l 14

L14-8 is a potent inducer of ferroptosis and facilitates the degradation of PLK1 through ubiquitination, while enhancing TP53 phosphorylation and SAT1 transcription, leading to ferroptosis and the death of cancer cells. L14-8 is applicable in studies of advanced prostate cancer.

Anti-Mouse L-Selectin/CD62L Antibody (Mel-14) is a rat-derived IgG2a, κ antibody inhibitor targeting mouse L-Selectin/CD62L.

L-Glucose-1-14C is the L-isomer of glucose. It also is the enantiomer of the more common D-glucose.

L-Glutamic-5-14C acid is a bioactive chemical.

PD-1/PD-L1-IN-14 (compound 17) is an inhibitor of PD-1/PD-L1 interaction (IC50=27.8 nM) that promotes PD-L1 dimerization, endocytosis, and degradation.

Beclin1-ATG14L Interaction Inhibitor 1 (COM 19) is a selective inhibitor targeting the specific interaction between Beclin1 and ATG14L. It impedes the formation of complex I in the lipid kinase VPS34, thus inhibiting autophagy, while leaving complex II intact, which relies on the Beclin 1-UVRAG interaction for its integrity and is essential for vesicle transport [1].

C14:1 L-Carnitine chloride is an acylcarnitine lipid.

Pharmatose DCL 14 (D-Lactose monohydrate) is the major sugar present in milk and the main source of energy supplied to the newborn mammalian in its mother's milk. Pharmatose DCL 14 is also an important osmotic regulator of lactation. It could regulate human's intestinal microflora.

ML 145 is a selective and potent antagonist of human GPR35, with no significant activity against GPR35 in any of its immediate rodent homologs.ML 145 has potential anti-inflammatory activity for the study of immunoinflammation.ML 145 is a novel non-steroidal anti-inflammatory agent for the study of rheumatoid arthritis.

JYL 1421 (SC 0030) is an antagonist of TRPV1 receptor (IC50 = 8 nM).

Fpl 14294 is a novel CCK-8 agonist with effective intranasal anorectic activity in the rat.

LysoFos Glycerol 14 is a useful organic compound for research related to life sciences. The catalog number is TF0117 and the CAS number is 326495-21-0.

Pharmatose DCL 14 (Standard) is the standard substance of Pharmatose DCL 14, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Pharmatose DCL 14 (D-Lactose monohydrate) is the major sugar present in milk and the main source of energy supplied to the newborn mammalian in its mother's milk. Pharmatose DCL 14 is also an important osmotic regulator of lactation. It could regulate human's intestinal microflora.

Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.

Methotrexate (WR19039) is a folate analog, an inhibitor of the dihydrofolate reductase DHFR. Methotrexate has antimetabolic, antitumor, and immunosuppressive activities, and is commonly used in rheumatoid arthritis and various tumors.

Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor

PSEM 89S TFA is a brain-penetrant and selective ion channels agonist, and is orthogonally selective for Q79G and L141F, respectively.

CHEMBRDG-BB 7118966 is an inhibitor of Bromodomain-containing protein 4 (human).

D-myo-Inositol-1,4,5,6-tetrahosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella.[1] D-myo-Inositol-1,4,5,6-tetraphosphate (sodium salt) (Ins(1,4,5,6)-P4) is one of several different inositol oligophosphate isomers implicated in signal transduction. Production of Ins(1,4,5,6)-P4 by intestinal epithelial cells increases approximately 2-14 fold, depending on the strain and incubation time, following infection with Salmonella. Ins(1,4,5,6)-P4 antagonizes epidermal growth factor (EGF) signalling through the phosphatidylinositol 3-kinase pathway. Ins(1,4,5,6)-P4 (tested as the D/L racemic mixture) is ~1,000-fold less potent than Ins(1,4,5)-P3 at initiating Ca2+ release when injected into Xenopus oocytes.[2]

MSI-1436 is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTB1B) with an IC50 of approximately 1 μM.

MSI-1436 lactate is a selective, non-competitive inhibitor of the enzyme protein-tyrosine phosphatase 1B (PTP1B) with an IC50 of approximately 1 μM.

3-(Hydroxymethyl)-3-nitro-1-(4-octylphenyl)-1,4-butanediol is a useful organic compound for research related to life sciences and the catalog number is T123968.

3-Amino-3-(hydroxymethyl)-1-(4-octylphenyl)-1,4-butanediol is a useful organic compound for research related to life sciences and the catalog number is T125665.

Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo