity. It was once widely used in the treatment of parasitic infections ...
T36061	N-Desmethyl Sildenafil	139755-82-1	98%
T36061	N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T20723	LGE-899	1221722-10-6	98%
T20723	LGE-899 is a main metabolite of Sonidegib which is an inhibitor of the hedgehog pathway. The Tmax of LGE-899(60 h) is much longer than Sonidegib.
T12095	Monomethyl fumarate	2756-87-8
T12095	Monomethyl fumarate is a potent agonist of GPR109A .
T11641	N-Desmethyl imatinib	404844-02-6
T11641	N-Desmethyl imatinib is a metabolite of Imatinib, which is a multi-target inhibitor of c-Kit, v-Abl, and PDGFR.
T24047	Etilevodopa hydrochloride	39740-30-2
T24047	Etilevodopa HCl is a prodrug of levodopa. It also has greater gastric solubility and significant brain penetration.
T2687	Omeprazole sulfide	73590-85-9	100%
T2687	Omeprazole sulfide is a metabolite of Omeprazole, which is a proton pump inhibitor.
T4282	S-methyl-KE-298	143584-75-2	96.90%
T4282	S-methyl-KE-298 is the second main metabolite in plasma,is a methyl conjugate of deacetyl-KE-298.KE-298 inhibits matrix metalloproteinase (MMP-1) production from...
T4350	Palifosfamide	31645-39-3	97%
T4350	Palifosfamide lysine (ZIO-201) is a stable form of palifosfamide. Palifosfamide lysine has broad activity in sarcoma lines in vitro. The IC50 ranges from 2.25 to...
TQ0045	2-Hydroxy atorvastatin calcium salt	265989-46-6	97.06%
TQ0045	2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt which is a potent HMG-CoA reductase inhibitor (IC50 = 8 nM).
T5320	Tulipalin A	547-65-9	98%
T5320	Tulipalin A (2-Methylenebutyrolactone) which has some phytotoxicity is a natural compound extracted from Tulipa gesneriana.
T7440	P,p'-DDE	72-55-9	98%
T7440	4,4'-DDE is a metabolite and degradation product of the organochlorine pesticide DDT
T10157	Regorafénib N-oxyde (M2)	835621-11-9	98.03%
T10157	Regorafénib N-oxyde M2 is an active metabolite of Regorafenib. Regorafenib is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, RET, Kit, and Raf-1 (IC50s: 13/4.2...
T10152	4-Methylamino antipyrine	519-98-2	98.20%
T10152	4-Methylamino antipyrine is an active metabolite of Metamizole. Metamizole is a pyrazolone non-steroidal anti-inflammatory drug (NSAID) and inhibits COX. 4-Methy...
T4000	(±)-Equol	94105-90-5	98.28%
T4000	Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora. The estrogen receptor (E...
T4710	3-Methoxytyramine hydrochloride	1477-68-5	98.42%
T4710	3-Methoxytyramine hydrochloride is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be foun...
T5158	N-Desmethylclozapine	6104-71-8	98.45%
T5158	N-Desmethylclozapine is an antagonist of serotonin (5-HT) receptor subtype 5-HT2C (IC50: 7.1 nM). It also is an antagonist at dopamine D4 receptors, an agonist a...
T0050	Ampyrone	83-07-8	98.57%
T0050	4-Aminoantipyrine is a reagent for glucose determination in the presence of peroxidase and phenol.