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Results for "

motility

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    120
    TargetMol | Inhibitors_Agonists
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    2
    TargetMol | Compound_Libraries
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    TargetMol | Inhibitors_Agonists
Sperm motility agonist-1
T874301796991-30-4
Sperm motility agonist-1 (compound 745) serves as an agonist for sperm motility and is applicable in researching infertility and promoting fertility enhancement [1].
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10-14 weeks
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Sperm motility agonist-2
T87431926079-67-6
Sperm Motility Agonist-2 (compound 797) serves as a sperm motility enhancer, useful for research in both infertility and fertility enhancement [1].
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10-14 weeks
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Cyclic-di-GMP disodium
5GP-5GP disodium, c-di-GMP disodium, 3',5'-Cyclic diguanylic acid, cyclic diguanylate disodium, Cyclic di-GMP (sodium salt)
T369832222132-40-1
Cyclic-di-GMP disodium (5GP-5GP disodium) is a STING agonist and a second messenger in bacteria. It is involved in a variety of processes in prokaryotes, including biofilm formation, motility, and cell cycle progression. Cyclic-di-GMP disodium (5GP-5GP disodium) exhibits antiproliferative activity against cancer cells, inducing increased CD4 receptor expression and cell cycle arrest, and is a novel therapeutic agent that can be developed to prevent or treat cancer.
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GP2-114
T19345130783-39-0In house
GP2-114 is a catecholamine motility mimetic that produces current-dependent cardiovascular effects when administered via transdermal iontophoresis and can be used to study coronary artery disease (CAD).
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6-8 weeks
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Ecabapide
DQ-2511, DQ2511, DQ 2511
T31597104775-36-2In house
Ecabapide (DQ-2511) is a novel gastrointestinal motility promoter that significantly enhances gastric emptying in SHRSP.Ecabapide activates cyclic GMP-dependent housekeeping Cl- channels in rabbit gastric wall cells.
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6-8 weeks
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Palmitoyl glutamic acid
Palmitoylglutaminic acid, N-Palmitoyl-L-glutamic acid
T3386838079-66-2In house
Palmitoyl glutamic acid (N-Palmitoyl-L-glutamic acid) is an acyl amino acid that inhibits aortic constriction and counteracts haloperidol-induced oral motility disorders.
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6-8weeks
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Relenopride
YKP 10811, SKL-IBS
T839811221416-43-8In house
Relenopride (YKP 10811) is a selective 5-HT4 receptor agonist that promotes intestinal motility and is used in the study of intestinal disorders.
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Carbachol
Carbamoylcholine chloride
T010551-83-2
Carbachol (Carbamoylcholine chloride), an analog of acetylcholine, serves as a valuable tool in the investigation of various physiological responses mediated by nicotinic (nAChR) and muscarinic (mAChR) acetylcholine receptors. These responses include smooth muscle contraction, gut motility, and neuronal signaling. Known for its agonistic properties, Carbachol activates both nAChR and mAChR, with reported Ki values ranging from 10 to 10,000 nM for different receptor types and experimental preparations.
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Trimebutine
Mebutin
T091839133-31-8
Trimebutine (Mebutin) is a spasmolytic agent that regulates intestinal and colonic motility and relieves abdominal pain with antimuscarinic and weak mu-opioid agonist effects. It is marketed for the treatment of irritable bowel syndrome (IBS) and lower gastrointestinal tract motility disorders, with IBS being one of the most common multifactorial GI disorders. It is used to restore normal bowel function and is commonly present in pharmaceutical mixtures as trimebutine maleate salt form. Trimebutine is not an FDA-Approved Clinical drug, but it is available in Canada and several other international countries.
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Propantheline bromide
Neopepulsan, Pro-Banthine, Neometantyl
T100650-34-0
Propantheline bromide (Pro-Banthine) competitively antagonizes acetylcholine activity mediated by muscarinic receptors at neuroeffector sites on smooth muscle and exocrine gland cells. Propantheline Bromide is the bromide salt form of propantheline, a quaternary ammonium compound structurally related to belladonna alkaloids. An aspartic acid residue present in the N-terminal portion of the third transmembrane helix of the muscarinic receptor is believed to form an ionic bond with the tertiary or quaternary nitrogen of the antagonist. Antagonism leads to a reduction of exocrine glands secretions and to relax the bronchial muscle and reduce tone and motility of intestinal smooth muscle.
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Proglumide
T10526620-60-6
Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is used clinically in the drug therapy of gastrointestinal ulcers.
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Chloramphenicol
Levomycetin, Chloromycetin, Chlornitromycin
T120556-75-7
Chloramphenicol (Chloromycetin) is a broad-spectrum antibiotic that inhibits the biosynthesis of bacterial proteins. Chloramphenicol acts primarily on the 50S subunit of the bacterial 70S ribosome and is active against peptidyltransferases, inhibiting the formation of peptide bonds.
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D-Panthenol
Pantothenol, Ilopan, D-Pantothenyl alcohol, Dexpanthenol
T143781-13-0
D-Panthenol (D-Pantothenyl alcohol) is an alcoholic analogue of D-pantothenic acid and cholinergic agent. D-Panthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of D-Panthenol is unclear, it may enhance the effect of acetylcholine. D-Panthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.
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Acotiamide monohydrochloride trihydrate
Acotiamide hydrochloride, YM-443 HCl, Z-338 HCl
T2319773092-05-0
Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
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Sodium lauryl sulfoacetate
Sodium houttuyfonate
T36031847-58-1
Sodium lauryl sulfoacetate (Sodium houttuyfonate) is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
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7-10 days
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sodium lauroyl-α-hydroxyethyl sulfonate
T7283112714-99-5
Sodium houttuyfonate is anti-pseudomonas agents, inhibits virulence-related motility of Pseudomonas.
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Ridaforolimus
MK-8669, Deforolimus, AP23573
T6334572924-54-0
Ridaforolimus (AP23573) is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K Akt signaling pathway.
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Zamifenacin fumarate
UK-76654 fumarate
T13385127308-98-9
Zamifenacin fumarate (UK-76654 fumarate) is a potent, gut-selective antagonist of the muscarinic M3 receptor.
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6-8 weeks
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KBU2046
T156461143863-69-7
KBU2046 is an orally administered compound that inhibits cell motility and invasion, effectively suppressing cancer metastasis and extending lifespan. This compound uniquely targets and binds to chaperone heterocomplexes, selectively modifying the interaction of client proteins involved in motility regulation, while avoiding the characteristics typical of classical HSP90 inhibitors.
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Alosetron hydrochloride
Lotronex, GR 68755C, GR 68755, GR 68755X
T2525122852-69-1
Alosetron hydrochloride (GR 68755) is the hydrochloride salt form of alosetron, a potent and selective 5-HT3 receptor antagonist. Alosetron blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons, thereby affecting the regulation of visceral pain, decreasing gastrointestinal contraction and motility, and decreasing gastrointestinal secretions.
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Betrixaban maleate
T4980936539-80-9
Betrixaban maleate is a non-vitamin K oral anticoagulant whose action is driven by the competitive and reversible inhibition of the factor Xa.
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7-10 days
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Speract TFA(76901-59-2(free base))
T7487L
Speract TFA is a sea urchin egg peptide that regulates sperm motility, also stimulates sperm mitochondrial metabolism.
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RS-25344
T9239152814-89-6
RS-25344 is a potent and selective phosphodiesterase (PDE) 4 inhibitor. It inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.
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pp60 c-src (521-533) (phosphorylated) acetate
TP2137L
pp60 c-src (521-533) (phosphorylated) acetate is a regulator of focal adhesion formation and cell spreading. pp60 c-src (521-533) (phosphorylated) acetate also regulates cell motility and is a key component in the signaling pathway triggered by the motogenic hyaluronan receptor RHAMM.
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