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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11831 | LDN-27219 | Others | |
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM. | |||
T12909 | SID 26681509 | Cysteine Protease , Parasite | |
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM). | |||
T24932 | Vatanidipine | AE-0047,AE 0047,AE0047 | Calcium Channel |
Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi... | |||
T70470L | Isomer-CM 352 | isomer-1542205-83-3 | MMP |
isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage. | |||
T25372 | EMD57033 | EMD-57033,(+)-EMD 57033,EMD 57033 | Calcium Channel , Carbonic Anhydrase |
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction. | |||
T9597 | H2S Donor 5a | Endogenous Metabolite | |
H2S Donor 5a is a H2S donor that could mimic the slow and continuous H(2)S generation process. | |||
T20206 | Oxymethurea | CSI Paste,Carbamol,Caurite,Dimethylolurea | Others |
Oxymethurea (CSI Paste) is a modified urea and can be used as in agricultural fields as a slow-release fertilizer. | |||
T24421 | LY-2624803 | DB-7,LY2624803,HY-10275,LY 2624803 | 5-HT Receptor , Histamine Receptor |
LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep. | |||
T28748 | Selodenoson | RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009 | Adenosine Receptor |
Selodenoson (RG-14202) is a selective adenosine A1 receptor agonist used to slow the heart rate in patients with atrial fibrillation and to treat arrhythmias. | |||
T0377 | Clofazimine | NSC-141046 | DNA , Antibacterial , Antibiotic |
Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria. | |||
T21769L | β-Pompilidotoxin Acetate | β-Pompilidotoxin Acetate(216064-36-7 Free base) | Sodium Channel |
β-Pompilidotoxin Acetate is a wasp venom peptide. β-Pompilidotoxin Acetate can slow sodium channel inactivation and increase steady-state sodium current in cells. | |||
T26822 | Bisaramil hydrochloride | RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957 | Potassium Channel , Adrenergic Receptor |
Bisaramil hydrochloride (Bisaramil) is a novel diazabicyclononane antiarrhythmic compound that inhibits the generation of free radicals.Bisaramil hydrochloride blocks sodium currents and inhibits the slow Ca(2+) action p... | |||
T22830 | GYY4137 | GYY 4137 morpholine salt | Others |
GYY4137 (GYY 4137 morpholine salt) is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity. | |||
T30188L | Atagabalin HCl | PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base) | Calcium Channel |
Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia. | |||
TP1545L1 | FFAGLDD amine salt | Others | |
FFAGLDD amine salt is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release. | |||
T7502L | PF 05089771 | PF-05089771,PF05089771 | Sodium Channel |
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent. | |||
T3193 | Pimelic diphenylamide 106 | Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 | HDAC |
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs. | |||
T17197 | UCL 2077 | ||
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker,with IC50 of 500 nM in hippocampal neurons in culture, having minima... | |||
T1439 | Lacidipine | SN-305,GX-1048,GR-43659X | Apoptosis , Calcium Channel , Reactive Oxygen Species |
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi... | |||
T0029 | Procaine | Duracaine,Spinocaine,Novocaine,Vitamin H3 | Histone Demethylase , DNA/RNA Synthesis , Sodium Channel |
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. | |||
T5117 | Hexaflumuron | Others | |
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies. Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also b... | |||
T12425 | PF-06424439 methanesulfonate | Acyltransferase , Transferase | |
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh... | |||
T6541 | Ibutilide Fumarate | Corvert Fumarate,U70226E | Calcium Channel , Sodium Channel |
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar... | |||
T61111 | UCB-5307 | TNF | |
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas... | |||
T24415 | Lotrifen | Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta | Others |
Lotrifen (Privaprol), an agent of non-hormonal antifertility, causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slo... | |||
T1641 | Strontium ranelate | Distrontium renelate,S12911 | Calcium Channel , CaSR |
Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in... | |||
T13387L | Zatebradine hydrochloride | UL-FS-49CL,UL-FS-49 | Others , HCN Channel |
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl... | |||
T4440 | Saclofen | GABA Receptor | |
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function... | |||
T15257 | Etripamil | MSP-2017,(-)-MSP-2017 | Calcium Channel |
Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells... | |||
T6707 | Tiotropium Bromide hydrate | BA-679 BR hydrate,BA 679BR | AChR |
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a... | |||
T0866 | Propafenone | Rythmol,Propafenonum | Potassium Channel , MRP , Sodium Channel |
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.... | |||
T22662 | Chromanol 293B | Others | |
slow delayed rectifier K+ current (IKs) blocker | |||
T35323 | ZYZ-803 | ZYZ 803 | |
ZYZ-803 is a slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure. | |||
T71836 | 2-FPBA | ||
2-FPBA is a potent, reversible and slow-onset inhibitor of mandelate racemase (MR). | |||
T69375 | Oxarbazole | ||
Oxarbazole is an antagonist of slow-reacting substance of anaphylaxis. | |||
T38456 | Tribenuron | ||
Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed. | |||
T23710 | Watanidipine dihydrochloride | ||
Watanidipine dihydrochloride is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions. | |||
T28393 | Pfn1-IN-C2 | Pfn1 inhibitor C2 | |
Pfn1-IN-C2, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ... | |||
T38050 | CP-609754 | Transferase | |
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... | |||
T24348 | L 708286 | L708286,L-708286,DFKi | |
L 708286 is an agent of peptide-based phenethylcarbamoyldifluoromethylene. It is a slow-binding inhibitor of human leucocyte elastase (HLE). | |||
T28798 | SL-25.1188 | SL25.1188 | |
SL-25.1188 is a monoamine oxidase B (MAO-B) inhibitor. SL-25.1188 is characterized by reversible binding, high brain uptake, and very slow plasma metabolism in vivo. | |||
T38730 | Ara-F-NAD+ | ||
Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM. | |||
T34750 | Sut 8701 | Sut8701,Sut-8701 | |
Sut 8701 is a cholecystokinin analog that prevents cholinergic degeneration in the rat cerebral cortex following basal forebrain lesioning and can slow down the degenerative processes in Alzheimer's disease. | |||
T74032 | Ara-F-NAD+ sodium | ||
Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2]. | |||
T37494 | 11-trans Leukotriene E4 | 11-trans Leukotriene E4 | |
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum. | |||
T31119 | CVT-2759 | UNII-42E8N8RC9Z,CVT2759 | |
CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias... | |||
T15361 | FW1256 | Others | |
FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for can... | |||
T28392 | Pfn1-IN-C1 | Pfn1INC1,Pfn1 IN C1,Pfn1 inhibitor C1 | |
Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ... | |||
T81586 | Oxonol V | ||
Oxonol V serves as a (slow-response) [sensitive] probe designed for the quantification of cellular membrane potential. | |||
T15285 | FK706 | Serine Protease | |
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively)... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8195 | Lotusine | Others | |
Lotusine is a pure alkaloid extracted from the Nelumbo nucifera Gaertn. It shows effects on the action potentials in the myocardium and slow inward current in cardiac Purkinje fibers. | |||
TMS2182 | Trans-Zeatinriboside | Ribosylzeatin,Zeatin Riboside,Trans-Zeatin Riboside | Others |
trans-Zeatinriboside (Ribosylzeatin) is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process,... | |||
TN4368 | Kaempferol-3,7-di-O-β-glucoside | Kaempferol 3,7-di-O-glucoside | Glucosidase , Amylase |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena, It can inhibit α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3, 7-di-o-β-Glucoside has neuroprotective ac... | |||
T1591 | Ancitabine hydrochloride | NSC 145668 HCl,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C | Others , DNA/RNA Synthesis , Autophagy |
Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytar... | |||
T3606 | γ-Oryzanol | Gamma-Oryzanol,Oliver,Gammariza | DNA Methyltransferase |
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b... | |||
TN3540 | Broussonin C | Tyrosinase , Antifection | |
Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase. | |||
T78489 | Lotusine hydroxide | ||
Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1]. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03957 | Troponin C Protein, Human, Recombinant | Human | E. coli |
Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin int... | |||
TMPY-02219 | Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) | H1N1 | E. coli |
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N... | |||
TMPH-03071 | TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO) | Ornithodoros moubata | E. coli |
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa. | |||
TMPH-03070 | TAP Protein, Ornithodoros moubata, Recombinant (His) | Ornithodoros moubata | P. pastoris (Yeast) |
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa. | |||
TMPH-00782 | OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO) | Haemophilus influenzae | E. coli |
Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows... | |||
TMPH-00674 | OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) | E. coli | E. coli |
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow... | |||
TMPH-02377 | OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc) | Klebsiella pneumoniae | E. coli |
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow... | |||
TMPH-03472 | OmpA Protein, Salmonella typhi, Recombinant (His) | Salmonella typhi | E. coli |
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow... | |||
TMPY-03603 | AHSP Protein, Human, Recombinant | Human | E. coli |
AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globi... | |||
TMPH-00056 | Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) | Anemonia sulcata | P. pastoris (Yeast) |
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent... | |||
TMPY-01479 | SPG3A Protein, Human, Recombinant (GST) | Human | Baculovirus Insect Cells |
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin... |
Cat No. | Product Name | ||
---|---|---|---|
L9860 | Antidepressant Compound Library | 1163 compounds | |
1163 compounds associated with depression that can be used for high-throughput and high-content screening | |||
L9830 | Anti-Parkinson's Disease Compound Library | 857 compounds | |
A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS. | |||
L7110 | Anti-Hypertension Compound Library | 678 compounds | |
678 hypertension-related small molecules for high-throughput and high-content screening. |