il-17a

IL-17A & IL-17F Heterodimer Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 31 kDa and the accession number is NP_002181.1&NP_443104.1.

Expression system: CHO Cells
Length: 1-155, Full Length
Activity: ELISA、SPR、Cells

Expression system: HEK293 Cells
Length: 24-155, Full Length of Mature Protein
Activity: ELISA

Expression system: E. coli
Length: 20-155 & 31-163, Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 22-158, Partial
Activity: ELISA、Cells

Expression system: E. coli
Length: 20-155, Full Length of Mature Protein
Activity: Cell Activity

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

Expression system: E. coli
Length: 18-150, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 24-155 (mutation), Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 20-155, Full Length of Mature Protein
Activity: Not Tested

IL-17A Protein, Mouse, Recombinant (CHO) is expressed in CHO Cells. The accession number is Q62386.

IL-17A Protein, Human, Recombinant (His) is expressed in CHO Cells. The accession number is Q16552.

Expression system: HEK293 Cells
Length: 26-158, Partial
Activity: ELISA

Expression system: HEK293 Cells
Length: 22-158, Partial
Activity: BLI、Cells

IL-17A Protein, Cynomolgus, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 18.2 kDa and the accession number is A0A2K5TTB0.

Expression system: HEK293 Cells
Length: 24-155, Full Length of Mature Protein
Activity: ELISA、SPR

Expression system: HEK293 Cells
Length: 26-158, Partial
Activity: ELISA

IL-17A & IL-17F Heterodimer Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.5 kDa and the accession number is XP_001106391.1&NP_001248216.1.

IL-17A Protein, Cynomolgus, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 15.1 kDa and the accession number is A0A2K5TTB0.

IL-17A Protein, Pig, Recombinant (His & Myc) is expressed in E. coli. The accession number is Q60I29.

IL-21 and IL-21R were highly expressed in the lesional skin and peripheral blood of psoriasis patients. IL-21 promoted CD4 T cells proliferation and Th17 cells differentiation and inhibiting Treg cells differentiation by upregulating RORγt expression and downregulating Foxp3 expression, with increased expression and secretion of IL-17A and IL-22.Microbial translocation and the associated immune activation during HIV-1 infection may lead to high expression levels of the IL-21R activation marker in RM B cells, a feature associated with increased apoptosis and a reduced number of these cells in the circulation.

Expression system: E. coli
Length: 21-180, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 19-197, Full Length of Mature Protein
Activity: SPR

Expression system: E. coli
Length: 31-163, Full Length of Mature Protein
Activity: BLI、ELISA、Cells