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Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing/counteracting diabetic e

I2-IRs ligand-1 (Compound 12d) is an orally active compound capable of crossing the blood-brain barrier. It exhibits high affinity for imidazoline I2 receptors (I2-IRs) with a pKi of 9.98. This compound can enhance cognitive deficits in aging mice and possesses analgesic, anti-inflammatory, and neuroprotective properties. I2-IRs ligand-1 is applicable for research in Alzheimer's disease and related pain disorders.

Cholesterol is the primary sterol in mammals, accounting for approximately 20–25% of the plasma membrane structure. It plays a key role in regulating membrane fluidity, permeability, and protein function. As an endogenous agonist of estrogen-related receptor α (ERRα), cholesterol is widely involved in metabolic regulation and serves as a precursor for the synthesis of hormones and bile acids. It is commonly used in experimental models of hyperlipidemia.

MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction. It disrupts molecular association of MG53 with IRS-1 and abolishes MG53-induced IRS-1 ubiquitination and degradation in skeletal muscle, leading to elevated IRS-1 expression level and increased insulin signaling and glucose uptake

Irsogladine maleate ,with CAS No. 84504-69-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Irsogladine maleate provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.

Cirsiliol is a 5-lipoxygenase (5-LOX) inhibitor and low affinity benzodiazepine receptor ligand.Cirsiliol inhibits cell proliferation and promotes apoptosis of OS cells.Cirsiliol shows antitumor activity against OS cells in an in situ xenograft tumor model and can be used to study colon cancer.

Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 receptor and inhibitory effect on phosphodiesterase.

Firsocostat S enantiomer is the less active S enantiomer of Firsocostat.

Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.

Custirsen sodium is a highly specific antisense oligonucleotide that inhibits the production of clusterin, an anti-apoptotic protein. Clusterin expression is upregulated in response to chemotherapy and contributes to drug resistance.

Danvantisen sodium is an antisense oligonucleotide targeting STAT3 with potential antineoplastic properties. It binds to STAT3 mRNA, thereby inhibiting the translation of the transcript. Suppressing STAT3 expression can lead to the induction of tumor cell apoptosis and inhibition of tumor cell growth.

Zotadirsen is a phosphorodiamidate morpholino oligomer (PMO) that targets exon 44 of the dystrophin gene. It is utilized in the synthesis of AOC drugs, such as Delpacibart zotadirsen, and is applicable in the study of Duchenne muscular dystrophy (DM).

Rostudirsen is an oligonucleotide and a component of Zelecimentrostudirsen. This compound is created by linking Rostudirsen with a fragment antibody known as Zeleciment. Zeleciment specifically binds to transferrin receptor 1 (TfR1), which is highly expressed in muscle tissue. Zelecimentrostudirsen targets muscle tissue, facilitating exon 51 skipping within cells, thus enabling muscle cells to produce dystrophin protein close to its full-length form.

Lufepirsen is an unmodified antisense oligonucleotide that targets Connexin43, a specific protein in the eye involved in the wound healing process.

Opemalirsen is an antisense oligonucleotide targeting apolipoprotein L1 (APOL1), employed in kidney disease research.

Lufepirsen sodium is an unmodified antisense oligonucleotide that targets Connexin43. Connexin43 is a specific protein found in the eye involved in the wound healing process.

Nivudirsen is an antisense oligonucleotide that enhances the synthesis of functional dystrophin protein.

Afovirsen is a phosphorothioate oligonucleotide. It is complementary to the mRNA sequence of the initiation codon for the E2 protein, which is essential for the replication of HPV types 6 and 11.

Nivudirsen sodium is an antisense oligonucleotide that facilitates the synthesis of functional dystrophin protein.

Afovirsen sodium is a phosphorothioate oligonucleotide. It is complementary to the mRNA sequence that encodes the start codon of the E2 protein, which is essential for the replication of HPV type 6 and type 11.

Frenlosirsen is an antisense oligonucleotide that targets IRF4. It is utilized in studies related to relapsed/refractory multiple myeloma (RRMM).

Frenlosirsen sodium is an antisense oligonucleotide targeting IRF4. It is utilized in research related to relapsed or refractory multiple myeloma (RRMM).

Renadirsen is an antisense oligonucleotide designed to induce exon 45 skipping of the dystrophin protein in vivo.