c 33

PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research.

C33:0-CoA (C33:0-Coenzyme A) is a derivative of coenzyme A.

KRAS G12C inhibitor 33 is a KRAS G12C inhibitor used in cancer research.

NSC 330770 is a demethylated hydrogenated molecule and a potent inhibitor of tubulin polymerization (IC50 = 2 μM). It induces GTPase activity and promotes the formation of abnormal polymers.

NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.

DRC 3321 is a bioactive chemical.

SC 33459 is a hypolipidemic agent.

Formiminoglutamic acid (NSC 334078) is a biomarker for formylaminoglutaminuria, an indicator of folate deficiency.

Chloroquinoxaline sulfonamide (Chloroquinoxaline) is a topoisomerase II alpha/beta toxin with antitumor activity and immunosuppressive properties that inhibits the proliferation of B16 melanoma cells in mice, and can be used to study metastatic colorectal cancer. It can be used to study metastatic colorectal cancer.

K777 is a potent, orally active, and irreversible inhibitor of cysteine protease, functioning as a potent CYP3A4 inhibitor (IC50 = 60 nM) and a selective CCR4 antagonist, which inhibits chemotaxis. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypanosoma cruzi, and cathepsins B and L, targeting cathepsin-mediated cell entry and exhibiting broad-spectrum antiviral activity. It inhibits EBOV and SARS-CoV pseudovirus entry with IC50 values of 0.87 nM and 0.68 nM, respectively.

Clopimozide (R-29764) acts as a calcium channel antagonist and inhibits [3H] nilandipine binding.Clopimozide is a novel and orally available long-acting antischizophrenic psychostatic compound.

Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity.

Clorprenaline hydrochloride (Clorprenaline HCl) is a beta-2 adrenergic agonist with bronchodilator activity.

Aminoglutethimide (BA-16038), an aromatase inhibitor, is used in the therapy of advanced BREAST Y.

Phenyl salicylate (NSC-33406) is a chemical substance. It is synthesized by heating salicylic acid with phenol.

NPC 15199 (FMOC-L-Leucine) is an anti-inflammatory agent.

K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.

Hexadecanolide is an agent of bioactive chemicals.

MC3343, a DNMT inhibitor with IC50 values of 5.7 μM for DNMT1 and 1.7 μM for DNMT3a, affects tumor proliferation by blocking osteosarcoma cells in the G1 or G2/M phase and induces osteogenic differentiation by specifically re-expressing genes that regulate this physiological process, and is able to show synergistic effects in combination with adriamycin and cisplatin (CDDP).

Diglycyl-histidine is a tripeptide complexed with cupric ion designed to mimic specific Cu(II) transport site of ascorbate on albumin molecule.

Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins and attenuates the occurrence of torsade de pointes, and may be used in the study of glaucoma in adolescents.

Clonixeril (NSC 335504) is a non-nucleotide modulator of hSTING. It exhibits weak agonistic activity at micromolar concentrations and can antagonize the hSTINGWT pathway at low femtomolar (10^-15 M) and even attomolar (10^-18 M) concentrations in some cases. Clonixeril inhibits hSTING oligomerization at concentrations ranging from 1 aM to 1 pM.

NSC339614 potassium is a selective GluN1/GluN2C and GluN1/GluN2D receptors potentiator.

C-333H is a new PPARalpha/gamma dual agonist.