hsv-1

B220, an antiviral agent, inhibits the growth of HSV-1, HSV-2, and human cytomegalovirus (CMV).

Brivudine (BVDU), an antiviral medicine, is used in the therapy of herpes zoster.

Oxytetracycline (Terramycin) is a TETRACYCLINE analog isolated from the actinomycete STREPTOMYCES rimosus and used in a wide variety of clinical conditions.

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects.

Penciclovir (BRL 39123) is a Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited.

Oxytetracycline Hydrochloride (Dalimycin) is a tetracycline derivative produced by Streptomyces rimosus with antimicrobial activity. It interferes with the binding of aminoacyl-tRNA to the mRNA-ribosome complex, resulting in preventing peptide elongation and inhibiting protein synthesis.

Ganciclovir sodium (Cytovene IV sodium) is the sodium salt of Ganciclovir with antiviral activity, especially against cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1).

Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.

1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.

Oxytetracycline Dihydrate (Terramycin Dihydrate) is a prescription antibiotic, interfering with the ability of bacteria to produce essential proteins.

Gallic aldehyde shows potent antiviral activity against HSV-1.

Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities

BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).

SIBA (5'-Deoxy-5'-isobutylthioadenosine) is a synthetic analogue of SAH, acts as an inhibitor of S-adenosylmethionine-mediated transmethylation. SIBA can interfere with a variety of enzymatic activities in vitro, such as SAH hydrolase, methylthioadenosine phosphorylase and cAMP phosphodiesterase. SIBA reversibly blocks the multiplication of herpes simplex type 1 virus (HSV)

Tromantadine is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).

Tromantadine hydrochloride is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).

Pritelivir (BAY 57-1293) (BAY 57-1293) is a potent helicase-primase inhibitor with active against HSV-1 and HSV-2 (IC50: 20 nM).

1. (2S)-Isoxanthohumol shows an antiviral activity towards herpes viruses (HSV1 and HSV2) and bovine viral diarrhea virus (BVDV). 2. Isoxanthohumol is a polyphenol with antioxidant, anti-inflammatory, and antiangiogenic properties, seems to regulate in vivo vascular proliferation and stabilization and the EC-VSMC-inflammatory crosstalk.

Oxytetracycline (OTC) is a broad-spectrum antibiotic that acts by inhibiting protein synthesis in bacteria. Oxytetracycline prevents the binding from aminoacil-tRNA to the complex m-ribosomal RNA. Oxytetracycline also possesses anti-HSV-1 activity[1][2][3

1. Betulonic acid (Liquidambaric acid) amide stimulated the regenerative response in hepatocytes under conditions of combined toxic exposure and promoted recovery of their qualitative and quantitative characteristics, which was accompanied by a significant decrease in the severity of liver fibrosis and the absence of cirrhotic transformation of the liver. 2. Betulonic acid derivatives have a promising cytostatic activity in vitro and could be used as potential leads for the development of new type of anti-cancer agents. 3. Betulonic acid has antiholestatic effects in mice.

Isatin-β-thiosemicarbazone is a potent inhibitor of herpes simplex virus (HSV), exhibiting antiviral activity against both HSV-1 and HSV-2. Moreover, it is an effective anti-poxvirus agent for the treatment of monkeypox, orthopox, and cowpox viruses.

FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.

HSV-1-IN-2 (compound 5i) is a potent inhibitor of Herpes Simplex Virus type 1 (HSV-1), with an EC50 of 1.95 μM. This compound suppresses apoptosis and enhances survival rates in mouse models of herpes encephalitis.

HSV-1/HSV-2-IN-2 is an inhibitor of HSV-1, HSV-2, and VV, exhibiting antiviral activity with EC50 values of 6.8, 8.9, and 8.9 μM, respectively [1].