c26

C26 Sphingomyelin (d18:1/26:0) is a sphingolipid used in the study of neurological diseases.

Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.

LX-5 is a selective activator of the p38 mitogen-activated protein kinase (MAPK) pathway. LX-5 de-represses a subset of endogenous genes repressed by DNA methylation.

C26:1 Sphingomyelin (d18:1/26:1(17Z)) is a lipid molecule that can be used in life science related research. The CAS number of C26:1 Sphingomyelin (d18:1/26:1(17Z)) is 1448012-56-3.

C26:0 Lyso PC-d9 is a deuterated compound of C26:0 Lyso PC. C26:0 Lyso PC has a CAS number of 1213783-80-2.

C26-Ceramide (Standard) is a reference standard for research and analysis in studies involving C26-Ceramide. C26-Ceramide is a lipid composed of two hydrophobic tails, one saturated and the other unsaturated. It can be utilized in the development of lipid nanoparticles or liposomes.

C26-Ceramide is a lipid composed of two hydrophobic tails, one saturated and the other unsaturated. It can be utilized in the development of lipid nanoparticles or liposomes.

SLC26A3-IN-1 is an inhibitor of the anion-exchange protein SLC26A3 with an IC50 value of 340 nM. SLC26A3, a solute carrier (SLC) protein and member of the SLC26 family, exhibits a wide range of anionic specificities for chloride, bicarbonate, sulfate, and oxalate. Downregulated in adenomas (DRA), SLC26A3 is involved in intestinal absorption of chloride and oxalate and is associated with chloride-losing diarrhea.

E64FC26 is a potent protein disulfide isomerase (PDI) family pan-inhibitor with antitumor activity, inhibits PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6, and can be used in the study of multiple myeloma and pancreatic cancer.

AC260584 is an allosteric agonist of the M1 muscarinic receptor with a pEC50 of 7.6.

NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.

AIC263282 is a potent capsid assembly modulator for the hepatitis B virus (HBV) with an EC50 of 3.8 nM. It exhibits an IC50 of 61 nM against hERG and effectively inhibits viral replication and hepatitis B surface antigen (HBsAG) in primary human hepatocytes.

MC2646 is an effective antiparasitic agent that induces autophagy (autophagic) and activates the AMPK/TFEB pathway.

IC261 (SU-5607) is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.

AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity that inhibits neuroblastoma tumour growth by inducing differentiation.AC265347 can be used to study neuroblastoma.

NSC265473 is an ABCG2 substrate.

CC260, a selective inhibitor for PI5P4Kα and PI5P4Kβ with Kis of 40 nM and 30 nM respectively, exhibits minimal to no inhibition against other protein kinases like Plk1 and RSK2. It is applicable in the research of cell energy metabolism, diabetes, and cancer[1].

EC2629 is a highly potent DNA crosslinking agent targeting the folate receptor.

(E/Z)-E64FC26 is a potent protein disulfide isomerase (PDI) family inhibitor with potential antitumor activity and affinity for PDIA1, PDIA3, PDIA4, TXNDC5 and PDIA6. (E/Z)-E64FC26 can be used for myeloma research.

MC2652 (compound 1a) is a potent LSD1 inhibitor with high inhibitory effects in MV4-11 and NB4 leukemia cells and exhibits antiproliferative activity against LNCaP prostate cancer cells [1].

FLC26 is a CK2 inhibitor with IC50 = 9 nM

DC260126 is a small-molecule antagonist of FFA1 (GPR40)

SLC26A3-IN-2 is an orally available and highly potent inhibitor of the anion-exchange protein SLC26A3 for the study of constipation. dCMP disodium (2'2'') is a potent inhibitor of the anion-exchange protein SLC26A3.

NSC260594 is a chemical compound that promotes apoptosis by binding to the shallow groove of the Mcl-1 protein and suppressing its expression through down-regulation of Wnt signaling proteins. Additionally, it can identify the G9-G10-A11-G12 RNA tetraloop of HIV, thereby obstructing the attachment of the Gag protein to the 5'-UTR. This compound demonstrates the potential to impede tumor proliferation and is utilized in the study of Triple-negative breast cancers (TNBCs) [1].