rsv

Ziresovir (RO-0529) is a respiratory syncytial virus fusion protein (RSV F) inhibitor that inhibits RSV activity and can be used in the study of syncytial virus sensing.

Ribavirin (Tribavirin) is a synthetic nucleoside analog of ribofuranose with activity against hepatitis C virus and other RNA viruses.

RSV L-protein-IN-4 (Compound C) is a noncompetitive inhibitor of the RSV polymerase, exhibiting an IC50 of 0.88 μM and demonstrating potent antiviral activity against RSV strains with an EC50 of 0.25 μM [1].

RSV L-protein-IN-3 is an inhibitor of wild-type RSV polymerase with an IC50 of 10.4 μM and an EC50 of 2.1 μM (against RSV) and exhibits lower cytotoxicity than the clinical agent Ribavirin [1].

RSV L-protein-IN-5 (Compound E) serves as a potent inhibitor of the Respiratory Syncytial Virus (RSV), with an EC50 value of 0.1 μM. It targets RSV polymerase with an IC50 of 0.66 μM and impedes RSV mRNA synthesis through the inhibition of transcript guanylation. The compound demonstrates moderate cytotoxicity, with a CC50 of 10.7 μM in HEp-2 cells, and effectively reduces viral titers in mouse models of RSV infection [1].

RSV L-protein-IN-2 (Compound A) is a noncompetitive inhibitor of the RSV polymerase with an IC50 of 4.5 μM and demonstrates antiviral activity against long RSV strains with an EC50 of 1.3 μM [1].

AVG-233 is an orally available RNA-dependent RNA polymerase (RdRp) inhibitor with antiviral activity that blocks respiratory syncytial virus and SARS-CoV-2 replication.AVG-233 is used in the study of respiratory syncytial virus infections.

RSV-IN-1 is an inhibitor of human respiratory syncytical virus (hRSV) and reduced the virus infectivity with IC50 value of 0.11 μM.

RSV IAV-IN-2 (compound 14c) is a potent dual inhibitor of RSV IAV, demonstrating lower cytotoxicity than the clinical drug Ribavirin, and shows potential for RSV and or IAV infection research [1].

RSV-IN-6 (Compound 53) is a specific inhibitor of the respiratory syncytial virus (RSV) that targets the M2-1 protein, demonstrating strong potency with EC50 values of 4.4 μM against RSV-A and 1.3 μM against RSV-B strains [1].

RSV-IN-3 (Compound 1) is a dual inhibitor targeting both the respiratory syncytial virus (RSV) and influenza virus A (IAV), with an anti-RSV efficacy demonstrated by an EC50 of 32.70 μM [1].

RSV-IN-7 (example 253) is a RSV inhibitor ( EC 50 : < 0.4 μΜ) .

RSV-IN-13 (compound 5c) exhibits antiviral activity against RSV with an EC50 value of 0.78 nM. It is utilized in the study of respiratory infections.

Anti-RSV-F HMPV-F Antibody (MPE8) is an antibody. Its expression system is CHO cells, the clone number is MPE8, and the isotype control is IgG1, Lambda.

RSV-IN-2 is a powerful compound that acts as a dual inhibitor of both wild-type and mutant respiratory syncytial virus (RSV) fusion proteins. It efficiently inhibits the activity of these proteins, with an EC50 value of 0.27 nM for the wild-type and 0.70 nM for the D486N-mutant protein.

Anti-RSV-F Antibody (4D7) is an antibody. Its expression system is CHO cells, the clone number is 4D7, and the isotype control is IgG1, Kappa.

RSV IAV-IN-3 (compound 14'i) is a dual inhibitor of respiratory syncytial virus (RSV) with an EC50 of 2.92 μM and influenza A virus (IAV) with an EC50 of 1.90 μM. RSV IAV-IN-3 significantly inhibits luciferase activity in a dose-dependent manner (EC50: 3.89 μM) and suppresses IAV infection, RdRp activity, as well as post-entry replication of IAV and RSV.

Anti-RSV-F Antibody (AM22) is an antibody. Its expression system is CHO cells, the clone number is AM22, and the isotype control is IgG1, Kappa.

RSV-IN-4 (Compound 2) is a dual inhibitor of respiratory syncytial virus (RSV) and influenza virus A (IAV), demonstrating anti-RSV activity with an EC50 of 11.76 μM.

RSV-IN-5 is a potent dual inhibitor of wild-type and mutant respiratory syncytial virus (RSV) fusion proteins.RSV-IN-5 was able to act on wild-type A2 F protein and D486N mutant F protein with EC50 values of 2.0 nM and 8.1 nM, respectively, and exhibited potent anti-RSV effects.

RSV IAV-IN-1 (compound 14e) is a potent dual inhibitor of RSV IAV, exhibiting lower cytotoxicity than Ribavirin and indicating significant potential for researching RSV and or IAV infections [1].

Anti-Human respiratory syncytial virus (RSV) Fusion Glycoprotein RSV-F Antibody (1B191) is a Rabbit IgG monoclonal antibody targeting RSV Human respiratory syncytial virus (RSV) Fusion Glycoprotein RSV-F.

HRSV HMPV-IN-1 (compound 3) is an inhibitor targeting HRSV HMPV, exhibiting EC50 values of < 0.2 μM against human RSV-A and < 0.5 μM for human MPV A2 TN 94-49. This compound is utilized in the study of bronchiolitis and pneumonia.

HRSV hCoV-229E-IN-1 (compound 8X) is an effective inhibitor of HRSV and hCoV-229E, with an IC50 value of 2.1 µM for hCoV-229E. Additionally, HRSV hCoV-229E-IN-1 can inhibit cell viability.