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Search Results for " slow "

Targets

80

Compounds

7

Natural Products

11

Recombinant Proteins

3

Libraries

Cat No. Product Name Synonyms Targets
T11831 LDN-27219 Others
LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.
T12909 SID 26681509 Cysteine Protease , Parasite
SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).
T24932 Vatanidipine AE-0047,AE 0047,AE0047 Calcium Channel
Vatanidipine (AE0047) is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.A slow-onset and long-lasting hypotensive action was observed in various experimental hypertensi...
T70470L Isomer-CM 352 isomer-1542205-83-3 MMP
isomer-CM 352 is a metalase inhibitor that can be used to slow brain damage.
T25372 EMD57033 EMD-57033,(+)-EMD 57033,EMD 57033 Calcium Channel , Carbonic Anhydrase
EMD57033 is a cardiac troponin C (cTnC) activator, a dominant Ca2+ sensitizer, which functions by binding to cardiac/slow skeletal troponin C heterodimers to promote cardiac contraction.
T9597 H2S Donor 5a Endogenous Metabolite
H2S Donor 5a is a H2S donor that could mimic the slow and continuous H(2)S generation process.
T20206 Oxymethurea CSI Paste,Carbamol,Caurite,Dimethylolurea Others
Oxymethurea (CSI Paste) is a modified urea and can be used as in agricultural fields as a slow-release fertilizer.
T24421 LY-2624803 DB-7,LY2624803,HY-10275,LY 2624803 5-HT Receptor , Histamine Receptor
LY-2624803 is a 5-HT2A receptor antagonist and histamine receptor inverse agonist that can be used to improve slow wave sleep.
T28748 Selodenoson RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009 Adenosine Receptor
Selodenoson (RG-14202) is a selective adenosine A1 receptor agonist used to slow the heart rate in patients with atrial fibrillation and to treat arrhythmias.
T0377 Clofazimine NSC-141046 DNA , Antibacterial , Antibiotic
Clofazimine (NSC-141046) is a phenazine dye with anti-mycobacterial and anti-inflammatory activities. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
T21769L β-Pompilidotoxin Acetate β-Pompilidotoxin Acetate(216064-36-7 Free base) Sodium Channel
β-Pompilidotoxin Acetate is a wasp venom peptide. β-Pompilidotoxin Acetate can slow sodium channel inactivation and increase steady-state sodium current in cells.
T26822 Bisaramil hydrochloride RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957 Potassium Channel , Adrenergic Receptor
Bisaramil hydrochloride (Bisaramil) is a novel diazabicyclononane antiarrhythmic compound that inhibits the generation of free radicals.Bisaramil hydrochloride blocks sodium currents and inhibits the slow Ca(2+) action p...
T22830 GYY4137 GYY 4137 morpholine salt Others
GYY4137 (GYY 4137 morpholine salt) is a novel water-soluble and slow releasing H2S donor with vasodilator and antihypertensive activity. GYY4137 also exhibits anti-inflammatory and anticancer activity.
T30188L Atagabalin HCl PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base) Calcium Channel
Atagabalin HCl is a novel voltage-dependent calcium channel (VDCC) α2δ subunit (1 and 2) ligand that affects slow-wave sleep and can be used to treat insomnia.
TP1545L1 FFAGLDD amine salt Others
FFAGLDD amine salt is MMP9 selective cleavage peptides, which used for cytosolic delivery of Doxorubi-cin (DOX) and achieve temporally and spatially controlled slow drug delivery and release.
T7502L PF 05089771 PF-05089771,PF05089771 Sodium Channel
PF 05089771 is a Selective inhibitor of Nav1.7 (IC50 = 11 nM) that interacts with the voltage-sensor domain of domain IV. It shows a slow onset of the block that is depolarization and concentration-dependent.
T3193 Pimelic diphenylamide 106 Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8 HDAC
Pimelic diphenylamide 106 (RGFA-8) is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs.
T17197 UCL 2077
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker,with IC50 of 500 nM in hippocampal neurons in culture, having minima...
T1439 Lacidipine SN-305,GX-1048,GR-43659X Apoptosis , Calcium Channel , Reactive Oxygen Species
Lacidipine (SN-305) is a lipophilic dihydropyridine calcium antagonist with an intrinsically slow onset of activity. Due to its long duration of action, lacidipine does not lead to reflex tachycardia. It displays specifi...
T0029 Procaine Duracaine,Spinocaine,Novocaine,Vitamin H3 Histone Demethylase , DNA/RNA Synthesis , Sodium Channel
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
T5117 Hexaflumuron Others
Hexaflumuron is a chitin synthesis inhibitor used to bait and eliminate termite colonies. Termites are unable to metabolize hexaflumuron and clearance is slow, resulting in up to 100% elimination. Hexaflumuron has also b...
T12425 PF-06424439 methanesulfonate Acyltransferase , Transferase
PF-06424439 methanesulfonate, an orally administered, potent, and selective imidazopyridine diacylglycerol acyltransferase 2 (DGAT2) inhibitor with an IC50 of 14 nM, demonstrates slow reversibility and time-dependent inh...
T6541 Ibutilide Fumarate Corvert Fumarate,U70226E Calcium Channel , Sodium Channel
Ibutilide Fumarate (U70226E) is the fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outwar...
T61111 UCB-5307 TNF
UCB-5307 is a small molecule compound that inhibits TNFR1 signal transduction and downstream function in vitro. The KD of human TNFα is 9 nM. The TNF was directly bound by slow binding kinetics,KD= 6 nM. UCB-5307 can pas...
T24415 Lotrifen Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta Others
Lotrifen (Privaprol), an agent of non-hormonal antifertility, causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slo...
T1641 Strontium ranelate Distrontium renelate,S12911 Calcium Channel , CaSR
Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis. Studies indicate it can also slow the course of osteoarthritis of the knee. The drug is unusual in that it both in...
T13387L Zatebradine hydrochloride UL-FS-49CL,UL-FS-49 Others , HCN Channel
Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochl...
T4440 Saclofen GABA Receptor
Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50: 7.8 μM).1 This compound can be used to determine the function...
T15257 Etripamil MSP-2017,(-)-MSP-2017 Calcium Channel
Etripamil (MSP-2017) displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells...
T6707 Tiotropium Bromide hydrate BA-679 BR hydrate,BA 679BR AChR
Tiotropium Bromide hydrate (BA-679 BR hydrate) is a potent anticholinergic and bronchodilator, serving as a muscarinic receptor antagonist, specifically targeting mAChR. It is developed for treating chronic obstructive a...
T0866 Propafenone Rythmol,Propafenonum Potassium Channel , MRP , Sodium Channel
Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity....
T22662 Chromanol 293B Others
slow delayed rectifier K+ current (IKs) blocker
T35323 ZYZ-803 ZYZ 803
ZYZ-803 is a slow H2S-NO-releasing hybrid, attenuating cardiac dysfunction after heart failure.
T71836 2-FPBA
2-FPBA is a potent, reversible and slow-onset inhibitor of mandelate racemase (MR).
T69375 Oxarbazole
Oxarbazole is an antagonist of slow-reacting substance of anaphylaxis.
T38456 Tribenuron
Tribenuron, a slow acting sulfonylurea herbicide, controls broadleaf weed.
T23710 Watanidipine dihydrochloride
Watanidipine dihydrochloride is a novel dihydropyridine (DHP)-type calcium channel blocker with slow-onset pharmacological actions.
T28393 Pfn1-IN-C2 Pfn1 inhibitor C2
Pfn1-IN-C2, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ...
T38050 CP-609754 Transferase
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n...
T24348 L 708286 L708286,L-708286,DFKi
L 708286 is an agent of peptide-based phenethylcarbamoyldifluoromethylene. It is a slow-binding inhibitor of human leucocyte elastase (HLE).
T28798 SL-25.1188 SL25.1188
SL-25.1188 is a monoamine oxidase B (MAO-B) inhibitor. SL-25.1188 is characterized by reversible binding, high brain uptake, and very slow plasma metabolism in vivo.
T38730 Ara-F-NAD+
Ara-F-NAD+, an arabino analogue of NAD + , is a potent, slow-binding CD38 NADase inhibitor, with a K i of 169 nM.
T34750 Sut 8701 Sut8701,Sut-8701
Sut 8701 is a cholecystokinin analog that prevents cholinergic degeneration in the rat cerebral cortex following basal forebrain lesioning and can slow down the degenerative processes in Alzheimer's disease.
T74032 Ara-F-NAD+ sodium
Ara-F-NAD+ sodium, an arabino analogue of NAD+, serves as a potent, reversible, and slow-binding inhibitor of the CD38 NADase [1] [2].
T37494 11-trans Leukotriene E4 11-trans Leukotriene E4
Slow isomerization of the C-11 double bond of LTE4 leads to the formation of 11-trans LTE4. 11-trans LTE4 is equipotent to LTE4 in contracting guinea pig ileum.
T31119 CVT-2759 UNII-42E8N8RC9Z,CVT2759
CVT-2759 is A potential partial agonist for A(1)-ADORs, and it may be useful to slow atrioventricular node conduction to reduce ventricular rate without causing the atrioventricular block, bradycardia, atrial arrhythmias...
T15361 FW1256 Others
FW1256 is a phenyl analog. It also a slow-releasing hydrogen sulfide (H2S) donor. FW1256 inhibits NF-κB activity and causes cell apoptosis. FW1256 shows potent anti-inflammatory effects. It also has the potential for can...
T28392 Pfn1-IN-C1 Pfn1INC1,Pfn1 IN C1,Pfn1 inhibitor C1
Pfn1-IN-C1, an inhibitor of Profilin1 (Pfn1), has been shown to reduce the overall level of cellular filamentous (F)-actin, slow EC migration and proliferation, and inhibit the angiogenic ability of EC both in vitro and ...
T81586 Oxonol V
Oxonol V serves as a (slow-response) [sensitive] probe designed for the quantification of cellular membrane potential.
T15285 FK706 Serine Protease
FK706 is a slow-binding and competitive human neutrophil elastase inhibitor (IC50: 83 nM; Ki: 4.2 nM). FK706 also inhibits mouse neutrophil elastase and porcine pancreatic elastase (IC50s: 22 nM and 100 nM, respectively)...

Compounds

LDN-27219
T11831
Synonym:
Target: Others
SID 26681509
T12909
Synonym:
Target: Cysteine Protease, Parasite
Vatanidipine
T24932
Synonym: AE-0047,AE 0047,AE0047
Target: Calcium Channel
isomer-CM 352
T70470L
Synonym: isomer-1542205-83-3
Target: MMP
EMD57033
T25372
Synonym: EMD-57033,(+)-EMD 57033,EMD 57033
Target: Calcium Channel, Carbonic Anhydrase
H2S Donor 5a
T9597
Synonym:
Target: Endogenous Metabolite
Oxymethurea
T20206
Synonym: CSI Paste,Carbamol,Caurite,Dimethylolurea
Target: Others
LY-2624803
T24421
Synonym: DB-7,LY2624803,HY-10275,LY 2624803
Target: 5-HT Receptor, Histamine Receptor
Selodenoson
T28748
Synonym: RG14202,DTI0009,DTI-0009,RG-14202,DT-009,DT009
Target: Adenosine Receptor
Clofazimine
T0377
Synonym: NSC-141046
Target: DNA, Antibacterial, Antibiotic
β-Pompilidotoxin Acetate
T21769L
Synonym: β-Pompilidotoxin Acetate(216064-36-7 Free base)
Target: Sodium Channel
Bisaramil hydrochloride
T26822
Synonym: RGH-2957,NK 1556,NK1556,Bisaramil,NK-1556,RGH 2957
Target: Potassium Channel, Adrenergic Receptor
GYY4137
T22830
Synonym: GYY 4137 morpholine salt
Target: Others
Atagabalin HCl
T30188L
Synonym: PD-0200390 HCl,Atagabalin HCl(223445-75-8 Free base)
Target: Calcium Channel
FFAGLDD amine salt
TP1545L1
Synonym:
Target: Others
PF 05089771
T7502L
Synonym: PF-05089771,PF05089771
Target: Sodium Channel
Pimelic diphenylamide 106
T3193
Synonym: Histone Deacetylase Inhibitor VII,TC-H 106,RGFA-8
Target: HDAC
UCL 2077
T17197
Synonym:
Target:
Lacidipine
T1439
Synonym: SN-305,GX-1048,GR-43659X
Target: Apoptosis, Calcium Channel, Reactive Oxygen Species
Procaine
T0029
Synonym: Duracaine,Spinocaine,Novocaine,Vitamin H3
Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel
Hexaflumuron
T5117
Synonym:
Target: Others
PF-06424439 methanesulfonate
T12425
Synonym:
Target: Acyltransferase, Transferase
Ibutilide Fumarate
T6541
Synonym: Corvert Fumarate,U70226E
Target: Calcium Channel, Sodium Channel
UCB-5307
T61111
Synonym:
Target: TNF
Lotrifen
T24415
Synonym: Privaprol,L-12717,DL 717-IT,L 12717,L12717,Canocenta
Target: Others
Strontium ranelate
T1641
Synonym: Distrontium renelate,S12911
Target: Calcium Channel, CaSR
Zatebradine hydrochloride
T13387L
Synonym: UL-FS-49CL,UL-FS-49
Target: Others, HCN Channel
Saclofen
T4440
Synonym:
Target: GABA Receptor
Etripamil
T15257
Synonym: MSP-2017,(-)-MSP-2017
Target: Calcium Channel
Tiotropium Bromide hydrate
T6707
Synonym: BA-679 BR hydrate,BA 679BR
Target: AChR
Propafenone
T0866
Synonym: Rythmol,Propafenonum
Target: Potassium Channel, MRP, Sodium Channel
Chromanol 293B
T22662
Synonym:
Target: Others
ZYZ-803
T35323
Synonym: ZYZ 803
Target:
2-FPBA
T71836
Synonym:
Target:
Oxarbazole
T69375
Synonym:
Target:
Tribenuron
T38456
Synonym:
Target:
Watanidipine dihydrochloride
T23710
Synonym:
Target:
Pfn1-IN-C2
T28393
Synonym: Pfn1 inhibitor C2
Target:
CP-609754
T38050
Synonym:
Target: Transferase
L 708286
T24348
Synonym: L708286,L-708286,DFKi
Target:
SL-25.1188
T28798
Synonym: SL25.1188
Target:
Ara-F-NAD+
T38730
Synonym:
Target:
Sut 8701
T34750
Synonym: Sut8701,Sut-8701
Target:
Ara-F-NAD+ sodium
T74032
Synonym:
Target:
11-trans Leukotriene E4
T37494
Synonym: 11-trans Leukotriene E4
Target:
CVT-2759
T31119
Synonym: UNII-42E8N8RC9Z,CVT2759
Target:
FW1256
T15361
Synonym:
Target: Others
Pfn1-IN-C1
T28392
Synonym: Pfn1INC1,Pfn1 IN C1,Pfn1 inhibitor C1
Target:
Oxonol V
T81586
Synonym:
Target:
FK706
T15285
Synonym:
Target: Serine Protease
1 2
Cat No. Product Name Synonyms Targets
T8195 Lotusine Others
Lotusine is a pure alkaloid extracted from the Nelumbo nucifera Gaertn. It shows effects on the action potentials in the myocardium and slow inward current in cardiac Purkinje fibers.
TMS2182 Trans-Zeatinriboside Ribosylzeatin,Zeatin Riboside,Trans-Zeatin Riboside Others
trans-Zeatinriboside (Ribosylzeatin) is the most active and ubiquitous form of the naturally occurring cytokinins that promote cell division, stimulate shoot proliferation, inhibit root formation, slow the aging process,...
TN4368 Kaempferol-3,7-di-O-β-glucoside Kaempferol 3,7-di-O-glucoside Glucosidase , Amylase
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena, It can inhibit α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3, 7-di-o-β-Glucoside has neuroprotective ac...
T1591 Ancitabine hydrochloride NSC 145668 HCl,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C Others , DNA/RNA Synthesis , Autophagy
Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytar...
T3606 γ-Oryzanol Gamma-Oryzanol,Oliver,Gammariza DNA Methyltransferase
γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the destruction of free radicals in the skin. It has recently b...
TN3540 Broussonin C Tyrosinase , Antifection
Broussonin C and broussin are antifungal compounds. Broussonin C exerts simple reversible slow-binding inhibition against diphenolase.
T78489 Lotusine hydroxide
Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1].

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-03957 Troponin C Protein, Human, Recombinant Human E. coli
Troponin I, also known as TNNC1, is part of the troponin complex. This complex contains 3 subunits: troponin I (TnI), troponin T (TnT) and troponin C (TnC). Troponin I is the inhibitory subunit, blocking actin-myosin int...
TMPY-02219 Influenza A H1N1 (A/Puerto Rico/8/34/Mount Sinai) Non-structural/NS1 Protein (His) H1N1 E. coli
The NS1 Influenza protein is created by the internal protein-encoding, linear negative-sense, single-stranded RNA, NS gene segment and which also codes for the nuclear export protein or NEP, formerly referred to as the N...
TMPH-03071 TAP Protein, Ornithodoros moubata, Recombinant (His & Myc & SUMO) Ornithodoros moubata E. coli
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.
TMPH-03070 TAP Protein, Ornithodoros moubata, Recombinant (His) Ornithodoros moubata P. pastoris (Yeast)
TAP is a slow, tight-binding inhibitor of blood coagulation, specific for factor Xa.
TMPH-00782 OMP P5 Protein, Haemophilus influenzae, Recombinant (His & Myc & SUMO) Haemophilus influenzae E. coli
Acts as a fimbriae subunit, allowing adhesion to host cells.; With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows...
TMPH-00674 OmpA Protein, E. coli O157:H7, Recombinant (His & SUMO) E. coli E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-02377 OmpA Protein, Klebsiella pneumoniae, Recombinant (His & Myc) Klebsiella pneumoniae E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPH-03472 OmpA Protein, Salmonella typhi, Recombinant (His) Salmonella typhi E. coli
With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows dow...
TMPY-03603 AHSP Protein, Human, Recombinant Human E. coli
AHSP, also known as ERAF, is a conserved mammalian erythroid protein which belongs to the AHSP family. It is expressed in blood and bone marrow. AHSP facilitates the production of Hemoglobin A by stabilizing free α-globi...
TMPH-00056 Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) Anemonia sulcata P. pastoris (Yeast)
Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent...
TMPY-01479 SPG3A Protein, Human, Recombinant (GST) Human Baculovirus Insect Cells
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin...
Cat No. Product Name
L9860 Antidepressant Compound Library

1163 compounds
1163 compounds associated with depression that can be used for high-throughput and high-content screening
L9830 Anti-Parkinson's Disease Compound Library

857 compounds
A unique collection of 857 compounds with anti-PD activities or acting on main drug targets of PD can be used for HTS and HCS.
L7110 Anti-Hypertension Compound Library

678 compounds
678 hypertension-related small molecules for high-throughput and high-content screening.
TargetMol