degeneration — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5447	Anle138b		Beta Amyloid , Others
	Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease		Beta Amyloid , Others
T3849	Kinsenoside	(+)-Kinsenoside	Apoptosis , Nrf2
	Kinsenoside ((+)-Kinsenoside) shows significant antihepatotoxic, and anti-inflammatory activities. Kinsenoside could be useful for repairing beta cells in pancreatic islet injury as well as improving its function, it cou...		Apoptosis , Nrf2
T9928	Ranibizumab		VEGFR
	Ranibizumab is a humanized monoclonal antibody fragment designed to target and inhibit vascular endothelial growth factor (VEGF), including VEGF110, VEGF121, and VEGF165. Ranibizumab's ability to selectively target and n...		VEGFR
T10122	Anti-neurodegeneration agent 1		Others
	Anti-neurodegeneration agent 1 a neurodegeneration-targeting agent.		Others
T5359	RCGD423		Interleukin
	RCGD423, a small molecule gp130 modulator, prevents articular cartilage degeneration and promotes repair.		Interleukin
T13157	TG 100801	TG100801,TG 100572	VEGFR , Src
	TG 100801 is a dual inhibitor of VEGFr2 and Src family (Src and YES) kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).		VEGFR , Src
T27084	Crisdesalazine	AAD2004,AAD 2004,AAD-2004	Prostaglandin Receptor
	Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre...		Prostaglandin Receptor
T2706	Palomid 529	P529,SG 00529	Apoptosis , mTOR
	Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.		Apoptosis , mTOR
T77600	Methyl-4-oxoretinoate		Apoptosis
	Methyl-4-oxoretinoate is a synthetic retinoid compound with anticancer compounds that can induce differentiation and apoptosis in cancer cells.Methyl-4-oxoretinoate is used in the treatment of acne, psoriasis, and other ...		Apoptosis
T7493	AG-13958	AG-013958	VEGFR
	AG-13958 (AG-013958) (AG-013958), a potent VEGFR tyrosine kinase inhibitor, for the treatment of age-related macular degeneration.		VEGFR
TMS0418	Dihydroergotoxine mesylate	Ergoloid mesylates	GABA Receptor
	Dihydroergotoxine mesylate (Ergoloid mesylates) is mainly used to improve symptoms and physical symptoms of mental degeneration related to aging.		GABA Receptor
T19739	Simazine	Tafazine,Aquazine,Radocon,Herbex	Others
	Simazine (Tafazine) is a chlorotriazine herbicide and pesticide. Simazine may lead to testicular degeneration, neuroendocrine disruption, mammary cancer, and fetal developmental delays.		Others
T10531	BGB-102	JNJ-26483327	EGFR , VEGFR , FLT , Src
	BGB-102 (JNJ-26483327) is a kinase inhibitor targeting FLT3 and YES1 and an antagonist targeting EGFR and VEGFR3, which may be useful in the study of macular degeneration and diseases associated with genetic disorders an...		EGFR , VEGFR , FLT , Src
T34399	Rovatirelin	KPS-0373,S0373,S-0373,S 0373	AChE
	Rovatirelin (S-0373) is a newly synthesized thyrotropin-releasing hormone (TRH) analog that ameliorates cytosine arabinoside-induced motor dysfunction in a rat model of spinal cerebellar degeneration via acetylcholine an...		AChE
TN1833	Karacoline		NF-κB
	Karacolinem is a natural product, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway.		NF-κB
T3S1858	Lutein	Vegetable Lutein,Xanthophyll,Bo-Xan,Xantofyl	Antibacterial
	1. Lutein (Xantofyl) has antitumour action. 2. Lutein has antimutagenic action. 3. Lutein has a wide range of antimicrobial action. 4. Lutein is potentially useful for treating macular degeneration.		Antibacterial
T28273L	OT-551 HCl	OT-551 HCl（627085-11-4 Free base）	NF-κB
	OT-551 HCl is an NF-Κb inhibitor, a disubstituted hydroxylamine with antioxidant properties can be used for the treatment of cataracts and age-related macular degeneration and geographic atrophy (GA).		NF-κB
T8860	DSRM-3716		Androgen Receptor
	Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.		Androgen Receptor
T13048	SynuClean-D	SC-D	Others
	SynuClean-D (SC-D) is an α-synuclein aggregation inhibitor preventing fibril propagation, disrupting mature amyloid fibrils, and abolishing the degeneration of dopaminergic neurons in an animal model of Parkinson’s disea...		Others
T35182	Xinidamine	BRN 0891979,Xinidaminum,Xinidamino
	Xinidamine (BRN 0891979) has antitumor activity and can be used to study benign prostatic hyperplasia, macular degeneration and prostatic intraepithelial neoplasia .Xinidamine inhibits the proliferation of PWR-1E cells w...